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The map label for this gene is tdcB [H]

Identifier: 51894378

GI number: 51894378

Start: 3457637

End: 3458869

Strand: Reverse

Name: tdcB [H]

Synonym: STH3243

Alternate gene names: 51894378

Gene position: 3458869-3457637 (Counterclockwise)

Preceding gene: 51894379

Following gene: 51894377

Centisome position: 96.99

GC content: 67.4

Gene sequence:

>1233_bases
GTGACGGTAACCTTTGCGGACATCGAGAAGGCGCGCATTCTGCTGAGCGGACACATCAAGCGGACACCCATGCTTCAGAG
CCCTGGCATCACCGAGCACCTGGGACTTCCGGTCTACCTGAAGGCCGAGAACCTGCAGCGGGCCGGGTCGTTCAAGGTGC
GGGGAGCGCTCAACAAGATCCACTCGCTGACTGAGGAAGAGAAGGCGCGCGGCGTCATCGCGGCGTCGGCCGGCAACCAC
GCGCAGGGCGTGGCCCTGGCGGCGTCCAGTCTCGGCATCCGGTCGGTCATCTGCATGCCGGAGGGCGCCCCGATCGCCAA
GCTGGAGGCGACCCAGGGCTACGGCGCCCAGGTGGTCCTGCACGGCGAGACCTACGACGACGCCTACCAGAAGGCGCGGG
CGCTGCAGGCGGAGCACGGGTACACGTTCATCCACGGCTTCGATGACCCGTACACCATCGCCGGCCAGGGGACGGTCGGG
CTGGAGATCGTGGAGGACCTGCCCGACATCGCGACGGTGGTGGTGCCGATCGGCGGCGGCGGCCTCATGGCGGGCGTTGC
CCTGGCGGTCAAGTCCCTGAAGCCCGGCGTACGGGTGGTGGGGGTCCAGGCCGCGGGCGCGCCGGCGGTCTTCCTCAGCC
GGCAGCAGGGCAAGCTGGTGGCGACCGACTCGGTCCACACCATCGCGGACGGCATTGCCATCAAGAAGCCGGGGGCGCTG
TGCTGGGAGATTATCCGGGAACACGTGGACGACATCGTGCTGGTGGACGAGGAGGAGATCGCACAGTCGATCCTCTTCCT
GCTGGAGCGTGCGAAGGTCATCGTCGAGGGCGCCGGCGCCGTGGGCATGGCCGCGCTCCTCGGCGACAAGATCCCGGATC
TGCAGGGACCGGTCTGCGTCGTGCTCTCGGGCGGCAACATTGACGTGAACATCATCTCCCGCATCATCGAGCGCGGTCTG
GTGAAGGCGGGGCGGTACATCCGGATCTCCACGTTCGTGCCCGACCGGCCCGGCGGGCTGCAGCAGCTCCTCGCGACCGT
GGCCCAGGCCGGGGCCAACGTGATCGACGTGCGTCATGAGCGCTGGCTGAACAAGGTGACCATCGGCGAGGTGGAGATCA
CCCTGGCGCTGGAGACTCGCAACGCCCGCCATGTCGATGAGATTCTCGCCACCCTCAAGGCGAAGGGGTATCATGTCTGG
ATCATTCCGCCGTATCGTCCCAACGACTGGTAG

Upstream 100 bases:

>100_bases
CAGCGCTACGTGTCGCTGCTCACGCTGGAGCAGGTGGACGAGGTGGCCCGCACGGTCCGGGTGGTTCCGGCCGACCGACT
GACGAAGGAGTGAACCGTGG

Downstream 100 bases:

>100_bases
GAGGTGTGAGCGATGGCGCATCGGCCTGCCTCGTGGTTCCGGAATGTGGCGGTCGCCGGCCTGGTGGTCGCGCTGGCCAT
GGTTCCGGCGATCGCGGCGC

Product: threonine dehydratase

Products: NA

Alternate protein names: Threonine deaminase [H]

Number of amino acids: Translated: 410; Mature: 409

Protein sequence:

>410_residues
MTVTFADIEKARILLSGHIKRTPMLQSPGITEHLGLPVYLKAENLQRAGSFKVRGALNKIHSLTEEEKARGVIAASAGNH
AQGVALAASSLGIRSVICMPEGAPIAKLEATQGYGAQVVLHGETYDDAYQKARALQAEHGYTFIHGFDDPYTIAGQGTVG
LEIVEDLPDIATVVVPIGGGGLMAGVALAVKSLKPGVRVVGVQAAGAPAVFLSRQQGKLVATDSVHTIADGIAIKKPGAL
CWEIIREHVDDIVLVDEEEIAQSILFLLERAKVIVEGAGAVGMAALLGDKIPDLQGPVCVVLSGGNIDVNIISRIIERGL
VKAGRYIRISTFVPDRPGGLQQLLATVAQAGANVIDVRHERWLNKVTIGEVEITLALETRNARHVDEILATLKAKGYHVW
IIPPYRPNDW

Sequences:

>Translated_410_residues
MTVTFADIEKARILLSGHIKRTPMLQSPGITEHLGLPVYLKAENLQRAGSFKVRGALNKIHSLTEEEKARGVIAASAGNH
AQGVALAASSLGIRSVICMPEGAPIAKLEATQGYGAQVVLHGETYDDAYQKARALQAEHGYTFIHGFDDPYTIAGQGTVG
LEIVEDLPDIATVVVPIGGGGLMAGVALAVKSLKPGVRVVGVQAAGAPAVFLSRQQGKLVATDSVHTIADGIAIKKPGAL
CWEIIREHVDDIVLVDEEEIAQSILFLLERAKVIVEGAGAVGMAALLGDKIPDLQGPVCVVLSGGNIDVNIISRIIERGL
VKAGRYIRISTFVPDRPGGLQQLLATVAQAGANVIDVRHERWLNKVTIGEVEITLALETRNARHVDEILATLKAKGYHVW
IIPPYRPNDW
>Mature_409_residues
TVTFADIEKARILLSGHIKRTPMLQSPGITEHLGLPVYLKAENLQRAGSFKVRGALNKIHSLTEEEKARGVIAASAGNHA
QGVALAASSLGIRSVICMPEGAPIAKLEATQGYGAQVVLHGETYDDAYQKARALQAEHGYTFIHGFDDPYTIAGQGTVGL
EIVEDLPDIATVVVPIGGGGLMAGVALAVKSLKPGVRVVGVQAAGAPAVFLSRQQGKLVATDSVHTIADGIAIKKPGALC
WEIIREHVDDIVLVDEEEIAQSILFLLERAKVIVEGAGAVGMAALLGDKIPDLQGPVCVVLSGGNIDVNIISRIIERGLV
KAGRYIRISTFVPDRPGGLQQLLATVAQAGANVIDVRHERWLNKVTIGEVEITLALETRNARHVDEILATLKAKGYHVWI
IPPYRPNDW

Specific function: Acts on both serine and threonine, and properly considered as a hydroxy amino acid deaminase [H]

COG id: COG1171

COG function: function code E; Threonine dehydratase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the serine/threonine dehydratase family [H]

Homologues:

Organism=Homo sapiens, GI11345492, Length=318, Percent_Identity=38.6792452830189, Blast_Score=213, Evalue=3e-55,
Organism=Homo sapiens, GI19923959, Length=310, Percent_Identity=29.0322580645161, Blast_Score=93, Evalue=4e-19,
Organism=Homo sapiens, GI33469958, Length=321, Percent_Identity=28.6604361370716, Blast_Score=87, Evalue=2e-17,
Organism=Escherichia coli, GI1789505, Length=325, Percent_Identity=48, Blast_Score=255, Evalue=3e-69,
Organism=Escherichia coli, GI1790207, Length=380, Percent_Identity=32.8947368421053, Blast_Score=190, Evalue=2e-49,
Organism=Escherichia coli, GI1789235, Length=227, Percent_Identity=27.3127753303965, Blast_Score=64, Evalue=1e-11,
Organism=Caenorhabditis elegans, GI71991565, Length=392, Percent_Identity=40.5612244897959, Blast_Score=272, Evalue=3e-73,
Organism=Caenorhabditis elegans, GI17537387, Length=383, Percent_Identity=38.6422976501305, Blast_Score=209, Evalue=3e-54,
Organism=Caenorhabditis elegans, GI17508781, Length=315, Percent_Identity=32.0634920634921, Blast_Score=157, Evalue=7e-39,
Organism=Saccharomyces cerevisiae, GI6322631, Length=313, Percent_Identity=40.2555910543131, Blast_Score=221, Evalue=1e-58,
Organism=Saccharomyces cerevisiae, GI6320930, Length=393, Percent_Identity=32.3155216284987, Blast_Score=188, Evalue=1e-48,
Organism=Saccharomyces cerevisiae, GI6319788, Length=291, Percent_Identity=24.7422680412371, Blast_Score=77, Evalue=6e-15,
Organism=Drosophila melanogaster, GI21355833, Length=393, Percent_Identity=39.6946564885496, Blast_Score=234, Evalue=6e-62,
Organism=Drosophila melanogaster, GI24645328, Length=297, Percent_Identity=39.0572390572391, Blast_Score=166, Evalue=3e-41,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001926
- InterPro:   IPR000634
- InterPro:   IPR005789 [H]

Pfam domain/function: PF00291 PALP [H]

EC number: =4.3.1.19 [H]

Molecular weight: Translated: 43656; Mature: 43525

Theoretical pI: Translated: 6.80; Mature: 6.80

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.7 %Cys     (Translated Protein)
1.2 %Met     (Translated Protein)
2.0 %Cys+Met (Translated Protein)
0.7 %Cys     (Mature Protein)
1.0 %Met     (Mature Protein)
1.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTVTFADIEKARILLSGHIKRTPMLQSPGITEHLGLPVYLKAENLQRAGSFKVRGALNKI
CEEEEECHHHHEEEEECCCCCCCCCCCCCCHHHCCCCEEEECCCCCCCCCEEEHHHHHHH
HSLTEEEKARGVIAASAGNHAQGVALAASSLGIRSVICMPEGAPIAKLEATQGYGAQVVL
HHHHHHHHHCEEEEECCCCCCCCEEEEHHCCCCEEEEECCCCCCEEEEECCCCCCEEEEE
HGETYDDAYQKARALQAEHGYTFIHGFDDPYTIAGQGTVGLEIVEDLPDIATVVVPIGGG
ECCCCHHHHHHHHHHHHCCCEEEEEECCCCEEEECCCCCCHHHHHCCCCEEEEEEEECCC
GLMAGVALAVKSLKPGVRVVGVQAAGAPAVFLSRQQGKLVATDSVHTIADGIAIKKPGAL
HHHHHHHHHHHHCCCCEEEEEEECCCCCEEEEECCCCCEEEECCHHHHHCCEEECCCCHH
CWEIIREHVDDIVLVDEEEIAQSILFLLERAKVIVEGAGAVGMAALLGDKIPDLQGPVCV
HHHHHHHHCCCEEEECHHHHHHHHHHHHHHHHEEEECCCHHHHHHHHCCCCCCCCCCEEE
VLSGGNIDVNIISRIIERGLVKAGRYIRISTFVPDRPGGLQQLLATVAQAGANVIDVRHE
EEECCCEEHHHHHHHHHHHHHHCCCEEEEEEECCCCCCHHHHHHHHHHHCCCCEEEHHHH
RWLNKVTIGEVEITLALETRNARHVDEILATLKAKGYHVWIIPPYRPNDW
HHHCCEEECEEEEEEEEECCCCHHHHHHHHHHHCCCEEEEEECCCCCCCC
>Mature Secondary Structure 
TVTFADIEKARILLSGHIKRTPMLQSPGITEHLGLPVYLKAENLQRAGSFKVRGALNKI
EEEEECHHHHEEEEECCCCCCCCCCCCCCHHHCCCCEEEECCCCCCCCCEEEHHHHHHH
HSLTEEEKARGVIAASAGNHAQGVALAASSLGIRSVICMPEGAPIAKLEATQGYGAQVVL
HHHHHHHHHCEEEEECCCCCCCCEEEEHHCCCCEEEEECCCCCCEEEEECCCCCCEEEEE
HGETYDDAYQKARALQAEHGYTFIHGFDDPYTIAGQGTVGLEIVEDLPDIATVVVPIGGG
ECCCCHHHHHHHHHHHHCCCEEEEEECCCCEEEECCCCCCHHHHHCCCCEEEEEEEECCC
GLMAGVALAVKSLKPGVRVVGVQAAGAPAVFLSRQQGKLVATDSVHTIADGIAIKKPGAL
HHHHHHHHHHHHCCCCEEEEEEECCCCCEEEEECCCCCEEEECCHHHHHCCEEECCCCHH
CWEIIREHVDDIVLVDEEEIAQSILFLLERAKVIVEGAGAVGMAALLGDKIPDLQGPVCV
HHHHHHHHCCCEEEECHHHHHHHHHHHHHHHHEEEECCCHHHHHHHHCCCCCCCCCCEEE
VLSGGNIDVNIISRIIERGLVKAGRYIRISTFVPDRPGGLQQLLATVAQAGANVIDVRHE
EEECCCEEHHHHHHHHHHHHHHCCCEEEEEEECCCCCCHHHHHHHHHHHCCCCEEEHHHH
RWLNKVTIGEVEITLALETRNARHVDEILATLKAKGYHVWIIPPYRPNDW
HHHCCEEECEEEEEEEEECCCCHHHHHHHHHHHCCCEEEEEECCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA