Click here to switch to the map view.

The map label for this gene is murQ

Identifier: 52784024

GI number: 52784024

Start: 174528

End: 175442

Strand: Reverse

Name: murQ

Synonym: BLi00191

Alternate gene names: 52784024

Gene position: 175442-174528 (Counterclockwise)

Preceding gene: 52784025

Following gene: 52784023

Centisome position: 4.15

GC content: 48.52

Gene sequence:

>915_bases
ATGGAAAACAGCCATTTAGGTTCCTTAACGACCGAACGCCGCAATGAAAGATCCAAGCGCATTCACCAGGCAGAAACGAT
CGATATGTTGAAAATCATGAATGATGAAGATAAAACGGTAGCCGAAGCTGTACAAGAAGTCTTGCCCGATGTTAAGACCG
CCGTTGACTACGCCGTCGGGTCGTTAAAGAAAGGGGGACGGATCATCTACATCGGTGCCGGTACAAGCGGGAGGCTCGGC
GTACTTGATGCAGCTGAATGCCCGCCGACATTCAGCATATCTCCCGAGTCGGTCATAGGCATCATTGCAGGGGGAGAAAA
AGCTTTGTACAATGCCGTCGAAGGCGCTGAAGATCATGAGGCTTTTGGCAGACGGGATTTAGAAGCCGTTAACCTCTCAA
ACAATGATACCGTAATCGGAATCGCCGCCAGCGGCCGAACTCCGTACGTCCTAGGCGCCCTGAAGTATGCCAAGAAAACA
GGTGCCAAGGCCATATCGCTGACATGCAATGAAAACTCGGCGATCAGCCAGGCGGCAGATCACAGCATAGAAGTAGTCGT
CGGCCCTGAAGTCATTGCCGGATCGACGAGAATGAAAGCCGCAACCGCTCATAAAATGATTTTAAACATGATCTCAACGG
CGGCCATGATCAAAATGGGGAAAGTCTATGAAAACCTCATGGTAGATGTAAAAGTAAGCAATGACAAATTAAAGGAGCGG
GCGATCCGCATCATCCAAACGGTCACAGGTATGCCAAATGAAACAGCGGCGCAAGCATTGGAAATGTCCAATAACCAAGT
CAAAACCGCCATCATCATGCTGAAAACAAACGAAGATGCAGCCGCTGCAGAAAAACTGCTGGAGAAATCAGAAGGCGATA
TTGAAAAGGCCCTATCCATTTATGAAAAATCTTAA

Upstream 100 bases:

>100_bases
AAAATTTTAATATTTATCTTTTGTTATTGAAATTATATTTCAGCCATAATATACTGAAAATTGAGAAATATATGCATTTT
ATGATCAGGAGGATTTGTCG

Downstream 100 bases:

>100_bases
ATAAGAAAGGAAGAAACAATGGCTGCAGGAGGATTGGAAATCATTCAGAATATGCTTCACAAATTGCCGCAATCTGAACG
AAAGCTTGCCGAATACATTT

Product: N-acetylmuramic acid-6-phosphate etherase

Products: NA

Alternate protein names: MurNAc-6-P etherase 1; N-acetylmuramic acid 6-phosphate hydrolase 1; N-acetylmuramic acid 6-phosphate lyase 1

Number of amino acids: Translated: 304; Mature: 304

Protein sequence:

>304_residues
MENSHLGSLTTERRNERSKRIHQAETIDMLKIMNDEDKTVAEAVQEVLPDVKTAVDYAVGSLKKGGRIIYIGAGTSGRLG
VLDAAECPPTFSISPESVIGIIAGGEKALYNAVEGAEDHEAFGRRDLEAVNLSNNDTVIGIAASGRTPYVLGALKYAKKT
GAKAISLTCNENSAISQAADHSIEVVVGPEVIAGSTRMKAATAHKMILNMISTAAMIKMGKVYENLMVDVKVSNDKLKER
AIRIIQTVTGMPNETAAQALEMSNNQVKTAIIMLKTNEDAAAAEKLLEKSEGDIEKALSIYEKS

Sequences:

>Translated_304_residues
MENSHLGSLTTERRNERSKRIHQAETIDMLKIMNDEDKTVAEAVQEVLPDVKTAVDYAVGSLKKGGRIIYIGAGTSGRLG
VLDAAECPPTFSISPESVIGIIAGGEKALYNAVEGAEDHEAFGRRDLEAVNLSNNDTVIGIAASGRTPYVLGALKYAKKT
GAKAISLTCNENSAISQAADHSIEVVVGPEVIAGSTRMKAATAHKMILNMISTAAMIKMGKVYENLMVDVKVSNDKLKER
AIRIIQTVTGMPNETAAQALEMSNNQVKTAIIMLKTNEDAAAAEKLLEKSEGDIEKALSIYEKS
>Mature_304_residues
MENSHLGSLTTERRNERSKRIHQAETIDMLKIMNDEDKTVAEAVQEVLPDVKTAVDYAVGSLKKGGRIIYIGAGTSGRLG
VLDAAECPPTFSISPESVIGIIAGGEKALYNAVEGAEDHEAFGRRDLEAVNLSNNDTVIGIAASGRTPYVLGALKYAKKT
GAKAISLTCNENSAISQAADHSIEVVVGPEVIAGSTRMKAATAHKMILNMISTAAMIKMGKVYENLMVDVKVSNDKLKER
AIRIIQTVTGMPNETAAQALEMSNNQVKTAIIMLKTNEDAAAAEKLLEKSEGDIEKALSIYEKS

Specific function: Specifically catalyzes the cleavage of the D-lactyl ether substituent of MurNAc 6-phosphate, producing GlcNAc 6- phosphate and D-lactate

COG id: COG2103

COG function: function code R; Predicted sugar phosphate isomerase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 SIS domain

Homologues:

Organism=Escherichia coli, GI1788768, Length=290, Percent_Identity=50.3448275862069, Blast_Score=298, Evalue=4e-82,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): MURQ1_BACLD (Q65P54)

Other databases:

- EMBL:   AE017333
- EMBL:   CP000002
- RefSeq:   YP_077453.1
- RefSeq:   YP_089853.1
- HSSP:   P44862
- ProteinModelPortal:   Q65P54
- SMR:   Q65P54
- STRING:   Q65P54
- EnsemblBacteria:   EBBACT00000054231
- EnsemblBacteria:   EBBACT00000060530
- GeneID:   3027350
- GeneID:   3097630
- GenomeReviews:   AE017333_GR
- GenomeReviews:   CP000002_GR
- KEGG:   bld:BLi00191
- KEGG:   bli:BL02720
- NMPDR:   fig|279010.5.peg.1774
- eggNOG:   COG2103
- GeneTree:   EBGT00050000002902
- HOGENOM:   HBG703490
- OMA:   HLLTEQI
- ProtClustDB:   PRK05441
- BioCyc:   BLIC279010-1:BLI00191-MONOMER
- BioCyc:   BLIC279010:BL02720-MONOMER
- HAMAP:   MF_00068
- InterPro:   IPR005486
- InterPro:   IPR005488
- InterPro:   IPR001347
- TIGRFAMs:   TIGR00274

Pfam domain/function: PF01380 SIS

EC number: NA

Molecular weight: Translated: 32520; Mature: 32520

Theoretical pI: Translated: 5.76; Mature: 5.76

Prosite motif: PS01272 GCKR; PS51464 SIS

Important sites: ACT_SITE 86-86 ACT_SITE 117-117

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.7 %Cys     (Translated Protein)
3.9 %Met     (Translated Protein)
4.6 %Cys+Met (Translated Protein)
0.7 %Cys     (Mature Protein)
3.9 %Met     (Mature Protein)
4.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MENSHLGSLTTERRNERSKRIHQAETIDMLKIMNDEDKTVAEAVQEVLPDVKTAVDYAVG
CCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHH
SLKKGGRIIYIGAGTSGRLGVLDAAECPPTFSISPESVIGIIAGGEKALYNAVEGAEDHE
HHCCCCEEEEEECCCCCCEEEEECCCCCCCCCCCHHHEEEEEECCHHHHHHHHCCCCHHH
AFGRRDLEAVNLSNNDTVIGIAASGRTPYVLGALKYAKKTGAKAISLTCNENSAISQAAD
HHCCCCCEEEECCCCCEEEEEEECCCCCCHHHHHHHHHHCCCEEEEEEECCCCHHHHHCC
HSIEVVVGPEVIAGSTRMKAATAHKMILNMISTAAMIKMGKVYENLMVDVKVSNDKLKER
CCEEEEECCCEEECCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHCEEEEEEECCHHHHHH
AIRIIQTVTGMPNETAAQALEMSNNQVKTAIIMLKTNEDAAAAEKLLEKSEGDIEKALSI
HHHHHHHHCCCCCHHHHHHHHHCCCEEEEEEEEEECCCCHHHHHHHHHHCCCCHHHHHHH
YEKS
HCCC
>Mature Secondary Structure
MENSHLGSLTTERRNERSKRIHQAETIDMLKIMNDEDKTVAEAVQEVLPDVKTAVDYAVG
CCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHH
SLKKGGRIIYIGAGTSGRLGVLDAAECPPTFSISPESVIGIIAGGEKALYNAVEGAEDHE
HHCCCCEEEEEECCCCCCEEEEECCCCCCCCCCCHHHEEEEEECCHHHHHHHHCCCCHHH
AFGRRDLEAVNLSNNDTVIGIAASGRTPYVLGALKYAKKTGAKAISLTCNENSAISQAAD
HHCCCCCEEEECCCCCEEEEEEECCCCCCHHHHHHHHHHCCCEEEEEEECCCCHHHHHCC
HSIEVVVGPEVIAGSTRMKAATAHKMILNMISTAAMIKMGKVYENLMVDVKVSNDKLKER
CCEEEEECCCEEECCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHCEEEEEEECCHHHHHH
AIRIIQTVTGMPNETAAQALEMSNNQVKTAIIMLKTNEDAAAAEKLLEKSEGDIEKALSI
HHHHHHHHCCCCCHHHHHHHHHCCCEEEEEEEEEECCCCHHHHHHHHHHCCCCHHHHHHH
YEKS
HCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA