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The map label for this gene is ydhC [C]

Identifier: 52142065

GI number: 52142065

Start: 3302351

End: 3303550

Strand: Reverse

Name: ydhC [C]

Synonym: BCZK3177

Alternate gene names: 52142065

Gene position: 3303550-3302351 (Counterclockwise)

Preceding gene: 52142062

Following gene: 52142066

Centisome position: 62.32

GC content: 34.58

Gene sequence:

>1200_bases
ATGAAAAAAGTCTCAGTACCATCACTTTTGTTAATGATTATTCTTGTCGCATTTCCGCAAATTAGTGAAACGATCTACAC
ACCGTCTTTACCGGATATTTCAAAGGCGTTACATGTAAGTAATAATGAGGTACAGTTAACACTTAGTGTGTATTTTGCTG
GATTTGCTTTAGGTGTATTTTTTATTGGATGGCTATCAGATATAATTGGTCGTCGCCCAGCAATGTTATTTGGAATTGTT
GTATATGGCGTTGGGAGTTTCTTATGCTTTATTGCAAATTCCATTGAAGTTTTATTAGTAAGTCGTTTTATTCAAGCCTT
TGGAGCGAGTGCAGGATCAGTTGTGACGCAAACAATTCTTCGTGAAAGTGTAGAAGGACATAAGAGGCATGTTATGTTTG
CTCAAATCTCGGCAGTTATTGCTTTTACACCAGCGATAGGACCGTTAATTGGTGGTTTTCTTGATCAAATGTTTGGATTT
AAAATAGTATTTTTAAGTTTAGTAGTTATGAGTGTCGGTATTTTTCTATATACGTTTGTTTCTCTTCCAGAAACAAAAAC
GGACTCGGTAACGAATAAAATAAATGTGTTTGCAGTCTTAAAGAAGTTAATTACAAATCCGAAAGTAGTAACGTATGGGC
TATTAATTGGAGGAGCAAATGGTGTTTTATTTAGCTATTATGCAGAAGCACCGTTTATCTTTATGGAATACTTTCAGTTA
TCGCCTAGTATGTATGGATTTCTAGGAATTGTTGTTGCTTCTGCTTCTATTATTGGAGCGAAAGTTTCAAAACGATTGCT
TGCAACTTATAAACCAGAGAAAATTATATATATCGGTTGTCTTGTAATGGTAGTTGGAGCAGTCGCTTTATCTATTATTA
CTTCAGTTGGATCAAATCCAAACATAATATATATGATTGGATTTTTAGTAGCGATGTTTATATTGCTATTAGGAATCGGG
ATAGCGCTACCTAACTGTTTAAGTTTAGCGTTAGTAGATTTCCAAGATGTTATTGGTACAGCAGGAGCTTTATTTAGCTT
AGGGTACTATGTAATTGTAACGATGACAATTTGGGGAATGAGCCAGCTGCATACAGGTTCGTTACTGGTGATGCCACTTT
ATTTTCTAGCTATAGTAGTTATCATGATGGTGTTTACTAAAGTGTTTATTTTAGGGAAACAAACTTCAAAAGCAATTTAA

Upstream 100 bases:

>100_bases
TTGTTTTATGAGCGAATTTCTATAATGGCCCCTCCTGTTCCGTAGCTAAGGAAAGTCTTTTTATTTCTGAGATTTTCAAA
GTTATAGGAGGGTATGAAAA

Downstream 100 bases:

>100_bases
ATATGAAATGGTAAAAGAGTCTCATTTTTTAATGAGACTCTTTTATATTTTATGAAAATGATTAGTGGATATACGAACAA
AAATTAAAGGTATTGTTGAT

Product: Bcr/CflA subfamily drug resistance transporter

Products: Proton [Cytoplasm]; drug [Periplasm] [C]

Alternate protein names: NA

Number of amino acids: Translated: 399; Mature: 399

Protein sequence:

>399_residues
MKKVSVPSLLLMIILVAFPQISETIYTPSLPDISKALHVSNNEVQLTLSVYFAGFALGVFFIGWLSDIIGRRPAMLFGIV
VYGVGSFLCFIANSIEVLLVSRFIQAFGASAGSVVTQTILRESVEGHKRHVMFAQISAVIAFTPAIGPLIGGFLDQMFGF
KIVFLSLVVMSVGIFLYTFVSLPETKTDSVTNKINVFAVLKKLITNPKVVTYGLLIGGANGVLFSYYAEAPFIFMEYFQL
SPSMYGFLGIVVASASIIGAKVSKRLLATYKPEKIIYIGCLVMVVGAVALSIITSVGSNPNIIYMIGFLVAMFILLLGIG
IALPNCLSLALVDFQDVIGTAGALFSLGYYVIVTMTIWGMSQLHTGSLLVMPLYFLAIVVIMMVFTKVFILGKQTSKAI

Sequences:

>Translated_399_residues
MKKVSVPSLLLMIILVAFPQISETIYTPSLPDISKALHVSNNEVQLTLSVYFAGFALGVFFIGWLSDIIGRRPAMLFGIV
VYGVGSFLCFIANSIEVLLVSRFIQAFGASAGSVVTQTILRESVEGHKRHVMFAQISAVIAFTPAIGPLIGGFLDQMFGF
KIVFLSLVVMSVGIFLYTFVSLPETKTDSVTNKINVFAVLKKLITNPKVVTYGLLIGGANGVLFSYYAEAPFIFMEYFQL
SPSMYGFLGIVVASASIIGAKVSKRLLATYKPEKIIYIGCLVMVVGAVALSIITSVGSNPNIIYMIGFLVAMFILLLGIG
IALPNCLSLALVDFQDVIGTAGALFSLGYYVIVTMTIWGMSQLHTGSLLVMPLYFLAIVVIMMVFTKVFILGKQTSKAI
>Mature_399_residues
MKKVSVPSLLLMIILVAFPQISETIYTPSLPDISKALHVSNNEVQLTLSVYFAGFALGVFFIGWLSDIIGRRPAMLFGIV
VYGVGSFLCFIANSIEVLLVSRFIQAFGASAGSVVTQTILRESVEGHKRHVMFAQISAVIAFTPAIGPLIGGFLDQMFGF
KIVFLSLVVMSVGIFLYTFVSLPETKTDSVTNKINVFAVLKKLITNPKVVTYGLLIGGANGVLFSYYAEAPFIFMEYFQL
SPSMYGFLGIVVASASIIGAKVSKRLLATYKPEKIIYIGCLVMVVGAVALSIITSVGSNPNIIYMIGFLVAMFILLLGIG
IALPNCLSLALVDFQDVIGTAGALFSLGYYVIVTMTIWGMSQLHTGSLLVMPLYFLAIVVIMMVFTKVFILGKQTSKAI

Specific function: Unknown

COG id: NA

COG function: NA

Gene ontology:

Cell location: Cell inner membrane; Multi-pass membrane protein (Potential) [H]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the major facilitator superfamily. Bcr/CmlA family [H]

Homologues:

Organism=Escherichia coli, GI48994889, Length=324, Percent_Identity=25.9259259259259, Blast_Score=102, Evalue=3e-23,
Organism=Escherichia coli, GI1788509, Length=233, Percent_Identity=28.755364806867, Blast_Score=95, Evalue=1e-20,
Organism=Escherichia coli, GI87082312, Length=326, Percent_Identity=25.4601226993865, Blast_Score=93, Evalue=3e-20,
Organism=Escherichia coli, GI1790146, Length=338, Percent_Identity=21.5976331360947, Blast_Score=90, Evalue=2e-19,
Organism=Escherichia coli, GI1787065, Length=340, Percent_Identity=24.4117647058824, Blast_Score=76, Evalue=3e-15,
Organism=Escherichia coli, GI1790794, Length=390, Percent_Identity=23.3333333333333, Blast_Score=66, Evalue=4e-12,
Organism=Saccharomyces cerevisiae, GI6324264, Length=164, Percent_Identity=31.0975609756098, Blast_Score=70, Evalue=5e-13,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR004812
- InterPro:   IPR020846
- InterPro:   IPR011701
- InterPro:   IPR016196
- InterPro:   IPR005829 [H]

Pfam domain/function: PF07690 MFS_1 [H]

EC number: NA

Molecular weight: Translated: 43145; Mature: 43145

Theoretical pI: Translated: 9.57; Mature: 9.57

Prosite motif: PS50850 MFS ; PS00216 SUGAR_TRANSPORT_1

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.8 %Cys     (Translated Protein)
4.0 %Met     (Translated Protein)
4.8 %Cys+Met (Translated Protein)
0.8 %Cys     (Mature Protein)
4.0 %Met     (Mature Protein)
4.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure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HHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHCCCHHCCC
>Mature Secondary Structure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HHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHCCCHHCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: Proton [Periplasm]; drug [Cytoplasm] [C]

Specific reaction: Proton [Periplasm] + drug [Cytoplasm] = Proton [Cytoplasm] + drug [Periplasm] [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: NA