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The map label for this gene is phoR [H]

Identifier: 52140921

GI number: 52140921

Start: 4443482

End: 4445245

Strand: Reverse

Name: phoR [H]

Synonym: BCZK4329

Alternate gene names: 52140921

Gene position: 4445245-4443482 (Counterclockwise)

Preceding gene: 52140920

Following gene: 52140922

Centisome position: 83.86

GC content: 34.86

Gene sequence:

>1764_bases
ATGAATAAATTTCGTTCCAGGCTTCTTTTTACATTTGTTTCTCTTATTGTATTTATTTTAGTGGGACTCGGTTTATTGCT
AGAAACTGTGTTTGAAAACTATTATATAGATCATGCAAAAGAGAGAATGGTAAAAGAGACAGAGTATGTTGCGGTATTAG
CAGAAGAACAAGGTTTTGATGATGTTTTAAAAAATCCATATATATTTGAAAAGTTAGAAGAAAAAATACAGGCTTCTATT
GCATTTATAGATGAAAAAAAGAAGGTTCAATATAGCGGGGGAGAACCGTCTACTTTTAGCCAAGGGACAATAAAAGAACT
TTCCTCTGAAACAACGAAACAAAGAAATAAAGTCATTACGAAAGAAACAGATCAAAATAATGAATTTTACCATGCGGTGT
TCGTGCAAGATGTAGCAGGGAAACAAGGATACATTTTGGTGAAAAGCACAATTGAGCCTTTGAAAGACGTTCATCAAAAA
ACGTGGGGATTATTAATTATCGGATTTGTTATTGCGTGTCTTGTAGTCGTATTTTTAGGTATGAAAATTACAGGGCAATA
TATTAGGCCGATTGAGTCCGTTACGAAAGTTGCCATCGAATTAGCGAAGGGTAATTATAAAGCACGTGCTTATGAAAGTC
ATTCGGATGAAACGGGAATGTTAAGTAAAGCGATTAATATTTTAGCTCGTAATTTACAAGAGATGACACTTGAGCAAGAA
ATGCAACAAGATCGTCTGCATACGTTAATTGAAAATATGGGCAGTGGAATGATTTTAATTGATAGCCGCGGTTATATCAA
CCTTGTAAACCGTTCGTATAAGGAAACTTTCCACGTCACAGATGAAGAATATTTAGATCGTTTATATTATGAGTCGTTTC
ATCATCCGGAAATTATAGAGCTTGTGGAAGAAATCTTTATGACAGAAGTGAAAGTGCGCAAACAAATGTTATTGCCACTT
GGAATTGAGCGAAAGCATTTTGAGGTATATGGAGCACCGATTATCGGGACGAACCATGAATGGAAAGGGATTGTCCTTGT
ATTCCATGACATTACTGAGCTGAAAAAGTTAGAACAAATGAGAAAAGACTTTTTAGCGAATGTTTCCCATGAACTAAAAA
CGCCGATTACTTCTATTAAAGGTTTTTCAGAAACACTTTTAGACGGTGCTATGGATAATAAAAAATTCTGCGAACATTTC
TTGCACATTATTTTAAAAGAAAGTGAACGTATGCAAGGATTAATTGAAGATTTATTAGATTTATCAAAGATTGAGCAACA
AGGATTTAAATTGAATATGGGTACCGTTGATATGAAGGGACTTCTTGAAGATATTCATATGGTGCTTGATAATAAAGCGG
GAGAAAAAGAAATCTCTTTACAAGTAAATGCATTAAAACGTGTCTCTGTCATTGGAGATCCAAGTCGTTTGCAGCAAATC
TTTATTAATTTAATGAATAACGCAATCGTATATACACCGGCTGGAGGCGTTGTTTCTGTAGAATTAGCAGAAGATAAATA
TAATGCTTATATAAAAGTGTCGGATACTGGAATTGGTATTAGTAAAGATGAAATTCCGCGTATTTTCGAACGCTTTTACC
GAGTTGATAAAGCGAGAAGTAGAAATACTGGTGGTACAGGTCTTGGGTTATCAATCGTAAAGCATTTAGTCGAGGCCCAT
CACGGTACGATTACAGTGGATAGTGAAGTAGGAGAAGGGACAACCTTTACAGTTGTTTTACCAAAATCAGCAACTGAAAA
ATAG

Upstream 100 bases:

>100_bases
ATTAGCCATTTGCGCGATAAAATTGAACAAAATACGAAAAAACCGACGTACATTAAAACGATACGTGGTTTAGGATATAA
ATTAGAGGAGCCAAAAGGGG

Downstream 100 bases:

>100_bases
GATGAAGGATGTTTACAATATATTAACAATGGCTTAATTAAATATTAATAAAGCTCTGTTAATATAATACATGAAAACCC
CTTCATCCAAGGAGTAATTT

Product: phosphate regulon sensor protein

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 587; Mature: 587

Protein sequence:

>587_residues
MNKFRSRLLFTFVSLIVFILVGLGLLLETVFENYYIDHAKERMVKETEYVAVLAEEQGFDDVLKNPYIFEKLEEKIQASI
AFIDEKKKVQYSGGEPSTFSQGTIKELSSETTKQRNKVITKETDQNNEFYHAVFVQDVAGKQGYILVKSTIEPLKDVHQK
TWGLLIIGFVIACLVVVFLGMKITGQYIRPIESVTKVAIELAKGNYKARAYESHSDETGMLSKAINILARNLQEMTLEQE
MQQDRLHTLIENMGSGMILIDSRGYINLVNRSYKETFHVTDEEYLDRLYYESFHHPEIIELVEEIFMTEVKVRKQMLLPL
GIERKHFEVYGAPIIGTNHEWKGIVLVFHDITELKKLEQMRKDFLANVSHELKTPITSIKGFSETLLDGAMDNKKFCEHF
LHIILKESERMQGLIEDLLDLSKIEQQGFKLNMGTVDMKGLLEDIHMVLDNKAGEKEISLQVNALKRVSVIGDPSRLQQI
FINLMNNAIVYTPAGGVVSVELAEDKYNAYIKVSDTGIGISKDEIPRIFERFYRVDKARSRNTGGTGLGLSIVKHLVEAH
HGTITVDSEVGEGTTFTVVLPKSATEK

Sequences:

>Translated_587_residues
MNKFRSRLLFTFVSLIVFILVGLGLLLETVFENYYIDHAKERMVKETEYVAVLAEEQGFDDVLKNPYIFEKLEEKIQASI
AFIDEKKKVQYSGGEPSTFSQGTIKELSSETTKQRNKVITKETDQNNEFYHAVFVQDVAGKQGYILVKSTIEPLKDVHQK
TWGLLIIGFVIACLVVVFLGMKITGQYIRPIESVTKVAIELAKGNYKARAYESHSDETGMLSKAINILARNLQEMTLEQE
MQQDRLHTLIENMGSGMILIDSRGYINLVNRSYKETFHVTDEEYLDRLYYESFHHPEIIELVEEIFMTEVKVRKQMLLPL
GIERKHFEVYGAPIIGTNHEWKGIVLVFHDITELKKLEQMRKDFLANVSHELKTPITSIKGFSETLLDGAMDNKKFCEHF
LHIILKESERMQGLIEDLLDLSKIEQQGFKLNMGTVDMKGLLEDIHMVLDNKAGEKEISLQVNALKRVSVIGDPSRLQQI
FINLMNNAIVYTPAGGVVSVELAEDKYNAYIKVSDTGIGISKDEIPRIFERFYRVDKARSRNTGGTGLGLSIVKHLVEAH
HGTITVDSEVGEGTTFTVVLPKSATEK
>Mature_587_residues
MNKFRSRLLFTFVSLIVFILVGLGLLLETVFENYYIDHAKERMVKETEYVAVLAEEQGFDDVLKNPYIFEKLEEKIQASI
AFIDEKKKVQYSGGEPSTFSQGTIKELSSETTKQRNKVITKETDQNNEFYHAVFVQDVAGKQGYILVKSTIEPLKDVHQK
TWGLLIIGFVIACLVVVFLGMKITGQYIRPIESVTKVAIELAKGNYKARAYESHSDETGMLSKAINILARNLQEMTLEQE
MQQDRLHTLIENMGSGMILIDSRGYINLVNRSYKETFHVTDEEYLDRLYYESFHHPEIIELVEEIFMTEVKVRKQMLLPL
GIERKHFEVYGAPIIGTNHEWKGIVLVFHDITELKKLEQMRKDFLANVSHELKTPITSIKGFSETLLDGAMDNKKFCEHF
LHIILKESERMQGLIEDLLDLSKIEQQGFKLNMGTVDMKGLLEDIHMVLDNKAGEKEISLQVNALKRVSVIGDPSRLQQI
FINLMNNAIVYTPAGGVVSVELAEDKYNAYIKVSDTGIGISKDEIPRIFERFYRVDKARSRNTGGTGLGLSIVKHLVEAH
HGTITVDSEVGEGTTFTVVLPKSATEK

Specific function: Member of the two-component regulatory system phoP/phoR involved in the alkaline phosphatase genes regulation. PhoR may function as a membrane-associated protein kinase that phosphorylates phoP in response to environmental signals [H]

COG id: NA

COG function: NA

Gene ontology:

Cell location: Cell membrane; Multi-pass membrane protein (Probable) [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 PAS (PER-ARNT-SIM) domain [H]

Homologues:

Organism=Escherichia coli, GI1786600, Length=269, Percent_Identity=37.9182156133829, Blast_Score=175, Evalue=9e-45,
Organism=Escherichia coli, GI1788393, Length=230, Percent_Identity=33.4782608695652, Blast_Score=147, Evalue=2e-36,
Organism=Escherichia coli, GI48994928, Length=336, Percent_Identity=30.6547619047619, Blast_Score=130, Evalue=3e-31,
Organism=Escherichia coli, GI1789149, Length=224, Percent_Identity=34.8214285714286, Blast_Score=125, Evalue=6e-30,
Organism=Escherichia coli, GI1786783, Length=246, Percent_Identity=32.1138211382114, Blast_Score=123, Evalue=3e-29,
Organism=Escherichia coli, GI145693157, Length=237, Percent_Identity=34.1772151898734, Blast_Score=122, Evalue=8e-29,
Organism=Escherichia coli, GI1790436, Length=238, Percent_Identity=32.7731092436975, Blast_Score=121, Evalue=1e-28,
Organism=Escherichia coli, GI1788713, Length=227, Percent_Identity=33.0396475770925, Blast_Score=117, Evalue=2e-27,
Organism=Escherichia coli, GI1790861, Length=228, Percent_Identity=31.5789473684211, Blast_Score=112, Evalue=6e-26,
Organism=Escherichia coli, GI1788549, Length=383, Percent_Identity=26.8929503916449, Blast_Score=109, Evalue=4e-25,
Organism=Escherichia coli, GI1790346, Length=264, Percent_Identity=32.5757575757576, Blast_Score=108, Evalue=8e-25,
Organism=Escherichia coli, GI87081816, Length=262, Percent_Identity=28.2442748091603, Blast_Score=105, Evalue=8e-24,
Organism=Escherichia coli, GI87082128, Length=237, Percent_Identity=29.957805907173, Blast_Score=100, Evalue=4e-22,
Organism=Escherichia coli, GI1786912, Length=231, Percent_Identity=28.5714285714286, Blast_Score=89, Evalue=1e-18,
Organism=Escherichia coli, GI1787894, Length=262, Percent_Identity=28.2442748091603, Blast_Score=86, Evalue=6e-18,
Organism=Escherichia coli, GI1788279, Length=231, Percent_Identity=27.2727272727273, Blast_Score=83, Evalue=5e-17,
Organism=Escherichia coli, GI1789808, Length=239, Percent_Identity=26.7782426778243, Blast_Score=80, Evalue=3e-16,
Organism=Escherichia coli, GI1789403, Length=205, Percent_Identity=29.7560975609756, Blast_Score=79, Evalue=6e-16,
Organism=Escherichia coli, GI1790551, Length=283, Percent_Identity=26.1484098939929, Blast_Score=75, Evalue=1e-14,
Organism=Escherichia coli, GI1790300, Length=238, Percent_Identity=26.0504201680672, Blast_Score=72, Evalue=1e-13,
Organism=Escherichia coli, GI1790567, Length=350, Percent_Identity=25.7142857142857, Blast_Score=63, Evalue=6e-11,
Organism=Saccharomyces cerevisiae, GI6322044, Length=77, Percent_Identity=44.1558441558442, Blast_Score=66, Evalue=1e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003594
- InterPro:   IPR000014
- InterPro:   IPR013767
- InterPro:   IPR004358
- InterPro:   IPR003661
- InterPro:   IPR005467
- InterPro:   IPR009082 [H]

Pfam domain/function: PF02518 HATPase_c; PF00512 HisKA; PF00989 PAS [H]

EC number: =2.7.13.3 [H]

Molecular weight: Translated: 66760; Mature: 66760

Theoretical pI: Translated: 6.06; Mature: 6.06

Prosite motif: PS50885 HAMP ; PS50112 PAS ; PS50109 HIS_KIN

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.3 %Cys     (Translated Protein)
2.9 %Met     (Translated Protein)
3.2 %Cys+Met (Translated Protein)
0.3 %Cys     (Mature Protein)
2.9 %Met     (Mature Protein)
3.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MNKFRSRLLFTFVSLIVFILVGLGLLLETVFENYYIDHAKERMVKETEYVAVLAEEQGFD
CCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHEEEEECCCCCH
DVLKNPYIFEKLEEKIQASIAFIDEKKKVQYSGGEPSTFSQGTIKELSSETTKQRNKVIT
HHHCCCHHHHHHHHHHHHHHHHEECCCEEEECCCCCCCCCCHHHHHHHHHHHHHHCCCCC
KETDQNNEFYHAVFVQDVAGKQGYILVKSTIEPLKDVHQKTWGLLIIGFVIACLVVVFLG
CCCCCCCCEEEEEEEEHHCCCCCEEEEHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHC
MKITGQYIRPIESVTKVAIELAKGNYKARAYESHSDETGMLSKAINILARNLQEMTLEQE
HHHCCHHHHHHHHHHHHHHHHHCCCCEEEEECCCCCCHHHHHHHHHHHHHHHHHHHHHHH
MQQDRLHTLIENMGSGMILIDSRGYINLVNRSYKETFHVTDEEYLDRLYYESFHHPEIIE
HHHHHHHHHHHHCCCCEEEEECCCEEEHHHHHHHHHCCCCCHHHHHHHHHHCCCCCHHHH
LVEEIFMTEVKVRKQMLLPLGIERKHFEVYGAPIIGTNHEWKGIVLVFHDITELKKLEQM
HHHHHHHHHHHHHHHHHCCCCCCCCEEEEECCCEECCCCCCCEEEEEEHHHHHHHHHHHH
RKDFLANVSHELKTPITSIKGFSETLLDGAMDNKKFCEHFLHIILKESERMQGLIEDLLD
HHHHHHHHHHHHHCCHHHHCCHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHH
LSKIEQQGFKLNMGTVDMKGLLEDIHMVLDNKAGEKEISLQVNALKRVSVIGDPSRLQQI
HHHHHHCCCEEECCCCCHHHHHHHHHHHHCCCCCCCEEEEEEHHHHHHHCCCCHHHHHHH
FINLMNNAIVYTPAGGVVSVELAEDKYNAYIKVSDTGIGISKDEIPRIFERFYRVDKARS
HHHHHCCEEEEECCCCEEEEEEECCCCCEEEEEECCCCCCCHHHHHHHHHHHHHHHHHHC
RNTGGTGLGLSIVKHLVEAHHGTITVDSEVGEGTTFTVVLPKSATEK
CCCCCCCHHHHHHHHHHHHCCCEEEEECCCCCCCEEEEEECCCCCCC
>Mature Secondary Structure
MNKFRSRLLFTFVSLIVFILVGLGLLLETVFENYYIDHAKERMVKETEYVAVLAEEQGFD
CCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHEEEEECCCCCH
DVLKNPYIFEKLEEKIQASIAFIDEKKKVQYSGGEPSTFSQGTIKELSSETTKQRNKVIT
HHHCCCHHHHHHHHHHHHHHHHEECCCEEEECCCCCCCCCCHHHHHHHHHHHHHHCCCCC
KETDQNNEFYHAVFVQDVAGKQGYILVKSTIEPLKDVHQKTWGLLIIGFVIACLVVVFLG
CCCCCCCCEEEEEEEEHHCCCCCEEEEHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHC
MKITGQYIRPIESVTKVAIELAKGNYKARAYESHSDETGMLSKAINILARNLQEMTLEQE
HHHCCHHHHHHHHHHHHHHHHHCCCCEEEEECCCCCCHHHHHHHHHHHHHHHHHHHHHHH
MQQDRLHTLIENMGSGMILIDSRGYINLVNRSYKETFHVTDEEYLDRLYYESFHHPEIIE
HHHHHHHHHHHHCCCCEEEEECCCEEEHHHHHHHHHCCCCCHHHHHHHHHHCCCCCHHHH
LVEEIFMTEVKVRKQMLLPLGIERKHFEVYGAPIIGTNHEWKGIVLVFHDITELKKLEQM
HHHHHHHHHHHHHHHHHCCCCCCCCEEEEECCCEECCCCCCCEEEEEEHHHHHHHHHHHH
RKDFLANVSHELKTPITSIKGFSETLLDGAMDNKKFCEHFLHIILKESERMQGLIEDLLD
HHHHHHHHHHHHHCCHHHHCCHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHH
LSKIEQQGFKLNMGTVDMKGLLEDIHMVLDNKAGEKEISLQVNALKRVSVIGDPSRLQQI
HHHHHHCCCEEECCCCCHHHHHHHHHHHHCCCCCCCEEEEEEHHHHHHHCCCCHHHHHHH
FINLMNNAIVYTPAGGVVSVELAEDKYNAYIKVSDTGIGISKDEIPRIFERFYRVDKARS
HHHHHCCEEEEECCCCEEEEEEECCCCCEEEEEECCCCCCCHHHHHHHHHHHHHHHHHHC
RNTGGTGLGLSIVKHLVEAHHGTITVDSEVGEGTTFTVVLPKSATEK
CCCCCCCHHHHHHHHHHHHCCCEEEEECCCCCCCEEEEEECCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 3142862; 9387221; 9384377 [H]