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The map label for this gene is hisI [H]

Identifier: 52143932

GI number: 52143932

Start: 1389025

End: 1389330

Strand: Direct

Name: hisI [H]

Synonym: BCZK1296

Alternate gene names: 52143932

Gene position: 1389025-1389330 (Clockwise)

Preceding gene: 52143934

Following gene: 52143933

Centisome position: 26.2

GC content: 33.66

Gene sequence:

>306_bases
ATGAAACCTAACTTTTCAAAAGGATTACTACCAGCAGTTGTAATTGAAGAAGGTACAAAAGAAGTTTTAATGCTAGCTTA
TATGAATGAAGAAGCATATGAAAAAACGCTAAAAACGAAAAGAACATGGTTTTATTCTCGTTCAAGAAGGTCGTTATGGA
ATAAAGGAGAAACATCAGGTCATGTCCAACATGTGCAATCTCTTTATTTAGATTGTGATCAAGATGCAATTGTTGTTGTC
GTAAAGCAAGTAGGACCTGCTTGCCATACGGGAGAAAAAACGTGTTTTCATTACAAAATTATATAG

Upstream 100 bases:

>100_bases
CAGTTGATGCAGCGTTAGCGGCATCAATCTTTCATTACGGTGAGGCGACGATAGGGGGCGTAAAGAGAAAGTTAAGAAAT
GCAAACGTCGAGGTGCGGTT

Downstream 100 bases:

>100_bases
GGGGATACATATGAGAAATGCCTTTACATTACTATTTGAAACAATTGAAGAACGAAAGAATAATCCACTTCCACAATCAT
ATACAAATTATTTGTTTTCA

Product: phosphoribosyl-AMP cyclohydrolase

Products: NA

Alternate protein names: PRA-CH [H]

Number of amino acids: Translated: 101; Mature: 101

Protein sequence:

>101_residues
MKPNFSKGLLPAVVIEEGTKEVLMLAYMNEEAYEKTLKTKRTWFYSRSRRSLWNKGETSGHVQHVQSLYLDCDQDAIVVV
VKQVGPACHTGEKTCFHYKII

Sequences:

>Translated_101_residues
MKPNFSKGLLPAVVIEEGTKEVLMLAYMNEEAYEKTLKTKRTWFYSRSRRSLWNKGETSGHVQHVQSLYLDCDQDAIVVV
VKQVGPACHTGEKTCFHYKII
>Mature_101_residues
MKPNFSKGLLPAVVIEEGTKEVLMLAYMNEEAYEKTLKTKRTWFYSRSRRSLWNKGETSGHVQHVQSLYLDCDQDAIVVV
VKQVGPACHTGEKTCFHYKII

Specific function: Histidine biosynthesis; second step. Histidine biosynthesis; third step. [C]

COG id: COG0139

COG function: function code E; Phosphoribosyl-AMP cyclohydrolase

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the PRA-CH family [H]

Homologues:

Organism=Escherichia coli, GI2367128, Length=91, Percent_Identity=46.1538461538462, Blast_Score=100, Evalue=3e-23,
Organism=Saccharomyces cerevisiae, GI6319819, Length=91, Percent_Identity=37.3626373626374, Blast_Score=60, Evalue=6e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR002496
- ProDom:   PD002610 [H]

Pfam domain/function: PF01502 PRA-CH [H]

EC number: =3.5.4.19 [H]

Molecular weight: Translated: 11608; Mature: 11608

Theoretical pI: Translated: 8.82; Mature: 8.82

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

3.0 %Cys     (Translated Protein)
3.0 %Met     (Translated Protein)
5.9 %Cys+Met (Translated Protein)
3.0 %Cys     (Mature Protein)
3.0 %Met     (Mature Protein)
5.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKPNFSKGLLPAVVIEEGTKEVLMLAYMNEEAYEKTLKTKRTWFYSRSRRSLWNKGETSG
CCCCCCCCCCCEEEECCCCCCEEEEEECCHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCH
HVQHVQSLYLDCDQDAIVVVVKQVGPACHTGEKTCFHYKII
HHHHHHHHHHCCCCCEEEEEEECCCCCCCCCCCEEEEEEEC
>Mature Secondary Structure
MKPNFSKGLLPAVVIEEGTKEVLMLAYMNEEAYEKTLKTKRTWFYSRSRRSLWNKGETSG
CCCCCCCCCCCEEEECCCCCCEEEEEECCHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCH
HVQHVQSLYLDCDQDAIVVVVKQVGPACHTGEKTCFHYKII
HHHHHHHHHHCCCCCEEEEEEECCCCCCCCCCCEEEEEEEC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA