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The map label for this gene is flp [H]

Identifier: 52143219

GI number: 52143219

Start: 2138559

End: 2140016

Strand: Reverse

Name: flp [H]

Synonym: BCZK2018

Alternate gene names: 52143219

Gene position: 2140016-2138559 (Counterclockwise)

Preceding gene: 52143211

Following gene: 52143220

Centisome position: 40.37

GC content: 35.94

Gene sequence:

>1458_bases
ATGTCTAAAATTGAAACGCCTGTTATGACTTCTTTACAAACAACGGTTGAAAAAATGATGAAGGATTTAAACGTTCCGGG
AGCTGCTGTAGCTATTATAAAAGACGGTGAAGTTATTATTTCAGAAGGATTTGGCTATCGAAATCTAGAGACAAAAGAAC
CAGTTACACCGCGTACTTTGTTTGCAATTGGTTCCTCAACGAAAGCTTTTGGCACACTTTCATTAAGTTTGTTAGCACAG
CAAAAAAGGTTTAATTGGGATACTCCTGTCCAGTCTTATATACAAAACTTCTCTTTATCTGAACTACTTGCTAGCTCACA
AGTTACCGGACGAGATTTAGCTTCTCATCGAACTGGCGTAAGCCGCCATGAAGCTCTTTGGTATAGCTCTTCCTTATCTC
GAAAAAATCTCGTTGAAAAAATAAAACATTTACCACTTGATGCACCGTTTCGGACTTCATTTCTATATAACAACTTAATG
TATGCGACAATTAGCTATATTGTAGAAAACATCACAAATCAAACGTGGGAGCAATACGCTACAGAACATATTTTAGAGCC
TTTAAATATGAGCCATACAAACTTCTCTGTTATAGATTCACAAACTACAGATGATTATGCTTTACCTTACATTGAAAATG
ATGGTGAAATAAAAGAAGTTCCATTCCGTAACATCGATACAGTCGGCGCTGCTGGATGTATTAATTCTACAATTAAAGAT
ATGGCCAATTGGGTCCTTCTTCACTTAAAACAAGGAAAATTTGGAGAGTATAAATTAATTTCTCCTGAATTATTACAACA
AATGTATACACCGCACAATTCTATTCCAGATCAACCAGTTTTATCACTTCCTGAATCTCCATTAAATAGTTACGGCCTTG
GTTGGTTTATTAGCGCTTATCGTGGTAATAAGGTGATTCATCATGGTGGTAATATTGATGGATTTTCAGCGCTTGTTTCT
TTCATACCAACAGAAAACATCGGCCTTGTCATTTTAACGAATGCTGGAGGCACATTACTGCCTACTTATCTTGCTAATCA
AATTTATGACGAACTGCTTGCATTAGAAACCATTGATTGGCATAAACGCGCTGTAGAAGATACGGAAAAAATGAAGGAAA
TGATGAAAGAAGCAACCGAATCCGTTCCAGAACAAATTAAAGGGACTACACCTTCTCACAAATTAGAGGATTACACTGGT
ACTTTCGAACATCCTGCATACGGAACATTACAAGTATACAAACGAGATGATTCGTTATTTGTACAATTTATGGAGATGGA
CATTCAATTAACGCATCATCATTACGACATCTTTTCTGCAAAAGTTGACTTATTCCAAATGAAAATGAGTTTATTATTCG
CTTATGAAATGAATTTGAGTGGTGAATTTCCATCGCTTCAGTTACATGTGCCAGCTATGTTAAGTACTCAGCCGCTTGCA
TTTAAGAAAATTAAATAA

Upstream 100 bases:

>100_bases
CCTTACAAAATTATTAACTTTCCATAATTATAAAGGGTTTCATTTTCTATTACCGAAAGTATAGTGCGGTAGAACAAAAT
TATATTTGGAGGTTAGAAGT

Downstream 100 bases:

>100_bases
AGTTTTAATAGAGGGATGATAACACGTCCCTCTATTTTTCATTACAATCCCCATCCAAATAAAGGATTTTAAGCATTGAA
TAAAGAATCCCTTTATTTAA

Product: penicillin-binding protein

Products: A Substituted Beta- Amino Acid. [C]

Alternate protein names: FmtA-like protein [H]

Number of amino acids: Translated: 485; Mature: 484

Protein sequence:

>485_residues
MSKIETPVMTSLQTTVEKMMKDLNVPGAAVAIIKDGEVIISEGFGYRNLETKEPVTPRTLFAIGSSTKAFGTLSLSLLAQ
QKRFNWDTPVQSYIQNFSLSELLASSQVTGRDLASHRTGVSRHEALWYSSSLSRKNLVEKIKHLPLDAPFRTSFLYNNLM
YATISYIVENITNQTWEQYATEHILEPLNMSHTNFSVIDSQTTDDYALPYIENDGEIKEVPFRNIDTVGAAGCINSTIKD
MANWVLLHLKQGKFGEYKLISPELLQQMYTPHNSIPDQPVLSLPESPLNSYGLGWFISAYRGNKVIHHGGNIDGFSALVS
FIPTENIGLVILTNAGGTLLPTYLANQIYDELLALETIDWHKRAVEDTEKMKEMMKEATESVPEQIKGTTPSHKLEDYTG
TFEHPAYGTLQVYKRDDSLFVQFMEMDIQLTHHHYDIFSAKVDLFQMKMSLLFAYEMNLSGEFPSLQLHVPAMLSTQPLA
FKKIK

Sequences:

>Translated_485_residues
MSKIETPVMTSLQTTVEKMMKDLNVPGAAVAIIKDGEVIISEGFGYRNLETKEPVTPRTLFAIGSSTKAFGTLSLSLLAQ
QKRFNWDTPVQSYIQNFSLSELLASSQVTGRDLASHRTGVSRHEALWYSSSLSRKNLVEKIKHLPLDAPFRTSFLYNNLM
YATISYIVENITNQTWEQYATEHILEPLNMSHTNFSVIDSQTTDDYALPYIENDGEIKEVPFRNIDTVGAAGCINSTIKD
MANWVLLHLKQGKFGEYKLISPELLQQMYTPHNSIPDQPVLSLPESPLNSYGLGWFISAYRGNKVIHHGGNIDGFSALVS
FIPTENIGLVILTNAGGTLLPTYLANQIYDELLALETIDWHKRAVEDTEKMKEMMKEATESVPEQIKGTTPSHKLEDYTG
TFEHPAYGTLQVYKRDDSLFVQFMEMDIQLTHHHYDIFSAKVDLFQMKMSLLFAYEMNLSGEFPSLQLHVPAMLSTQPLA
FKKIK
>Mature_484_residues
SKIETPVMTSLQTTVEKMMKDLNVPGAAVAIIKDGEVIISEGFGYRNLETKEPVTPRTLFAIGSSTKAFGTLSLSLLAQQ
KRFNWDTPVQSYIQNFSLSELLASSQVTGRDLASHRTGVSRHEALWYSSSLSRKNLVEKIKHLPLDAPFRTSFLYNNLMY
ATISYIVENITNQTWEQYATEHILEPLNMSHTNFSVIDSQTTDDYALPYIENDGEIKEVPFRNIDTVGAAGCINSTIKDM
ANWVLLHLKQGKFGEYKLISPELLQQMYTPHNSIPDQPVLSLPESPLNSYGLGWFISAYRGNKVIHHGGNIDGFSALVSF
IPTENIGLVILTNAGGTLLPTYLANQIYDELLALETIDWHKRAVEDTEKMKEMMKEATESVPEQIKGTTPSHKLEDYTGT
FEHPAYGTLQVYKRDDSLFVQFMEMDIQLTHHHYDIFSAKVDLFQMKMSLLFAYEMNLSGEFPSLQLHVPAMLSTQPLAF
KKIK

Specific function: Its precise function is unknown. Has no penicillin- binding activity and is not involved in methicillin resistance [H]

COG id: NA

COG function: NA

Gene ontology:

Cell location: Cell membrane; Multi-pass membrane protein (Potential) [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: NA

Homologues:

Organism=Homo sapiens, GI239747261, Length=385, Percent_Identity=24.9350649350649, Blast_Score=79, Evalue=9e-15,
Organism=Homo sapiens, GI239752721, Length=385, Percent_Identity=24.9350649350649, Blast_Score=79, Evalue=9e-15,
Organism=Homo sapiens, GI239741085, Length=385, Percent_Identity=24.9350649350649, Blast_Score=79, Evalue=9e-15,
Organism=Escherichia coli, GI87082101, Length=317, Percent_Identity=22.7129337539432, Blast_Score=64, Evalue=2e-11,
Organism=Caenorhabditis elegans, GI17550934, Length=190, Percent_Identity=30, Blast_Score=89, Evalue=4e-18,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR012338
- InterPro:   IPR001466 [H]

Pfam domain/function: PF00144 Beta-lactamase [H]

EC number: 3.5.2.6 [C]

Molecular weight: Translated: 54714; Mature: 54583

Theoretical pI: Translated: 5.70; Mature: 5.70

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.2 %Cys     (Translated Protein)
3.5 %Met     (Translated Protein)
3.7 %Cys+Met (Translated Protein)
0.2 %Cys     (Mature Protein)
3.3 %Met     (Mature Protein)
3.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSKIETPVMTSLQTTVEKMMKDLNVPGAAVAIIKDGEVIISEGFGYRNLETKEPVTPRTL
CCCCCCHHHHHHHHHHHHHHHHCCCCCEEEEEEECCCEEEECCCCCCCCCCCCCCCCCEE
FAIGSSTKAFGTLSLSLLAQQKRFNWDTPVQSYIQNFSLSELLASSQVTGRDLASHRTGV
EEECCCCCHHHHHHHHHHHHHHCCCCCCHHHHHHHCCCHHHHHHHCCCCHHHHHHHHCCC
SRHEALWYSSSLSRKNLVEKIKHLPLDAPFRTSFLYNNLMYATISYIVENITNQTWEQYA
CHHHHHHHHCCCCHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
TEHILEPLNMSHTNFSVIDSQTTDDYALPYIENDGEIKEVPFRNIDTVGAAGCINSTIKD
HHHHHCCCCCCCCCEEEEECCCCCCCCCCEECCCCCEEECCCCCCCCCCCHHHHHHHHHH
MANWVLLHLKQGKFGEYKLISPELLQQMYTPHNSIPDQPVLSLPESPLNSYGLGWFISAY
HHHHHEEEEECCCCCCEEECCHHHHHHHCCCCCCCCCCCHHCCCCCCCCCCCCHHEEEEE
RGNKVIHHGGNIDGFSALVSFIPTENIGLVILTNAGGTLLPTYLANQIYDELLALETIDW
CCCEEEECCCCCCHHHHHHHHCCCCCCCEEEEECCCCCCHHHHHHHHHHHHHHHHHHHHH
HKRAVEDTEKMKEMMKEATESVPEQIKGTTPSHKLEDYTGTFEHPAYGTLQVYKRDDSLF
HHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCCCCEEEEEECCHHHH
VQFMEMDIQLTHHHYDIFSAKVDLFQMKMSLLFAYEMNLSGEFPSLQLHVPAMLSTQPLA
HHHHHHCEEEEEEEHHHHHHHHHHHHHHHHHHHHEEECCCCCCCCEEEECCHHHCCCCCH
FKKIK
HCCCC
>Mature Secondary Structure 
SKIETPVMTSLQTTVEKMMKDLNVPGAAVAIIKDGEVIISEGFGYRNLETKEPVTPRTL
CCCCCHHHHHHHHHHHHHHHHCCCCCEEEEEEECCCEEEECCCCCCCCCCCCCCCCCEE
FAIGSSTKAFGTLSLSLLAQQKRFNWDTPVQSYIQNFSLSELLASSQVTGRDLASHRTGV
EEECCCCCHHHHHHHHHHHHHHCCCCCCHHHHHHHCCCHHHHHHHCCCCHHHHHHHHCCC
SRHEALWYSSSLSRKNLVEKIKHLPLDAPFRTSFLYNNLMYATISYIVENITNQTWEQYA
CHHHHHHHHCCCCHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
TEHILEPLNMSHTNFSVIDSQTTDDYALPYIENDGEIKEVPFRNIDTVGAAGCINSTIKD
HHHHHCCCCCCCCCEEEEECCCCCCCCCCEECCCCCEEECCCCCCCCCCCHHHHHHHHHH
MANWVLLHLKQGKFGEYKLISPELLQQMYTPHNSIPDQPVLSLPESPLNSYGLGWFISAY
HHHHHEEEEECCCCCCEEECCHHHHHHHCCCCCCCCCCCHHCCCCCCCCCCCCHHEEEEE
RGNKVIHHGGNIDGFSALVSFIPTENIGLVILTNAGGTLLPTYLANQIYDELLALETIDW
CCCEEEECCCCCCHHHHHHHHCCCCCCCEEEEECCCCCCHHHHHHHHHHHHHHHHHHHHH
HKRAVEDTEKMKEMMKEATESVPEQIKGTTPSHKLEDYTGTFEHPAYGTLQVYKRDDSLF
HHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCCCCEEEEEECCHHHH
VQFMEMDIQLTHHHYDIFSAKVDLFQMKMSLLFAYEMNLSGEFPSLQLHVPAMLSTQPLA
HHHHHHCEEEEEEEHHHHHHHHHHHHHHHHHHHHEEECCCCCCCCEEEECCHHHCCCCCH
FKKIK
HCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: A Beta-Lactam; H2O [C]

Specific reaction: A Beta-Lactam + H2O = A Substituted Beta- Amino Acid. [C]

General reaction: Carboxylic acid amide hydrolysis [C]

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: NA