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The map label for this gene is bioA [H]

Identifier: 52143752

GI number: 52143752

Start: 1574511

End: 1575860

Strand: Direct

Name: bioA [H]

Synonym: BCZK1481

Alternate gene names: 52143752

Gene position: 1574511-1575860 (Clockwise)

Preceding gene: 52143754

Following gene: 52143750

Centisome position: 29.7

GC content: 38.0

Gene sequence:

>1350_bases
ATGAAAACGAAACAGACTGATGAAATATTAGCAAAAGATGAGCAATATGTTTGGCACGGAATGCGTCCCTTTAGTCCAAA
TAGTACAATGGTAGGGGCAAAAGCAGAAGGGTGCTGGGTTGAAGATATACAAGGGAAAAGATATTTAGATGGTATGAGTG
GTCTTTGGTGTGTGAATAGTGGATATGGAAGAAAAGAGCTCGCAGAGGCGGCATATAAGCAATTACAAACATTATCATAC
TTTCCGATGTCACAATCGCATGAACCGGCTATAAAACTTGCCGAAAAATTAAATGAGTGGCTTGGAGGGGAGTATGTTAT
TTTCTTCTCTAATAGTGGTTCGGAAGCGAACGAAACAGCTTTTAAAATTGCAAGACAATACTATGCTCAAAAAGGAGAAC
CACATCGTTATAAATTTATGTCACGTTACCGCGGGTATCATGGGAATACAATGGCAACGATGGCAGCGACGGGACAAGCA
CAGCGTAGATATCAATATGAGCCATTTGCTTCAGGGTTTTTACATGTAACGCCGCCAGATTGTTATCGTATGCCTGGAAT
AGAAAGAGAGAACATTTATGATGTCGAATGTGTAAAAGAAGTAGATCGGGTCATGACATGGGAATTAAGTGAAACGATTG
CAGCTTTTATTATGGAACCAATTATTACGGGCGGAGGCATTTTAATGCCGCCACAAGACTATATGAAAGCTGTTCATGAA
ACGTGTCAAAAACATGGTGCCTTGCTCATTAGCGATGAAGTAATTTGCGGTTTTGGACGTACAGGAAAGGCATTTGGATT
TATGAATTATGATGTGAAACCAGATATTATTACAATGGCAAAAGGTATTACGAGTGCATATTTACCATTATCAGCAACAG
CTGTGAAAAAAGAAATATATGAAGCATTTAAAGGGAAGGGAGAATATGAATTCTTCCGTCATATTAATACATTTGGTGGA
AATCCTGCGGCTTGTGCATTAGCGCTTAAAAACTTAGAAATTATGGAAAATGAAAATTTAATTGAGCGATCTGCACAAAT
GGGTTCGCTTTTATTAGAGCAATTAAAAGAAGAAATTGGAGAACATCCACTTGTAGGAGATATTAGAGGAAAAGGTCTAC
TAGTTGGAATCGAACTAGTAAATGATAAAGAGACGAAAGAGCCAATTGATAACGACAAAATTGCAAGTGTTGTAAACGCT
TGTAAAGAAAAAGGTTTAATTATAGGGCGAAACGGTATGACAACAGCAGGATATAATAACGTCTTGACATTAGCACCACC
GCTTGTTATTTCAAGTGAAGAAATTGCCTTTGTTATTGGAACGTTGAAGACAGCGATGGAACGTATTTAA

Upstream 100 bases:

>100_bases
TTAATTTTGTGGAATGAAAATAGCAGGGAGAAATTTAAGCCATCATGGCACCAGCGCAGCTTTTGTGAAAAATAAGTTGT
TATGGAAGGTGGAAGAAATG

Downstream 100 bases:

>100_bases
TGAATGAAGCGAGCTGTACTATACAGCTCGCTTTTGTTTATGAGGTGAAATATGATGAATTTTCAAAGAGAGGGGAATTT
ATTATGAAGAAATATGATTC

Product: aminotransferase

Products: S-adenosyl-4-methylthio-2-oxobutanoate; 7,8-diaminononanoate

Alternate protein names: NA

Number of amino acids: Translated: 449; Mature: 449

Protein sequence:

>449_residues
MKTKQTDEILAKDEQYVWHGMRPFSPNSTMVGAKAEGCWVEDIQGKRYLDGMSGLWCVNSGYGRKELAEAAYKQLQTLSY
FPMSQSHEPAIKLAEKLNEWLGGEYVIFFSNSGSEANETAFKIARQYYAQKGEPHRYKFMSRYRGYHGNTMATMAATGQA
QRRYQYEPFASGFLHVTPPDCYRMPGIERENIYDVECVKEVDRVMTWELSETIAAFIMEPIITGGGILMPPQDYMKAVHE
TCQKHGALLISDEVICGFGRTGKAFGFMNYDVKPDIITMAKGITSAYLPLSATAVKKEIYEAFKGKGEYEFFRHINTFGG
NPAACALALKNLEIMENENLIERSAQMGSLLLEQLKEEIGEHPLVGDIRGKGLLVGIELVNDKETKEPIDNDKIASVVNA
CKEKGLIIGRNGMTTAGYNNVLTLAPPLVISSEEIAFVIGTLKTAMERI

Sequences:

>Translated_449_residues
MKTKQTDEILAKDEQYVWHGMRPFSPNSTMVGAKAEGCWVEDIQGKRYLDGMSGLWCVNSGYGRKELAEAAYKQLQTLSY
FPMSQSHEPAIKLAEKLNEWLGGEYVIFFSNSGSEANETAFKIARQYYAQKGEPHRYKFMSRYRGYHGNTMATMAATGQA
QRRYQYEPFASGFLHVTPPDCYRMPGIERENIYDVECVKEVDRVMTWELSETIAAFIMEPIITGGGILMPPQDYMKAVHE
TCQKHGALLISDEVICGFGRTGKAFGFMNYDVKPDIITMAKGITSAYLPLSATAVKKEIYEAFKGKGEYEFFRHINTFGG
NPAACALALKNLEIMENENLIERSAQMGSLLLEQLKEEIGEHPLVGDIRGKGLLVGIELVNDKETKEPIDNDKIASVVNA
CKEKGLIIGRNGMTTAGYNNVLTLAPPLVISSEEIAFVIGTLKTAMERI
>Mature_449_residues
MKTKQTDEILAKDEQYVWHGMRPFSPNSTMVGAKAEGCWVEDIQGKRYLDGMSGLWCVNSGYGRKELAEAAYKQLQTLSY
FPMSQSHEPAIKLAEKLNEWLGGEYVIFFSNSGSEANETAFKIARQYYAQKGEPHRYKFMSRYRGYHGNTMATMAATGQA
QRRYQYEPFASGFLHVTPPDCYRMPGIERENIYDVECVKEVDRVMTWELSETIAAFIMEPIITGGGILMPPQDYMKAVHE
TCQKHGALLISDEVICGFGRTGKAFGFMNYDVKPDIITMAKGITSAYLPLSATAVKKEIYEAFKGKGEYEFFRHINTFGG
NPAACALALKNLEIMENENLIERSAQMGSLLLEQLKEEIGEHPLVGDIRGKGLLVGIELVNDKETKEPIDNDKIASVVNA
CKEKGLIIGRNGMTTAGYNNVLTLAPPLVISSEEIAFVIGTLKTAMERI

Specific function: Essential for glycerol catabolism [H]

COG id: COG0161

COG function: function code H; Adenosylmethionine-8-amino-7-oxononanoate aminotransferase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family [H]

Homologues:

Organism=Homo sapiens, GI13994255, Length=430, Percent_Identity=32.093023255814, Blast_Score=218, Evalue=1e-56,
Organism=Homo sapiens, GI24119277, Length=446, Percent_Identity=30.9417040358744, Blast_Score=205, Evalue=8e-53,
Organism=Homo sapiens, GI37574042, Length=449, Percent_Identity=32.293986636971, Blast_Score=199, Evalue=3e-51,
Organism=Homo sapiens, GI226442705, Length=450, Percent_Identity=32.4444444444444, Blast_Score=197, Evalue=1e-50,
Organism=Homo sapiens, GI226442709, Length=396, Percent_Identity=34.3434343434343, Blast_Score=192, Evalue=5e-49,
Organism=Homo sapiens, GI4557809, Length=432, Percent_Identity=27.5462962962963, Blast_Score=157, Evalue=2e-38,
Organism=Homo sapiens, GI284507298, Length=327, Percent_Identity=30.5810397553517, Blast_Score=137, Evalue=2e-32,
Organism=Homo sapiens, GI188536080, Length=428, Percent_Identity=24.0654205607477, Blast_Score=87, Evalue=3e-17,
Organism=Homo sapiens, GI38679950, Length=428, Percent_Identity=24.0654205607477, Blast_Score=87, Evalue=3e-17,
Organism=Homo sapiens, GI38679946, Length=428, Percent_Identity=24.0654205607477, Blast_Score=87, Evalue=3e-17,
Organism=Escherichia coli, GI1789016, Length=433, Percent_Identity=30.2540415704388, Blast_Score=193, Evalue=2e-50,
Organism=Escherichia coli, GI1789759, Length=413, Percent_Identity=30.7506053268765, Blast_Score=192, Evalue=3e-50,
Organism=Escherichia coli, GI145693181, Length=407, Percent_Identity=30.7125307125307, Blast_Score=188, Evalue=6e-49,
Organism=Escherichia coli, GI1787560, Length=420, Percent_Identity=31.1904761904762, Blast_Score=177, Evalue=8e-46,
Organism=Escherichia coli, GI1786991, Length=447, Percent_Identity=31.0961968680089, Blast_Score=172, Evalue=4e-44,
Organism=Escherichia coli, GI1788044, Length=429, Percent_Identity=27.972027972028, Blast_Score=165, Evalue=6e-42,
Organism=Caenorhabditis elegans, GI32564660, Length=463, Percent_Identity=31.9654427645788, Blast_Score=207, Evalue=1e-53,
Organism=Caenorhabditis elegans, GI71992977, Length=466, Percent_Identity=30.2575107296137, Blast_Score=192, Evalue=3e-49,
Organism=Caenorhabditis elegans, GI25144271, Length=437, Percent_Identity=28.1464530892449, Blast_Score=172, Evalue=3e-43,
Organism=Caenorhabditis elegans, GI25144274, Length=291, Percent_Identity=30.5841924398625, Blast_Score=133, Evalue=2e-31,
Organism=Caenorhabditis elegans, GI17541228, Length=383, Percent_Identity=23.7597911227154, Blast_Score=69, Evalue=4e-12,
Organism=Saccharomyces cerevisiae, GI6323470, Length=459, Percent_Identity=30.0653594771242, Blast_Score=183, Evalue=5e-47,
Organism=Saccharomyces cerevisiae, GI6324432, Length=398, Percent_Identity=27.6381909547739, Blast_Score=146, Evalue=6e-36,
Organism=Saccharomyces cerevisiae, GI6324386, Length=472, Percent_Identity=26.9067796610169, Blast_Score=141, Evalue=2e-34,
Organism=Drosophila melanogaster, GI161085790, Length=431, Percent_Identity=32.0185614849188, Blast_Score=214, Evalue=1e-55,
Organism=Drosophila melanogaster, GI28574759, Length=430, Percent_Identity=31.6279069767442, Blast_Score=208, Evalue=7e-54,
Organism=Drosophila melanogaster, GI21356575, Length=459, Percent_Identity=30.2832244008715, Blast_Score=176, Evalue=3e-44,
Organism=Drosophila melanogaster, GI21357415, Length=435, Percent_Identity=28.0459770114943, Blast_Score=157, Evalue=1e-38,
Organism=Drosophila melanogaster, GI281366494, Length=385, Percent_Identity=22.5974025974026, Blast_Score=74, Evalue=2e-13,
Organism=Drosophila melanogaster, GI24667139, Length=385, Percent_Identity=22.5974025974026, Blast_Score=74, Evalue=2e-13,
Organism=Drosophila melanogaster, GI24667143, Length=385, Percent_Identity=22.5974025974026, Blast_Score=74, Evalue=2e-13,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR005814
- InterPro:   IPR015424
- InterPro:   IPR015421
- InterPro:   IPR015422 [H]

Pfam domain/function: PF00202 Aminotran_3 [H]

EC number: 2.6.1.62

Molecular weight: Translated: 50131; Mature: 50131

Theoretical pI: Translated: 5.90; Mature: 5.90

Prosite motif: PS00600 AA_TRANSFER_CLASS_3

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.8 %Cys     (Translated Protein)
4.2 %Met     (Translated Protein)
6.0 %Cys+Met (Translated Protein)
1.8 %Cys     (Mature Protein)
4.2 %Met     (Mature Protein)
6.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKTKQTDEILAKDEQYVWHGMRPFSPNSTMVGAKAEGCWVEDIQGKRYLDGMSGLWCVNS
CCCCCCHHHHHCCCHHHHCCCCCCCCCCCEEECCCCCCCCCCCCCCHHHCCCCCEEEECC
GYGRKELAEAAYKQLQTLSYFPMSQSHEPAIKLAEKLNEWLGGEYVIFFSNSGSEANETA
CCCHHHHHHHHHHHHHHHHCCCCCCCCCHHHHHHHHHHHHHCCCEEEEEECCCCCHHHHH
FKIARQYYAQKGEPHRYKFMSRYRGYHGNTMATMAATGQAQRRYQYEPFASGFLHVTPPD
HHHHHHHHHCCCCCHHHHHHHHHCCCCCCEEEEEECCCHHHHCCCCCCHHCCEEECCCCH
CYRMPGIERENIYDVECVKEVDRVMTWELSETIAAFIMEPIITGGGILMPPQDYMKAVHE
HHCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCEECCCHHHHHHHHH
TCQKHGALLISDEVICGFGRTGKAFGFMNYDVKPDIITMAKGITSAYLPLSATAVKKEIY
HHHHCCCEEEECCEEECCCCCCCEEEEECCCCCCCHHHHHHHHHHHCCCCHHHHHHHHHH
EAFKGKGEYEFFRHINTFGGNPAACALALKNLEIMENENLIERSAQMGSLLLEQLKEEIG
HHHCCCCCHHHHHHHHHCCCCHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHC
EHPLVGDIRGKGLLVGIELVNDKETKEPIDNDKIASVVNACKEKGLIIGRNGMTTAGYNN
CCCCEECCCCCEEEEEEEEECCCCCCCCCCCHHHHHHHHHHHHCCEEEECCCCCCCCCCC
VLTLAPPLVISSEEIAFVIGTLKTAMERI
EEEECCCEEECCCCHHHHHHHHHHHHHCC
>Mature Secondary Structure
MKTKQTDEILAKDEQYVWHGMRPFSPNSTMVGAKAEGCWVEDIQGKRYLDGMSGLWCVNS
CCCCCCHHHHHCCCHHHHCCCCCCCCCCCEEECCCCCCCCCCCCCCHHHCCCCCEEEECC
GYGRKELAEAAYKQLQTLSYFPMSQSHEPAIKLAEKLNEWLGGEYVIFFSNSGSEANETA
CCCHHHHHHHHHHHHHHHHCCCCCCCCCHHHHHHHHHHHHHCCCEEEEEECCCCCHHHHH
FKIARQYYAQKGEPHRYKFMSRYRGYHGNTMATMAATGQAQRRYQYEPFASGFLHVTPPD
HHHHHHHHHCCCCCHHHHHHHHHCCCCCCEEEEEECCCHHHHCCCCCCHHCCEEECCCCH
CYRMPGIERENIYDVECVKEVDRVMTWELSETIAAFIMEPIITGGGILMPPQDYMKAVHE
HHCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCEECCCHHHHHHHHH
TCQKHGALLISDEVICGFGRTGKAFGFMNYDVKPDIITMAKGITSAYLPLSATAVKKEIY
HHHHCCCEEEECCEEECCCCCCCEEEEECCCCCCCHHHHHHHHHHHCCCCHHHHHHHHHH
EAFKGKGEYEFFRHINTFGGNPAACALALKNLEIMENENLIERSAQMGSLLLEQLKEEIG
HHHCCCCCHHHHHHHHHCCCCHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHC
EHPLVGDIRGKGLLVGIELVNDKETKEPIDNDKIASVVNACKEKGLIIGRNGMTTAGYNN
CCCCEECCCCCEEEEEEEEECCCCCCCCCCCHHHHHHHHHHHHCCEEEECCCCCCCCCCC
VLTLAPPLVISSEEIAFVIGTLKTAMERI
EEEECCCEEECCCCHHHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: S-adenosyl-L-methionine; 8-amino-7-oxononanoate

Specific reaction: S-adenosyl-L-methionine + 8-amino-7-oxononanoate = S-adenosyl-4-methylthio-2-oxobutanoate + 7,8-diaminononanoate

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 9579061; 9384377; 8969498; 8436953 [H]