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The map label for this gene is atoA [H]

Identifier: 52143163

GI number: 52143163

Start: 2198919

End: 2199581

Strand: Direct

Name: atoA [H]

Synonym: BCZK2075

Alternate gene names: 52143163

Gene position: 2198919-2199581 (Clockwise)

Preceding gene: 52143164

Following gene: 52143162

Centisome position: 41.48

GC content: 37.56

Gene sequence:

>663_bases
ATGGGTATGGGCGTAGAAGTGAGAGATAAAATTGCTAGACGTGCGGCGAAAGAAATACAGAATGGAATGATTGTAAATTT
AGGTATTGGTATACCATCGCTTGTACCAAATCATTTGCCTGACGATATAAACGTTATGTTTCATGCGGAAAATGGAATTG
TAGGTATGGGACCTACGCCAAGTAAAGGAAATGAAGACGAAAATTTATGTAACGCAGCAGGTTTGCCAACTTCTCTTATT
ACAGGAGCAAGTTATTTTGATAGTTGCACAGCGTTTGGGATGATTCGAAAAGGTTTACTAGACATAACAATTCTTGGTTC
ATTACAAGTAAGTGAGAATGGTGATTTAGCGAACTGGATTGTTCCAGGAAAACGCGTTCCAGGTATTGGGGGAGCAATGG
ATTTAGCTCAAAAAGCGAAGCGGGTCGTTGTTGTGATGAATCATGTCGATAAATACGGAAATGCAAAAATTGTTTCGGAG
TGTACATTACCATTAACTTCAAAAAAATGTGTAGATTTAATTATTACGGATATGGCAGTAATGGAAGTAACGGAGGGTGG
ACTTATTTTGCAAGAATTGATGAGCCCTTACACAGTGGAAGATATAAAGCAACATACAGAAGCAAATTTTAAAATTGGCT
CTAACTTACTAGTAATTGAATGA

Upstream 100 bases:

>100_bases
CAGAGGAAATCGTTCCACTTGGAAGTTTAGATCCAGAAGAAATTGTTGTCCCAGGAGTATTTGTAAATTATATCGTACCG
TCGGAAGGAGTGAATTGGAA

Downstream 100 bases:

>100_bases
GGGGAGATGTAATATATGGAGCAATTAAAAAAACAAATTTGTGATTATATTGAGAGTCAAGAAGAAGAGAGCGTAAAATT
TTTAAAACGATTAATTCAAG

Product: aetate CoA-transferase, beta subunit

Products: fatty acid anion; acetyl-CoA

Alternate protein names: Probable CoA-transferase subunit beta [H]

Number of amino acids: Translated: 220; Mature: 219

Protein sequence:

>220_residues
MGMGVEVRDKIARRAAKEIQNGMIVNLGIGIPSLVPNHLPDDINVMFHAENGIVGMGPTPSKGNEDENLCNAAGLPTSLI
TGASYFDSCTAFGMIRKGLLDITILGSLQVSENGDLANWIVPGKRVPGIGGAMDLAQKAKRVVVVMNHVDKYGNAKIVSE
CTLPLTSKKCVDLIITDMAVMEVTEGGLILQELMSPYTVEDIKQHTEANFKIGSNLLVIE

Sequences:

>Translated_220_residues
MGMGVEVRDKIARRAAKEIQNGMIVNLGIGIPSLVPNHLPDDINVMFHAENGIVGMGPTPSKGNEDENLCNAAGLPTSLI
TGASYFDSCTAFGMIRKGLLDITILGSLQVSENGDLANWIVPGKRVPGIGGAMDLAQKAKRVVVVMNHVDKYGNAKIVSE
CTLPLTSKKCVDLIITDMAVMEVTEGGLILQELMSPYTVEDIKQHTEANFKIGSNLLVIE
>Mature_219_residues
GMGVEVRDKIARRAAKEIQNGMIVNLGIGIPSLVPNHLPDDINVMFHAENGIVGMGPTPSKGNEDENLCNAAGLPTSLIT
GASYFDSCTAFGMIRKGLLDITILGSLQVSENGDLANWIVPGKRVPGIGGAMDLAQKAKRVVVVMNHVDKYGNAKIVSEC
TLPLTSKKCVDLIITDMAVMEVTEGGLILQELMSPYTVEDIKQHTEANFKIGSNLLVIE

Specific function: SHORT-CHAIN FATTY ACIDS METABOLISM. [C]

COG id: COG2057

COG function: function code I; Acyl CoA:acetate/3-ketoacid CoA transferase, beta subunit

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the 3-oxoacid CoA-transferase subunit B family [H]

Homologues:

Organism=Homo sapiens, GI4557817, Length=219, Percent_Identity=46.5753424657534, Blast_Score=199, Evalue=1e-51,
Organism=Homo sapiens, GI11545841, Length=213, Percent_Identity=47.4178403755869, Blast_Score=197, Evalue=5e-51,
Organism=Escherichia coli, GI1788552, Length=212, Percent_Identity=41.9811320754717, Blast_Score=197, Evalue=3e-52,
Organism=Caenorhabditis elegans, GI17531517, Length=211, Percent_Identity=52.60663507109, Blast_Score=211, Evalue=2e-55,
Organism=Drosophila melanogaster, GI21358325, Length=212, Percent_Identity=49.5283018867925, Blast_Score=206, Evalue=1e-53,
Organism=Drosophila melanogaster, GI24655794, Length=212, Percent_Identity=49.5283018867925, Blast_Score=205, Evalue=2e-53,

Paralogues:

None

Copy number: 369 Molecules/Cell In: Growth Phase, Glucose-minimal MOPS Media. [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR012791
- InterPro:   IPR004165 [H]

Pfam domain/function: PF01144 CoA_trans [H]

EC number: 2.8.3.8

Molecular weight: Translated: 23517; Mature: 23386

Theoretical pI: Translated: 5.05; Mature: 5.05

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.8 %Cys     (Translated Protein)
5.0 %Met     (Translated Protein)
6.8 %Cys+Met (Translated Protein)
1.8 %Cys     (Mature Protein)
4.6 %Met     (Mature Protein)
6.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MGMGVEVRDKIARRAAKEIQNGMIVNLGIGIPSLVPNHLPDDINVMFHAENGIVGMGPTP
CCCCCHHHHHHHHHHHHHHHCCEEEEECCCCHHHCCCCCCCCCEEEEEECCCEEECCCCC
SKGNEDENLCNAAGLPTSLITGASYFDSCTAFGMIRKGLLDITILGSLQVSENGDLANWI
CCCCCCHHHHHHCCCCHHHHHCCHHHHHHHHHHHHHHCCEEEEEEEEEEECCCCCEEEEE
VPGKRVPGIGGAMDLAQKAKRVVVVMNHVDKYGNAKIVSECTLPLTSKKCVDLIITDMAV
CCCCCCCCCCHHHHHHHHHHEEEEEEEHHCCCCCEEEEEECCCCCCCHHHHHHHHHHHHH
MEVTEGGLILQELMSPYTVEDIKQHTEANFKIGSNLLVIE
HHHCCCCHHHHHHCCCCCHHHHHHHHCCCEEECCEEEEEC
>Mature Secondary Structure 
GMGVEVRDKIARRAAKEIQNGMIVNLGIGIPSLVPNHLPDDINVMFHAENGIVGMGPTP
CCCCHHHHHHHHHHHHHHHCCEEEEECCCCHHHCCCCCCCCCEEEEEECCCEEECCCCC
SKGNEDENLCNAAGLPTSLITGASYFDSCTAFGMIRKGLLDITILGSLQVSENGDLANWI
CCCCCCHHHHHHCCCCHHHHHCCHHHHHHHHHHHHHHCCEEEEEEEEEEECCCCCEEEEE
VPGKRVPGIGGAMDLAQKAKRVVVVMNHVDKYGNAKIVSECTLPLTSKKCVDLIITDMAV
CCCCCCCCCCHHHHHHHHHHEEEEEEEHHCCCCCEEEEEECCCCCCCHHHHHHHHHHHHH
MEVTEGGLILQELMSPYTVEDIKQHTEANFKIGSNLLVIE
HHHCCCCHHHHHHCCCCCHHHHHHHHCCCEEECCEEEEEC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: acyl-CoA; acetate

Specific reaction: acyl-CoA + acetate = a fatty acid anion + acetyl-CoA

General reaction: Coenzyme A transfer [C]

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 9734814; 9384377 [H]