Click here to switch to the map view.

The map label for this gene is acr3 [H]

Identifier: 52142343

GI number: 52142343

Start: 3027536

End: 3028576

Strand: Reverse

Name: acr3 [H]

Synonym: BCZK2899

Alternate gene names: 52142343

Gene position: 3028576-3027536 (Counterclockwise)

Preceding gene: 52142342

Following gene: 52142346

Centisome position: 57.13

GC content: 36.7

Gene sequence:

>1041_bases
ATGAAACGCTTATCCTTTCTAGACCGATATTTAACATTATGGATTTTTCTAGCGATGGCTGTTGGGATTGGTTTAGGGTT
TGTATTCCCTAGTGTAGTAGACGGACTGAATACATTACAAGTTGGAACGACGTCTATTCCGCTTGCAGTTGGTTTAATTG
TCATGATGTATCCACCGTTAGCGAAAGTTCGCTATGAGGAAATGGGCCGAGTATTTAAAGATGTTAAAGTGTTAGTTTTA
TCATTAGTACAAAACTGGATTATTGGTCCGGTACTTATGTTTGTTTTAGCAATTATTTTTCTTCCTGATAAACCAGAATA
CATGGTTGGTCTCATTATGATTGGATTAGCACGTTGCATTGCAATGGTCATTGTTTGGAACGATCTTGCCGATGGGGATA
AAGAGTATGCGGCAGGTTTAGTGGCTTTTAACTCGGTATTTCAAATGTTATTCTTCTCCATTTATGCATACGTGTTTGTA
ACAGTCATTCCAGAATGGTTAGGGATTGAAGGTGCTATTGTCGATATTACAATGATAGAAGTAGCAAAATCAGTGTTTAT
CTATTTGGGAATTCCTTTTATAGCAGGTATGTTGACGCGCTTTGTACTAGTTAAGTTAAAAGGAAGACAGTGGTATGAAA
AGGTGTTTATACCTAAGATTAGTCCACTTACATTGATTGCATTACTATTTACGGTCATCGTTATGTTCTCTTTAAAAGGA
GAGATGATTGTTAGTGTGCCACTAGATGTGGTAAGGATAGCGATTCCGTTATTAATCTATTTTATTGTAATGTTTTTTGT
TTCTTTCTTTATGGGAAGAAAGGTTGGTGCAAACTATCCGGTGACTACAACATTAGCATTTACAGCAGGTAGCAATAATT
TCGAGTTAGCGATTGCTGTAGCAGTTGGTGTGTTTGGTATTCATTCGGGCGCAGCATTTGCAGCTGTTATTGGTCCTTTA
GTTGAAGTACCTGTCATGATTGCACTTGTAAACGTTGCTTTTTGGTTTAAACGTAAATATTTTAATGATCAATCAGTCTA
A

Upstream 100 bases:

>100_bases
AGCACATAGTGATGTTCACAAAATTGAAGAGTCATCATGTTGCACGACTGCAAATGAGGTAGCTAAAAATTCTTGTTGTT
AATAGGAGATGGAAAATAAA

Downstream 100 bases:

>100_bases
ATTTAAAAATAAAGGTGGAAAACAACATGGAGAACAAAAAGACAATCTACTTTTTATGTACAGGAAATTCATGCCGAAGC
CAAATGGCAGAAGCATGGGG

Product: arsenical-resistance protein

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 346; Mature: 346

Protein sequence:

>346_residues
MKRLSFLDRYLTLWIFLAMAVGIGLGFVFPSVVDGLNTLQVGTTSIPLAVGLIVMMYPPLAKVRYEEMGRVFKDVKVLVL
SLVQNWIIGPVLMFVLAIIFLPDKPEYMVGLIMIGLARCIAMVIVWNDLADGDKEYAAGLVAFNSVFQMLFFSIYAYVFV
TVIPEWLGIEGAIVDITMIEVAKSVFIYLGIPFIAGMLTRFVLVKLKGRQWYEKVFIPKISPLTLIALLFTVIVMFSLKG
EMIVSVPLDVVRIAIPLLIYFIVMFFVSFFMGRKVGANYPVTTTLAFTAGSNNFELAIAVAVGVFGIHSGAAFAAVIGPL
VEVPVMIALVNVAFWFKRKYFNDQSV

Sequences:

>Translated_346_residues
MKRLSFLDRYLTLWIFLAMAVGIGLGFVFPSVVDGLNTLQVGTTSIPLAVGLIVMMYPPLAKVRYEEMGRVFKDVKVLVL
SLVQNWIIGPVLMFVLAIIFLPDKPEYMVGLIMIGLARCIAMVIVWNDLADGDKEYAAGLVAFNSVFQMLFFSIYAYVFV
TVIPEWLGIEGAIVDITMIEVAKSVFIYLGIPFIAGMLTRFVLVKLKGRQWYEKVFIPKISPLTLIALLFTVIVMFSLKG
EMIVSVPLDVVRIAIPLLIYFIVMFFVSFFMGRKVGANYPVTTTLAFTAGSNNFELAIAVAVGVFGIHSGAAFAAVIGPL
VEVPVMIALVNVAFWFKRKYFNDQSV
>Mature_346_residues
MKRLSFLDRYLTLWIFLAMAVGIGLGFVFPSVVDGLNTLQVGTTSIPLAVGLIVMMYPPLAKVRYEEMGRVFKDVKVLVL
SLVQNWIIGPVLMFVLAIIFLPDKPEYMVGLIMIGLARCIAMVIVWNDLADGDKEYAAGLVAFNSVFQMLFFSIYAYVFV
TVIPEWLGIEGAIVDITMIEVAKSVFIYLGIPFIAGMLTRFVLVKLKGRQWYEKVFIPKISPLTLIALLFTVIVMFSLKG
EMIVSVPLDVVRIAIPLLIYFIVMFFVSFFMGRKVGANYPVTTTLAFTAGSNNFELAIAVAVGVFGIHSGAAFAAVIGPL
VEVPVMIALVNVAFWFKRKYFNDQSV

Specific function: Seems to confer resistance to arsenite by allowing cells to extrude this compound. Could be part of an arsenite extrusion pump [H]

COG id: COG0798

COG function: function code P; Arsenite efflux pump ACR3 and related permeases

Gene ontology:

Cell location: Cell membrane; Multi-pass membrane protein (Potential) [H]

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: Belongs to the ACR3 family [H]

Homologues:

Organism=Saccharomyces cerevisiae, GI6325459, Length=337, Percent_Identity=36.7952522255193, Blast_Score=181, Evalue=2e-46,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR004706
- InterPro:   IPR002657 [H]

Pfam domain/function: PF01758 SBF [H]

EC number: NA

Molecular weight: Translated: 38396; Mature: 38396

Theoretical pI: Translated: 9.34; Mature: 9.34

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.3 %Cys     (Translated Protein)
4.9 %Met     (Translated Protein)
5.2 %Cys+Met (Translated Protein)
0.3 %Cys     (Mature Protein)
4.9 %Met     (Mature Protein)
5.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKRLSFLDRYLTLWIFLAMAVGIGLGFVFPSVVDGLNTLQVGTTSIPLAVGLIVMMYPPL
CCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHCCCCCHHHHHHHHHHHHCCCH
AKVRYEEMGRVFKDVKVLVLSLVQNWIIGPVLMFVLAIIFLPDKPEYMVGLIMIGLARCI
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHH
AMVIVWNDLADGDKEYAAGLVAFNSVFQMLFFSIYAYVFVTVIPEWLGIEGAIVDITMIE
HHHHHHCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHH
VAKSVFIYLGIPFIAGMLTRFVLVKLKGRQWYEKVFIPKISPLTLIALLFTVIVMFSLKG
HHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHCCCCCCHHHHHHHHHHHHHHHHCCC
EMIVSVPLDVVRIAIPLLIYFIVMFFVSFFMGRKVGANYPVTTTLAFTAGSNNFELAIAV
CEEEECCHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCEEEEEEEEECCCCCEEHHHH
AVGVFGIHSGAAFAAVIGPLVEVPVMIALVNVAFWFKRKYFNDQSV
HHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCC
>Mature Secondary Structure
MKRLSFLDRYLTLWIFLAMAVGIGLGFVFPSVVDGLNTLQVGTTSIPLAVGLIVMMYPPL
CCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHCCCCCHHHHHHHHHHHHCCCH
AKVRYEEMGRVFKDVKVLVLSLVQNWIIGPVLMFVLAIIFLPDKPEYMVGLIMIGLARCI
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHH
AMVIVWNDLADGDKEYAAGLVAFNSVFQMLFFSIYAYVFVTVIPEWLGIEGAIVDITMIE
HHHHHHCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHH
VAKSVFIYLGIPFIAGMLTRFVLVKLKGRQWYEKVFIPKISPLTLIALLFTVIVMFSLKG
HHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHCCCCCCHHHHHHHHHHHHHHHHCCC
EMIVSVPLDVVRIAIPLLIYFIVMFFVSFFMGRKVGANYPVTTTLAFTAGSNNFELAIAV
CEEEECCHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCEEEEEEEEECCCCCEEHHHH
AVGVFGIHSGAAFAAVIGPLVEVPVMIALVNVAFWFKRKYFNDQSV
HHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 7.0

TargetDB status: NA

Availability: NA

References: 7704261; 8969508; 9384377; 7489895; 9537360 [H]