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The map label for this gene is clpP [H]

Identifier: 52142722

GI number: 52142722

Start: 2646633

End: 2647214

Strand: Reverse

Name: clpP [H]

Synonym: BCZK2518

Alternate gene names: 52142722

Gene position: 2647214-2646633 (Counterclockwise)

Preceding gene: 52142720

Following gene: 52142724

Centisome position: 49.94

GC content: 34.54

Gene sequence:

>582_bases
ATGAATGCAATTCCATATGTTGTAGAACAAACGAAATTAGGAGAGCGTTCCTATGATATATATTCAAGGTTATTAAAAGA
CCGTATTATTATTATCGGTTCAGAAATAAATGATCAAGTAGCGAGTAGTGTCGTAGCTCAATTGTTATTTTTAGAAGCAG
AAGATGCAGAGAAAGATATATTTTTATACATTAATAGCCCCGGCGGATCAACGACAGCGGGATTTGCTATATTAGATACA
ATGAATTTAATTAAACCTGATGTGCAAACGCTATGTATGGGCTTTGCAGCATCATTTGGTGCATTGTTATTATTATCAGG
TGCAAAAGGAAAACGATTTGCACTCCCAAATAGTGAAATTATGATTCATCAGCCACTTGGTGGTGCAAAAGGGCAAGCAA
CAGAAATTGAAATAACAGCAAAAAGGATATTAAAGTTAAAGCATGATATTAATAAAATGATTGCAGAAAAAACGGGGCAA
CCGATTGAAAGAGTAGCACATGATACAGAAAGAGATTATTTTATGACTGCAGAAGAAGCGAAGGCATATGGGATTGTAGA
TGATGTGGTTACGAAAAAATAA

Upstream 100 bases:

>100_bases
GTTACCATCTAAACAGCCAGTCTTAGTATTTAATGTAAAAAAACCTTCTTCCTACAGTTGTATGCTTTGCGCCGCATAAC
AATTATTGGAGGGATATAAA

Downstream 100 bases:

>100_bases
AATAAAACAGGCTAGGGGATATGATAATCCTCTAGCCTGTTTTATTAATCTTTTATCCATTCATCGACTAACGCTTGATT
CTTTTTAATCCATTTCCGCG

Product: ATP-dependent Clp protease, proteolytic subunit

Products: NA

Alternate protein names: Endopeptidase Clp 1 [H]

Number of amino acids: Translated: 193; Mature: 193

Protein sequence:

>193_residues
MNAIPYVVEQTKLGERSYDIYSRLLKDRIIIIGSEINDQVASSVVAQLLFLEAEDAEKDIFLYINSPGGSTTAGFAILDT
MNLIKPDVQTLCMGFAASFGALLLLSGAKGKRFALPNSEIMIHQPLGGAKGQATEIEITAKRILKLKHDINKMIAEKTGQ
PIERVAHDTERDYFMTAEEAKAYGIVDDVVTKK

Sequences:

>Translated_193_residues
MNAIPYVVEQTKLGERSYDIYSRLLKDRIIIIGSEINDQVASSVVAQLLFLEAEDAEKDIFLYINSPGGSTTAGFAILDT
MNLIKPDVQTLCMGFAASFGALLLLSGAKGKRFALPNSEIMIHQPLGGAKGQATEIEITAKRILKLKHDINKMIAEKTGQ
PIERVAHDTERDYFMTAEEAKAYGIVDDVVTKK
>Mature_193_residues
MNAIPYVVEQTKLGERSYDIYSRLLKDRIIIIGSEINDQVASSVVAQLLFLEAEDAEKDIFLYINSPGGSTTAGFAILDT
MNLIKPDVQTLCMGFAASFGALLLLSGAKGKRFALPNSEIMIHQPLGGAKGQATEIEITAKRILKLKHDINKMIAEKTGQ
PIERVAHDTERDYFMTAEEAKAYGIVDDVVTKK

Specific function: Cleaves peptides in various proteins in a process that requires ATP hydrolysis. Has a chymotrypsin-like activity. Plays a major role in the degradation of misfolded proteins [H]

COG id: COG0740

COG function: function code OU; Protease subunit of ATP-dependent Clp proteases

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the peptidase S14 family [H]

Homologues:

Organism=Homo sapiens, GI5174419, Length=187, Percent_Identity=54.0106951871658, Blast_Score=205, Evalue=2e-53,
Organism=Escherichia coli, GI1786641, Length=193, Percent_Identity=60.6217616580311, Blast_Score=254, Evalue=3e-69,
Organism=Caenorhabditis elegans, GI17538017, Length=191, Percent_Identity=48.1675392670157, Blast_Score=196, Evalue=4e-51,
Organism=Drosophila melanogaster, GI20129427, Length=190, Percent_Identity=54.7368421052632, Blast_Score=217, Evalue=4e-57,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001907
- InterPro:   IPR018215 [H]

Pfam domain/function: PF00574 CLP_protease [H]

EC number: =3.4.21.92 [H]

Molecular weight: Translated: 21193; Mature: 21193

Theoretical pI: Translated: 5.34; Mature: 5.34

Prosite motif: PS00382 CLP_PROTEASE_HIS

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.5 %Cys     (Translated Protein)
3.1 %Met     (Translated Protein)
3.6 %Cys+Met (Translated Protein)
0.5 %Cys     (Mature Protein)
3.1 %Met     (Mature Protein)
3.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MNAIPYVVEQTKLGERSYDIYSRLLKDRIIIIGSEINDQVASSVVAQLLFLEAEDAEKDI
CCCCCCHHHHHHCCCCHHHHHHHHHHCCEEEEECCCCHHHHHHHHHHHHHHCCCCCCCEE
FLYINSPGGSTTAGFAILDTMNLIKPDVQTLCMGFAASFGALLLLSGAKGKRFALPNSEI
EEEEECCCCCCHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHEEEECCCCCEEECCCCCE
MIHQPLGGAKGQATEIEITAKRILKLKHDINKMIAEKTGQPIERVAHDTERDYFMTAEEA
EEECCCCCCCCCCEEEEHHHHHHHHHHHHHHHHHHHHCCCHHHHHHCCCCCCEEEEHHHH
KAYGIVDDVVTKK
HHHCCHHHHHCCC
>Mature Secondary Structure
MNAIPYVVEQTKLGERSYDIYSRLLKDRIIIIGSEINDQVASSVVAQLLFLEAEDAEKDI
CCCCCCHHHHHHCCCCHHHHHHHHHHCCEEEEECCCCHHHHHHHHHHHHHHCCCCCCCEE
FLYINSPGGSTTAGFAILDTMNLIKPDVQTLCMGFAASFGALLLLSGAKGKRFALPNSEI
EEEEECCCCCCHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHEEEECCCCCEEECCCCCE
MIHQPLGGAKGQATEIEITAKRILKLKHDINKMIAEKTGQPIERVAHDTERDYFMTAEEA
EEECCCCCCCCCCEEEEHHHHHHHHHHHHHHHHHHHHCCCHHHHHHCCCCCCEEEEHHHH
KAYGIVDDVVTKK
HHHCCHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 12721629 [H]