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The map label for this gene is devR [H]

Identifier: 51894231

GI number: 51894231

Start: 3296671

End: 3297306

Strand: Reverse

Name: devR [H]

Synonym: STH3096

Alternate gene names: 51894231

Gene position: 3297306-3296671 (Counterclockwise)

Preceding gene: 51894232

Following gene: 51894228

Centisome position: 92.46

GC content: 68.55

Gene sequence:

>636_bases
ATGCCCATCCGTGTCCTGATCGTGGACGACCATGAGCTGCTGAGGGAGGGGCTGAAGTCGCTGCTCTCCCGGGAGGAGGA
CATGGAGGTGGTGGGGGAGGCCGCGGGGGGACGGGAGGCCGTCGCCCTCTGCCGGAGCCTGCGGCCGGACGTGGTGGTGC
TGGACGCCCGGCTGCCCGATGTGGACGGGGTGGAGGTCTGCCGGCAACTGCAGGAGGAGATGCCCGAGGTGGCCGTGCTC
ATGCTGACCACCTTCAGCGACTCGGACCTGGTGCTGGGCGCGGTGCGGGCCGGCGCCAGGGGGTACGTGGTGAAGGACGT
GCTCGGCATGGACCTGAAGCGATCGATCCGGGCGGTGGCGCGGGGCGAGGTGGCCATGGATCCCAAGGTGGTGGGCTACC
TCATGCAGCAGATGCGTTCGCCGTCGGCGGACAAGGAGGAGCGCATCCCCCTCAACCGGCAGCAGCTGGCGATCATCCGC
CTGGTGGCCCAGGGGTACACCAACCGGGAGATCGCGGAGCGCATGTTCCTGAGCGAGAAGACCGTGAAGGGCTACCTGGC
GGAAGCCATGCGGCGCATGGGCGTGAAGAACCGGGTGGAGGCGGCGATGGTCGCGTCAAAAAACGGCTGGATCTGA

Upstream 100 bases:

>100_bases
GAGCGGGTGGCCCGGCTGGGGGGACGGCTGGAGCTGGTGGACGGCGACGAGGGCGGTCTCCTGGTCAGGGCCTCGGTGCC
GCTGAAGGGGGTGGACACGC

Downstream 100 bases:

>100_bases
CCGCGCGGAAGGACAGGCAAGGGCCCGGTCCGGGAAGGACCGGGCCCTCGCTCATGGCCGGCGGGTGGTCACTGTGGGGG
GTGGGTGGCCGACTCAGCCA

Product: two-component response regulator

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 211; Mature: 210

Protein sequence:

>211_residues
MPIRVLIVDDHELLREGLKSLLSREEDMEVVGEAAGGREAVALCRSLRPDVVVLDARLPDVDGVEVCRQLQEEMPEVAVL
MLTTFSDSDLVLGAVRAGARGYVVKDVLGMDLKRSIRAVARGEVAMDPKVVGYLMQQMRSPSADKEERIPLNRQQLAIIR
LVAQGYTNREIAERMFLSEKTVKGYLAEAMRRMGVKNRVEAAMVASKNGWI

Sequences:

>Translated_211_residues
MPIRVLIVDDHELLREGLKSLLSREEDMEVVGEAAGGREAVALCRSLRPDVVVLDARLPDVDGVEVCRQLQEEMPEVAVL
MLTTFSDSDLVLGAVRAGARGYVVKDVLGMDLKRSIRAVARGEVAMDPKVVGYLMQQMRSPSADKEERIPLNRQQLAIIR
LVAQGYTNREIAERMFLSEKTVKGYLAEAMRRMGVKNRVEAAMVASKNGWI
>Mature_210_residues
PIRVLIVDDHELLREGLKSLLSREEDMEVVGEAAGGREAVALCRSLRPDVVVLDARLPDVDGVEVCRQLQEEMPEVAVLM
LTTFSDSDLVLGAVRAGARGYVVKDVLGMDLKRSIRAVARGEVAMDPKVVGYLMQQMRSPSADKEERIPLNRQQLAIIRL
VAQGYTNREIAERMFLSEKTVKGYLAEAMRRMGVKNRVEAAMVASKNGWI

Specific function: Member of the two-component regulatory system devR/devS (dosR/dosS) involved in onset of the dormancy response. When phosphorylated binds the promoter of at least its own and Acr (hspX) gene in response to hypoxia. Activates its own transcription under hy

COG id: COG2197

COG function: function code TK; Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain

Gene ontology:

Cell location: Cytoplasmic [H]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 response regulatory domain [H]

Homologues:

Organism=Escherichia coli, GI1788222, Length=207, Percent_Identity=30.4347826086957, Blast_Score=113, Evalue=1e-26,
Organism=Escherichia coli, GI1788521, Length=203, Percent_Identity=32.512315270936, Blast_Score=106, Evalue=1e-24,
Organism=Escherichia coli, GI1787473, Length=203, Percent_Identity=33.4975369458128, Blast_Score=103, Evalue=1e-23,
Organism=Escherichia coli, GI1790102, Length=200, Percent_Identity=33.5, Blast_Score=100, Evalue=1e-22,
Organism=Escherichia coli, GI1788712, Length=206, Percent_Identity=26.6990291262136, Blast_Score=93, Evalue=1e-20,
Organism=Escherichia coli, GI1786747, Length=199, Percent_Identity=24.6231155778894, Blast_Score=91, Evalue=7e-20,
Organism=Escherichia coli, GI1788546, Length=200, Percent_Identity=24.5, Blast_Score=70, Evalue=1e-13,
Organism=Escherichia coli, GI87082052, Length=105, Percent_Identity=35.2380952380952, Blast_Score=66, Evalue=2e-12,
Organism=Escherichia coli, GI1788550, Length=118, Percent_Identity=29.6610169491525, Blast_Score=62, Evalue=2e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR011006
- InterPro:   IPR001789
- InterPro:   IPR011990
- InterPro:   IPR000792
- InterPro:   IPR011991 [H]

Pfam domain/function: PF00196 GerE; PF00072 Response_reg [H]

EC number: NA

Molecular weight: Translated: 23450; Mature: 23319

Theoretical pI: Translated: 6.08; Mature: 6.08

Prosite motif: PS50110 RESPONSE_REGULATORY ; PS50043 HTH_LUXR_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.9 %Cys     (Translated Protein)
5.7 %Met     (Translated Protein)
6.6 %Cys+Met (Translated Protein)
1.0 %Cys     (Mature Protein)
5.2 %Met     (Mature Protein)
6.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MPIRVLIVDDHELLREGLKSLLSREEDMEVVGEAAGGREAVALCRSLRPDVVVLDARLPD
CCEEEEEECCHHHHHHHHHHHHCCHHHHHHHHHCCCCHHHHHHHHHCCCCEEEEECCCCC
VDGVEVCRQLQEEMPEVAVLMLTTFSDSDLVLGAVRAGARGYVVKDVLGMDLKRSIRAVA
CCHHHHHHHHHHHCHHHEEHHEEECCCCCHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHH
RGEVAMDPKVVGYLMQQMRSPSADKEERIPLNRQQLAIIRLVAQGYTNREIAERMFLSEK
CCCCCCCHHHHHHHHHHHCCCCCCCHHCCCCCHHHHHHHHHHHHCCCCHHHHHHHHHHHH
TVKGYLAEAMRRMGVKNRVEAAMVASKNGWI
HHHHHHHHHHHHCCCHHHHHHHHHHCCCCCC
>Mature Secondary Structure 
PIRVLIVDDHELLREGLKSLLSREEDMEVVGEAAGGREAVALCRSLRPDVVVLDARLPD
CEEEEEECCHHHHHHHHHHHHCCHHHHHHHHHCCCCHHHHHHHHHCCCCEEEEECCCCC
VDGVEVCRQLQEEMPEVAVLMLTTFSDSDLVLGAVRAGARGYVVKDVLGMDLKRSIRAVA
CCHHHHHHHHHHHCHHHEEHHEEECCCCCHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHH
RGEVAMDPKVVGYLMQQMRSPSADKEERIPLNRQQLAIIRLVAQGYTNREIAERMFLSEK
CCCCCCCHHHHHHHHHHHCCCCCCCHHCCCCCHHHHHHHHHHHHCCCCHHHHHHHHHHHH
TVKGYLAEAMRRMGVKNRVEAAMVASKNGWI
HHHHHHHHHHHHCCCHHHHHHHHHHCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: DNA [C]

Specific reaction: Protein + DNA = Protein-DNA [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 9634230; 12218036 [H]