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The map label for this gene is yclK [H]

Identifier: 52143462

GI number: 52143462

Start: 1899035

End: 1900078

Strand: Direct

Name: yclK [H]

Synonym: BCZK1773

Alternate gene names: 52143462

Gene position: 1899035-1900078 (Clockwise)

Preceding gene: 52143461

Following gene: 52143458

Centisome position: 35.82

GC content: 34.1

Gene sequence:

>1044_bases
ATGAGTAAATTCAAGATGCTGAAAGTAACGGGAGCGATAATAGCACTCTTTTCTTTTCTTACTATTATTTGGTCTACAGC
ATTTTATGTATCATCTAGTATATTGGATGCCCTTGCAATACATCTATCTCCTTTTGTTACGTACCTCATTAGTGACATAC
TCAGTTTTATATTTATGATTCTTCTTTGGATATTAATTGCAGTATTAATGAGACCGAAGCGAGAGGCGATGATTTGGACT
ATTATTGAACCGATACAAAAAATTGCAAAAGGGGACTTCTCGGTAAAAATAAGAAATGAAGAAAAGTATGATGGGGAAAT
TGGTGTGCTCGTAAAAAGTATAAACGATATGACAGATGAACTGAATGCGATGGAGAAGATGCGTCAGGAATTTGTTTCGA
ATGTTTCTCATGAAATACAGTCACCATTAACTTCTATAAAAGGATTTGCTAGAGCACTACAAGATACTAATCTTCCTGAG
GAAAAAAGAAAGCATTATCTTACCATTATTGAAACAGAAACGACGAGATTATCTAAACTAAGTCAAAATTTACTGAAACT
CACCCTATTAGAGTCGGAAGAATATACACCAGAAAGAGTTACTTATCGATTAGATCAACAGTTAAAGCAAATTGTGTTAA
ATAGTGAACCGCTTTGGGCTGAGAAAGAAATTGAATTAGACCTTGATTTAGAAAAAGTGCATATAACTGCTGACCAAGAA
AGTATGAGTCAAGTTTGGATTAATTTAATTCATAATAGTATTAAATTTACTCCAAGTAGCGGTGCGATTTCAATCAAGCT
AAAAGAATATGAGACATTAGTAGAAGTACGTATACGTGATACGGGAATTGGTATATCCGAAGAACAGAAGCAACATATTT
TTGAGCGTTTTTATAAAGCAGATTCTTCACGAAATCGTGCTTATGGAGGAAGTGGTTTAGGTTTAGCGATTGTGAAAAAA
GTACTCGATCTTCATCAGGGGGAAATAAAAGTTGAGAGTGAGGAAGGGAATGGTACGGAATTTATTGTTCGTATTTCTCT
TTAA

Upstream 100 bases:

>100_bases
TACGTGAGAAGTTTCAAGAAGAGAAGTCGAAATTTAGTATTAAAACAATAAGGGGTTTAGGATATCGCTTAGAGGTAAGT
AAATGAGAAAAAGAGAACGA

Downstream 100 bases:

>100_bases
AAATACATTTCCCATTACTGCAACTATATTGATAAGCTTTTCCTTCATTATTCATACGGTATGAATAATCTGATTTTTTA
TCTTTCTTAAAGTCAACGTA

Product: sensor histidine kinase

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 347; Mature: 346

Protein sequence:

>347_residues
MSKFKMLKVTGAIIALFSFLTIIWSTAFYVSSSILDALAIHLSPFVTYLISDILSFIFMILLWILIAVLMRPKREAMIWT
IIEPIQKIAKGDFSVKIRNEEKYDGEIGVLVKSINDMTDELNAMEKMRQEFVSNVSHEIQSPLTSIKGFARALQDTNLPE
EKRKHYLTIIETETTRLSKLSQNLLKLTLLESEEYTPERVTYRLDQQLKQIVLNSEPLWAEKEIELDLDLEKVHITADQE
SMSQVWINLIHNSIKFTPSSGAISIKLKEYETLVEVRIRDTGIGISEEQKQHIFERFYKADSSRNRAYGGSGLGLAIVKK
VLDLHQGEIKVESEEGNGTEFIVRISL

Sequences:

>Translated_347_residues
MSKFKMLKVTGAIIALFSFLTIIWSTAFYVSSSILDALAIHLSPFVTYLISDILSFIFMILLWILIAVLMRPKREAMIWT
IIEPIQKIAKGDFSVKIRNEEKYDGEIGVLVKSINDMTDELNAMEKMRQEFVSNVSHEIQSPLTSIKGFARALQDTNLPE
EKRKHYLTIIETETTRLSKLSQNLLKLTLLESEEYTPERVTYRLDQQLKQIVLNSEPLWAEKEIELDLDLEKVHITADQE
SMSQVWINLIHNSIKFTPSSGAISIKLKEYETLVEVRIRDTGIGISEEQKQHIFERFYKADSSRNRAYGGSGLGLAIVKK
VLDLHQGEIKVESEEGNGTEFIVRISL
>Mature_346_residues
SKFKMLKVTGAIIALFSFLTIIWSTAFYVSSSILDALAIHLSPFVTYLISDILSFIFMILLWILIAVLMRPKREAMIWTI
IEPIQKIAKGDFSVKIRNEEKYDGEIGVLVKSINDMTDELNAMEKMRQEFVSNVSHEIQSPLTSIKGFARALQDTNLPEE
KRKHYLTIIETETTRLSKLSQNLLKLTLLESEEYTPERVTYRLDQQLKQIVLNSEPLWAEKEIELDLDLEKVHITADQES
MSQVWINLIHNSIKFTPSSGAISIKLKEYETLVEVRIRDTGIGISEEQKQHIFERFYKADSSRNRAYGGSGLGLAIVKKV
LDLHQGEIKVESEEGNGTEFIVRISL

Specific function: Could be member of the two-component regulatory system yclK/yclJ. Potentially phosphorylates yclJ [H]

COG id: COG0642

COG function: function code T; Signal transduction histidine kinase

Gene ontology:

Cell location: Cell membrane; Multi-pass membrane protein (Potential) [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 histidine kinase domain [H]

Homologues:

Organism=Escherichia coli, GI1788393, Length=276, Percent_Identity=27.8985507246377, Blast_Score=132, Evalue=2e-32,
Organism=Escherichia coli, GI1786783, Length=305, Percent_Identity=27.2131147540984, Blast_Score=124, Evalue=6e-30,
Organism=Escherichia coli, GI145693157, Length=239, Percent_Identity=30.5439330543933, Blast_Score=121, Evalue=6e-29,
Organism=Escherichia coli, GI1789149, Length=230, Percent_Identity=32.6086956521739, Blast_Score=120, Evalue=1e-28,
Organism=Escherichia coli, GI1786600, Length=229, Percent_Identity=29.2576419213974, Blast_Score=115, Evalue=4e-27,
Organism=Escherichia coli, GI1788549, Length=245, Percent_Identity=28.1632653061224, Blast_Score=98, Evalue=9e-22,
Organism=Escherichia coli, GI1788713, Length=254, Percent_Identity=27.1653543307087, Blast_Score=98, Evalue=1e-21,
Organism=Escherichia coli, GI1790861, Length=229, Percent_Identity=31.8777292576419, Blast_Score=97, Evalue=2e-21,
Organism=Escherichia coli, GI1787894, Length=362, Percent_Identity=25.6906077348066, Blast_Score=96, Evalue=3e-21,
Organism=Escherichia coli, GI48994928, Length=239, Percent_Identity=28.4518828451883, Blast_Score=93, Evalue=2e-20,
Organism=Escherichia coli, GI1790436, Length=230, Percent_Identity=28.2608695652174, Blast_Score=93, Evalue=2e-20,
Organism=Escherichia coli, GI1789403, Length=312, Percent_Identity=26.2820512820513, Blast_Score=88, Evalue=1e-18,
Organism=Escherichia coli, GI87082128, Length=242, Percent_Identity=26.8595041322314, Blast_Score=87, Evalue=1e-18,
Organism=Escherichia coli, GI1790346, Length=239, Percent_Identity=27.1966527196653, Blast_Score=86, Evalue=3e-18,
Organism=Escherichia coli, GI1788279, Length=315, Percent_Identity=26.031746031746, Blast_Score=78, Evalue=9e-16,
Organism=Escherichia coli, GI1790551, Length=247, Percent_Identity=25.5060728744939, Blast_Score=75, Evalue=6e-15,
Organism=Escherichia coli, GI1786912, Length=222, Percent_Identity=26.5765765765766, Blast_Score=75, Evalue=7e-15,
Organism=Escherichia coli, GI1789808, Length=297, Percent_Identity=22.2222222222222, Blast_Score=73, Evalue=2e-14,
Organism=Escherichia coli, GI1790300, Length=238, Percent_Identity=26.4705882352941, Blast_Score=71, Evalue=1e-13,
Organism=Escherichia coli, GI87081816, Length=231, Percent_Identity=25.5411255411255, Blast_Score=66, Evalue=4e-12,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003594
- InterPro:   IPR003660
- InterPro:   IPR004358
- InterPro:   IPR003661
- InterPro:   IPR005467
- InterPro:   IPR009082 [H]

Pfam domain/function: PF00672 HAMP; PF02518 HATPase_c; PF00512 HisKA [H]

EC number: =2.7.13.3 [H]

Molecular weight: Translated: 39716; Mature: 39584

Theoretical pI: Translated: 5.72; Mature: 5.72

Prosite motif: PS50885 HAMP ; PS50109 HIS_KIN

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
2.6 %Met     (Translated Protein)
2.6 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
2.3 %Met     (Mature Protein)
2.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSKFKMLKVTGAIIALFSFLTIIWSTAFYVSSSILDALAIHLSPFVTYLISDILSFIFMI
CCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
LLWILIAVLMRPKREAMIWTIIEPIQKIAKGDFSVKIRNEEKYDGEIGVLVKSINDMTDE
HHHHHHHHHHCCCHHHHHHHHHHHHHHHHCCCCEEEEECCCCCCCHHHHHHHHHHHHHHH
LNAMEKMRQEFVSNVSHEIQSPLTSIKGFARALQDTNLPEEKRKHYLTIIETETTRLSKL
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHCCEEEEEECCHHHHHHH
SQNLLKLTLLESEEYTPERVTYRLDQQLKQIVLNSEPLWAEKEIELDLDLEKVHITADQE
HHHHHHHHEECCCCCCHHHHHHHHHHHHHHHHCCCCCCCCCCCEEEEECEEEEEEECCHH
SMSQVWINLIHNSIKFTPSSGAISIKLKEYETLVEVRIRDTGIGISEEQKQHIFERFYKA
HHHHHHHHHHHHHCEECCCCCEEEEEEHHHHHHHHEEEECCCCCCCHHHHHHHHHHHHHC
DSSRNRAYGGSGLGLAIVKKVLDLHQGEIKVESEEGNGTEFIVRISL
CCCCCCCCCCCCHHHHHHHHHHHCCCCCEEEECCCCCCCEEEEEEEC
>Mature Secondary Structure 
SKFKMLKVTGAIIALFSFLTIIWSTAFYVSSSILDALAIHLSPFVTYLISDILSFIFMI
CCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
LLWILIAVLMRPKREAMIWTIIEPIQKIAKGDFSVKIRNEEKYDGEIGVLVKSINDMTDE
HHHHHHHHHHCCCHHHHHHHHHHHHHHHHCCCCEEEEECCCCCCCHHHHHHHHHHHHHHH
LNAMEKMRQEFVSNVSHEIQSPLTSIKGFARALQDTNLPEEKRKHYLTIIETETTRLSKL
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHCCEEEEEECCHHHHHHH
SQNLLKLTLLESEEYTPERVTYRLDQQLKQIVLNSEPLWAEKEIELDLDLEKVHITADQE
HHHHHHHHEECCCCCCHHHHHHHHHHHHHHHHCCCCCCCCCCCEEEEECEEEEEEECCHH
SMSQVWINLIHNSIKFTPSSGAISIKLKEYETLVEVRIRDTGIGISEEQKQHIFERFYKA
HHHHHHHHHHHHHCEECCCCCEEEEEEHHHHHHHHEEEECCCCCCCHHHHHHHHHHHHHC
DSSRNRAYGGSGLGLAIVKKVLDLHQGEIKVESEEGNGTEFIVRISL
CCCCCCCCCCCCHHHHHHHHHHHCCCCCEEEECCCCCCCEEEEEEEC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 7.0

TargetDB status: NA

Availability: NA

References: 8969502; 9384377 [H]