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The map label for this gene is spoVC

Identifier: 51894373

GI number: 51894373

Start: 3453613

End: 3454182

Strand: Reverse

Name: spoVC

Synonym: STH3238

Alternate gene names: 51894373

Gene position: 3454182-3453613 (Counterclockwise)

Preceding gene: 51894374

Following gene: 51894372

Centisome position: 96.86

GC content: 70.0

Gene sequence:

>570_bases
ATGGCCAAGCTCATCGTCGGCCTCGGCAACCCCGGGCCCCGGTACGCCGCCACCCGCCACAACGCCGGCTGGATGCTGCT
GGACGCGTTCGCCCGCAAACACGGGGTGGCGATCGAGCAGCGCGGCTTTGAAGGGCTGTACGGCGAACTGCGGTGGGGAG
CGGAGGCCGAGAAGGTGATCCTGCTCAAACCGCTCACCTACATGAACCTCAGCGGACGGTCGGTGGCCCAGGCCGCCCGC
TTCTATCGCATTGCCCCCGCCGACATCCTGGTCCTGTTCGACGATCTGGATCTGGAACCGGGGCGGCTGCGGCTGCGCGC
GAAAGGGAGCGCGGGCGGCCACAACGGCGTGAAATCGGTCATCGCGGAGCTGGGCACGGCGGAGTTTCCCCGCCTCCGGA
TCGGGATCGGCCGGCCGGCGCCCGGCTGGGAGGTTATCGACTGGGTACTGGCGCCGTTCGGCCCCGACGACGCCGCGGCG
GTGGCCGCCGCGCTGCCGCGGGCGGTGGAGGCGGTGGAGTGCTTCCTCACCGAGGGCATCCTGGCGGCGATGAACCGTTA
CAATACATAG

Upstream 100 bases:

>100_bases
GTTCCGGGGTGCCGCTGCGTTCTGGTCCGCCGTTTTCCGCGGTCCGGGACTATGGTAAAGTAGACCCTGTCGACCCCTGC
ACAAGGAGATCGTGTGCGCA

Downstream 100 bases:

>100_bases
TGAGGCATAGCGAGAGAGGGATTCGCGGTGGATCTGGCGGCATCGGTCAAGCAGGGAACCCGGGCCGGCCTCCTGGTGCT
GTGGGAGCTGGCCAAGGTGA

Product: peptidyl-tRNA hydrolase

Products: NA

Alternate protein names: PTH

Number of amino acids: Translated: 189; Mature: 188

Protein sequence:

>189_residues
MAKLIVGLGNPGPRYAATRHNAGWMLLDAFARKHGVAIEQRGFEGLYGELRWGAEAEKVILLKPLTYMNLSGRSVAQAAR
FYRIAPADILVLFDDLDLEPGRLRLRAKGSAGGHNGVKSVIAELGTAEFPRLRIGIGRPAPGWEVIDWVLAPFGPDDAAA
VAAALPRAVEAVECFLTEGILAAMNRYNT

Sequences:

>Translated_189_residues
MAKLIVGLGNPGPRYAATRHNAGWMLLDAFARKHGVAIEQRGFEGLYGELRWGAEAEKVILLKPLTYMNLSGRSVAQAAR
FYRIAPADILVLFDDLDLEPGRLRLRAKGSAGGHNGVKSVIAELGTAEFPRLRIGIGRPAPGWEVIDWVLAPFGPDDAAA
VAAALPRAVEAVECFLTEGILAAMNRYNT
>Mature_188_residues
AKLIVGLGNPGPRYAATRHNAGWMLLDAFARKHGVAIEQRGFEGLYGELRWGAEAEKVILLKPLTYMNLSGRSVAQAARF
YRIAPADILVLFDDLDLEPGRLRLRAKGSAGGHNGVKSVIAELGTAEFPRLRIGIGRPAPGWEVIDWVLAPFGPDDAAAV
AAALPRAVEAVECFLTEGILAAMNRYNT

Specific function: The natural substrate for this enzyme may be peptidyl- tRNAs which drop off the ribosome during protein synthesis

COG id: COG0193

COG function: function code J; Peptidyl-tRNA hydrolase

Gene ontology:

Cell location: Cytoplasm

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the PTH family

Homologues:

Organism=Homo sapiens, GI50897284, Length=170, Percent_Identity=38.2352941176471, Blast_Score=103, Evalue=8e-23,
Organism=Escherichia coli, GI1787455, Length=188, Percent_Identity=43.0851063829787, Blast_Score=121, Evalue=3e-29,
Organism=Saccharomyces cerevisiae, GI6321983, Length=165, Percent_Identity=33.3333333333333, Blast_Score=77, Evalue=1e-15,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): PTH_SYMTH (Q67JD0)

Other databases:

- EMBL:   AP006840
- RefSeq:   YP_077064.1
- ProteinModelPortal:   Q67JD0
- SMR:   Q67JD0
- GeneID:   2980264
- GenomeReviews:   AP006840_GR
- KEGG:   sth:STH3238
- NMPDR:   fig|292459.1.peg.3108
- HOGENOM:   HBG610927
- OMA:   AMHRLHS
- ProtClustDB:   PRK05426
- BioCyc:   STHE292459:STH3238-MONOMER
- BRENDA:   3.1.1.29
- GO:   GO:0005737
- GO:   GO:0006412
- HAMAP:   MF_00083
- InterPro:   IPR001328
- InterPro:   IPR018171
- Gene3D:   G3DSA:3.40.50.1470
- PANTHER:   PTHR17224
- TIGRFAMs:   TIGR00447

Pfam domain/function: PF01195 Pept_tRNA_hydro; SSF53178 Pept_tRNA_hydro

EC number: =3.1.1.29

Molecular weight: Translated: 20391; Mature: 20260

Theoretical pI: Translated: 9.04; Mature: 9.04

Prosite motif: PS01195 PEPT_TRNA_HYDROL_1; PS01196 PEPT_TRNA_HYDROL_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.5 %Cys     (Translated Protein)
2.1 %Met     (Translated Protein)
2.6 %Cys+Met (Translated Protein)
0.5 %Cys     (Mature Protein)
1.6 %Met     (Mature Protein)
2.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MAKLIVGLGNPGPRYAATRHNAGWMLLDAFARKHGVAIEQRGFEGLYGELRWGAEAEKVI
CCEEEEECCCCCCCCEEECCCCCCHHHHHHHHHHCCEEECCCCCCCCHHCCCCCCCCEEE
LLKPLTYMNLSGRSVAQAARFYRIAPADILVLFDDLDLEPGRLRLRAKGSAGGHNGVKSV
EECCCEEECCCCHHHHHHHHHHEECCCEEEEEEECCCCCCCEEEEEECCCCCCCHHHHHH
IAELGTAEFPRLRIGIGRPAPGWEVIDWVLAPFGPDDAAAVAAALPRAVEAVECFLTEGI
HHHHCCCCCCEEEEECCCCCCCHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHHHHH
LAAMNRYNT
HHHHHHCCC
>Mature Secondary Structure 
AKLIVGLGNPGPRYAATRHNAGWMLLDAFARKHGVAIEQRGFEGLYGELRWGAEAEKVI
CEEEEECCCCCCCCEEECCCCCCHHHHHHHHHHCCEEECCCCCCCCHHCCCCCCCCEEE
LLKPLTYMNLSGRSVAQAARFYRIAPADILVLFDDLDLEPGRLRLRAKGSAGGHNGVKSV
EECCCEEECCCCHHHHHHHHHHEECCCEEEEEEECCCCCCCEEEEEECCCCCCCHHHHHH
IAELGTAEFPRLRIGIGRPAPGWEVIDWVLAPFGPDDAAAVAAALPRAVEAVECFLTEGI
HHHHCCCCCCEEEEECCCCCCCHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHHHHH
LAAMNRYNT
HHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA