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The map label for this gene is purM [H]

Identifier: 52784502

GI number: 52784502

Start: 705458

End: 706501

Strand: Direct

Name: purM [H]

Synonym: BLi00701

Alternate gene names: 52784502

Gene position: 705458-706501 (Clockwise)

Preceding gene: 52784501

Following gene: 52784503

Centisome position: 16.71

GC content: 52.39

Gene sequence:

>1044_bases
GTGTTGTCTGAAAGCTATAAAAACGCCGGGGTTGATATTGAAGCCGGATATGAAGCCGTAAAACGAATGAAAAAACATGT
GGAAAGAACGAAGCGAATCGGCGCAATGGGCGGACTTGGCGGGTTTGGCGGCATGTTTGACCTGTCGGAACTGCCGTACA
AACAGCCGGTTCTCATTTCGGGAACGGACGGTGTCGGCACAAAACTGAAGCTCGCTTTTGCGATGGACAAGCATGACACG
ATCGGCATCGATGCCGTCGCGATGTGTGTCAACGATGTGCTCGCTCAAGGAGCGGAGCCGCTTTTCTTCCTCGATTACCT
TGCGGTCGGAAAAGCCGATCCCGTCAAAATTGAAGAGATCGTAAAAGGCGTCGCAGAAGGCTGCGTACAGTCGGGATCAG
CGCTTGTCGGCGGAGAAACGGCGGAAATGCCGGGGCTTTATACAGAGGATGAATACGATATCGCCGGGTTCTCGGTCGGA
GCTGCCGAAAAAGATGGCATCGTCACGGGCGAAAATATCAGCGAAGGGCACCTTTTAATCGGACTTTCTTCAAGCGGCCT
TCACAGCAACGGCTTCTCTCTCGTTCGGAAAGTTCTTCTTGAAGATGCCGGTCTGAACCTTGATGAGACGTATGCACCTT
TTGAACGGCCTCTTGGCGAAGAGCTTTTAGAGCCGACGAAAATCTATGTCAAGCCTGTCCTTGAAGCGGTGAAATCAGGC
AAAATCGCCGGCATGGCGCACGTGACCGGCGGCGGTTTTATCGAAAACCTGCCGCGCATGATGCCCGATGGCCTCGGCGT
TGAAATCGACATCGGCTCCTGGCCCGTTCCTCCTATCTTCCCGTTCATTCAGGAGAAAGGCGGCCTGAAATCCGAGGAAA
TGTTTAATGTTTTCAATATGGGAATCGGCTTTGTTCTTGCGGTGAAAGAAGAGGATATGACAGACGTGATCCAAACGCTC
GAAAACAACGGTGAAAAAGCCTATCTCATCGGCAGAGTGAAAGCCGGAAGCGGCGTTGTGTTTGGCGGTGCCGGTCTTTC
ATGA

Upstream 100 bases:

>100_bases
CGCCTGGCCTGCTGAAATGAATAAAGGGCAGCAGAGGCAATGCGGCTGCTCTTTTGATTTTGAATATCACGAATGGACAA
GCGCGGAATAAGGAGTGATT

Downstream 100 bases:

>100_bases
AAAAATTCGCGGTATTTGCATCAGGAAGCGGAACGAATTTTGAAGCAATCGAAAGAAGAATGAGAGAAGAGAACTGGGAT
GCCGAAATTGTCCTCGTCGT

Product: phosphoribosylaminoimidazole synthetase

Products: NA

Alternate protein names: AIR synthase; AIRS; Phosphoribosyl-aminoimidazole synthetase [H]

Number of amino acids: Translated: 347; Mature: 347

Protein sequence:

>347_residues
MLSESYKNAGVDIEAGYEAVKRMKKHVERTKRIGAMGGLGGFGGMFDLSELPYKQPVLISGTDGVGTKLKLAFAMDKHDT
IGIDAVAMCVNDVLAQGAEPLFFLDYLAVGKADPVKIEEIVKGVAEGCVQSGSALVGGETAEMPGLYTEDEYDIAGFSVG
AAEKDGIVTGENISEGHLLIGLSSSGLHSNGFSLVRKVLLEDAGLNLDETYAPFERPLGEELLEPTKIYVKPVLEAVKSG
KIAGMAHVTGGGFIENLPRMMPDGLGVEIDIGSWPVPPIFPFIQEKGGLKSEEMFNVFNMGIGFVLAVKEEDMTDVIQTL
ENNGEKAYLIGRVKAGSGVVFGGAGLS

Sequences:

>Translated_347_residues
MLSESYKNAGVDIEAGYEAVKRMKKHVERTKRIGAMGGLGGFGGMFDLSELPYKQPVLISGTDGVGTKLKLAFAMDKHDT
IGIDAVAMCVNDVLAQGAEPLFFLDYLAVGKADPVKIEEIVKGVAEGCVQSGSALVGGETAEMPGLYTEDEYDIAGFSVG
AAEKDGIVTGENISEGHLLIGLSSSGLHSNGFSLVRKVLLEDAGLNLDETYAPFERPLGEELLEPTKIYVKPVLEAVKSG
KIAGMAHVTGGGFIENLPRMMPDGLGVEIDIGSWPVPPIFPFIQEKGGLKSEEMFNVFNMGIGFVLAVKEEDMTDVIQTL
ENNGEKAYLIGRVKAGSGVVFGGAGLS
>Mature_347_residues
MLSESYKNAGVDIEAGYEAVKRMKKHVERTKRIGAMGGLGGFGGMFDLSELPYKQPVLISGTDGVGTKLKLAFAMDKHDT
IGIDAVAMCVNDVLAQGAEPLFFLDYLAVGKADPVKIEEIVKGVAEGCVQSGSALVGGETAEMPGLYTEDEYDIAGFSVG
AAEKDGIVTGENISEGHLLIGLSSSGLHSNGFSLVRKVLLEDAGLNLDETYAPFERPLGEELLEPTKIYVKPVLEAVKSG
KIAGMAHVTGGGFIENLPRMMPDGLGVEIDIGSWPVPPIFPFIQEKGGLKSEEMFNVFNMGIGFVLAVKEEDMTDVIQTL
ENNGEKAYLIGRVKAGSGVVFGGAGLS

Specific function: De novo purine biosynthesis; fifth step. [C]

COG id: COG0150

COG function: function code F; Phosphoribosylaminoimidazole (AIR) synthetase

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the AIR synthase family [H]

Homologues:

Organism=Homo sapiens, GI4503915, Length=337, Percent_Identity=49.2581602373887, Blast_Score=330, Evalue=2e-90,
Organism=Homo sapiens, GI209869995, Length=337, Percent_Identity=49.2581602373887, Blast_Score=330, Evalue=2e-90,
Organism=Homo sapiens, GI209869993, Length=337, Percent_Identity=49.2581602373887, Blast_Score=330, Evalue=2e-90,
Organism=Escherichia coli, GI1788845, Length=333, Percent_Identity=51.9519519519519, Blast_Score=345, Evalue=2e-96,
Organism=Caenorhabditis elegans, GI17567511, Length=347, Percent_Identity=38.328530259366, Blast_Score=229, Evalue=2e-60,
Organism=Saccharomyces cerevisiae, GI6321203, Length=339, Percent_Identity=45.1327433628319, Blast_Score=296, Evalue=3e-81,
Organism=Drosophila melanogaster, GI24582400, Length=294, Percent_Identity=44.5578231292517, Blast_Score=233, Evalue=1e-61,

Paralogues:

None

Copy number: 180 Molecules/Cell In: Growth-Phase, Minimal-Media (Based on E. coli). [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000728
- InterPro:   IPR010918
- InterPro:   IPR004733
- InterPro:   IPR016188 [H]

Pfam domain/function: PF00586 AIRS; PF02769 AIRS_C [H]

EC number: =6.3.3.1 [H]

Molecular weight: Translated: 36698; Mature: 36698

Theoretical pI: Translated: 4.40; Mature: 4.40

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.6 %Cys     (Translated Protein)
3.7 %Met     (Translated Protein)
4.3 %Cys+Met (Translated Protein)
0.6 %Cys     (Mature Protein)
3.7 %Met     (Mature Protein)
4.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MLSESYKNAGVDIEAGYEAVKRMKKHVERTKRIGAMGGLGGFGGMFDLSELPYKQPVLIS
CCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCHHHCCCCCCEEEE
GTDGVGTKLKLAFAMDKHDTIGIDAVAMCVNDVLAQGAEPLFFLDYLAVGKADPVKIEEI
CCCCCCCEEEEEEEECCCCCCCHHHHHHHHHHHHHCCCCCEEEHHHHHHCCCCCCCHHHH
VKGVAEGCVQSGSALVGGETAEMPGLYTEDEYDIAGFSVGAAEKDGIVTGENISEGHLLI
HHHHHHHHHHCCCEEECCCCCCCCCCCCCCCCCCCCEEECCCCCCCEEECCCCCCCEEEE
GLSSSGLHSNGFSLVRKVLLEDAGLNLDETYAPFERPLGEELLEPTKIYVKPVLEAVKSG
EECCCCCCCCHHHHHHHHHHHHCCCCCCCCCCCHHCCCCHHHHCHHHHHHHHHHHHHHCC
KIAGMAHVTGGGFIENLPRMMPDGLGVEIDIGSWPVPPIFPFIQEKGGLKSEEMFNVFNM
CCEEEEEECCCHHHHHHHHHCCCCCCEEEECCCCCCCCHHHHHHHCCCCCHHHHHHHHHC
GIGFVLAVKEEDMTDVIQTLENNGEKAYLIGRVKAGSGVVFGGAGLS
CCEEEEEECCCCHHHHHHHHHCCCCEEEEEEEEECCCEEEECCCCCC
>Mature Secondary Structure
MLSESYKNAGVDIEAGYEAVKRMKKHVERTKRIGAMGGLGGFGGMFDLSELPYKQPVLIS
CCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCHHHCCCCCCEEEE
GTDGVGTKLKLAFAMDKHDTIGIDAVAMCVNDVLAQGAEPLFFLDYLAVGKADPVKIEEI
CCCCCCCEEEEEEEECCCCCCCHHHHHHHHHHHHHCCCCCEEEHHHHHHCCCCCCCHHHH
VKGVAEGCVQSGSALVGGETAEMPGLYTEDEYDIAGFSVGAAEKDGIVTGENISEGHLLI
HHHHHHHHHHCCCEEECCCCCCCCCCCCCCCCCCCCEEECCCCCCCEEECCCCCCCEEEE
GLSSSGLHSNGFSLVRKVLLEDAGLNLDETYAPFERPLGEELLEPTKIYVKPVLEAVKSG
EECCCCCCCCHHHHHHHHHHHHCCCCCCCCCCCHHCCCCHHHHCHHHHHHHHHHHHHHCC
KIAGMAHVTGGGFIENLPRMMPDGLGVEIDIGSWPVPPIFPFIQEKGGLKSEEMFNVFNM
CCEEEEEECCCHHHHHHHHHCCCCCCEEEECCCCCCCCHHHHHHHCCCCCHHHHHHHHHC
GIGFVLAVKEEDMTDVIQTLENNGEKAYLIGRVKAGSGVVFGGAGLS
CCEEEEEECCCCHHHHHHHHHCCCCEEEEEEEEECCCEEEECCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA