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The map label for this gene is guaA [H]

Identifier: 52784488

GI number: 52784488

Start: 691050

End: 692591

Strand: Direct

Name: guaA [H]

Synonym: BLi00686

Alternate gene names: 52784488

Gene position: 691050-692591 (Clockwise)

Preceding gene: 52784487

Following gene: 52784489

Centisome position: 16.37

GC content: 48.18

Gene sequence:

>1542_bases
ATGACGAAGTTAGTAAATGAAATGATTCTTGTGTTGGATTTTGGAAGTCAGTACAACCAGCTGATTACCCGCCGCATTCG
TGAGTTTGGTGTATATAGTGAATTGCATCCTCATACGTTGACGGCAGAGGAAATCAAAAAAATGAATCCGAAAGGAATTA
TTTTGTCCGGCGGTCCGAACAGCGTTTACGACGAAGGATCTTTCCGCTGCGACGAAAAGATTTTCGAACTGGACATCCCT
GTTCTTGGAATTTGCTACGGCATGCAGCTGATGACGCATTACCTTGGCGGAAAAGTAGAAGCGGCAAGCCAGCGCGAATA
CGGAAAAGCAAACATTCATATCGAGGGTGAACCGGATCTGTTTAAAGATCTTCCAAACGAACAAGTCGTCTGGATGAGTC
ATGGTGATCTAGTAGTTGAAGTTCCAGAAGGCTTTACCGTTGATGCGACAAGCCATCATTGCCCGAACTCAGCAATGAGC
AAGAAGGATAAGAAATGGTACGGCGTTCAATTTCATCCGGAAGTCCGCCATTCAGAATACGGAAACGACCTTTTGAAGAA
CTTCGTTTTCGGTGTTTGTGAATGCGTCGGCGAATGGTCAATGGAAAACTTTATTGAGATTGAAATGCAGAAAATCCGCG
AAACAGTCGGCGACAAGCAAGTACTGTGCGCGTTGAGCGGCGGGGTTGACTCCTCTGTCGTTGCGGTCTTGATCCATAAA
GCGATCGGCGACCAGCTGACTTGTATTTTCGTAGACCACGGGCTCCTTCGAAAAGGTGAAGCGGAAGGCGTGATGAAAAC
GTTCAGTGAAGGCTTCAACATGAACGTGATCAAAGTGGATGCGAAAGATCGCTTCCTGAACAAGCTTAAAGGCGTCTCAG
ACCCTGAACAAAAACGCAAAATCATCGGTAATGAGTTTATCTACGTGTTTGACGATGAAGCGGAAAAACTGAAAGGAATT
GACTTCCTTGCACAGGGAACGCTATACACTGACATTATCGAGAGCGGAACAGCGACGGCTCAGACGATCAAGTCGCATCA
CAATGTCGGCGGCCTTCCTGAAGACATGCAGTTTGAACTGATCGAACCGCTGAATACGCTCTTCAAAGACGAAGTGCGCG
CGCTCGGAACCGAGCTTGGCATCCCTGACGAAATTGTTTGGCGCCAGCCGTTCCCAGGTCCGGGCCTCGGCATCCGCGTT
CTTGGAGAAGTGACGGAGGAAAAGCTTGAAATCGTCCGCGAATCAGACGCGATCCTCCGCGAAGAAATCGCCAAAGCTGA
TCTTGAAAAAGATATTTGGCAATACTTCACCGTTCTTCCTGATATCCGCAGCGTCGGCGTCATGGGAGACGCAAGAACTT
ATGACTATACGATCGGCATTCGCGCCGTGACATCGATTGACGGCATGACATCAGACTGGGCGAGAATTCCTTGGGATGTC
CTTGAGAAAATCTCGACACGGATCGTCAATGAAGTGAAGCACATTAACCGCGTGGTTTACGATATTACGAGCAAGCCGCC
TGCAACAATCGAGTGGGAATAA

Upstream 100 bases:

>100_bases
CGGACAAGCCGGGCCTTGTCCCGTGAATGGGGGCAGGACGGCCGTGTGTCTGCCGCCATTTTTTCTGTGCAAAAAGACAA
TTTGATAAAGAGGTGACACC

Downstream 100 bases:

>100_bases
GAAAAATGCCTCAGCCGCATGAAGCTGGGGCATTTTTTATTGGTGGAGCAGTAGATTGGATGATATAACGCTTATATCTT
CCGTTTTCATCGCCGCAGCC

Product: GMP synthase

Products: NA

Alternate protein names: GMP synthetase; Glutamine amidotransferase [H]

Number of amino acids: Translated: 513; Mature: 512

Protein sequence:

>513_residues
MTKLVNEMILVLDFGSQYNQLITRRIREFGVYSELHPHTLTAEEIKKMNPKGIILSGGPNSVYDEGSFRCDEKIFELDIP
VLGICYGMQLMTHYLGGKVEAASQREYGKANIHIEGEPDLFKDLPNEQVVWMSHGDLVVEVPEGFTVDATSHHCPNSAMS
KKDKKWYGVQFHPEVRHSEYGNDLLKNFVFGVCECVGEWSMENFIEIEMQKIRETVGDKQVLCALSGGVDSSVVAVLIHK
AIGDQLTCIFVDHGLLRKGEAEGVMKTFSEGFNMNVIKVDAKDRFLNKLKGVSDPEQKRKIIGNEFIYVFDDEAEKLKGI
DFLAQGTLYTDIIESGTATAQTIKSHHNVGGLPEDMQFELIEPLNTLFKDEVRALGTELGIPDEIVWRQPFPGPGLGIRV
LGEVTEEKLEIVRESDAILREEIAKADLEKDIWQYFTVLPDIRSVGVMGDARTYDYTIGIRAVTSIDGMTSDWARIPWDV
LEKISTRIVNEVKHINRVVYDITSKPPATIEWE

Sequences:

>Translated_513_residues
MTKLVNEMILVLDFGSQYNQLITRRIREFGVYSELHPHTLTAEEIKKMNPKGIILSGGPNSVYDEGSFRCDEKIFELDIP
VLGICYGMQLMTHYLGGKVEAASQREYGKANIHIEGEPDLFKDLPNEQVVWMSHGDLVVEVPEGFTVDATSHHCPNSAMS
KKDKKWYGVQFHPEVRHSEYGNDLLKNFVFGVCECVGEWSMENFIEIEMQKIRETVGDKQVLCALSGGVDSSVVAVLIHK
AIGDQLTCIFVDHGLLRKGEAEGVMKTFSEGFNMNVIKVDAKDRFLNKLKGVSDPEQKRKIIGNEFIYVFDDEAEKLKGI
DFLAQGTLYTDIIESGTATAQTIKSHHNVGGLPEDMQFELIEPLNTLFKDEVRALGTELGIPDEIVWRQPFPGPGLGIRV
LGEVTEEKLEIVRESDAILREEIAKADLEKDIWQYFTVLPDIRSVGVMGDARTYDYTIGIRAVTSIDGMTSDWARIPWDV
LEKISTRIVNEVKHINRVVYDITSKPPATIEWE
>Mature_512_residues
TKLVNEMILVLDFGSQYNQLITRRIREFGVYSELHPHTLTAEEIKKMNPKGIILSGGPNSVYDEGSFRCDEKIFELDIPV
LGICYGMQLMTHYLGGKVEAASQREYGKANIHIEGEPDLFKDLPNEQVVWMSHGDLVVEVPEGFTVDATSHHCPNSAMSK
KDKKWYGVQFHPEVRHSEYGNDLLKNFVFGVCECVGEWSMENFIEIEMQKIRETVGDKQVLCALSGGVDSSVVAVLIHKA
IGDQLTCIFVDHGLLRKGEAEGVMKTFSEGFNMNVIKVDAKDRFLNKLKGVSDPEQKRKIIGNEFIYVFDDEAEKLKGID
FLAQGTLYTDIIESGTATAQTIKSHHNVGGLPEDMQFELIEPLNTLFKDEVRALGTELGIPDEIVWRQPFPGPGLGIRVL
GEVTEEKLEIVRESDAILREEIAKADLEKDIWQYFTVLPDIRSVGVMGDARTYDYTIGIRAVTSIDGMTSDWARIPWDVL
EKISTRIVNEVKHINRVVYDITSKPPATIEWE

Specific function: Catalyzes the synthesis of GMP from XMP [H]

COG id: COG0519

COG function: function code F; GMP synthase, PP-ATPase domain/subunit

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 GMP-binding domain [H]

Homologues:

Organism=Homo sapiens, GI4504035, Length=547, Percent_Identity=36.745886654479, Blast_Score=306, Evalue=2e-83,
Organism=Escherichia coli, GI1788854, Length=516, Percent_Identity=52.3255813953488, Blast_Score=563, Evalue=1e-161,
Organism=Escherichia coli, GI1789760, Length=157, Percent_Identity=35.031847133758, Blast_Score=75, Evalue=1e-14,
Organism=Caenorhabditis elegans, GI71992717, Length=570, Percent_Identity=36.3157894736842, Blast_Score=311, Evalue=5e-85,
Organism=Caenorhabditis elegans, GI71992710, Length=570, Percent_Identity=36.3157894736842, Blast_Score=311, Evalue=7e-85,
Organism=Caenorhabditis elegans, GI133901714, Length=570, Percent_Identity=36.3157894736842, Blast_Score=310, Evalue=8e-85,
Organism=Saccharomyces cerevisiae, GI6323873, Length=516, Percent_Identity=53.8759689922481, Blast_Score=536, Evalue=1e-153,
Organism=Saccharomyces cerevisiae, GI6322638, Length=154, Percent_Identity=30.5194805194805, Blast_Score=66, Evalue=1e-11,
Organism=Drosophila melanogaster, GI281365319, Length=550, Percent_Identity=36.9090909090909, Blast_Score=301, Evalue=7e-82,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR006220
- InterPro:   IPR001962
- InterPro:   IPR001317
- InterPro:   IPR011702
- InterPro:   IPR017926
- InterPro:   IPR000991
- InterPro:   IPR001674
- InterPro:   IPR004739
- InterPro:   IPR022955
- InterPro:   IPR014729 [H]

Pfam domain/function: PF00733 Asn_synthase; PF00117 GATase; PF00958 GMP_synt_C [H]

EC number: =6.3.5.2 [H]

Molecular weight: Translated: 57806; Mature: 57675

Theoretical pI: Translated: 4.71; Mature: 4.71

Prosite motif: PS00442 GATASE_TYPE_I

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.4 %Cys     (Translated Protein)
2.7 %Met     (Translated Protein)
4.1 %Cys+Met (Translated Protein)
1.4 %Cys     (Mature Protein)
2.5 %Met     (Mature Protein)
3.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTKLVNEMILVLDFGSQYNQLITRRIREFGVYSELHPHTLTAEEIKKMNPKGIILSGGPN
CCHHHHHEEEEEECCHHHHHHHHHHHHHHCCHHCCCCCCCCHHHHHHCCCCEEEEECCCC
SVYDEGSFRCDEKIFELDIPVLGICYGMQLMTHYLGGKVEAASQREYGKANIHIEGEPDL
CCCCCCCCCCCCHHEEECCCHHHHHHHHHHHHHHHCCCEECCCCCCCCCEEEEECCCCHH
FKDLPNEQVVWMSHGDLVVEVPEGFTVDATSHHCPNSAMSKKDKKWYGVQFHPEVRHSEY
HHHCCCCEEEEEECCCEEEECCCCEEECCCCCCCCCHHHCCCCCCEECEEECCCCCHHHH
GNDLLKNFVFGVCECVGEWSMENFIEIEMQKIRETVGDKQVLCALSGGVDSSVVAVLIHK
HHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHCCCEEEEEECCCCCHHHHHHHHHH
AIGDQLTCIFVDHGLLRKGEAEGVMKTFSEGFNMNVIKVDAKDRFLNKLKGVSDPEQKRK
HHCCCEEEEEECCCHHCCCCHHHHHHHHHCCCCEEEEEECHHHHHHHHHCCCCCHHHHHH
IIGNEFIYVFDDEAEKLKGIDFLAQGTLYTDIIESGTATAQTIKSHHNVGGLPEDMQFEL
HCCCCEEEEECCCHHHHCCCHHHHCCCHHHHHHHCCCHHHHHHHHHCCCCCCCCCCHHHH
IEPLNTLFKDEVRALGTELGIPDEIVWRQPFPGPGLGIRVLGEVTEEKLEIVRESDAILR
HHHHHHHHHHHHHHHHHHCCCCCCEEECCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHH
EEIAKADLEKDIWQYFTVLPDIRSVGVMGDARTYDYTIGIRAVTSIDGMTSDWARIPWDV
HHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCEEEEEEEEEEEEECCCCCCCHHCCCHHH
LEKISTRIVNEVKHINRVVYDITSKPPATIEWE
HHHHHHHHHHHHHHHHHHHHHHCCCCCCCEECC
>Mature Secondary Structure 
TKLVNEMILVLDFGSQYNQLITRRIREFGVYSELHPHTLTAEEIKKMNPKGIILSGGPN
CHHHHHEEEEEECCHHHHHHHHHHHHHHCCHHCCCCCCCCHHHHHHCCCCEEEEECCCC
SVYDEGSFRCDEKIFELDIPVLGICYGMQLMTHYLGGKVEAASQREYGKANIHIEGEPDL
CCCCCCCCCCCCHHEEECCCHHHHHHHHHHHHHHHCCCEECCCCCCCCCEEEEECCCCHH
FKDLPNEQVVWMSHGDLVVEVPEGFTVDATSHHCPNSAMSKKDKKWYGVQFHPEVRHSEY
HHHCCCCEEEEEECCCEEEECCCCEEECCCCCCCCCHHHCCCCCCEECEEECCCCCHHHH
GNDLLKNFVFGVCECVGEWSMENFIEIEMQKIRETVGDKQVLCALSGGVDSSVVAVLIHK
HHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHCCCEEEEEECCCCCHHHHHHHHHH
AIGDQLTCIFVDHGLLRKGEAEGVMKTFSEGFNMNVIKVDAKDRFLNKLKGVSDPEQKRK
HHCCCEEEEEECCCHHCCCCHHHHHHHHHCCCCEEEEEECHHHHHHHHHCCCCCHHHHHH
IIGNEFIYVFDDEAEKLKGIDFLAQGTLYTDIIESGTATAQTIKSHHNVGGLPEDMQFEL
HCCCCEEEEECCCHHHHCCCHHHHCCCHHHHHHHCCCHHHHHHHHHCCCCCCCCCCHHHH
IEPLNTLFKDEVRALGTELGIPDEIVWRQPFPGPGLGIRVLGEVTEEKLEIVRESDAILR
HHHHHHHHHHHHHHHHHHCCCCCCEEECCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHH
EEIAKADLEKDIWQYFTVLPDIRSVGVMGDARTYDYTIGIRAVTSIDGMTSDWARIPWDV
HHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCEEEEEEEEEEEEECCCCCCCHHCCCHHH
LEKISTRIVNEVKHINRVVYDITSKPPATIEWE
HHHHHHHHHHHHHHHHHHHHHHCCCCCCCEECC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA