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The map label for this gene is ykvZ [H]

Identifier: 52141285

GI number: 52141285

Start: 4082830

End: 4083807

Strand: Direct

Name: ykvZ [H]

Synonym: BCZK3965

Alternate gene names: 52141285

Gene position: 4082830-4083807 (Clockwise)

Preceding gene: 52141286

Following gene: 52141283

Centisome position: 77.02

GC content: 38.14

Gene sequence:

>978_bases
ATGGCCAATATAAAACAAATTGCAAAAACCGCTGGTGTATCCATATCAACTGTTTCTCGTGTCCTGAATAATCACCCTTA
CGTAAAAGAAGAAAAACGTAAGCGTGTTCTAGATGCTGTTGAAGAATTGAACTATGCCAAAAATATAAATGCTATTCATT
TAATAAAGGGAAAAACATATACGATCGGTGTTATGCTCCCTTTCATTAACCTTCCATACTTCAGTACCATTATTGAAGGA
ATCGGTAACGAAGCGTTAGCAGCTGGCTATCACATTAATTTATGTCAAACGAATTACGATAGTATTGAAGAAATTCGTGT
TCTGGAAATGATGAAAATGAAACAATTCGACGGGATGATTATTTGCTCTCGAACAAGTTCATGGGAACAAATTGAACCTT
TCGCAAAATTTGCTCCTATTATTTCATGCGAAAAAATGAACCACCCTCTCATTTCATCCGTCTACGTAGATCATTATGAA
GGATTCCGTCTCGGCACCGCCTATTTACTCAAGAAAGGCCATGAAAAAATCGGAATTTGTTTAGCAAGAAAAACGAGCGC
AAATTCTATGGAGCGCGAAAAGGCGTTTGCTGATACACTTCGTAAGGAAGGCAAAACGTTACATCCCGAATGGATTTTTC
ATCAATGCTATACAATGCAAGACGGTGCACAATTACTCCATCGTATTGTAAACATGAAAAATCGTCCAACCGCTATTTTT
ACAGCGAACGATCAAGTTGCAGCAGGTTTATTAACAGAGGCTCGAAAGCAAGGTCTTCGAGTACCCGAAGATCTTGCTAT
CCTGGGATTTGATAATCATGAAATTTCAAAGGCGTTAGAAATTTCAACAATTGAACATCCCGGTCTCGAAATGGGCTCAC
ATGCGTTTTCTTTATTCCATAAACAAATCCAAAGCGAGCAAATTATCGGGAACGCAAAAGAGCTTTCATTCCATTTAATC
GAACGAGATACTGTCTAA

Upstream 100 bases:

>100_bases
AGAAGTCTTATTCATACCATAGTTTGTGAAAAGCTTTTCAGGTCAAGATTTTTTCTTTCTTATTATTTTCCCTTTATAAT
AAGAGGAAGAGGTGATACAT

Downstream 100 bases:

>100_bases
TAAGAGCGTTACCTATAGCGCTCTTTTTCAGCTCTTCACCTATTGACTTTATATTTTTACTCGCATATAATAAACCTAAC
GAACGGTAGGTAGGGGATGA

Product: LacI family transcription regulator

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 325; Mature: 324

Protein sequence:

>325_residues
MANIKQIAKTAGVSISTVSRVLNNHPYVKEEKRKRVLDAVEELNYAKNINAIHLIKGKTYTIGVMLPFINLPYFSTIIEG
IGNEALAAGYHINLCQTNYDSIEEIRVLEMMKMKQFDGMIICSRTSSWEQIEPFAKFAPIISCEKMNHPLISSVYVDHYE
GFRLGTAYLLKKGHEKIGICLARKTSANSMEREKAFADTLRKEGKTLHPEWIFHQCYTMQDGAQLLHRIVNMKNRPTAIF
TANDQVAAGLLTEARKQGLRVPEDLAILGFDNHEISKALEISTIEHPGLEMGSHAFSLFHKQIQSEQIIGNAKELSFHLI
ERDTV

Sequences:

>Translated_325_residues
MANIKQIAKTAGVSISTVSRVLNNHPYVKEEKRKRVLDAVEELNYAKNINAIHLIKGKTYTIGVMLPFINLPYFSTIIEG
IGNEALAAGYHINLCQTNYDSIEEIRVLEMMKMKQFDGMIICSRTSSWEQIEPFAKFAPIISCEKMNHPLISSVYVDHYE
GFRLGTAYLLKKGHEKIGICLARKTSANSMEREKAFADTLRKEGKTLHPEWIFHQCYTMQDGAQLLHRIVNMKNRPTAIF
TANDQVAAGLLTEARKQGLRVPEDLAILGFDNHEISKALEISTIEHPGLEMGSHAFSLFHKQIQSEQIIGNAKELSFHLI
ERDTV
>Mature_324_residues
ANIKQIAKTAGVSISTVSRVLNNHPYVKEEKRKRVLDAVEELNYAKNINAIHLIKGKTYTIGVMLPFINLPYFSTIIEGI
GNEALAAGYHINLCQTNYDSIEEIRVLEMMKMKQFDGMIICSRTSSWEQIEPFAKFAPIISCEKMNHPLISSVYVDHYEG
FRLGTAYLLKKGHEKIGICLARKTSANSMEREKAFADTLRKEGKTLHPEWIFHQCYTMQDGAQLLHRIVNMKNRPTAIFT
ANDQVAAGLLTEARKQGLRVPEDLAILGFDNHEISKALEISTIEHPGLEMGSHAFSLFHKQIQSEQIIGNAKELSFHLIE
RDTV

Specific function: This Protein Negatively Controls The Transcription Initiation Of Genes Such As Deocabd, Udp, And Cdd Encoding Catabolizing Enzymes And Nupc, Nupg, And Tsx Encoding Transporting And Pore-Forming Proteins. Binds Cytidine And Adenosine As Effectors. [C]

COG id: NA

COG function: NA

Gene ontology:

Cell location: Cytoplasmic

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 HTH lacI-type DNA-binding domain [H]

Homologues:

Organism=Escherichia coli, GI1790369, Length=327, Percent_Identity=29.3577981651376, Blast_Score=157, Evalue=6e-40,
Organism=Escherichia coli, GI1787948, Length=340, Percent_Identity=29.7058823529412, Blast_Score=141, Evalue=5e-35,
Organism=Escherichia coli, GI1790194, Length=328, Percent_Identity=27.7439024390244, Blast_Score=134, Evalue=9e-33,
Organism=Escherichia coli, GI1788474, Length=303, Percent_Identity=28.0528052805281, Blast_Score=123, Evalue=2e-29,
Organism=Escherichia coli, GI1789068, Length=298, Percent_Identity=27.8523489932886, Blast_Score=113, Evalue=2e-26,
Organism=Escherichia coli, GI48994940, Length=320, Percent_Identity=25.9375, Blast_Score=111, Evalue=7e-26,
Organism=Escherichia coli, GI1789202, Length=298, Percent_Identity=24.1610738255034, Blast_Score=110, Evalue=1e-25,
Organism=Escherichia coli, GI1786540, Length=323, Percent_Identity=26.0061919504644, Blast_Score=100, Evalue=1e-22,
Organism=Escherichia coli, GI1787580, Length=317, Percent_Identity=25.5520504731861, Blast_Score=99, Evalue=4e-22,
Organism=Escherichia coli, GI1787906, Length=263, Percent_Identity=24.3346007604563, Blast_Score=95, Evalue=5e-21,
Organism=Escherichia coli, GI1790715, Length=333, Percent_Identity=24.3243243243243, Blast_Score=92, Evalue=7e-20,
Organism=Escherichia coli, GI1786268, Length=292, Percent_Identity=22.9452054794521, Blast_Score=80, Evalue=2e-16,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000843
- InterPro:   IPR010982
- InterPro:   IPR001761 [H]

Pfam domain/function: PF00356 LacI; PF00532 Peripla_BP_1 [H]

EC number: NA

Molecular weight: Translated: 36759; Mature: 36628

Theoretical pI: Translated: 7.98; Mature: 7.98

Prosite motif: PS50932 HTH_LACI_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.5 %Cys     (Translated Protein)
3.4 %Met     (Translated Protein)
4.9 %Cys+Met (Translated Protein)
1.5 %Cys     (Mature Protein)
3.1 %Met     (Mature Protein)
4.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MANIKQIAKTAGVSISTVSRVLNNHPYVKEEKRKRVLDAVEELNYAKNINAIHLIKGKTY
CCCHHHHHHHHCCHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHHHCCCEEEEECCCEE
TIGVMLPFINLPYFSTIIEGIGNEALAAGYHINLCQTNYDSIEEIRVLEMMKMKQFDGMI
EEEEEECHHCCHHHHHHHHHCCCCHHHCCEEEEEECCCCCHHHHHHHHHHHHHHHCCCEE
ICSRTSSWEQIEPFAKFAPIISCEKMNHPLISSVYVDHYEGFRLGTAYLLKKGHEKIGIC
EEECCCCHHHHHHHHHHCCHHHHHHCCCCHHHHHHHHCCCCCCHHHHHHHHCCCCEEEEE
LARKTSANSMEREKAFADTLRKEGKTLHPEWIFHQCYTMQDGAQLLHRIVNMKNRPTAIF
EEECCCCCHHHHHHHHHHHHHHCCCCCCHHHHHHHHHCCCHHHHHHHHHHCCCCCCCEEE
TANDQVAAGLLTEARKQGLRVPEDLAILGFDNHEISKALEISTIEHPGLEMGSHAFSLFH
ECCCHHHHHHHHHHHHCCCCCCCCEEEEECCCHHHHHHHEEEECCCCCCHHHHHHHHHHH
KQIQSEQIIGNAKELSFHLIERDTV
HHHHHHHHHCCHHHHEEEEEECCCC
>Mature Secondary Structure 
ANIKQIAKTAGVSISTVSRVLNNHPYVKEEKRKRVLDAVEELNYAKNINAIHLIKGKTY
CCHHHHHHHHCCHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHHHCCCEEEEECCCEE
TIGVMLPFINLPYFSTIIEGIGNEALAAGYHINLCQTNYDSIEEIRVLEMMKMKQFDGMI
EEEEEECHHCCHHHHHHHHHCCCCHHHCCEEEEEECCCCCHHHHHHHHHHHHHHHCCCEE
ICSRTSSWEQIEPFAKFAPIISCEKMNHPLISSVYVDHYEGFRLGTAYLLKKGHEKIGIC
EEECCCCHHHHHHHHHHCCHHHHHHCCCCHHHHHHHHCCCCCCHHHHHHHHCCCCEEEEE
LARKTSANSMEREKAFADTLRKEGKTLHPEWIFHQCYTMQDGAQLLHRIVNMKNRPTAIF
EEECCCCCHHHHHHHHHHHHHHCCCCCCHHHHHHHHHCCCHHHHHHHHHHCCCCCCCEEE
TANDQVAAGLLTEARKQGLRVPEDLAILGFDNHEISKALEISTIEHPGLEMGSHAFSLFH
ECCCHHHHHHHHHHHHCCCCCCCCEEEEECCCHHHHHHHEEEECCCCCCHHHHHHHHHHH
KQIQSEQIIGNAKELSFHLIERDTV
HHHHHHHHHCCHHHHEEEEEECCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: DNA [C]

Specific reaction: Protein + DNA = Protein-DNA [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 9384377 [H]