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The map label for this gene is lon2 [H]

Identifier: 51894450

GI number: 51894450

Start: 3544479

End: 3546458

Strand: Reverse

Name: lon2 [H]

Synonym: STH3316

Alternate gene names: 51894450

Gene position: 3546458-3544479 (Counterclockwise)

Preceding gene: 51894451

Following gene: 51894449

Centisome position: 99.45

GC content: 68.74

Gene sequence:

>1980_bases
GTGTGGGCTTCGGCCGCTATGATGAAGGAATTCCTGGACAAGCTCATGCGCGGCGCCCAGCCGGAGGACGCGGAAGCCCT
GAACCAGAGGCTCTCGGCCGAAGAGCGGCAGGCCCGGCAGGTCGGCGCGCTCTTCAACGTGCTCATGGGCGTCTGGGGGC
CGGAGCGTCTGGTGGTCAAGGCCGGCAAGCTGGACGCCCTCGGGCTGATGAAGTCCGAGAAGGTGGAGGAGCAGGTGCTG
GCCCTGCAGCGCCTCGTCTATGAGGACCCGACGCTCGACACCGTCCCGGACCCCCGGGAACTGCCGGAGATCCTGGACCA
GCTGGAGGACGCTGTGGCTGACCTGGCGGCCCGGCGCACGGTGGAGGACCGGATCGAGCGGAAGATCCAGACCCGCATGC
AGGAGCGGCAGGATGACTACTACCGGGAGATCAAGCAGCAGGTGCTGAAGGAGGAGGCCGGGCCCGAGACCAGCTCGACG
ATGAAGCGGCTGGAGTGGCTCGAGTCGCTGGAGAAGAAGTCGCTGCACCGCAGCGCGGCGGAGCTGCTCCGCCCGCGCGC
GCTGGAGGAGGTCGTGGGCCAGGACCGGGCGATCCAGGCCCTGCTGGCCAAGGTCGCCTCTCCGTTCCCGCAGCACGTCA
TCCTCTACGGCCCGCCCGGGGTCGGCAAGACGACTGTGGCCCGGCTGGTGCTGGAGAAGGCCAAGACGATGCCGCACACT
CCGTTTGCGGAGGACGCGCCCTTCGTGGAGGTGGACGGCACGACCCTGCGGTGGGACCCCCGGGAGGTGACGAACCCGCT
GTTGGGCTCCGTGCACGATCCCATCTACCAGGGCGCCCGGCGTGACCTGGCGGAGAGCGGTGTTCCCGAGCCGCGCACCG
GGCTGGTGACCGACGCGCACGGCGGGGTGCTCTTCATCGACGAGATCGGCGAGATGGATCCGCTGCTCCAGACGAAGCTG
CTGAAGGTGCTGGAGGATAAGCGGGTTACCTTCGAATCCAGCTATTACGACGAGAACGACCCCAACGTGCCCAAGTACAT
CAAGAAGCTGTTCGAGGAGGGGGCGCCGGCCGACTTCGTGCTGATCGGCGCGACCACCCGGGATCCCGAAGACATCAACC
CGGCCCTGCGTTCCCGCTGCGCAGAAGTCTTCTTCGAGCCGCTCACCCCCGAGGACATTGCGCTCATCGTCCGCCAGGCC
GCGGAGAGGATCGGCGCGCACCTCGCCGCCGGGGTGGAGGCCATCATCGCCGACTACACCATCGAGGGACGCAAGGCGGT
GGGCATCCTGGCTGACGCCTACGGCCTCGCCCTGTACCGGGCGGCGGAGGCCGGGAAGGAGAACGAGCCCATCACCATCA
CCCAGGAGCTGGTCTACGAGGTCATCCAGTCCAGCCGGCTGTCGCCCTACGTCACCCGCAAGGCGTCGCCCACGGCGGAG
GTGGGGCGCATCTTCGGGCTGGGCGTGCTGGGCTTTGTCGGCTCGGTGCTGGAGATCGAGGCGGTCGCCTTCCCGGCGCG
GGAGCCGGGCAAGGGCGTGCTGCGCATCAACGACACCGCGGGCTCCATGACCAAGGACTCGCTGTTCAACGCGGCTGCGG
TGGTCCGCAGGGTCACCGGCGAGGACCTGTCCAACTGGGATGTGCACGTGAACGTCATCGGCGGCGGCCGGATCGACGGC
CCCAGCGCCGGCACGGCCATCTACCTGGCGATGATCTCGGCGATGCAGGGGCGCCCGATCCGGCAGGACGTCGCCATCAC
CGGTGAGGTCTCGATCCGCGGCGGCATCCGGGCCGTGGGCGGTATCTATGAGAAGATCTACGGCGCCAAACAGGCGGGCA
TGGCCCGGGTGGTGCTGCCCGAGGAGAACCGCAAGGACGTACCGCAGCAGGTGCCGGGCATCGAGGTCTGCTTCGCCTCC
ACCATCGAGGAGGCGATGCGCCTGGTTATGGCCGCGCCCGGCGGTGAGGGGGCGAGCTAG

Upstream 100 bases:

>100_bases
GGCAAGGTCAACGTGGAGGTCTTGCCCGAGTGACAGCCATCGGCCCGGCCGGCTGTGCCAGCCTGGGCCTTCGCTGATTG
CGGTCCTCGCGTGGAAGGAG

Downstream 100 bases:

>100_bases
CCGTGAACGCCTTCAGTGAGCGGGTTCCACCCCAGAACCTCGAGGCGGAGCAGTCTGTCCTGGGCGCAATGCTGATCGAC
CGGGAGGCGGTGGTCGCCGT

Product: Lon-like ATP-dependent protease

Products: NA

Alternate protein names: ATP-dependent protease La 2 [H]

Number of amino acids: Translated: 659; Mature: 659

Protein sequence:

>659_residues
MWASAAMMKEFLDKLMRGAQPEDAEALNQRLSAEERQARQVGALFNVLMGVWGPERLVVKAGKLDALGLMKSEKVEEQVL
ALQRLVYEDPTLDTVPDPRELPEILDQLEDAVADLAARRTVEDRIERKIQTRMQERQDDYYREIKQQVLKEEAGPETSST
MKRLEWLESLEKKSLHRSAAELLRPRALEEVVGQDRAIQALLAKVASPFPQHVILYGPPGVGKTTVARLVLEKAKTMPHT
PFAEDAPFVEVDGTTLRWDPREVTNPLLGSVHDPIYQGARRDLAESGVPEPRTGLVTDAHGGVLFIDEIGEMDPLLQTKL
LKVLEDKRVTFESSYYDENDPNVPKYIKKLFEEGAPADFVLIGATTRDPEDINPALRSRCAEVFFEPLTPEDIALIVRQA
AERIGAHLAAGVEAIIADYTIEGRKAVGILADAYGLALYRAAEAGKENEPITITQELVYEVIQSSRLSPYVTRKASPTAE
VGRIFGLGVLGFVGSVLEIEAVAFPAREPGKGVLRINDTAGSMTKDSLFNAAAVVRRVTGEDLSNWDVHVNVIGGGRIDG
PSAGTAIYLAMISAMQGRPIRQDVAITGEVSIRGGIRAVGGIYEKIYGAKQAGMARVVLPEENRKDVPQQVPGIEVCFAS
TIEEAMRLVMAAPGGEGAS

Sequences:

>Translated_659_residues
MWASAAMMKEFLDKLMRGAQPEDAEALNQRLSAEERQARQVGALFNVLMGVWGPERLVVKAGKLDALGLMKSEKVEEQVL
ALQRLVYEDPTLDTVPDPRELPEILDQLEDAVADLAARRTVEDRIERKIQTRMQERQDDYYREIKQQVLKEEAGPETSST
MKRLEWLESLEKKSLHRSAAELLRPRALEEVVGQDRAIQALLAKVASPFPQHVILYGPPGVGKTTVARLVLEKAKTMPHT
PFAEDAPFVEVDGTTLRWDPREVTNPLLGSVHDPIYQGARRDLAESGVPEPRTGLVTDAHGGVLFIDEIGEMDPLLQTKL
LKVLEDKRVTFESSYYDENDPNVPKYIKKLFEEGAPADFVLIGATTRDPEDINPALRSRCAEVFFEPLTPEDIALIVRQA
AERIGAHLAAGVEAIIADYTIEGRKAVGILADAYGLALYRAAEAGKENEPITITQELVYEVIQSSRLSPYVTRKASPTAE
VGRIFGLGVLGFVGSVLEIEAVAFPAREPGKGVLRINDTAGSMTKDSLFNAAAVVRRVTGEDLSNWDVHVNVIGGGRIDG
PSAGTAIYLAMISAMQGRPIRQDVAITGEVSIRGGIRAVGGIYEKIYGAKQAGMARVVLPEENRKDVPQQVPGIEVCFAS
TIEEAMRLVMAAPGGEGAS
>Mature_659_residues
MWASAAMMKEFLDKLMRGAQPEDAEALNQRLSAEERQARQVGALFNVLMGVWGPERLVVKAGKLDALGLMKSEKVEEQVL
ALQRLVYEDPTLDTVPDPRELPEILDQLEDAVADLAARRTVEDRIERKIQTRMQERQDDYYREIKQQVLKEEAGPETSST
MKRLEWLESLEKKSLHRSAAELLRPRALEEVVGQDRAIQALLAKVASPFPQHVILYGPPGVGKTTVARLVLEKAKTMPHT
PFAEDAPFVEVDGTTLRWDPREVTNPLLGSVHDPIYQGARRDLAESGVPEPRTGLVTDAHGGVLFIDEIGEMDPLLQTKL
LKVLEDKRVTFESSYYDENDPNVPKYIKKLFEEGAPADFVLIGATTRDPEDINPALRSRCAEVFFEPLTPEDIALIVRQA
AERIGAHLAAGVEAIIADYTIEGRKAVGILADAYGLALYRAAEAGKENEPITITQELVYEVIQSSRLSPYVTRKASPTAE
VGRIFGLGVLGFVGSVLEIEAVAFPAREPGKGVLRINDTAGSMTKDSLFNAAAVVRRVTGEDLSNWDVHVNVIGGGRIDG
PSAGTAIYLAMISAMQGRPIRQDVAITGEVSIRGGIRAVGGIYEKIYGAKQAGMARVVLPEENRKDVPQQVPGIEVCFAS
TIEEAMRLVMAAPGGEGAS

Specific function: ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced

COG id: COG1067

COG function: function code O; Predicted ATP-dependent protease

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the peptidase S16 family [H]

Homologues:

Organism=Homo sapiens, GI21396489, Length=179, Percent_Identity=36.3128491620112, Blast_Score=88, Evalue=3e-17,
Organism=Homo sapiens, GI31377667, Length=206, Percent_Identity=31.0679611650485, Blast_Score=86, Evalue=9e-17,
Organism=Escherichia coli, GI1786643, Length=628, Percent_Identity=24.6815286624204, Blast_Score=106, Evalue=5e-24,
Organism=Escherichia coli, GI1790850, Length=115, Percent_Identity=35.6521739130435, Blast_Score=70, Evalue=3e-13,
Organism=Escherichia coli, GI1789828, Length=167, Percent_Identity=35.3293413173653, Blast_Score=67, Evalue=3e-12,
Organism=Caenorhabditis elegans, GI17556486, Length=599, Percent_Identity=23.873121869783, Blast_Score=112, Evalue=7e-25,
Organism=Caenorhabditis elegans, GI17505831, Length=155, Percent_Identity=33.5483870967742, Blast_Score=77, Evalue=3e-14,
Organism=Drosophila melanogaster, GI24666867, Length=553, Percent_Identity=24.7739602169982, Blast_Score=99, Evalue=7e-21,
Organism=Drosophila melanogaster, GI221513036, Length=561, Percent_Identity=24.777183600713, Blast_Score=99, Evalue=8e-21,

Paralogues:

None

Copy number: 2,000 Molecules/Cell In: Glucose minimal media [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003593
- InterPro:   IPR003959
- InterPro:   IPR008269
- InterPro:   IPR008268
- InterPro:   IPR001984
- InterPro:   IPR020568
- InterPro:   IPR014251 [H]

Pfam domain/function: PF00004 AAA; PF05362 Lon_C [H]

EC number: =3.4.21.53 [H]

