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The map label for this gene is sdhA [H]

Identifier: 52141355

GI number: 52141355

Start: 4017582

End: 4018460

Strand: Reverse

Name: sdhA [H]

Synonym: BCZK3892

Alternate gene names: 52141355

Gene position: 4018460-4017582 (Counterclockwise)

Preceding gene: 52141356

Following gene: 52141360

Centisome position: 75.81

GC content: 44.14

Gene sequence:

>879_bases
ATGTTTCGGAACGCAGCGGAACTAGTGGCGCAAGCTAAAGAACAAAATGTAAAAATCGCAGAAATTATGATTCAATGTGA
AATGGAAACAAGAAGTATTTCACGTGAAGAAGTAATCGCTGGTATGGAAAAGAACTTAGTCGTGATGGAGCAAGCAGTAG
AACGTGGTATTCACGGTGTGAAATCACCAACTGGTTTAACTGGTGGAGATGCTGTAAAAGTTCAGGCGTATATGAAGAGC
GGAAAAGGCTTATCTGGAGATACGATTTTGGACGCGGTGAGTAAAGCTGTTGCAACAAATGAAGTAAACGCAGCGATGGG
AATTATTTGTGCAACACCAACAGCAGGGTCTGCTGGAACAGTGCCAGGTGTGCTATTTGCACTAAGAGAAAAGTTGCAAC
CTACACGTGAAGAAATGATTGAATTCTTATTTACAGCAGGAGCTTTCGGTATGGTTGTTGCAAATAATGCTTGTATTTCT
GGTGCAGCAGGAGGATGCCAAGCTGAAGTTGGTTCAGCAAGTGGAATGGCGGCCGCGGCTGCAGTTGAAATGGCTGGTGG
AACACAAGACCAAGCAGCTACAGCGATGGCAATTTCATTAAAGAACATGCTTGGTTTAGTATGCGATCCGGTGGCAGGAC
TTGTAGAAGTACCTTGCGTAAAACGTAATGCAGCAGGAGCTGCAAATGCGATGATTTCAGCTGATTTAGCATTAGCTGGT
GTAACGAGTACCATTCCATGTGATGAAGTAATTGAGGCAATGTTTAGAATCGGACAAACGATGCCAGTAGCACTTCGTGA
AACAGCTGAAGGTGGACTTGCAGCAACACCGACTGGTCGTCGTCTGCAAGAAGAGATTTTTGGGAAGAAGAATAACTAA

Upstream 100 bases:

>100_bases
AACAGATGAAATATTAGCAGATGAAGTAATTGAAGAAATAAAAGCGCAACAAAATATTTGTCAAGTAACTATTATGGAAT
AATTGCAGGGGGGACACACC

Downstream 100 bases:

>100_bases
ACAATATATGTTTATAAAAAAATGGAGCTCAAGTAAGATTGAGCTCCATTTTTTATTTTTCTTTTGTTAGTTGTTCTAAT
GTTTTCCCGAGATTATGCGA

Product: L-serine dehydratase, alpha subunit

Products: NA

Alternate protein names: SDH; L-serine deaminase; L-SD [H]

Number of amino acids: Translated: 292; Mature: 292

Protein sequence:

>292_residues
MFRNAAELVAQAKEQNVKIAEIMIQCEMETRSISREEVIAGMEKNLVVMEQAVERGIHGVKSPTGLTGGDAVKVQAYMKS
GKGLSGDTILDAVSKAVATNEVNAAMGIICATPTAGSAGTVPGVLFALREKLQPTREEMIEFLFTAGAFGMVVANNACIS
GAAGGCQAEVGSASGMAAAAAVEMAGGTQDQAATAMAISLKNMLGLVCDPVAGLVEVPCVKRNAAGAANAMISADLALAG
VTSTIPCDEVIEAMFRIGQTMPVALRETAEGGLAATPTGRRLQEEIFGKKNN

Sequences:

>Translated_292_residues
MFRNAAELVAQAKEQNVKIAEIMIQCEMETRSISREEVIAGMEKNLVVMEQAVERGIHGVKSPTGLTGGDAVKVQAYMKS
GKGLSGDTILDAVSKAVATNEVNAAMGIICATPTAGSAGTVPGVLFALREKLQPTREEMIEFLFTAGAFGMVVANNACIS
GAAGGCQAEVGSASGMAAAAAVEMAGGTQDQAATAMAISLKNMLGLVCDPVAGLVEVPCVKRNAAGAANAMISADLALAG
VTSTIPCDEVIEAMFRIGQTMPVALRETAEGGLAATPTGRRLQEEIFGKKNN
>Mature_292_residues
MFRNAAELVAQAKEQNVKIAEIMIQCEMETRSISREEVIAGMEKNLVVMEQAVERGIHGVKSPTGLTGGDAVKVQAYMKS
GKGLSGDTILDAVSKAVATNEVNAAMGIICATPTAGSAGTVPGVLFALREKLQPTREEMIEFLFTAGAFGMVVANNACIS
GAAGGCQAEVGSASGMAAAAAVEMAGGTQDQAATAMAISLKNMLGLVCDPVAGLVEVPCVKRNAAGAANAMISADLALAG
VTSTIPCDEVIEAMFRIGQTMPVALRETAEGGLAATPTGRRLQEEIFGKKNN

Specific function: Anaerobic degradation of L-threonine to propionate. [C]

COG id: COG1760

COG function: function code E; L-serine deaminase

Gene ontology:

Cell location: Cytoplasmic

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: Belongs to the iron-sulfur dependent L-serine dehydratase family [H]

Homologues:

Organism=Escherichia coli, GI48994925, Length=280, Percent_Identity=36.0714285714286, Blast_Score=155, Evalue=2e-39,
Organism=Escherichia coli, GI1788116, Length=280, Percent_Identity=35.3571428571429, Blast_Score=146, Evalue=1e-36,
Organism=Escherichia coli, GI1789161, Length=285, Percent_Identity=35.4385964912281, Blast_Score=139, Evalue=2e-34,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR005130
- InterPro:   IPR004642 [H]

Pfam domain/function: PF03313 SDH_alpha [H]

EC number: =4.3.1.17 [H]

Molecular weight: Translated: 29924; Mature: 29924

Theoretical pI: Translated: 4.68; Mature: 4.68

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.4 %Cys     (Translated Protein)
5.5 %Met     (Translated Protein)
7.9 %Cys+Met (Translated Protein)
2.4 %Cys     (Mature Protein)
5.5 %Met     (Mature Protein)
7.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MFRNAAELVAQAKEQNVKIAEIMIQCEMETRSISREEVIAGMEKNLVVMEQAVERGIHGV
CCCCHHHHHHHHHHCCCEEEHHHEEECHHHHHCCHHHHHHCCCCCHHHHHHHHHHHHCCC
KSPTGLTGGDAVKVQAYMKSGKGLSGDTILDAVSKAVATNEVNAAMGIICATPTAGSAGT
CCCCCCCCCCCEEEHHHHHCCCCCCCHHHHHHHHHHHHHHHHHHHEEEEEECCCCCCCCC
VPGVLFALREKLQPTREEMIEFLFTAGAFGMVVANNACISGAAGGCQAEVGSASGMAAAA
HHHHHHHHHHHCCHHHHHHHHHHHHCCHHHHEEECCCEECCCCCCCCCCCCCCCCHHHHH
AVEMAGGTQDQAATAMAISLKNMLGLVCDPVAGLVEVPCVKRNAAGAANAMISADLALAG
HHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCHHHHHHHHHHHHHC
VTSTIPCDEVIEAMFRIGQTMPVALRETAEGGLAATPTGRRLQEEIFGKKNN
CCCCCCHHHHHHHHHHCCCCCCHHHHHHCCCCEEECCCCHHHHHHHCCCCCC
>Mature Secondary Structure
MFRNAAELVAQAKEQNVKIAEIMIQCEMETRSISREEVIAGMEKNLVVMEQAVERGIHGV
CCCCHHHHHHHHHHCCCEEEHHHEEECHHHHHCCHHHHHHCCCCCHHHHHHHHHHHHCCC
KSPTGLTGGDAVKVQAYMKSGKGLSGDTILDAVSKAVATNEVNAAMGIICATPTAGSAGT
CCCCCCCCCCCEEEHHHHHCCCCCCCHHHHHHHHHHHHHHHHHHHEEEEEECCCCCCCCC
VPGVLFALREKLQPTREEMIEFLFTAGAFGMVVANNACISGAAGGCQAEVGSASGMAAAA
HHHHHHHHHHHCCHHHHHHHHHHHHCCHHHHEEECCCEECCCCCCCCCCCCCCCCHHHHH
AVEMAGGTQDQAATAMAISLKNMLGLVCDPVAGLVEVPCVKRNAAGAANAMISADLALAG
HHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCHHHHHHHHHHHHHC
VTSTIPCDEVIEAMFRIGQTMPVALRETAEGGLAATPTGRRLQEEIFGKKNN
CCCCCCHHHHHHHHHHCCCCCCHHHHHHCCCCEEECCCCHHHHHHHCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 9534248; 9384377 [H]