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The map label for this gene is csd [H]

Identifier: 51894266

GI number: 51894266

Start: 3330660

End: 3331829

Strand: Reverse

Name: csd [H]

Synonym: STH3131

Alternate gene names: 51894266

Gene position: 3331829-3330660 (Counterclockwise)

Preceding gene: 51894267

Following gene: 51894265

Centisome position: 93.43

GC content: 73.25

Gene sequence:

>1170_bases
ATGAGCGCCGAACTGATTTACCTGGACAACGCCGCCACCTCGTGGCCCAAGCCGGCGGCGGTGGTGCGGGCGATGGCCGA
GTGCCTGGAGAATGAGGCCGGCAATCCCGGCCGCTCCGGGCACCGGCTGTCGCTCGCCGCCGGCCGGCGGGTCTGGGCGG
TGCGGCAGGCCGTAGCCGAACTCTTCGGTGCCCCTGACCCGCTGCGCGTGATCTTCACCCACAACGGCACCATGGCCGTC
AACCTGGCCCTGGGCGGCCTGCTCTCTCCCGGCGACCGGGTGGTCTGCACGGGCATGGAGCACAACGCCGTCATCCGCCC
CCTGCGCGACCTGGAGGAGCTGGGGATCGAGGTCGTCATCGCCCCCTGCGATTCTGAGGGCCGGCTGGACCTGGAGGCGT
TCCGGCGGGTGGTGGAGGCTGCCCCGACCCGGATGGTGGCCCTGAACCATGCCAGCAACGTGACCGGCACCATCTGCCCT
GTCGCCGAGGCCGCCGCGATCGCGCACCGGGCAGGCGCGCTGGTGCTGGTCGACGCGGCGCAGAGCGCCGGCAGCGTCCC
CATCGATATGGGGGCGATGGGCATCGACCTCCTGGCCTTCACCGGCCACAAAGGGCTCCTGGGCCCCACCGGCACCGGGG
GGCTCATCCTGGGCGAGCGGGTCAACGCGGCCGAGATGAAGCCGCTGGTGCGGGGCGGGACGGGATCCCGCTCGGCAATG
GAGAGACAGCCGCCGGACCTGCCGGACCGGTTCGAGGCCGGCACGGTCAACTTCGTGGGCATCGCCGGCCTGGGCGCCGG
GATTCAGGCGCTGGCAGAACTGGGCGGGCCGGAGGAAATCGGCCGGCGGGAACGGCAGCTCGCCCGGCAGCTCTGGGAGG
GGCTCTCGGAGATCCCTGGCGTGCGGCTGTACGGCCCGGCGGACTTCAGCCAGCGGGTCGCGGTGGTCTCCTTCACCGTC
GAGGGGCGCACGGTGTCGGAGGTGGGCGGACGGCTGGACGAGGAGTTCGGGATCCTCGCCCGCGTCGGGCTGCACTGCGC
CCCGGTGGCCCACCGGACCCTGGGCACGTTCCCGCAGGGGACGGTGCGGCTGTCCCCGGGGCCTTTCAACACCCCGGAGC
AGATCGCGCGGGCGGTGGCGGCGGTCCGCCGGCTTGCCGAGGGGGCGTGA

Upstream 100 bases:

>100_bases
ACGGGCCGGCGGCGGTGATCATCGGGCTCATCGTCGTGGTCGTCCTGGGCTTCACCATGCGGGACGTGGCGGCGGGTGAG
GACCAGTCCCGGTCGGCGGC

Downstream 100 bases:

>100_bases
TGGGATGGACTACGGCGTGGCGCTCTTCCACACGACATCGATGGCCTTGAAGGCTGAGCAACGGCTGAAGGCGGCGGGGC
TGGCCGTCAAGCTCATCCCG

Product: cysteine desulfurase

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 389; Mature: 388

Protein sequence:

>389_residues
MSAELIYLDNAATSWPKPAAVVRAMAECLENEAGNPGRSGHRLSLAAGRRVWAVRQAVAELFGAPDPLRVIFTHNGTMAV
NLALGGLLSPGDRVVCTGMEHNAVIRPLRDLEELGIEVVIAPCDSEGRLDLEAFRRVVEAAPTRMVALNHASNVTGTICP
VAEAAAIAHRAGALVLVDAAQSAGSVPIDMGAMGIDLLAFTGHKGLLGPTGTGGLILGERVNAAEMKPLVRGGTGSRSAM
ERQPPDLPDRFEAGTVNFVGIAGLGAGIQALAELGGPEEIGRRERQLARQLWEGLSEIPGVRLYGPADFSQRVAVVSFTV
EGRTVSEVGGRLDEEFGILARVGLHCAPVAHRTLGTFPQGTVRLSPGPFNTPEQIARAVAAVRRLAEGA

Sequences:

>Translated_389_residues
MSAELIYLDNAATSWPKPAAVVRAMAECLENEAGNPGRSGHRLSLAAGRRVWAVRQAVAELFGAPDPLRVIFTHNGTMAV
NLALGGLLSPGDRVVCTGMEHNAVIRPLRDLEELGIEVVIAPCDSEGRLDLEAFRRVVEAAPTRMVALNHASNVTGTICP
VAEAAAIAHRAGALVLVDAAQSAGSVPIDMGAMGIDLLAFTGHKGLLGPTGTGGLILGERVNAAEMKPLVRGGTGSRSAM
ERQPPDLPDRFEAGTVNFVGIAGLGAGIQALAELGGPEEIGRRERQLARQLWEGLSEIPGVRLYGPADFSQRVAVVSFTV
EGRTVSEVGGRLDEEFGILARVGLHCAPVAHRTLGTFPQGTVRLSPGPFNTPEQIARAVAAVRRLAEGA
>Mature_388_residues
SAELIYLDNAATSWPKPAAVVRAMAECLENEAGNPGRSGHRLSLAAGRRVWAVRQAVAELFGAPDPLRVIFTHNGTMAVN
LALGGLLSPGDRVVCTGMEHNAVIRPLRDLEELGIEVVIAPCDSEGRLDLEAFRRVVEAAPTRMVALNHASNVTGTICPV
AEAAAIAHRAGALVLVDAAQSAGSVPIDMGAMGIDLLAFTGHKGLLGPTGTGGLILGERVNAAEMKPLVRGGTGSRSAME
RQPPDLPDRFEAGTVNFVGIAGLGAGIQALAELGGPEEIGRRERQLARQLWEGLSEIPGVRLYGPADFSQRVAVVSFTVE
GRTVSEVGGRLDEEFGILARVGLHCAPVAHRTLGTFPQGTVRLSPGPFNTPEQIARAVAAVRRLAEGA

Specific function: Cysteine Desulfurases Mobilize The Sulfur From L- Cysteine To Yield L-Alanine, An Essential Step In Sulfur Metabolism For Biosynthesis Of A Variety Of Sulfur-Containing Biomolecules. Component Of The Suf Operon, Which Is Activated And Required Under Speci

COG id: COG0520

COG function: function code E; Selenocysteine lyase

Gene ontology:

Cell location: Cytoplasmic

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the class-V pyridoxal-phosphate-dependent aminotransferase family. Csd subfamily [H]

Homologues:

Organism=Homo sapiens, GI32307132, Length=397, Percent_Identity=27.7078085642317, Blast_Score=108, Evalue=9e-24,
Organism=Homo sapiens, GI157388923, Length=384, Percent_Identity=24.4791666666667, Blast_Score=79, Evalue=8e-15,
Organism=Homo sapiens, GI156713448, Length=308, Percent_Identity=27.5974025974026, Blast_Score=75, Evalue=1e-13,
Organism=Escherichia coli, GI1787970, Length=391, Percent_Identity=34.0153452685422, Blast_Score=174, Evalue=7e-45,
Organism=Escherichia coli, GI1789175, Length=394, Percent_Identity=34.010152284264, Blast_Score=159, Evalue=4e-40,
Organism=Escherichia coli, GI48994898, Length=392, Percent_Identity=29.0816326530612, Blast_Score=127, Evalue=1e-30,
Organism=Caenorhabditis elegans, GI25143064, Length=224, Percent_Identity=33.9285714285714, Blast_Score=114, Evalue=1e-25,
Organism=Caenorhabditis elegans, GI193211090, Length=342, Percent_Identity=24.8538011695906, Blast_Score=74, Evalue=1e-13,
Organism=Saccharomyces cerevisiae, GI6319831, Length=236, Percent_Identity=30.5084745762712, Blast_Score=103, Evalue=5e-23,
Organism=Drosophila melanogaster, GI20129463, Length=236, Percent_Identity=33.0508474576271, Blast_Score=112, Evalue=4e-25,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000192
- InterPro:   IPR015424
- InterPro:   IPR015421
- InterPro:   IPR015422 [H]

Pfam domain/function: PF00266 Aminotran_5 [H]

EC number: =2.8.1.7 [H]

Molecular weight: Translated: 40700; Mature: 40569

Theoretical pI: Translated: 6.32; Mature: 6.32

Prosite motif: PS00595 AA_TRANSFER_CLASS_5

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.3 %Cys     (Translated Protein)
2.3 %Met     (Translated Protein)
3.6 %Cys+Met (Translated Protein)
1.3 %Cys     (Mature Protein)
2.1 %Met     (Mature Protein)
3.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSAELIYLDNAATSWPKPAAVVRAMAECLENEAGNPGRSGHRLSLAAGRRVWAVRQAVAE
CCCEEEEECCCCCCCCCHHHHHHHHHHHHHHCCCCCCCCCCEEEECCCCHHHHHHHHHHH
LFGAPDPLRVIFTHNGTMAVNLALGGLLSPGDRVVCTGMEHNAVIRPLRDLEELGIEVVI
HHCCCCCEEEEEECCCEEEEEEEECCCCCCCCEEEEECCCCCHHHHHHHHHHHCCEEEEE
APCDSEGRLDLEAFRRVVEAAPTRMVALNHASNVTGTICPVAEAAAIAHRAGALVLVDAA
EECCCCCCCCHHHHHHHHHHCCCEEEEEECCCCCCCCCCHHHHHHHHHHHCCCEEEEECC
QSAGSVPIDMGAMGIDLLAFTGHKGLLGPTGTGGLILGERVNAAEMKPLVRGGTGSRSAM
CCCCCCCEECCCCCEEEEEEECCCCCCCCCCCCCEEECCCCCHHHHCHHHCCCCCCCHHH
ERQPPDLPDRFEAGTVNFVGIAGLGAGIQALAELGGPEEIGRRERQLARQLWEGLSEIPG
HCCCCCCCCCCCCCCEEEEEECCCCHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHCCC
VRLYGPADFSQRVAVVSFTVEGRTVSEVGGRLDEEFGILARVGLHCAPVAHRTLGTFPQG
EEEECCCCCCCCEEEEEEEECCCCHHHHCCCCCHHHHHHHHHCCHHHHHHHHHHCCCCCC
TVRLSPGPFNTPEQIARAVAAVRRLAEGA
EEEECCCCCCCHHHHHHHHHHHHHHHCCC
>Mature Secondary Structure 
SAELIYLDNAATSWPKPAAVVRAMAECLENEAGNPGRSGHRLSLAAGRRVWAVRQAVAE
CCEEEEECCCCCCCCCHHHHHHHHHHHHHHCCCCCCCCCCEEEECCCCHHHHHHHHHHH
LFGAPDPLRVIFTHNGTMAVNLALGGLLSPGDRVVCTGMEHNAVIRPLRDLEELGIEVVI
HHCCCCCEEEEEECCCEEEEEEEECCCCCCCCEEEEECCCCCHHHHHHHHHHHCCEEEEE
APCDSEGRLDLEAFRRVVEAAPTRMVALNHASNVTGTICPVAEAAAIAHRAGALVLVDAA
EECCCCCCCCHHHHHHHHHHCCCEEEEEECCCCCCCCCCHHHHHHHHHHHCCCEEEEECC
QSAGSVPIDMGAMGIDLLAFTGHKGLLGPTGTGGLILGERVNAAEMKPLVRGGTGSRSAM
CCCCCCCEECCCCCEEEEEEECCCCCCCCCCCCCEEECCCCCHHHHCHHHCCCCCCCHHH
ERQPPDLPDRFEAGTVNFVGIAGLGAGIQALAELGGPEEIGRRERQLARQLWEGLSEIPG
HCCCCCCCCCCCCCCEEEEEECCCCHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHCCC
VRLYGPADFSQRVAVVSFTVEGRTVSEVGGRLDEEFGILARVGLHCAPVAHRTLGTFPQG
EEEECCCCCCCCEEEEEEEECCCCHHHHCCCCCHHHHHHHHHCCHHHHHHHHHHCCCCCC
TVRLSPGPFNTPEQIARAVAAVRRLAEGA
EEEECCCCCCCHHHHHHHHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 9371463 [H]