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The map label for this gene is vanSB [H]

Identifier: 52140693

GI number: 52140693

Start: 4651808

End: 4653661

Strand: Reverse

Name: vanSB [H]

Synonym: BCZK4563

Alternate gene names: 52140693

Gene position: 4653661-4651808 (Counterclockwise)

Preceding gene: 52140690

Following gene: 52140691

Centisome position: 87.79

GC content: 31.72

Gene sequence:

>1854_bases
ATGAGAAAGGGAATTGTACTAAAGTTATTTACTCTCACAACAGCATTATGTATGTTAATTTTAGCGACGATTTTTATTGG
ACAAACGATATTTTTTAAGCAATATTACGCGAATCGAAAAGTGGAAGATATTAAAGTGAATTTAAATTCCTTTGAGAAGA
ATTATTTAAACTATGCAGGAAATGTGGAAGAAATTAAGCGACTGGAGCAAGACTTTTTAAGAGAAAATAATACATGGATT
ACGACATTAGATCAAAATGGGAATTTAAAACATGCGGATGATTTTTATTTTGAGGTAACGATAGATCGTAGGCAACAAAA
GAGCTTTGGACAACAAATATTCAAAATTCCCTTATACAATCTCGTCAATATAGAAGAGATTGATAATAAATCATCAGATC
CATTTTTAGGACAAGAAATTTATTTTTCTGGCGTGAAAAAAGAAGAAAGTTTTATTCCATTCTCTTTTTCGCTAGGTAAG
CAAAATTTGAATGGATTTAATAAACCGTTAGAAAAAGCATTTAATGAGAAAATGAGTAAATTAGATCAGGAGAAAAAGAA
AGCAGCTGAGGAACAATTTGGTAAGGAAAAGCAGCCGGTCGTTCAGGAGCCAGCTGCCCAAGAATCAGATGTTTACATAA
GAGGGCGTGTTACGAAAGTCCAATTTCCCGATGTAAAAGGTCTTGTAAATCCAATTTATAAAAATAGCATATTCTTAGAT
AACATAAAAGAATTTCAAACGGATTTATTATTAAAAGAGAGCAAGCACATACAATATGCAATACAAACAATGGACTATGA
AAAAAATGATATTAAATATAAATTATTAGTGAAACCAATAAAAGAAAAAGATGGATCAGTAACTTATATATATGCGATGG
CTTCTTTACAGCCTGTAGATGAAGCTGTACAAATGGTGCAAGATTACTACATTTACATCATTGCATTTGTAGTTGTTCTT
ATTTTTCTAGCTTCGTTCTATTACTCTAAGCAAATCGCAAAGCCGTTATTAAAAATAAATGATACAACGAAGAAAATAGC
GCATTTAGATTTCACAGAACAAATACCAATTACTTCAAAAGATGAAATTGGTGATTTATCGAAAAATATTAATGTGCTAT
CGAATAAACTCAATTCACATATTGGACAGCTAGAACAAGATATTGAAAAGGAAAGAAAGTTAGAAAAGACGCGGAAAGAA
TTCATTTCTGGTGTTTCGCATGAACTAAAAACACCGCTGAGTATTATGAAAAGCTGTATTTCTATTTTAAAAGATGGAGT
AGCTGAGCATAAAAAAGAGTACTATTTTCAAGCGATGGAACGGGAAGTAGACAAAATGGATACTTTAATTTTGGATATGC
TGGAGTTAGCTAAGTTTGAGTCAGGCACATATAAAATGAAAAAGGATTCATTTTATATTGATACAGTAATTGAAGATATA
TGTGAACACCTTTCTGTAGAAATAGAGAAAAAAGAACTTCGTGTTCATAAACATATAGGTCCATTTGAAGTAGTCGCAAA
TCAAGGCCGGATTGAACAAGTCATCGTAAATTTCATTACGAATGCGATACGTTATACACCAAATAAAGAAGATATTATTA
TTTCTACAATAGATGAGAAGGATCGTATAAAAGTATGTATTGAAAATAAAGGTACTCACATTGAAGAAGAGCAATTAGAT
AAAATTTGGGATCGTTTTTATCGCGTAGATGCAGCTCGCCAGCGTTCGCAAGGAGGAACAGGTCTTGGACTTGCCATTTC
AAAGAATATTTTAGAACTACATGATGCTGAATATGGGGCAGAAAATACAGAAGATGGTGTGTTATTTTATTTCTATTTAC
CGAAAAAAGCGTAG

Upstream 100 bases:

>100_bases
CGGTTAATAGTCATATTCGTAATTTAAGAAATAAATTAGGAGAGAAAGCAAAGTACATTACAACTGTAGTACGAACGGGT
TATAAATTTGAGGGGAATGT

Downstream 100 bases:

>100_bases
ACAATATGATCTACGCTTTTTTTAATTTATTTTCATATTATCTTTACCTAATCTTTATTTTTAATCAGTATAATTTGTTT
AGAGAATGAGGTTATGTAAG

Product: sensor histidine kinase

Products: NA

Alternate protein names: Vancomycin B-type resistance protein vanSB; Vancomycin histidine protein kinase [H]

Number of amino acids: Translated: 617; Mature: 617

Protein sequence:

>617_residues
MRKGIVLKLFTLTTALCMLILATIFIGQTIFFKQYYANRKVEDIKVNLNSFEKNYLNYAGNVEEIKRLEQDFLRENNTWI
TTLDQNGNLKHADDFYFEVTIDRRQQKSFGQQIFKIPLYNLVNIEEIDNKSSDPFLGQEIYFSGVKKEESFIPFSFSLGK
QNLNGFNKPLEKAFNEKMSKLDQEKKKAAEEQFGKEKQPVVQEPAAQESDVYIRGRVTKVQFPDVKGLVNPIYKNSIFLD
NIKEFQTDLLLKESKHIQYAIQTMDYEKNDIKYKLLVKPIKEKDGSVTYIYAMASLQPVDEAVQMVQDYYIYIIAFVVVL
IFLASFYYSKQIAKPLLKINDTTKKIAHLDFTEQIPITSKDEIGDLSKNINVLSNKLNSHIGQLEQDIEKERKLEKTRKE
FISGVSHELKTPLSIMKSCISILKDGVAEHKKEYYFQAMEREVDKMDTLILDMLELAKFESGTYKMKKDSFYIDTVIEDI
CEHLSVEIEKKELRVHKHIGPFEVVANQGRIEQVIVNFITNAIRYTPNKEDIIISTIDEKDRIKVCIENKGTHIEEEQLD
KIWDRFYRVDAARQRSQGGTGLGLAISKNILELHDAEYGAENTEDGVLFYFYLPKKA

Sequences:

>Translated_617_residues
MRKGIVLKLFTLTTALCMLILATIFIGQTIFFKQYYANRKVEDIKVNLNSFEKNYLNYAGNVEEIKRLEQDFLRENNTWI
TTLDQNGNLKHADDFYFEVTIDRRQQKSFGQQIFKIPLYNLVNIEEIDNKSSDPFLGQEIYFSGVKKEESFIPFSFSLGK
QNLNGFNKPLEKAFNEKMSKLDQEKKKAAEEQFGKEKQPVVQEPAAQESDVYIRGRVTKVQFPDVKGLVNPIYKNSIFLD
NIKEFQTDLLLKESKHIQYAIQTMDYEKNDIKYKLLVKPIKEKDGSVTYIYAMASLQPVDEAVQMVQDYYIYIIAFVVVL
IFLASFYYSKQIAKPLLKINDTTKKIAHLDFTEQIPITSKDEIGDLSKNINVLSNKLNSHIGQLEQDIEKERKLEKTRKE
FISGVSHELKTPLSIMKSCISILKDGVAEHKKEYYFQAMEREVDKMDTLILDMLELAKFESGTYKMKKDSFYIDTVIEDI
CEHLSVEIEKKELRVHKHIGPFEVVANQGRIEQVIVNFITNAIRYTPNKEDIIISTIDEKDRIKVCIENKGTHIEEEQLD
KIWDRFYRVDAARQRSQGGTGLGLAISKNILELHDAEYGAENTEDGVLFYFYLPKKA
>Mature_617_residues
MRKGIVLKLFTLTTALCMLILATIFIGQTIFFKQYYANRKVEDIKVNLNSFEKNYLNYAGNVEEIKRLEQDFLRENNTWI
TTLDQNGNLKHADDFYFEVTIDRRQQKSFGQQIFKIPLYNLVNIEEIDNKSSDPFLGQEIYFSGVKKEESFIPFSFSLGK
QNLNGFNKPLEKAFNEKMSKLDQEKKKAAEEQFGKEKQPVVQEPAAQESDVYIRGRVTKVQFPDVKGLVNPIYKNSIFLD
NIKEFQTDLLLKESKHIQYAIQTMDYEKNDIKYKLLVKPIKEKDGSVTYIYAMASLQPVDEAVQMVQDYYIYIIAFVVVL
IFLASFYYSKQIAKPLLKINDTTKKIAHLDFTEQIPITSKDEIGDLSKNINVLSNKLNSHIGQLEQDIEKERKLEKTRKE
FISGVSHELKTPLSIMKSCISILKDGVAEHKKEYYFQAMEREVDKMDTLILDMLELAKFESGTYKMKKDSFYIDTVIEDI
CEHLSVEIEKKELRVHKHIGPFEVVANQGRIEQVIVNFITNAIRYTPNKEDIIISTIDEKDRIKVCIENKGTHIEEEQLD
KIWDRFYRVDAARQRSQGGTGLGLAISKNILELHDAEYGAENTEDGVLFYFYLPKKA

Specific function: Member of the two-component regulatory system vanS/vanR. Activates the transcription of vanH, vanA and vanX in response to vancomycin which results in vancomycin resistance. VanS activates vanR by phosphorylation [H]

COG id: NA

COG function: NA

Gene ontology:

Cell location: Cell membrane; Multi-pass membrane protein (Potential) [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 histidine kinase domain [H]

Homologues:

Organism=Escherichia coli, GI1788393, Length=287, Percent_Identity=26.8292682926829, Blast_Score=130, Evalue=2e-31,
Organism=Escherichia coli, GI1786600, Length=236, Percent_Identity=28.8135593220339, Blast_Score=114, Evalue=2e-26,
Organism=Escherichia coli, GI1790346, Length=225, Percent_Identity=26.6666666666667, Blast_Score=106, Evalue=5e-24,
Organism=Escherichia coli, GI1786783, Length=260, Percent_Identity=25.7692307692308, Blast_Score=100, Evalue=2e-22,
Organism=Escherichia coli, GI87081816, Length=334, Percent_Identity=23.0538922155689, Blast_Score=98, Evalue=2e-21,
Organism=Escherichia coli, GI1789149, Length=248, Percent_Identity=27.4193548387097, Blast_Score=95, Evalue=1e-20,
Organism=Escherichia coli, GI1787894, Length=335, Percent_Identity=22.089552238806, Blast_Score=93, Evalue=6e-20,
Organism=Escherichia coli, GI145693157, Length=227, Percent_Identity=25.9911894273128, Blast_Score=87, Evalue=2e-18,
Organism=Escherichia coli, GI1786912, Length=227, Percent_Identity=25.5506607929515, Blast_Score=87, Evalue=4e-18,
Organism=Escherichia coli, GI48994928, Length=202, Percent_Identity=25.2475247524752, Blast_Score=86, Evalue=6e-18,
Organism=Escherichia coli, GI1790861, Length=232, Percent_Identity=24.1379310344828, Blast_Score=84, Evalue=2e-17,
Organism=Escherichia coli, GI1788279, Length=364, Percent_Identity=26.0989010989011, Blast_Score=84, Evalue=4e-17,
Organism=Escherichia coli, GI1790436, Length=236, Percent_Identity=26.271186440678, Blast_Score=81, Evalue=2e-16,
Organism=Escherichia coli, GI1790551, Length=298, Percent_Identity=23.489932885906, Blast_Score=76, Evalue=5e-15,
Organism=Escherichia coli, GI1788713, Length=239, Percent_Identity=23.0125523012552, Blast_Score=76, Evalue=8e-15,
Organism=Escherichia coli, GI87082128, Length=315, Percent_Identity=20, Blast_Score=72, Evalue=9e-14,
Organism=Escherichia coli, GI1789808, Length=227, Percent_Identity=25.1101321585903, Blast_Score=69, Evalue=9e-13,
Organism=Escherichia coli, GI1787374, Length=376, Percent_Identity=21.2765957446809, Blast_Score=67, Evalue=3e-12,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003594
- InterPro:   IPR003660
- InterPro:   IPR003661
- InterPro:   IPR005467
- InterPro:   IPR009082 [H]

Pfam domain/function: PF00672 HAMP; PF02518 HATPase_c; PF00512 HisKA [H]

EC number: =2.7.13.3 [H]

Molecular weight: Translated: 71636; Mature: 71636

Theoretical pI: Translated: 6.33; Mature: 6.33

Prosite motif: PS50885 HAMP ; PS50109 HIS_KIN

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.6 %Cys     (Translated Protein)
1.8 %Met     (Translated Protein)
2.4 %Cys+Met (Translated Protein)
0.6 %Cys     (Mature Protein)
1.8 %Met     (Mature Protein)
2.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MRKGIVLKLFTLTTALCMLILATIFIGQTIFFKQYYANRKVEDIKVNLNSFEKNYLNYAG
CCCCCEEHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCEEEEEEHHHHHHHHHHCCC
NVEEIKRLEQDFLRENNTWITTLDQNGNLKHADDFYFEVTIDRRQQKSFGQQIFKIPLYN
CHHHHHHHHHHHHHCCCCEEEEECCCCCCCCCCCEEEEEEECHHHHHHHHHHHHHCCHHH
LVNIEEIDNKSSDPFLGQEIYFSGVKKEESFIPFSFSLGKQNLNGFNKPLEKAFNEKMSK
CCCHHHHCCCCCCCCCCHHHHHCCCCCCCCCCCEEHHCCCCCCCCCCHHHHHHHHHHHHH
LDQEKKKAAEEQFGKEKQPVVQEPAAQESDVYIRGRVTKVQFPDVKGLVNPIYKNSIFLD
HHHHHHHHHHHHHCCCCCCCCCCCCCCCCCEEEEEEEEEEECCCHHHHHHHHHCCCEEHH
NIKEFQTDLLLKESKHIQYAIQTMDYEKNDIKYKLLVKPIKEKDGSVTYIYAMASLQPVD
HHHHHHHHHHHHHCCHHHHHHHHCCCCCCCCEEEEEEEEHHCCCCCEEEEEEECCCCCHH
EAVQMVQDYYIYIIAFVVVLIFLASFYYSKQIAKPLLKINDTTKKIAHLDFTEQIPITSK
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHCCCCCCCCCCCCC
DEIGDLSKNINVLSNKLNSHIGQLEQDIEKERKLEKTRKEFISGVSHELKTPLSIMKSCI
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHH
SILKDGVAEHKKEYYFQAMEREVDKMDTLILDMLELAKFESGTYKMKKDSFYIDTVIEDI
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCEEEECCCCHHHHHHHHH
CEHLSVEIEKKELRVHKHIGPFEVVANQGRIEQVIVNFITNAIRYTPNKEDIIISTIDEK
HHHHCCEEHHHHHHHHHCCCHHHHHHCCCHHHHHHHHHHHHHHCCCCCCCCEEEEECCCC
DRIKVCIENKGTHIEEEQLDKIWDRFYRVDAARQRSQGGTGLGLAISKNILELHDAEYGA
CCEEEEEECCCCCCCHHHHHHHHHHHHHHHHHHHHCCCCCCEEHHHHHHHHHHHCCCCCC
ENTEDGVLFYFYLPKKA
CCCCCCEEEEEEECCCC
>Mature Secondary Structure
MRKGIVLKLFTLTTALCMLILATIFIGQTIFFKQYYANRKVEDIKVNLNSFEKNYLNYAG
CCCCCEEHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCEEEEEEHHHHHHHHHHCCC
NVEEIKRLEQDFLRENNTWITTLDQNGNLKHADDFYFEVTIDRRQQKSFGQQIFKIPLYN
CHHHHHHHHHHHHHCCCCEEEEECCCCCCCCCCCEEEEEEECHHHHHHHHHHHHHCCHHH
LVNIEEIDNKSSDPFLGQEIYFSGVKKEESFIPFSFSLGKQNLNGFNKPLEKAFNEKMSK
CCCHHHHCCCCCCCCCCHHHHHCCCCCCCCCCCEEHHCCCCCCCCCCHHHHHHHHHHHHH
LDQEKKKAAEEQFGKEKQPVVQEPAAQESDVYIRGRVTKVQFPDVKGLVNPIYKNSIFLD
HHHHHHHHHHHHHCCCCCCCCCCCCCCCCCEEEEEEEEEEECCCHHHHHHHHHCCCEEHH
NIKEFQTDLLLKESKHIQYAIQTMDYEKNDIKYKLLVKPIKEKDGSVTYIYAMASLQPVD
HHHHHHHHHHHHHCCHHHHHHHHCCCCCCCCEEEEEEEEHHCCCCCEEEEEEECCCCCHH
EAVQMVQDYYIYIIAFVVVLIFLASFYYSKQIAKPLLKINDTTKKIAHLDFTEQIPITSK
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHCCCCCCCCCCCCC
DEIGDLSKNINVLSNKLNSHIGQLEQDIEKERKLEKTRKEFISGVSHELKTPLSIMKSCI
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHH
SILKDGVAEHKKEYYFQAMEREVDKMDTLILDMLELAKFESGTYKMKKDSFYIDTVIEDI
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCEEEECCCCHHHHHHHHH
CEHLSVEIEKKELRVHKHIGPFEVVANQGRIEQVIVNFITNAIRYTPNKEDIIISTIDEK
HHHHCCEEHHHHHHHHHCCCHHHHHHCCCHHHHHHHHHHHHHHCCCCCCCCEEEEECCCC
DRIKVCIENKGTHIEEEQLDKIWDRFYRVDAARQRSQGGTGLGLAISKNILELHDAEYGA
CCEEEEEECCCCCCCHHHHHHHHHHHHHHHHHHHHCCCCCCEEHHHHHHHHHHHCCCCCC
ENTEDGVLFYFYLPKKA
CCCCCCEEEEEEECCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 8631706; 12663927 [H]