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The map label for this gene is apt [H]

Identifier: 52141098

GI number: 52141098

Start: 4258677

End: 4259189

Strand: Reverse

Name: apt [H]

Synonym: BCZK4152

Alternate gene names: 52141098

Gene position: 4259189-4258677 (Counterclockwise)

Preceding gene: 52141097

Following gene: 52141100

Centisome position: 80.35

GC content: 38.01

Gene sequence:

>513_bases
ATGGATTTCAAGCAACATATCGCAATTGTACCGGACTATCCAAAAGAAGGTATCGTGTTTAAAGACATTACACCGTTAAT
GAACGACGGTAAAGCATACAAAGCAGCAACAGATGCAATCGTTGAGTATGCAAAAGAGAGGGACATCGACGTTGTAGTAG
GTCCAGAAGCTCGTGGCTTTATTATTGGTTGCCCAGTTTCTTACGCATTAGAAGTAGGATTTGCGCCAGTTCGTAAATTA
GGAAAATTACCACGTGAAGTAATTACAGTTGACTACGGTAAAGAATATGGTAAAGATGTTTTAACAATCCATAAAGATGC
AATTAAGCCAGGCCAACGCGTATTAATTACAGATGATCTATTAGCTACAGGTGGAACAATCGAAGCGACAATTAAGCTAG
TTGAAGAGCTAGGCGGAGTTGTAGCAGGAATTGCATTCTTAGTAGAACTTACTTACTTAGATGGTCGTAAAATGTTAGAT
GGTTACGATGTATTAGTATTAGAAAAATACTAA

Upstream 100 bases:

>100_bases
ATACATGGTTTGAAACGATTCGTAATCATAAAGAAGTAGAACAGCTAGGGTAAAGGATTTGTATTTACAAACCTTTTAGA
TCTGAGGAGGATTCAGAAAT

Downstream 100 bases:

>100_bases
TCGCTATATAGGTAAAACTACGGTGATAAGAAGTACCCGTGAATCTCTTGGAGAGGAGCGGGTACTTTTGTATAATTGAA
CAAAAAATTATGGTGAAATG

Product: adenine phosphoribosyltransferase

Products: NA

Alternate protein names: APRT [H]

Number of amino acids: Translated: 170; Mature: 170

Protein sequence:

>170_residues
MDFKQHIAIVPDYPKEGIVFKDITPLMNDGKAYKAATDAIVEYAKERDIDVVVGPEARGFIIGCPVSYALEVGFAPVRKL
GKLPREVITVDYGKEYGKDVLTIHKDAIKPGQRVLITDDLLATGGTIEATIKLVEELGGVVAGIAFLVELTYLDGRKMLD
GYDVLVLEKY

Sequences:

>Translated_170_residues
MDFKQHIAIVPDYPKEGIVFKDITPLMNDGKAYKAATDAIVEYAKERDIDVVVGPEARGFIIGCPVSYALEVGFAPVRKL
GKLPREVITVDYGKEYGKDVLTIHKDAIKPGQRVLITDDLLATGGTIEATIKLVEELGGVVAGIAFLVELTYLDGRKMLD
GYDVLVLEKY
>Mature_170_residues
MDFKQHIAIVPDYPKEGIVFKDITPLMNDGKAYKAATDAIVEYAKERDIDVVVGPEARGFIIGCPVSYALEVGFAPVRKL
GKLPREVITVDYGKEYGKDVLTIHKDAIKPGQRVLITDDLLATGGTIEATIKLVEELGGVVAGIAFLVELTYLDGRKMLD
GYDVLVLEKY

Specific function: Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis [H]

COG id: COG0503

COG function: function code F; Adenine/guanine phosphoribosyltransferases and related PRPP-binding proteins

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the purine/pyrimidine phosphoribosyltransferase family [H]

Homologues:

Organism=Homo sapiens, GI4502171, Length=170, Percent_Identity=40.5882352941176, Blast_Score=127, Evalue=5e-30,
Organism=Homo sapiens, GI71773201, Length=124, Percent_Identity=41.9354838709677, Blast_Score=104, Evalue=3e-23,
Organism=Escherichia coli, GI1786675, Length=158, Percent_Identity=56.3291139240506, Blast_Score=169, Evalue=9e-44,
Organism=Caenorhabditis elegans, GI17509087, Length=169, Percent_Identity=42.603550295858, Blast_Score=121, Evalue=1e-28,
Organism=Saccharomyces cerevisiae, GI6323619, Length=155, Percent_Identity=42.5806451612903, Blast_Score=114, Evalue=9e-27,
Organism=Saccharomyces cerevisiae, GI6320649, Length=154, Percent_Identity=31.1688311688312, Blast_Score=76, Evalue=2e-15,
Organism=Drosophila melanogaster, GI17136334, Length=160, Percent_Identity=44.375, Blast_Score=132, Evalue=8e-32,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR005764
- InterPro:   IPR000836 [H]

Pfam domain/function: PF00156 Pribosyltran [H]

EC number: =2.4.2.7 [H]

Molecular weight: Translated: 18630; Mature: 18630

Theoretical pI: Translated: 4.76; Mature: 4.76

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.6 %Cys     (Translated Protein)
1.8 %Met     (Translated Protein)
2.4 %Cys+Met (Translated Protein)
0.6 %Cys     (Mature Protein)
1.8 %Met     (Mature Protein)
2.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MDFKQHIAIVPDYPKEGIVFKDITPLMNDGKAYKAATDAIVEYAKERDIDVVVGPEARGF
CCCCCCEEECCCCCCCCEEEECCCHHHCCCCHHHHHHHHHHHHHHHCCCEEEECCCCCCE
IIGCPVSYALEVGFAPVRKLGKLPREVITVDYGKEYGKDVLTIHKDAIKPGQRVLITDDL
EEECCHHHHHHCCCHHHHHHHCCCHHEEEEECCHHHCCCEEEEEHHHCCCCCEEEEECCH
LATGGTIEATIKLVEELGGVVAGIAFLVELTYLDGRKMLDGYDVLVLEKY
HHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCEECCCCEEEEEECC
>Mature Secondary Structure
MDFKQHIAIVPDYPKEGIVFKDITPLMNDGKAYKAATDAIVEYAKERDIDVVVGPEARGF
CCCCCCEEECCCCCCCCEEEECCCHHHCCCCHHHHHHHHHHHHHHHCCCEEEECCCCCCE
IIGCPVSYALEVGFAPVRKLGKLPREVITVDYGKEYGKDVLTIHKDAIKPGQRVLITDDL
EEECCHHHHHHCCCHHHHHHHCCCHHEEEEECCHHHCCCEEEEEHHHCCCCCEEEEECCH
LATGGTIEATIKLVEELGGVVAGIAFLVELTYLDGRKMLDGYDVLVLEKY
HHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCEECCCCEEEEEECC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA