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The map label for this gene is hutI

Identifier: 51894326

GI number: 51894326

Start: 3398847

End: 3400124

Strand: Reverse

Name: hutI

Synonym: STH3191

Alternate gene names: 51894326

Gene position: 3400124-3398847 (Counterclockwise)

Preceding gene: 51894327

Following gene: 51894325

Centisome position: 95.34

GC content: 72.14

Gene sequence:

>1278_bases
TTGAGGCCCGTGGATCTCCTGATCGTGGGCGCGGGCGAACTGGTGACGATGGCCGGGGGCCCGCGGCGGGGCGAGCGGAT
GAAGGACGCGGCCGTCATCCCCGGCGGGGCGCTCGCGGCCCGGGACGGACGCATCGTGGCCGTCGGGCCGGAGGACGAGG
TGCTGCGGACGGTGGAGACCGGCCCCGACACCCGGGTGATCGACGCCCGGGGGCGGGCCGTGATCCCGGGGTTCGTGGAC
CCGCACACGCACCTCTGTTTCGCCGGGGACCGGGCGGAGGAGTTTGCGCTGCGCCTGGGCGGAGCCACCTACCAGGAGAT
CGCCGCGCGGGGCGGCGGCATCCTGGAGACGGTGCGTGCCACCCGGGCCGCCAGCCAGGCCGAGTTGGTGGAGCTGGGCC
TCGCCCGGCTGGATCAGCTGGCCCTGAACGGGACGACGACGGTGGAGGTGAAGTCCGGCTACGGCCTGAGCCTGGCCGAC
GAGCTGAAGCAGCTCCGGGCGATCCGGGCGATGGCCCGCCGCCATCCGCTGACCGTGGTCCCCACCTTCATGGGGGCACA
CGAGGTGCCGCCGGAGTACCGCAGCCGCCGGGAGGCTTACGTGGACCTGCTGGTGGAGGAGATGCTGCCCGCGGTGGCCG
CGGAGCCGGGCCTGGCCCGGTTCGCCGATGTCTTCACCGAGGCGGGGGTCTTCTCGGTCGCGGAGTCCCGCCGGATCCTG
GAGCGGGCGAAGGCGCTGGGCTTCGGCGTGAAGGTGCACGCCGACGAGCTTTCCGACCTGGGCGGCGCGGCCTTGGCGGC
GGAGCTCGGAGCCATCAGCGCCGAGCACCTGCTCCACGCGTCGGACGAGGCGCTGGCGAAGCTGGCGGAGGCGGGCACGG
TGGCGGTCTGCCTGCCGGGCACGTCGTTCTGCCTGATGAACGCGCCCTACGCCCGGGCCCGCCGGATGATCGAGTTGGGC
TGCACCGTGGCCCTGGGCAGCGATTACAACCCAGGTTCCTGCCCGGCCTATGCGATGCCCTTCATCATCACCCTGGCCTG
CATGCACCTGGGGCTGAACCCCAGCGAGGCCCTGGCGGCGGCGACGATCAACGCCGCAGCTGCGATCGGGATGGAGGCCG
AGGTGGGCTCGCTGGAGGTGGGCAAGCTGGCCGACGTGGTGATCCTGTCGACGCCGACCCACTGGCACATTCCCTACCAC
ATGGGCATGGGTGTCGTGGCCAAGGTCGTGAAGCGGGGCAGGCTCATTGTGGACGAGGGAAAGGTACGCAGGAGGTAG

Upstream 100 bases:

>100_bases
ACGCTCTGGTGGGTGTGGCCCGCCACTACCTGCGGCTGGAGGGGTTCAAGACCGACCAGGTCCTGGAGAAGCGGCTGGTC
GACTGAGGGCGGTGATGCGG

Downstream 100 bases:

>100_bases
CGGTAGCCCATGCGCATCGGTGAACAGACGGTCAAGGGGTTCTGCGAGCAGGTGGCGGCCTCGACGCCGGCCCCCGGCGG
CGGCACGGTGGCCGCCGTGG

Product: imidazolonepropionase

Products: NA

Alternate protein names: Imidazolone-5-propionate hydrolase

Number of amino acids: Translated: 425; Mature: 425

Protein sequence:

>425_residues
MRPVDLLIVGAGELVTMAGGPRRGERMKDAAVIPGGALAARDGRIVAVGPEDEVLRTVETGPDTRVIDARGRAVIPGFVD
PHTHLCFAGDRAEEFALRLGGATYQEIAARGGGILETVRATRAASQAELVELGLARLDQLALNGTTTVEVKSGYGLSLAD
ELKQLRAIRAMARRHPLTVVPTFMGAHEVPPEYRSRREAYVDLLVEEMLPAVAAEPGLARFADVFTEAGVFSVAESRRIL
ERAKALGFGVKVHADELSDLGGAALAAELGAISAEHLLHASDEALAKLAEAGTVAVCLPGTSFCLMNAPYARARRMIELG
CTVALGSDYNPGSCPAYAMPFIITLACMHLGLNPSEALAAATINAAAAIGMEAEVGSLEVGKLADVVILSTPTHWHIPYH
MGMGVVAKVVKRGRLIVDEGKVRRR

Sequences:

>Translated_425_residues
MRPVDLLIVGAGELVTMAGGPRRGERMKDAAVIPGGALAARDGRIVAVGPEDEVLRTVETGPDTRVIDARGRAVIPGFVD
PHTHLCFAGDRAEEFALRLGGATYQEIAARGGGILETVRATRAASQAELVELGLARLDQLALNGTTTVEVKSGYGLSLAD
ELKQLRAIRAMARRHPLTVVPTFMGAHEVPPEYRSRREAYVDLLVEEMLPAVAAEPGLARFADVFTEAGVFSVAESRRIL
ERAKALGFGVKVHADELSDLGGAALAAELGAISAEHLLHASDEALAKLAEAGTVAVCLPGTSFCLMNAPYARARRMIELG
CTVALGSDYNPGSCPAYAMPFIITLACMHLGLNPSEALAAATINAAAAIGMEAEVGSLEVGKLADVVILSTPTHWHIPYH
MGMGVVAKVVKRGRLIVDEGKVRRR
>Mature_425_residues
MRPVDLLIVGAGELVTMAGGPRRGERMKDAAVIPGGALAARDGRIVAVGPEDEVLRTVETGPDTRVIDARGRAVIPGFVD
PHTHLCFAGDRAEEFALRLGGATYQEIAARGGGILETVRATRAASQAELVELGLARLDQLALNGTTTVEVKSGYGLSLAD
ELKQLRAIRAMARRHPLTVVPTFMGAHEVPPEYRSRREAYVDLLVEEMLPAVAAEPGLARFADVFTEAGVFSVAESRRIL
ERAKALGFGVKVHADELSDLGGAALAAELGAISAEHLLHASDEALAKLAEAGTVAVCLPGTSFCLMNAPYARARRMIELG
CTVALGSDYNPGSCPAYAMPFIITLACMHLGLNPSEALAAATINAAAAIGMEAEVGSLEVGKLADVVILSTPTHWHIPYH
MGMGVVAKVVKRGRLIVDEGKVRRR

Specific function: Unknown

COG id: COG1228

COG function: function code Q; Imidazolonepropionase and related amidohydrolases

Gene ontology:

Cell location: Cytoplasm (Potential)

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: Belongs to the hutI family

Homologues:

Organism=Homo sapiens, GI223972677, Length=427, Percent_Identity=39.8126463700234, Blast_Score=253, Evalue=2e-67,
Organism=Caenorhabditis elegans, GI17555004, Length=377, Percent_Identity=40.053050397878, Blast_Score=246, Evalue=1e-65,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): HUTI_SYMTH (Q67JH7)

Other databases:

- EMBL:   AP006840
- RefSeq:   YP_077017.1
- HSSP:   Q8U8Z6
- ProteinModelPortal:   Q67JH7
- SMR:   Q67JH7
- GeneID:   2982314
- GenomeReviews:   AP006840_GR
- KEGG:   sth:STH3191
- NMPDR:   fig|292459.1.peg.3062
- HOGENOM:   HBG686142
- OMA:   MNMACTL
- BioCyc:   STHE292459:STH3191-MONOMER
- BRENDA:   3.5.2.7
- GO:   GO:0005737
- HAMAP:   MF_00372
- InterPro:   IPR006680
- InterPro:   IPR005920
- TIGRFAMs:   TIGR01224

Pfam domain/function: PF01979 Amidohydro_1

EC number: =3.5.2.7

Molecular weight: Translated: 44842; Mature: 44842

Theoretical pI: Translated: 6.44; Mature: 6.44

Prosite motif: NA

Important sites: BINDING 91-91 BINDING 104-104 BINDING 154-154 BINDING 187-187 BINDING 256-256

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.4 %Cys     (Translated Protein)
3.1 %Met     (Translated Protein)
4.5 %Cys+Met (Translated Protein)
1.4 %Cys     (Mature Protein)
3.1 %Met     (Mature Protein)
4.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MRPVDLLIVGAGELVTMAGGPRRGERMKDAAVIPGGALAARDGRIVAVGPEDEVLRTVET
CCCEEEEEECCCCEEEECCCCCCCCCCCCCEECCCCCEEECCCEEEEECCCHHHHHHHCC
GPDTRVIDARGRAVIPGFVDPHTHLCFAGDRAEEFALRLGGATYQEIAARGGGILETVRA
CCCCEEEECCCCEECCCCCCCCCEEEEECCCHHHHHHHHCCCHHHHHHHCCCCHHHHHHH
TRAASQAELVELGLARLDQLALNGTTTVEVKSGYGLSLADELKQLRAIRAMARRHPLTVV
HHHHHHHHHHHHHHHHHHHHHCCCCEEEEECCCCCCCHHHHHHHHHHHHHHHHHCCCEEE
PTFMGAHEVPPEYRSRREAYVDLLVEEMLPAVAAEPGLARFADVFTEAGVFSVAESRRIL
EHHCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHCCHHHHHHHHHHH
ERAKALGFGVKVHADELSDLGGAALAAELGAISAEHLLHASDEALAKLAEAGTVAVCLPG
HHHHHHCCCEEEEHHHHHCCCCHHHHHHHHCCCHHHHHCCCHHHHHHHHCCCEEEEEECC
TSFCLMNAPYARARRMIELGCTVALGSDYNPGSCPAYAMPFIITLACMHLGLNPSEALAA
CCEEEECCCHHHHHHHHHHCCEEEECCCCCCCCCCHHHHHHHHHHHHHHCCCCHHHHHHH
ATINAAAAIGMEAEVGSLEVGKLADVVILSTPTHWHIPYHMGMGVVAKVVKRGRLIVDEG
HHHHHHHHCCCCCCCCCEECCCCCCEEEEECCCEEECHHHHHHHHHHHHHHCCCEEEECC
KVRRR
CCCCC
>Mature Secondary Structure
MRPVDLLIVGAGELVTMAGGPRRGERMKDAAVIPGGALAARDGRIVAVGPEDEVLRTVET
CCCEEEEEECCCCEEEECCCCCCCCCCCCCEECCCCCEEECCCEEEEECCCHHHHHHHCC
GPDTRVIDARGRAVIPGFVDPHTHLCFAGDRAEEFALRLGGATYQEIAARGGGILETVRA
CCCCEEEECCCCEECCCCCCCCCEEEEECCCHHHHHHHHCCCHHHHHHHCCCCHHHHHHH
TRAASQAELVELGLARLDQLALNGTTTVEVKSGYGLSLADELKQLRAIRAMARRHPLTVV
HHHHHHHHHHHHHHHHHHHHHCCCCEEEEECCCCCCCHHHHHHHHHHHHHHHHHCCCEEE
PTFMGAHEVPPEYRSRREAYVDLLVEEMLPAVAAEPGLARFADVFTEAGVFSVAESRRIL
EHHCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHCCHHHHHHHHHHH
ERAKALGFGVKVHADELSDLGGAALAAELGAISAEHLLHASDEALAKLAEAGTVAVCLPG
HHHHHHCCCEEEEHHHHHCCCCHHHHHHHHCCCHHHHHCCCHHHHHHHHCCCEEEEEECC
TSFCLMNAPYARARRMIELGCTVALGSDYNPGSCPAYAMPFIITLACMHLGLNPSEALAA
CCEEEECCCHHHHHHHHHHCCEEEECCCCCCCCCCHHHHHHHHHHHHHHCCCCHHHHHHH
ATINAAAAIGMEAEVGSLEVGKLADVVILSTPTHWHIPYHMGMGVVAKVVKRGRLIVDEG
HHHHHHHHCCCCCCCCCEECCCCCCEEEEECCCEEECHHHHHHHHHHHHHHCCCEEEECC
KVRRR
CCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA