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The map label for this gene is gyaR [H]

Identifier: 51894350

GI number: 51894350

Start: 3429021

End: 3430019

Strand: Reverse

Name: gyaR [H]

Synonym: STH3215

Alternate gene names: 51894350

Gene position: 3430019-3429021 (Counterclockwise)

Preceding gene: 51894352

Following gene: 51894349

Centisome position: 96.18

GC content: 71.07

Gene sequence:

>999_bases
ATGGCGAAACCGCGTGTCTTCGTCACCCGGCGGATTCCCGACGAGGCGCTAAGTATCTTGCGCACCGCATGCGAGGTGCA
CACCTGGGACCACGAGGACGAGCCGGTCCCGCAGGACGAACTGGTCCGTGGGCTCCAGGAGGCGGACGGCGCCCTCGTCG
TGGGTCCCCACCGGATCGACGCGGCGCTCATGGACGCGGCCCCCCGCTGCCGCGTGTACGCCAACATGGCGGTGGGCTAT
GACAACATCGACGTGGCGGCGGCCACGGCGCGCGGGATCCTGATCACCAACACGCCGGGCGTGCTGACCGAGACCACCGC
TGACCTGGCCTTCGGCCTGATGATCGCCGCTGCCCGCCGGCTGTACGAGGGGCAGCGGACCATCGTGGAAGGGCGGTGGA
AGGGCTGGTCGCCGATGTTCATGACCGGTCAGGACGTGTACGGCGCAACCCTGGGCATCGTCGGCGCCGGCCGCATCGGC
CAGGCGGTGGCCCGGCGGGCCCGGGGCTTCGACATGCGGATTCTGTACCACAACCGGCGGCCTAACCCGGCCTTCGAGGC
CGAGGTCGGGGCTTCCTATCGGCTGCTCGACGACCTGTTGCGGGAGTCTGACTTCGTCGTCGTGCTGGTGCCGTTGACGC
CCGAGACCCGGGGGCTTATCGGGGCCCGGGAGCTTGCCCTGATGAAGCCCACCGCGGTGCTGGTCAACGCCGCCCGGGGT
CCCGTGGTGGACGAACGGGCCCTGTACGAGGCCCTGCGGGACCGGCGCATCTACGCCGCGGGGCTGGACGTCTTCGACCG
GGAGCCCATTCCCGCCGATCACCCGCTGCTGTCGCTCCCCAACGTGACGGCCGTGCCTCACATCGGCTCCGCGACCGTGC
GGACCCGGACCCGGATGGCGACCCTGGCCGCCGAGAACCTGGTGGCCGCCCTCACGGGGAAGCAGCCGCCCACCCCCGTG
AACCCTGAGGTGCTCCGGCGGGAGGAGAGGCAGCCGTGA

Upstream 100 bases:

>100_bases
TTCGCTTGAAGACGCTGGTTCCCTGCGAGTTCCAGAGGCGGGAACCAGGCGAGGTATGGCGAATAAACCGTCGAGACTAC
CTCACGGGGAGGCACAAGCG

Downstream 100 bases:

>100_bases
CGGAGGGACGCCGCTTCCGCATCCTGATCGTCGAGGACGACGAGAAGATCGCGTCGATCCTGGCCGACGAGTTCGTCCGC
TACGGGTATGACGTCGTCCT

Product: putative glycerate dehydrogenase

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 332; Mature: 331

Protein sequence:

>332_residues
MAKPRVFVTRRIPDEALSILRTACEVHTWDHEDEPVPQDELVRGLQEADGALVVGPHRIDAALMDAAPRCRVYANMAVGY
DNIDVAAATARGILITNTPGVLTETTADLAFGLMIAAARRLYEGQRTIVEGRWKGWSPMFMTGQDVYGATLGIVGAGRIG
QAVARRARGFDMRILYHNRRPNPAFEAEVGASYRLLDDLLRESDFVVVLVPLTPETRGLIGARELALMKPTAVLVNAARG
PVVDERALYEALRDRRIYAAGLDVFDREPIPADHPLLSLPNVTAVPHIGSATVRTRTRMATLAAENLVAALTGKQPPTPV
NPEVLRREERQP

Sequences:

>Translated_332_residues
MAKPRVFVTRRIPDEALSILRTACEVHTWDHEDEPVPQDELVRGLQEADGALVVGPHRIDAALMDAAPRCRVYANMAVGY
DNIDVAAATARGILITNTPGVLTETTADLAFGLMIAAARRLYEGQRTIVEGRWKGWSPMFMTGQDVYGATLGIVGAGRIG
QAVARRARGFDMRILYHNRRPNPAFEAEVGASYRLLDDLLRESDFVVVLVPLTPETRGLIGARELALMKPTAVLVNAARG
PVVDERALYEALRDRRIYAAGLDVFDREPIPADHPLLSLPNVTAVPHIGSATVRTRTRMATLAAENLVAALTGKQPPTPV
NPEVLRREERQP
>Mature_331_residues
AKPRVFVTRRIPDEALSILRTACEVHTWDHEDEPVPQDELVRGLQEADGALVVGPHRIDAALMDAAPRCRVYANMAVGYD
NIDVAAATARGILITNTPGVLTETTADLAFGLMIAAARRLYEGQRTIVEGRWKGWSPMFMTGQDVYGATLGIVGAGRIGQ
AVARRARGFDMRILYHNRRPNPAFEAEVGASYRLLDDLLRESDFVVVLVPLTPETRGLIGARELALMKPTAVLVNAARGP
VVDERALYEALRDRRIYAAGLDVFDREPIPADHPLLSLPNVTAVPHIGSATVRTRTRMATLAAENLVAALTGKQPPTPVN
PEVLRREERQP

Specific function: Unknown

COG id: COG1052

COG function: function code CHR; Lactate dehydrogenase and related dehydrogenases

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family. GyaR subfamily [H]

Homologues:

Organism=Homo sapiens, GI6912396, Length=318, Percent_Identity=45.2830188679245, Blast_Score=258, Evalue=5e-69,
Organism=Homo sapiens, GI23308577, Length=294, Percent_Identity=34.0136054421769, Blast_Score=173, Evalue=2e-43,
Organism=Homo sapiens, GI145580578, Length=280, Percent_Identity=33.2142857142857, Blast_Score=130, Evalue=1e-30,
Organism=Homo sapiens, GI4557499, Length=280, Percent_Identity=33.2142857142857, Blast_Score=130, Evalue=1e-30,
Organism=Homo sapiens, GI61743967, Length=283, Percent_Identity=32.5088339222615, Blast_Score=128, Evalue=7e-30,
Organism=Homo sapiens, GI4557497, Length=283, Percent_Identity=32.5088339222615, Blast_Score=128, Evalue=8e-30,
Organism=Homo sapiens, GI145580575, Length=278, Percent_Identity=33.4532374100719, Blast_Score=125, Evalue=4e-29,
Organism=Escherichia coli, GI87082289, Length=324, Percent_Identity=46.9135802469136, Blast_Score=267, Evalue=9e-73,
Organism=Escherichia coli, GI1789279, Length=336, Percent_Identity=28.8690476190476, Blast_Score=123, Evalue=2e-29,
Organism=Escherichia coli, GI1787645, Length=193, Percent_Identity=35.2331606217617, Blast_Score=117, Evalue=7e-28,
Organism=Escherichia coli, GI87081824, Length=145, Percent_Identity=36.551724137931, Blast_Score=85, Evalue=8e-18,
Organism=Caenorhabditis elegans, GI17532191, Length=308, Percent_Identity=32.1428571428571, Blast_Score=146, Evalue=2e-35,
Organism=Caenorhabditis elegans, GI25147481, Length=279, Percent_Identity=28.673835125448, Blast_Score=116, Evalue=2e-26,
Organism=Saccharomyces cerevisiae, GI6324055, Length=262, Percent_Identity=39.6946564885496, Blast_Score=170, Evalue=3e-43,
Organism=Saccharomyces cerevisiae, GI6322116, Length=308, Percent_Identity=29.8701298701299, Blast_Score=136, Evalue=4e-33,
Organism=Saccharomyces cerevisiae, GI6320925, Length=302, Percent_Identity=30.4635761589404, Blast_Score=135, Evalue=7e-33,
Organism=Saccharomyces cerevisiae, GI6324964, Length=306, Percent_Identity=25.8169934640523, Blast_Score=104, Evalue=2e-23,
Organism=Saccharomyces cerevisiae, GI6321253, Length=173, Percent_Identity=33.5260115606936, Blast_Score=86, Evalue=1e-17,
Organism=Saccharomyces cerevisiae, GI6325144, Length=161, Percent_Identity=32.2981366459627, Blast_Score=83, Evalue=5e-17,
Organism=Saccharomyces cerevisiae, GI6324980, Length=191, Percent_Identity=28.7958115183246, Blast_Score=82, Evalue=1e-16,
Organism=Drosophila melanogaster, GI28571528, Length=317, Percent_Identity=44.794952681388, Blast_Score=261, Evalue=5e-70,
Organism=Drosophila melanogaster, GI45552429, Length=319, Percent_Identity=42.3197492163009, Blast_Score=240, Evalue=9e-64,
Organism=Drosophila melanogaster, GI45551003, Length=319, Percent_Identity=42.3197492163009, Blast_Score=239, Evalue=1e-63,
Organism=Drosophila melanogaster, GI28574284, Length=319, Percent_Identity=42.3197492163009, Blast_Score=239, Evalue=2e-63,
Organism=Drosophila melanogaster, GI24585514, Length=319, Percent_Identity=42.3197492163009, Blast_Score=239, Evalue=2e-63,
Organism=Drosophila melanogaster, GI28574282, Length=319, Percent_Identity=42.3197492163009, Blast_Score=239, Evalue=2e-63,
Organism=Drosophila melanogaster, GI28574286, Length=311, Percent_Identity=42.1221864951768, Blast_Score=227, Evalue=1e-59,
Organism=Drosophila melanogaster, GI24585516, Length=313, Percent_Identity=36.741214057508, Blast_Score=199, Evalue=2e-51,
Organism=Drosophila melanogaster, GI19921140, Length=296, Percent_Identity=32.7702702702703, Blast_Score=153, Evalue=1e-37,
Organism=Drosophila melanogaster, GI24646446, Length=292, Percent_Identity=32.5342465753425, Blast_Score=124, Evalue=1e-28,
Organism=Drosophila melanogaster, GI24646448, Length=292, Percent_Identity=32.5342465753425, Blast_Score=124, Evalue=1e-28,
Organism=Drosophila melanogaster, GI24646452, Length=292, Percent_Identity=32.5342465753425, Blast_Score=124, Evalue=1e-28,
Organism=Drosophila melanogaster, GI24646450, Length=292, Percent_Identity=32.5342465753425, Blast_Score=124, Evalue=1e-28,
Organism=Drosophila melanogaster, GI62472511, Length=292, Percent_Identity=32.5342465753425, Blast_Score=122, Evalue=3e-28,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR006139
- InterPro:   IPR006140
- InterPro:   IPR016040 [H]

Pfam domain/function: PF00389 2-Hacid_dh; PF02826 2-Hacid_dh_C [H]

EC number: =1.1.1.26 [H]

Molecular weight: Translated: 36345; Mature: 36214

Theoretical pI: Translated: 7.15; Mature: 7.15

Prosite motif: PS00065 D_2_HYDROXYACID_DH_1 ; PS00671 D_2_HYDROXYACID_DH_3

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.6 %Cys     (Translated Protein)
2.7 %Met     (Translated Protein)
3.3 %Cys+Met (Translated Protein)
0.6 %Cys     (Mature Protein)
2.4 %Met     (Mature Protein)
3.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MAKPRVFVTRRIPDEALSILRTACEVHTWDHEDEPVPQDELVRGLQEADGALVVGPHRID
CCCCCEEEEECCCHHHHHHHHHHHHHCCCCCCCCCCCHHHHHHHHHHCCCCEEECCHHHH
AALMDAAPRCRVYANMAVGYDNIDVAAATARGILITNTPGVLTETTADLAFGLMIAAARR
HHHHCCCCCCEEEEEEEECCCCCEEEEEEECCEEEECCCCCEEHHHHHHHHHHHHHHHHH
LYEGQRTIVEGRWKGWSPMFMTGQDVYGATLGIVGAGRIGQAVARRARGFDMRILYHNRR
HHCCCCEEEECCCCCCCCEEEECCCCCCHHEEEEECCHHHHHHHHHHCCCEEEEEEECCC
PNPAFEAEVGASYRLLDDLLRESDFVVVLVPLTPETRGLIGARELALMKPTAVLVNAARG
CCCCCCCCCCCHHHHHHHHHCCCCEEEEEEECCCCCCCCCCHHHHHHCCCHHHEEECCCC
PVVDERALYEALRDRRIYAAGLDVFDREPIPADHPLLSLPNVTAVPHIGSATVRTRTRMA
CCCHHHHHHHHHHCCEEEEECCCHHCCCCCCCCCCCEECCCCCCCCCCCCCHHHHHHHHH
TLAAENLVAALTGKQPPTPVNPEVLRREERQP
HHHHHHHHHHHCCCCCCCCCCHHHHHHHCCCC
>Mature Secondary Structure 
AKPRVFVTRRIPDEALSILRTACEVHTWDHEDEPVPQDELVRGLQEADGALVVGPHRID
CCCCEEEEECCCHHHHHHHHHHHHHCCCCCCCCCCCHHHHHHHHHHCCCCEEECCHHHH
AALMDAAPRCRVYANMAVGYDNIDVAAATARGILITNTPGVLTETTADLAFGLMIAAARR
HHHHCCCCCCEEEEEEEECCCCCEEEEEEECCEEEECCCCCEEHHHHHHHHHHHHHHHHH
LYEGQRTIVEGRWKGWSPMFMTGQDVYGATLGIVGAGRIGQAVARRARGFDMRILYHNRR
HHCCCCEEEECCCCCCCCEEEECCCCCCHHEEEEECCHHHHHHHHHHCCCEEEEEEECCC
PNPAFEAEVGASYRLLDDLLRESDFVVVLVPLTPETRGLIGARELALMKPTAVLVNAARG
CCCCCCCCCCCHHHHHHHHHCCCCEEEEEEECCCCCCCCCCHHHHHHCCCHHHEEECCCC
PVVDERALYEALRDRRIYAAGLDVFDREPIPADHPLLSLPNVTAVPHIGSATVRTRTRMA
CCCHHHHHHHHHHCCEEEEECCCHHCCCCCCCCCCCEECCCCCCCCCCCCCHHHHHHHHH
TLAAENLVAALTGKQPPTPVNPEVLRREERQP
HHHHHHHHHHHCCCCCCCCCCHHHHHHHCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA