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The map label for this gene is hssR [H]

Identifier: 52143461

GI number: 52143461

Start: 1898256

End: 1899020

Strand: Direct

Name: hssR [H]

Synonym: BCZK1772

Alternate gene names: 52143461

Gene position: 1898256-1899020 (Clockwise)

Preceding gene: 52143463

Following gene: 52143462

Centisome position: 35.81

GC content: 34.25

Gene sequence:

>765_bases
ATGAATCATCAGTGGGGATTGTACTCCACTGATGATTCATTTTTAAAAGTTTTGTTAAGGATGCTAATTAGAAAGGAAAT
GGTTTCTTTGATACCTAACATTTTAATAGTAGACGATGATCCGCATATTAGAGAACTCGTTTCTGTATTTTTAGAGCGTG
AAGGTTTTCAAACATATGAGGCAATTGATGGTCTAGATGCACTTCAAAAAATAAATGAAGTGAAAGTTGATATGGTTATT
CTTGATATCATGATGCCGAATATGGATGGATTTGATGTATGTTTCGAATTAAGAAAGTACTATGATATTCCGATTTTGAT
GTTAACTGCTAAAGGGGAAACGTCTCAAAAAGTAAAAGGATTTCATCTTGGTACGGATGATTATCTTGTAAAACCATTTG
ATCCGATAGAACTAGTAGTGAGGGTTAAGGCGTTATTGAAACGTTACCAAATTACAGTGTCGCAATCAATTCAAGTTGGA
ACTGTACTGTTAAATCGTAAAACATTTGAAGTTACAATTGGAGAACAAACGGTTACGTTACCGTTAAAAGAATTCGAATT
GCTCTTTACTTTAGGCTCTAAAGCGGGGAGAACTTGTTCGAGAGAGCAATTAATTGAAGATGTATGGGGATATGATTTTG
AAGGGAATGAACGCACACTAGACGTTCATATAAATCGGTTACGTGAGAAGTTTCAAGAAGAGAAGTCGAAATTTAGTATT
AAAACAATAAGGGGTTTAGGATATCGCTTAGAGGTAAGTAAATGA

Upstream 100 bases:

>100_bases
CTTACAGGAAGTGGTACACATGATGAATTATTACGCACACATGACATGTATCGTGAATTTGCAACGCAACAATTGAAAAT
TAAAGAGGCGGCATTATAAA

Downstream 100 bases:

>100_bases
GAAAAAGAGAACGAATGAGTAAATTCAAGATGCTGAAAGTAACGGGAGCGATAATAGCACTCTTTTCTTTTCTTACTATT
ATTTGGTCTACAGCATTTTA

Product: response regulator

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 254; Mature: 254

Protein sequence:

>254_residues
MNHQWGLYSTDDSFLKVLLRMLIRKEMVSLIPNILIVDDDPHIRELVSVFLEREGFQTYEAIDGLDALQKINEVKVDMVI
LDIMMPNMDGFDVCFELRKYYDIPILMLTAKGETSQKVKGFHLGTDDYLVKPFDPIELVVRVKALLKRYQITVSQSIQVG
TVLLNRKTFEVTIGEQTVTLPLKEFELLFTLGSKAGRTCSREQLIEDVWGYDFEGNERTLDVHINRLREKFQEEKSKFSI
KTIRGLGYRLEVSK

Sequences:

>Translated_254_residues
MNHQWGLYSTDDSFLKVLLRMLIRKEMVSLIPNILIVDDDPHIRELVSVFLEREGFQTYEAIDGLDALQKINEVKVDMVI
LDIMMPNMDGFDVCFELRKYYDIPILMLTAKGETSQKVKGFHLGTDDYLVKPFDPIELVVRVKALLKRYQITVSQSIQVG
TVLLNRKTFEVTIGEQTVTLPLKEFELLFTLGSKAGRTCSREQLIEDVWGYDFEGNERTLDVHINRLREKFQEEKSKFSI
KTIRGLGYRLEVSK
>Mature_254_residues
MNHQWGLYSTDDSFLKVLLRMLIRKEMVSLIPNILIVDDDPHIRELVSVFLEREGFQTYEAIDGLDALQKINEVKVDMVI
LDIMMPNMDGFDVCFELRKYYDIPILMLTAKGETSQKVKGFHLGTDDYLVKPFDPIELVVRVKALLKRYQITVSQSIQVG
TVLLNRKTFEVTIGEQTVTLPLKEFELLFTLGSKAGRTCSREQLIEDVWGYDFEGNERTLDVHINRLREKFQEEKSKFSI
KTIRGLGYRLEVSK

Specific function: Member of the two-component regulatory system hssS/hssR involved in intracellular heme homeostasis and tempering of staphylococcal virulence. Phosphorylated hssR binds to a direct repeat sequence within hrtAB promoter and activates the expression of hrtAB

COG id: NA

COG function: NA

Gene ontology:

Cell location: Cytoplasm (Potential) [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 response regulatory domain [H]

Homologues:

Organism=Escherichia coli, GI1786599, Length=221, Percent_Identity=38.9140271493213, Blast_Score=162, Evalue=3e-41,
Organism=Escherichia coli, GI87082012, Length=215, Percent_Identity=33.953488372093, Blast_Score=139, Evalue=2e-34,
Organism=Escherichia coli, GI1788394, Length=224, Percent_Identity=33.9285714285714, Blast_Score=137, Evalue=7e-34,
Organism=Escherichia coli, GI2367329, Length=224, Percent_Identity=36.6071428571429, Blast_Score=132, Evalue=1e-32,
Organism=Escherichia coli, GI1786784, Length=221, Percent_Identity=36.6515837104072, Blast_Score=132, Evalue=2e-32,
Organism=Escherichia coli, GI1790860, Length=222, Percent_Identity=35.1351351351351, Blast_Score=132, Evalue=3e-32,
Organism=Escherichia coli, GI1790552, Length=218, Percent_Identity=36.2385321100917, Blast_Score=131, Evalue=4e-32,
Organism=Escherichia coli, GI1789809, Length=224, Percent_Identity=33.4821428571429, Blast_Score=129, Evalue=2e-31,
Organism=Escherichia coli, GI1789402, Length=218, Percent_Identity=35.7798165137615, Blast_Score=127, Evalue=5e-31,
Organism=Escherichia coli, GI1790863, Length=236, Percent_Identity=30.9322033898305, Blast_Score=125, Evalue=3e-30,
Organism=Escherichia coli, GI1786911, Length=222, Percent_Identity=31.5315315315315, Blast_Score=121, Evalue=5e-29,
Organism=Escherichia coli, GI145693140, Length=229, Percent_Identity=28.3842794759825, Blast_Score=109, Evalue=1e-25,
Organism=Escherichia coli, GI1787375, Length=221, Percent_Identity=31.2217194570136, Blast_Score=105, Evalue=4e-24,
Organism=Escherichia coli, GI1787229, Length=210, Percent_Identity=27.6190476190476, Blast_Score=89, Evalue=4e-19,
Organism=Escherichia coli, GI1788550, Length=180, Percent_Identity=30, Blast_Score=88, Evalue=7e-19,
Organism=Escherichia coli, GI1788713, Length=102, Percent_Identity=39.2156862745098, Blast_Score=72, Evalue=2e-14,
Organism=Escherichia coli, GI145693157, Length=100, Percent_Identity=36, Blast_Score=68, Evalue=7e-13,
Organism=Escherichia coli, GI1790299, Length=143, Percent_Identity=30.0699300699301, Blast_Score=67, Evalue=8e-13,
Organism=Escherichia coli, GI1788191, Length=108, Percent_Identity=36.1111111111111, Blast_Score=65, Evalue=4e-12,
Organism=Escherichia coli, GI1789149, Length=169, Percent_Identity=28.9940828402367, Blast_Score=64, Evalue=9e-12,
Organism=Escherichia coli, GI1788905, Length=103, Percent_Identity=35.9223300970874, Blast_Score=64, Evalue=9e-12,
Organism=Escherichia coli, GI1787487, Length=100, Percent_Identity=35, Blast_Score=63, Evalue=2e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR011006
- InterPro:   IPR001867
- InterPro:   IPR001789
- InterPro:   IPR011991 [H]

Pfam domain/function: PF00072 Response_reg; PF00486 Trans_reg_C [H]

EC number: NA

Molecular weight: Translated: 29460; Mature: 29460

Theoretical pI: Translated: 5.47; Mature: 5.47

Prosite motif: PS50110 RESPONSE_REGULATORY

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.8 %Cys     (Translated Protein)
3.1 %Met     (Translated Protein)
3.9 %Cys+Met (Translated Protein)
0.8 %Cys     (Mature Protein)
3.1 %Met     (Mature Protein)
3.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MNHQWGLYSTDDSFLKVLLRMLIRKEMVSLIPNILIVDDDPHIRELVSVFLEREGFQTYE
CCCCCCCCCCCHHHHHHHHHHHHHHHHHHHCCCEEEECCCHHHHHHHHHHHHHCCCHHHH
AIDGLDALQKINEVKVDMVILDIMMPNMDGFDVCFELRKYYDIPILMLTAKGETSQKVKG
HHHHHHHHHHHHHHHHHHEEEEECCCCCCHHHHHHHHHHHCCCCEEEEEECCCCCCCCCC
FHLGTDDYLVKPFDPIELVVRVKALLKRYQITVSQSIQVGTVLLNRKTFEVTIGEQTVTL
EECCCCCCEECCCCHHHHHHHHHHHHHHHHHHHHCCEEEEEEEECCEEEEEEECCEEEEE
PLKEFELLFTLGSKAGRTCSREQLIEDVWGYDFEGNERTLDVHINRLREKFQEEKSKFSI
EHHHHHHHHHHCCCCCCCCCHHHHHHHHCCCCCCCCCEEEHHHHHHHHHHHHHHHHHEEH
KTIRGLGYRLEVSK
HHHHCCCEEEEECC
>Mature Secondary Structure
MNHQWGLYSTDDSFLKVLLRMLIRKEMVSLIPNILIVDDDPHIRELVSVFLEREGFQTYE
CCCCCCCCCCCHHHHHHHHHHHHHHHHHHHCCCEEEECCCHHHHHHHHHHHHHCCCHHHH
AIDGLDALQKINEVKVDMVILDIMMPNMDGFDVCFELRKYYDIPILMLTAKGETSQKVKG
HHHHHHHHHHHHHHHHHHEEEEECCCCCCHHHHHHHHHHHCCCCEEEEEECCCCCCCCCC
FHLGTDDYLVKPFDPIELVVRVKALLKRYQITVSQSIQVGTVLLNRKTFEVTIGEQTVTL
EECCCCCCEECCCCHHHHHHHHHHHHHHHHHHHHCCEEEEEEEECCEEEEEEECCEEEEE
PLKEFELLFTLGSKAGRTCSREQLIEDVWGYDFEGNERTLDVHINRLREKFQEEKSKFSI
EHHHHHHHHHHCCCCCCCCCHHHHHHHHCCCCCCCCCEEEHHHHHHHHHHHHHHHHHEEH
KTIRGLGYRLEVSK
HHHHCCCEEEEECC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA