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The map label for this gene is tdcB [H]

Identifier: 52143020

GI number: 52143020

Start: 2346749

End: 2347750

Strand: Direct

Name: tdcB [H]

Synonym: BCZK2218

Alternate gene names: 52143020

Gene position: 2346749-2347750 (Clockwise)

Preceding gene: 52143021

Following gene: 52143019

Centisome position: 44.27

GC content: 36.83

Gene sequence:

>1002_bases
ATGATAACTAAAAAACTACCATTACATATAGACGATATTAAGAAAGCTCAAAGCATTCTGGATAGAAATGCTCGTAAAAC
GCCATTAGTAAAATCATTTTATTTGACTAGTAAAACGGGTGGAGAAATTCACTTGAAATTAGAAAATATGCAATTAACAG
GTTCGTTTAAATTCCGTGGTGCGTTTAATAAAATGTCACAGCTGACAGATCAAGAAAAAGAGAGAGGAGTAATTGCTTGT
TCTGCTGGTAATCATGCGCAAGGAATTGCTTTATCTGCTCATTTACTCGGTATTAAAAGTAAAATTGTAATGCCGATTTC
TGCCCCTCAAGCGAAAGTTGATGCAACGAGAGGATATGGATCTGAAGTGGTTTTACATGGTGAAACCTTTGATGATGCGA
AGGCAAAATGTGAGGAGATTATTAGAGAAACAGGTGAAACATACTTACATCCATATGACGATGTAGAAGTAATGGCTGGT
CAAGGTACAATAGGATTAGATATTCTTGATGATATGTGGGATGTTGATACGGTCATTGTACCAATTGGTGGAGGAGGAAT
TATTTCTGGAATTGCTGTTGCATTAAAATCTTTTAATCCGTCGATTCATATAATTGGTGTCCAAGCAGAAAATGTTCATG
GGATGAAGGCATCTTATGACAAAGGTACAATTATAGAACATTATGAGGCACCTACGATAGCAGATGGTTGCGCGGTAAAA
ATACCAGGCAATTTAACTTTTGAAGTTGTAAAAGAATTAGTAGATGATATTGTAACAGTATCAGAAAAAGAGCTGGAATT
AGCGATGAAAGACTTATTACAACGCGGGAAAGCTGTTGTAGAAGGTGCAGGCGCATTAGCTACTGCTGCTCTACTTGCAG
GGAAAGTGGATACATATATTAAAGAGAAAAAAGTAGTAGCAGTTATATCTGGTGGGAACGTAGACTTACAGCGCATATCG
AGTGTTTGTGAGCAATTTTTTGTGGCGAATGAAGTGAAATAG

Upstream 100 bases:

>100_bases
AGGTACATATATAAAGACTTTTTCTTAATATAGATGGTTTCGTATAAAGGAGTTGCTACATACGAAAACTTAGGAATAGA
ACATTGGAAGGGGTGTTAGT

Downstream 100 bases:

>100_bases
TTTTATGAAAAAGGAGCTAAGTGAAATTATATTAGCTCCTTTTTCATTATGTTTGTGCGGGAGTAAATAATGACTCCATT
TTTATTTTGCTCTTTTCTCG

Product: threonine dehydratase

Products: NA

Alternate protein names: Threonine deaminase [H]

Number of amino acids: Translated: 333; Mature: 333

Protein sequence:

>333_residues
MITKKLPLHIDDIKKAQSILDRNARKTPLVKSFYLTSKTGGEIHLKLENMQLTGSFKFRGAFNKMSQLTDQEKERGVIAC
SAGNHAQGIALSAHLLGIKSKIVMPISAPQAKVDATRGYGSEVVLHGETFDDAKAKCEEIIRETGETYLHPYDDVEVMAG
QGTIGLDILDDMWDVDTVIVPIGGGGIISGIAVALKSFNPSIHIIGVQAENVHGMKASYDKGTIIEHYEAPTIADGCAVK
IPGNLTFEVVKELVDDIVTVSEKELELAMKDLLQRGKAVVEGAGALATAALLAGKVDTYIKEKKVVAVISGGNVDLQRIS
SVCEQFFVANEVK

Sequences:

>Translated_333_residues
MITKKLPLHIDDIKKAQSILDRNARKTPLVKSFYLTSKTGGEIHLKLENMQLTGSFKFRGAFNKMSQLTDQEKERGVIAC
SAGNHAQGIALSAHLLGIKSKIVMPISAPQAKVDATRGYGSEVVLHGETFDDAKAKCEEIIRETGETYLHPYDDVEVMAG
QGTIGLDILDDMWDVDTVIVPIGGGGIISGIAVALKSFNPSIHIIGVQAENVHGMKASYDKGTIIEHYEAPTIADGCAVK
IPGNLTFEVVKELVDDIVTVSEKELELAMKDLLQRGKAVVEGAGALATAALLAGKVDTYIKEKKVVAVISGGNVDLQRIS
SVCEQFFVANEVK
>Mature_333_residues
MITKKLPLHIDDIKKAQSILDRNARKTPLVKSFYLTSKTGGEIHLKLENMQLTGSFKFRGAFNKMSQLTDQEKERGVIAC
SAGNHAQGIALSAHLLGIKSKIVMPISAPQAKVDATRGYGSEVVLHGETFDDAKAKCEEIIRETGETYLHPYDDVEVMAG
QGTIGLDILDDMWDVDTVIVPIGGGGIISGIAVALKSFNPSIHIIGVQAENVHGMKASYDKGTIIEHYEAPTIADGCAVK
IPGNLTFEVVKELVDDIVTVSEKELELAMKDLLQRGKAVVEGAGALATAALLAGKVDTYIKEKKVVAVISGGNVDLQRIS
SVCEQFFVANEVK

Specific function: Acts on both serine and threonine, and properly considered as a hydroxy amino acid deaminase [H]

COG id: COG1171

COG function: function code E; Threonine dehydratase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the serine/threonine dehydratase family [H]

Homologues:

Organism=Homo sapiens, GI11345492, Length=311, Percent_Identity=36.0128617363344, Blast_Score=188, Evalue=5e-48,
Organism=Homo sapiens, GI33469958, Length=319, Percent_Identity=25.0783699059561, Blast_Score=72, Evalue=9e-13,
Organism=Homo sapiens, GI19923959, Length=302, Percent_Identity=26.8211920529801, Blast_Score=71, Evalue=1e-12,
Organism=Escherichia coli, GI1789505, Length=321, Percent_Identity=59.5015576323988, Blast_Score=346, Evalue=1e-96,
Organism=Escherichia coli, GI1790207, Length=304, Percent_Identity=42.7631578947368, Blast_Score=214, Evalue=7e-57,
Organism=Escherichia coli, GI2367138, Length=269, Percent_Identity=24.907063197026, Blast_Score=64, Evalue=2e-11,
Organism=Caenorhabditis elegans, GI71991565, Length=308, Percent_Identity=42.8571428571429, Blast_Score=223, Evalue=1e-58,
Organism=Caenorhabditis elegans, GI17537387, Length=318, Percent_Identity=34.2767295597484, Blast_Score=154, Evalue=8e-38,
Organism=Caenorhabditis elegans, GI17508781, Length=305, Percent_Identity=29.5081967213115, Blast_Score=131, Evalue=5e-31,
Organism=Saccharomyces cerevisiae, GI6322631, Length=311, Percent_Identity=40.5144694533762, Blast_Score=209, Evalue=4e-55,
Organism=Saccharomyces cerevisiae, GI6320930, Length=307, Percent_Identity=37.4592833876222, Blast_Score=189, Evalue=5e-49,
Organism=Saccharomyces cerevisiae, GI6319788, Length=281, Percent_Identity=24.5551601423488, Blast_Score=92, Evalue=1e-19,
Organism=Drosophila melanogaster, GI21355833, Length=318, Percent_Identity=38.0503144654088, Blast_Score=154, Evalue=6e-38,
Organism=Drosophila melanogaster, GI24645328, Length=226, Percent_Identity=38.4955752212389, Blast_Score=100, Evalue=2e-21,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001926
- InterPro:   IPR000634
- InterPro:   IPR005789 [H]

Pfam domain/function: PF00291 PALP [H]

EC number: =4.3.1.19 [H]

Molecular weight: Translated: 35815; Mature: 35815

Theoretical pI: Translated: 6.06; Mature: 6.06

Prosite motif: PS00165 DEHYDRATASE_SER_THR

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.2 %Cys     (Translated Protein)
2.4 %Met     (Translated Protein)
3.6 %Cys+Met (Translated Protein)
1.2 %Cys     (Mature Protein)
2.4 %Met     (Mature Protein)
3.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MITKKLPLHIDDIKKAQSILDRNARKTPLVKSFYLTSKTGGEIHLKLENMQLTGSFKFRG
CCCCCCCCCHHHHHHHHHHHHCCCCCCCCEEEEEEECCCCCEEEEEEEEEEEEEEEEECC
AFNKMSQLTDQEKERGVIACSAGNHAQGIALSAHLLGIKSKIVMPISAPQAKVDATRGYG
HHHHHHHHHHHHHHCCEEEEECCCCCCCEEEEEEEEECCCEEEEEECCCCCCCCCCCCCC
SEVVLHGETFDDAKAKCEEIIRETGETYLHPYDDVEVMAGQGTIGLDILDDMWDVDTVIV
CEEEEECCCCCHHHHHHHHHHHHCCCCCCCCCCCEEEEECCCCEEHHHHHCCCCCCEEEE
PIGGGGIISGIAVALKSFNPSIHIIGVQAENVHGMKASYDKGTIIEHYEAPTIADGCAVK
EECCCHHHHHHHHHHHHCCCCEEEEEEEECCCCCCCCCCCCCCEEEECCCCCCCCCCEEE
IPGNLTFEVVKELVDDIVTVSEKELELAMKDLLQRGKAVVEGAGALATAALLAGKVDTYI
ECCCCHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHCHHHECCCCHHHHHHHHHHHHHHHH
KEKKVVAVISGGNVDLQRISSVCEQFFVANEVK
CCCEEEEEEECCCCCHHHHHHHHHHHHHHCCCC
>Mature Secondary Structure
MITKKLPLHIDDIKKAQSILDRNARKTPLVKSFYLTSKTGGEIHLKLENMQLTGSFKFRG
CCCCCCCCCHHHHHHHHHHHHCCCCCCCCEEEEEEECCCCCEEEEEEEEEEEEEEEEECC
AFNKMSQLTDQEKERGVIACSAGNHAQGIALSAHLLGIKSKIVMPISAPQAKVDATRGYG
HHHHHHHHHHHHHHCCEEEEECCCCCCCEEEEEEEEECCCEEEEEECCCCCCCCCCCCCC
SEVVLHGETFDDAKAKCEEIIRETGETYLHPYDDVEVMAGQGTIGLDILDDMWDVDTVIV
CEEEEECCCCCHHHHHHHHHHHHCCCCCCCCCCCEEEEECCCCEEHHHHHCCCCCCEEEE
PIGGGGIISGIAVALKSFNPSIHIIGVQAENVHGMKASYDKGTIIEHYEAPTIADGCAVK
EECCCHHHHHHHHHHHHCCCCEEEEEEEECCCCCCCCCCCCCCEEEECCCCCCCCCCEEE
IPGNLTFEVVKELVDDIVTVSEKELELAMKDLLQRGKAVVEGAGALATAALLAGKVDTYI
ECCCCHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHCHHHECCCCHHHHHHHHHHHHHHHH
KEKKVVAVISGGNVDLQRISSVCEQFFVANEVK
CCCEEEEEEECCCCCHHHHHHHHHHHHHHCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA