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The map label for this gene is hisC [H]

Identifier: 52143831

GI number: 52143831

Start: 1489081

End: 1490193

Strand: Direct

Name: hisC [H]

Synonym: BCZK1400

Alternate gene names: 52143831

Gene position: 1489081-1490193 (Clockwise)

Preceding gene: 52143830

Following gene: 52143829

Centisome position: 28.09

GC content: 35.94

Gene sequence:

>1113_bases
ATGAGAGTGAAAGAGCAATTGTTAACTTTGAGAGCATATGTACCTGGGAAAAATATTGAAGAAGTAAAAAGGGAATATGG
GTTATCAAAAATTGTGAAATTGGCATCGAACGAAAATCCGTTCGGTTGCTCAGCACGTGTAACAGAAGCATTAACTTCTT
TAGCGAGTCAATATGCACTTTATCCAGATGGACATGCCTTTGAACTTCGGACACAAGTAGCAAAACATTTAGGTGTTAAA
GTGGAACAACTGTTATTTGGTAGTGGATTAGATGAAGTCATTCAAATGATTAGCCGTGCATTACTACACGAAGGAACAAA
TGTTGTAATGGCGAATCCAACATTCTCACAATACCATCACCATGCTGTTATTGAAGGAGCAGAAGTTCGTGAAGTATCAC
TTAAAGATGGCATTCACGATTTAGATGCGATGTTACAGCAAGTAGATGATCAAACGAAGATTGTATGGATTTGTAACCCG
AATAATCCGACAGGTACATATGTAGAGAAACAAAAATTACTTTCATTTTTAGAAGCAGTTCCTAAGTCAGCGCTTGTTAT
TATGGACGAAGCATATTATGAATATGCGGGAGCAGAAGACTATCCGCAAACATTACCACTTCTTGAAAAGTATGAAAATC
TTATGGTATTACGTACGTTTTCAAAAGCATATGGTCTAGCTGCTTTCCGTATCGGATATGCAGTTGGTAATACGGAGTTA
ATCGGGCAGTTAGAAGTAGCGAGGTTACCATTTAATACATCGACTGTAGCGCAATCTGTAGCACTTGCTGCATTAGAAGA
TCAAGCATTTTTACAAGAATGTGTGAAAAAGAATGAAGAAGGATTACATCAATATTACGCATTTTGTAAGGAATATAACG
TATTTTATTATCCATCTCAAACAAATTTCATTTTCTTAAAACTCGGTATTCCTGGTAATGAAGCTTTCGAACGATTAATG
AAAAAAGGATATATTGTTCGTTCTGGTGCTGCATTTGGTATCGATGATGGCATTCGTATTACTGTCGGTTTGAAAGAAGA
AAATGATGAAATTATAGAGTTACTGAAAGAACTTGTAAATGAGCAAGTACAGAAAGAGGAAACATATTCTTAA

Upstream 100 bases:

>100_bases
TGAGGTGTTTTCGTAATAGTGACGGTTAGGATAAAAGATTACAGTAAAGGACTAAAATTGTATTGTAATCGAATTCAATA
AAATGACTGGGGGAAGAAAA

Downstream 100 bases:

>100_bases
GAGATTGTGAAGGCTCCTATTAGAGGAGTCTTTTTTATCGCATTAAAAAAATTGAAGTTTAGTAATTAAGTTGTTCTGTA
AATCACGATTTGTATGGCTC

Product: histidinol-phosphate aminotransferase

Products: NA

Alternate protein names: Imidazole acetol-phosphate transaminase 1 [H]

Number of amino acids: Translated: 370; Mature: 370

Protein sequence:

>370_residues
MRVKEQLLTLRAYVPGKNIEEVKREYGLSKIVKLASNENPFGCSARVTEALTSLASQYALYPDGHAFELRTQVAKHLGVK
VEQLLFGSGLDEVIQMISRALLHEGTNVVMANPTFSQYHHHAVIEGAEVREVSLKDGIHDLDAMLQQVDDQTKIVWICNP
NNPTGTYVEKQKLLSFLEAVPKSALVIMDEAYYEYAGAEDYPQTLPLLEKYENLMVLRTFSKAYGLAAFRIGYAVGNTEL
IGQLEVARLPFNTSTVAQSVALAALEDQAFLQECVKKNEEGLHQYYAFCKEYNVFYYPSQTNFIFLKLGIPGNEAFERLM
KKGYIVRSGAAFGIDDGIRITVGLKEENDEIIELLKELVNEQVQKEETYS

Sequences:

>Translated_370_residues
MRVKEQLLTLRAYVPGKNIEEVKREYGLSKIVKLASNENPFGCSARVTEALTSLASQYALYPDGHAFELRTQVAKHLGVK
VEQLLFGSGLDEVIQMISRALLHEGTNVVMANPTFSQYHHHAVIEGAEVREVSLKDGIHDLDAMLQQVDDQTKIVWICNP
NNPTGTYVEKQKLLSFLEAVPKSALVIMDEAYYEYAGAEDYPQTLPLLEKYENLMVLRTFSKAYGLAAFRIGYAVGNTEL
IGQLEVARLPFNTSTVAQSVALAALEDQAFLQECVKKNEEGLHQYYAFCKEYNVFYYPSQTNFIFLKLGIPGNEAFERLM
KKGYIVRSGAAFGIDDGIRITVGLKEENDEIIELLKELVNEQVQKEETYS
>Mature_370_residues
MRVKEQLLTLRAYVPGKNIEEVKREYGLSKIVKLASNENPFGCSARVTEALTSLASQYALYPDGHAFELRTQVAKHLGVK
VEQLLFGSGLDEVIQMISRALLHEGTNVVMANPTFSQYHHHAVIEGAEVREVSLKDGIHDLDAMLQQVDDQTKIVWICNP
NNPTGTYVEKQKLLSFLEAVPKSALVIMDEAYYEYAGAEDYPQTLPLLEKYENLMVLRTFSKAYGLAAFRIGYAVGNTEL
IGQLEVARLPFNTSTVAQSVALAALEDQAFLQECVKKNEEGLHQYYAFCKEYNVFYYPSQTNFIFLKLGIPGNEAFERLM
KKGYIVRSGAAFGIDDGIRITVGLKEENDEIIELLKELVNEQVQKEETYS

Specific function: Histidine biosynthesis; seventh step. [C]

COG id: COG0079

COG function: function code E; Histidinol-phosphate/aromatic aminotransferase and cobyric acid decarboxylase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily [H]

Homologues:

Organism=Escherichia coli, GI1788332, Length=342, Percent_Identity=30.4093567251462, Blast_Score=137, Evalue=2e-33,
Organism=Escherichia coli, GI1788722, Length=367, Percent_Identity=26.158038147139, Blast_Score=79, Evalue=6e-16,
Organism=Escherichia coli, GI1788627, Length=239, Percent_Identity=25.5230125523013, Blast_Score=66, Evalue=4e-12,
Organism=Saccharomyces cerevisiae, GI6322075, Length=333, Percent_Identity=29.7297297297297, Blast_Score=125, Evalue=1e-29,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001917
- InterPro:   IPR004839
- InterPro:   IPR005861
- InterPro:   IPR015424
- InterPro:   IPR015421
- InterPro:   IPR015422 [H]

Pfam domain/function: PF00155 Aminotran_1_2 [H]

EC number: =2.6.1.9 [H]

Molecular weight: Translated: 41615; Mature: 41615

Theoretical pI: Translated: 4.91; Mature: 4.91

Prosite motif: PS00599 AA_TRANSFER_CLASS_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.1 %Cys     (Translated Protein)
1.9 %Met     (Translated Protein)
3.0 %Cys+Met (Translated Protein)
1.1 %Cys     (Mature Protein)
1.9 %Met     (Mature Protein)
3.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MRVKEQLLTLRAYVPGKNIEEVKREYGLSKIVKLASNENPFGCSARVTEALTSLASQYAL
CCHHHHHHHHHHHCCCCCHHHHHHHHCHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHCCC
YPDGHAFELRTQVAKHLGVKVEQLLFGSGLDEVIQMISRALLHEGTNVVMANPTFSQYHH
CCCCCHHHHHHHHHHHHCCHHHHHHHCCCHHHHHHHHHHHHHHCCCCEEEECCCHHHHHH
HAVIEGAEVREVSLKDGIHDLDAMLQQVDDQTKIVWICNPNNPTGTYVEKQKLLSFLEAV
HHHCCCCHHEEEHHHCCHHHHHHHHHHCCCCCEEEEEECCCCCCCCHHHHHHHHHHHHHC
PKSALVIMDEAYYEYAGAEDYPQTLPLLEKYENLMVLRTFSKAYGLAAFRIGYAVGNTEL
CCCEEEEEEHHHHHHCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHEECCCHH
IGQLEVARLPFNTSTVAQSVALAALEDQAFLQECVKKNEEGLHQYYAFCKEYNVFYYPSQ
HCCEEEEECCCCHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHCCEEEECCC
TNFIFLKLGIPGNEAFERLMKKGYIVRSGAAFGIDDGIRITVGLKEENDEIIELLKELVN
CCEEEEEECCCCHHHHHHHHHCCCEEECCCCCCCCCCCEEEEEECCCCHHHHHHHHHHHH
EQVQKEETYS
HHHHHHHCCC
>Mature Secondary Structure
MRVKEQLLTLRAYVPGKNIEEVKREYGLSKIVKLASNENPFGCSARVTEALTSLASQYAL
CCHHHHHHHHHHHCCCCCHHHHHHHHCHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHCCC
YPDGHAFELRTQVAKHLGVKVEQLLFGSGLDEVIQMISRALLHEGTNVVMANPTFSQYHH
CCCCCHHHHHHHHHHHHCCHHHHHHHCCCHHHHHHHHHHHHHHCCCCEEEECCCHHHHHH
HAVIEGAEVREVSLKDGIHDLDAMLQQVDDQTKIVWICNPNNPTGTYVEKQKLLSFLEAV
HHHCCCCHHEEEHHHCCHHHHHHHHHHCCCCCEEEEEECCCCCCCCHHHHHHHHHHHHHC
PKSALVIMDEAYYEYAGAEDYPQTLPLLEKYENLMVLRTFSKAYGLAAFRIGYAVGNTEL
CCCEEEEEEHHHHHHCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHEECCCHH
IGQLEVARLPFNTSTVAQSVALAALEDQAFLQECVKKNEEGLHQYYAFCKEYNVFYYPSQ
HCCEEEEECCCCHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHCCEEEECCC
TNFIFLKLGIPGNEAFERLMKKGYIVRSGAAFGIDDGIRITVGLKEENDEIIELLKELVN
CCEEEEEECCCCHHHHHHHHHCCCEEECCCCCCCCCCCEEEEEECCCCHHHHHHHHHHHH
EQVQKEETYS
HHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 12721629 [H]