Molecular weight: Translated: 72126; Mature: 72126

Theoretical pI: Translated: 4.76; Mature: 4.76

Prosite motif: PS50045 SIGMA54_INTERACT_4

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.3 %Cys     (Translated Protein)
2.4 %Met     (Translated Protein)
2.7 %Cys+Met (Translated Protein)
0.3 %Cys     (Mature Protein)
2.4 %Met     (Mature Protein)
2.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MWASAAMMKEFLDKLMRGAQPEDAEALNQRLSAEERQARQVGALFNVLMGVWGPERLVVK
CCCHHHHHHHHHHHHHCCCCCCHHHHHHHHHCHHHHHHHHHHHHHHHHHHCCCCCCEEEE
AGKLDALGLMKSEKVEEQVLALQRLVYEDPTLDTVPDPRELPEILDQLEDAVADLAARRT
CCCCHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHH
VEDRIERKIQTRMQERQDDYYREIKQQVLKEEAGPETSSTMKRLEWLESLEKKSLHRSAA
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHH
ELLRPRALEEVVGQDRAIQALLAKVASPFPQHVILYGPPGVGKTTVARLVLEKAKTMPHT
HHHCHHHHHHHHCCHHHHHHHHHHHHCCCCCCEEEECCCCCCHHHHHHHHHHHHHCCCCC
PFAEDAPFVEVDGTTLRWDPREVTNPLLGSVHDPIYQGARRDLAESGVPEPRTGLVTDAH
CCCCCCCEEEECCCEEEECHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCEEECC
GGVLFIDEIGEMDPLLQTKLLKVLEDKRVTFESSYYDENDPNVPKYIKKLFEEGAPADFV
CCEEEEECCCCCCHHHHHHHHHHHHHCCCEEECCCCCCCCCCHHHHHHHHHHCCCCCCEE
LIGATTRDPEDINPALRSRCAEVFFEPLTPEDIALIVRQAAERIGAHLAAGVEAIIADYT
EEECCCCCCCCCCHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCE
IEGRKAVGILADAYGLALYRAAEAGKENEPITITQELVYEVIQSSRLSPYVTRKASPTAE
ECCCHHHHHHHHHHHHHHHHHHHCCCCCCCEEEHHHHHHHHHHCCCCCCHHCCCCCCHHH
VGRIFGLGVLGFVGSVLEIEAVAFPAREPGKGVLRINDTAGSMTKDSLFNAAAVVRRVTG
HHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCEEEEECCCCCCHHHHHHHHHHHHHHHHC
EDLSNWDVHVNVIGGGRIDGPSAGTAIYLAMISAMQGRPIRQDVAITGEVSIRGGIRAVG
CCCCCCEEEEEEEECCCCCCCCCHHHHHHHHHHHHCCCCCCCCEEEEEEEEECCCHHHHH
GIYEKIYGAKQAGMARVVLPEENRKDVPQQVPGIEVCFASTIEEAMRLVMAAPGGEGAS
HHHHHHHCHHHCCCEEEEECCCCCCCCHHHCCCHHHHHHHHHHHHHHHHHCCCCCCCCC
>Mature Secondary Structure
MWASAAMMKEFLDKLMRGAQPEDAEALNQRLSAEERQARQVGALFNVLMGVWGPERLVVK
CCCHHHHHHHHHHHHHCCCCCCHHHHHHHHHCHHHHHHHHHHHHHHHHHHCCCCCCEEEE
AGKLDALGLMKSEKVEEQVLALQRLVYEDPTLDTVPDPRELPEILDQLEDAVADLAARRT
CCCCHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHH
VEDRIERKIQTRMQERQDDYYREIKQQVLKEEAGPETSSTMKRLEWLESLEKKSLHRSAA
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHH
ELLRPRALEEVVGQDRAIQALLAKVASPFPQHVILYGPPGVGKTTVARLVLEKAKTMPHT
HHHCHHHHHHHHCCHHHHHHHHHHHHCCCCCCEEEECCCCCCHHHHHHHHHHHHHCCCCC
PFAEDAPFVEVDGTTLRWDPREVTNPLLGSVHDPIYQGARRDLAESGVPEPRTGLVTDAH
CCCCCCCEEEECCCEEEECHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCEEECC
GGVLFIDEIGEMDPLLQTKLLKVLEDKRVTFESSYYDENDPNVPKYIKKLFEEGAPADFV
CCEEEEECCCCCCHHHHHHHHHHHHHCCCEEECCCCCCCCCCHHHHHHHHHHCCCCCCEE
LIGATTRDPEDINPALRSRCAEVFFEPLTPEDIALIVRQAAERIGAHLAAGVEAIIADYT
EEECCCCCCCCCCHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCE
IEGRKAVGILADAYGLALYRAAEAGKENEPITITQELVYEVIQSSRLSPYVTRKASPTAE
ECCCHHHHHHHHHHHHHHHHHHHCCCCCCCEEEHHHHHHHHHHCCCCCCHHCCCCCCHHH
VGRIFGLGVLGFVGSVLEIEAVAFPAREPGKGVLRINDTAGSMTKDSLFNAAAVVRRVTG
HHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCEEEEECCCCCCHHHHHHHHHHHHHHHHC
EDLSNWDVHVNVIGGGRIDGPSAGTAIYLAMISAMQGRPIRQDVAITGEVSIRGGIRAVG
CCCCCCEEEEEEEECCCCCCCCCHHHHHHHHHHHHCCCCCCCCEEEEEEEEECCCHHHHH
GIYEKIYGAKQAGMARVVLPEENRKDVPQQVPGIEVCFASTIEEAMRLVMAAPGGEGAS
HHHHHHHCHHHCCCEEEEECCCCCCCCHHHCCCHHHHHHHHHHHHHHHHHCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 8969504; 9384377; 7961402; 11325926 [H]