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The map label for this gene is lctP [H]

Identifier: 52784189

GI number: 52784189

Start: 343270

End: 344901

Strand: Direct

Name: lctP [H]

Synonym: BLi00367

Alternate gene names: 52784189

Gene position: 343270-344901 (Clockwise)

Preceding gene: 52784188

Following gene: 52784190

Centisome position: 8.13

GC content: 50.0

Gene sequence:

>1632_bases
ATGATGAAAATGTGGCAGCAGATATACGATCCGTTTGGAAATCTGTTTATCAGCGCTTTTGCCGCCATACTGCCGATTCT
TTTCTTTCTTCTTGCACTGACCGTGTTGAAGATGAAAGGAATCATTGCGTCATTTTTGACGCTGGCGGTCAGCTTTATTG
TAGCGGTGTTCTTCTTTCACATGCCGGCTGCGAAAGCTGTCTCCGCCGTTTTACTTGGAATTGCTAACGGCCTTTGGCCG
ATCGGATATATTGTCCTGATGGCTGTATGGCTTTACAAAATTTCTGTCAAAACCGGAAAGTTTAAAGTGATCAGAGCGAG
CATTGCCGGAATTTCGTCCGACCAGCGGCTTCAGCTATTGCTGATCGGGTTCAGTTTTAACGCCTTTTTGGAAGGTGCGG
CAGGCTTCGGTGTGCCGATTGCGATCAGCGCCGTTCTTCTTGTCGAGCTTGGTTTTAAACCTTTGAAAGCGGCATCCCTA
TGTTTAATAGCGAATGCGGCATCCGGAGCCTTTGGAGCCATCGGAATTCCGGTTATCACAGGAGCGCAGATGGGAGGCTT
AACACCGGTTGAGCTTTCCAGAACGCTCGCTTTGATGCTGCCGGTCATCGCTTTCTTTGTCCCGTTCCTGCTCGTTTTCA
TATTGGACGGGTTTAAAGGAATAAGGGAAACGCTGCCGGCTCTTCTCGTATTAAGCGGAAGCTATACGGCGGTGCAGACT
TTAACAATGATTAGTTTGGGGCCGGAGCTTGCCGACATTTTGGCCGCTTTAATCAGCATGGGAGCGCTGGCGCTGTTTTT
GAAAAAGTGGCAGCCGCGCCACATATACAGGGAAACCGGGAATGAACATGTGCCCGCTGAAAAATATCGTGCAGCAGACA
TTATGAACGCTTGGTCACCGTTTTATATTTTGACCGCCGTCATTGCGGTGTGGAGCCTGCCCGGTTTTAAGGGGCTTTTT
CAGGAAGGCGGATTCCTGAAGCAAACGACAATTTTATTCAACATGCCTTTTCTTCACCGGGAAGTGCTGAAAACGCCGCC
GATATCTCCGGAACAGGCACCGCTTGATGCTGTGATGAAGCTTGACTTCATTTCAGCGACGGGTACGGCGATCCTGATCG
CGGTGATCATCACGATTGTGATGAGCCGAAACATCAGTTTCCGCGGAGGACTTTCCAGTCTGAAAGAGACGGTCAAGGAA
CTGTGGCTTCCCGTTCTCACCATTTGCTTTGTGATGGGTTTTGCAAACTTGGCCAATTATGCCGGATTGAGTTCAACCAT
CGGACTGGCGCTCGCCAAAGCGGGGGATATCTTTCCGTTCGTCAGTCCCGTATTGGGCTGGATCGGTGTCTTTATCACAG
GTTCAGTCGTCAGCAACAACGCATTATTCGGCCACCTGCAAGCAGTCACCGGAGCGCAAATCGGGACAAGTTCGGCTTTG
CTGCTTGCCGCAAATACCGCGGGAGGCGTGATGGCCAAGCTGATCTCACCGCAGTCGATTGCGATTGCAACAGCCGCGGT
TAAAGAGACAGGGCAGGAATCAAAGCTTTTCAGCCAAACCGTTAAATACAGCCTGGTTCTGCTTTTCATCATTTGCATTT
GGACGTTTGCGCTATCAAAGCTTGGCATATAA

Upstream 100 bases:

>100_bases
AAGCATAGCGCAGGTGTGTTAAAAGCAATTTTAAAACCGCATTTTGAACTGCAGGCGTAACTGAACACCATGAAGATACT
AACATCATGAAGATTGCGAG

Downstream 100 bases:

>100_bases
AGAAGAGCCTTTTCCCATTGCGGGAAAAGGCTTTTTAAGCTGCTTGTTCTATCATGTCCTCTTTTTGAATACATTGTACA
AGTTATCCGCGGAAGGGGGA

Product: LctP

Products: Proton [Cytoplasm]; lactate [Cytoplasm] [C]

Alternate protein names: NA

Number of amino acids: Translated: 543; Mature: 543

Protein sequence:

>543_residues
MMKMWQQIYDPFGNLFISAFAAILPILFFLLALTVLKMKGIIASFLTLAVSFIVAVFFFHMPAAKAVSAVLLGIANGLWP
IGYIVLMAVWLYKISVKTGKFKVIRASIAGISSDQRLQLLLIGFSFNAFLEGAAGFGVPIAISAVLLVELGFKPLKAASL
CLIANAASGAFGAIGIPVITGAQMGGLTPVELSRTLALMLPVIAFFVPFLLVFILDGFKGIRETLPALLVLSGSYTAVQT
LTMISLGPELADILAALISMGALALFLKKWQPRHIYRETGNEHVPAEKYRAADIMNAWSPFYILTAVIAVWSLPGFKGLF
QEGGFLKQTTILFNMPFLHREVLKTPPISPEQAPLDAVMKLDFISATGTAILIAVIITIVMSRNISFRGGLSSLKETVKE
LWLPVLTICFVMGFANLANYAGLSSTIGLALAKAGDIFPFVSPVLGWIGVFITGSVVSNNALFGHLQAVTGAQIGTSSAL
LLAANTAGGVMAKLISPQSIAIATAAVKETGQESKLFSQTVKYSLVLLFIICIWTFALSKLGI

Sequences:

>Translated_543_residues
MMKMWQQIYDPFGNLFISAFAAILPILFFLLALTVLKMKGIIASFLTLAVSFIVAVFFFHMPAAKAVSAVLLGIANGLWP
IGYIVLMAVWLYKISVKTGKFKVIRASIAGISSDQRLQLLLIGFSFNAFLEGAAGFGVPIAISAVLLVELGFKPLKAASL
CLIANAASGAFGAIGIPVITGAQMGGLTPVELSRTLALMLPVIAFFVPFLLVFILDGFKGIRETLPALLVLSGSYTAVQT
LTMISLGPELADILAALISMGALALFLKKWQPRHIYRETGNEHVPAEKYRAADIMNAWSPFYILTAVIAVWSLPGFKGLF
QEGGFLKQTTILFNMPFLHREVLKTPPISPEQAPLDAVMKLDFISATGTAILIAVIITIVMSRNISFRGGLSSLKETVKE
LWLPVLTICFVMGFANLANYAGLSSTIGLALAKAGDIFPFVSPVLGWIGVFITGSVVSNNALFGHLQAVTGAQIGTSSAL
LLAANTAGGVMAKLISPQSIAIATAAVKETGQESKLFSQTVKYSLVLLFIICIWTFALSKLGI
>Mature_543_residues
MMKMWQQIYDPFGNLFISAFAAILPILFFLLALTVLKMKGIIASFLTLAVSFIVAVFFFHMPAAKAVSAVLLGIANGLWP
IGYIVLMAVWLYKISVKTGKFKVIRASIAGISSDQRLQLLLIGFSFNAFLEGAAGFGVPIAISAVLLVELGFKPLKAASL
CLIANAASGAFGAIGIPVITGAQMGGLTPVELSRTLALMLPVIAFFVPFLLVFILDGFKGIRETLPALLVLSGSYTAVQT
LTMISLGPELADILAALISMGALALFLKKWQPRHIYRETGNEHVPAEKYRAADIMNAWSPFYILTAVIAVWSLPGFKGLF
QEGGFLKQTTILFNMPFLHREVLKTPPISPEQAPLDAVMKLDFISATGTAILIAVIITIVMSRNISFRGGLSSLKETVKE
LWLPVLTICFVMGFANLANYAGLSSTIGLALAKAGDIFPFVSPVLGWIGVFITGSVVSNNALFGHLQAVTGAQIGTSSAL
LLAANTAGGVMAKLISPQSIAIATAAVKETGQESKLFSQTVKYSLVLLFIICIWTFALSKLGI

Specific function: May play a role in L-lactate transport [H]

COG id: COG1620

COG function: function code C; L-lactate permease

Gene ontology:

Cell location: Cell membrane; Multi-pass membrane protein (Probable) [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the lactate permease family [H]

Homologues:

Organism=Escherichia coli, GI1790031, Length=538, Percent_Identity=49.4423791821561, Blast_Score=486, Evalue=1e-138,
Organism=Escherichia coli, GI1789347, Length=549, Percent_Identity=47.1766848816029, Blast_Score=479, Evalue=1e-136,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003804 [H]

Pfam domain/function: PF02652 Lactate_perm [H]

EC number: NA

Molecular weight: Translated: 57976; Mature: 57976

Theoretical pI: Translated: 10.12; Mature: 10.12

Prosite motif: PS00456 NA_SOLUT_SYMP_1

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.6 %Cys     (Translated Protein)
2.9 %Met     (Translated Protein)
3.5 %Cys+Met (Translated Protein)
0.6 %Cys     (Mature Protein)
2.9 %Met     (Mature Protein)
3.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MMKMWQQIYDPFGNLFISAFAAILPILFFLLALTVLKMKGIIASFLTLAVSFIVAVFFFH
CHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
MPAAKAVSAVLLGIANGLWPIGYIVLMAVWLYKISVKTGKFKVIRASIAGISSDQRLQLL
CCHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHCCCCCEEEEEHHHHCCCCCCCEEEE
LIGFSFNAFLEGAAGFGVPIAISAVLLVELGFKPLKAASLCLIANAASGAFGAIGIPVIT
EEEECHHHHHCCCCCCCHHHHHHHHHHHHHCCCHHHHHHHHEEEECCCCCCCCCCCHHCC
GAQMGGLTPVELSRTLALMLPVIAFFVPFLLVFILDGFKGIRETLPALLVLSGSYTAVQT
CCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHH
LTMISLGPELADILAALISMGALALFLKKWQPRHIYRETGNEHVPAEKYRAADIMNAWSP
HHHHHCCHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHCCCCCCCHHHHHHHHHHHCCCH
FYILTAVIAVWSLPGFKGLFQEGGFLKQTTILFNMPFLHREVLKTPPISPEQAPLDAVMK
HHHHHHHHHHHCCCCHHHHHHCCCCEEHHHHEECCCHHHHHHHCCCCCCCCCCCHHHHHH
LDFISATGTAILIAVIITIVMSRNISFRGGLSSLKETVKELWLPVLTICFVMGFANLANY
HHHHHCCHHHHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
AGLSSTIGLALAKAGDIFPFVSPVLGWIGVFITGSVVSNNALFGHLQAVTGAQIGTSSAL
CCCHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHCCCCCCCCEE
LLAANTAGGVMAKLISPQSIAIATAAVKETGQESKLFSQTVKYSLVLLFIICIWTFALSK
EEEECCCCHHHHHHCCCCHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
LGI
HCC
>Mature Secondary Structure
MMKMWQQIYDPFGNLFISAFAAILPILFFLLALTVLKMKGIIASFLTLAVSFIVAVFFFH
CHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
MPAAKAVSAVLLGIANGLWPIGYIVLMAVWLYKISVKTGKFKVIRASIAGISSDQRLQLL
CCHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHCCCCCEEEEEHHHHCCCCCCCEEEE
LIGFSFNAFLEGAAGFGVPIAISAVLLVELGFKPLKAASLCLIANAASGAFGAIGIPVIT
EEEECHHHHHCCCCCCCHHHHHHHHHHHHHCCCHHHHHHHHEEEECCCCCCCCCCCHHCC
GAQMGGLTPVELSRTLALMLPVIAFFVPFLLVFILDGFKGIRETLPALLVLSGSYTAVQT
CCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHH
LTMISLGPELADILAALISMGALALFLKKWQPRHIYRETGNEHVPAEKYRAADIMNAWSP
HHHHHCCHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHCCCCCCCHHHHHHHHHHHCCCH
FYILTAVIAVWSLPGFKGLFQEGGFLKQTTILFNMPFLHREVLKTPPISPEQAPLDAVMK
HHHHHHHHHHHCCCCHHHHHHCCCCEEHHHHEECCCHHHHHHHCCCCCCCCCCCHHHHHH
LDFISATGTAILIAVIITIVMSRNISFRGGLSSLKETVKELWLPVLTICFVMGFANLANY
HHHHHCCHHHHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
AGLSSTIGLALAKAGDIFPFVSPVLGWIGVFITGSVVSNNALFGHLQAVTGAQIGTSSAL
CCCHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHCCCCCCCCEE
LLAANTAGGVMAKLISPQSIAIATAAVKETGQESKLFSQTVKYSLVLLFIICIWTFALSK
EEEECCCCHHHHHHCCCCHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
LGI
HCC

PDB accession: NA

Resolution: NA

Structure class: Alpha

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: Proton [Periplasm]; lactate [Periplasm] [C]

Specific reaction: Proton [Periplasm] + lactate [Periplasm] = Proton [Cytoplasm] + lactate [Cytoplasm] [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 8969502; 9384377; 10809684 [H]