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The map label for this gene is adk

Identifier: 51894189

GI number: 51894189

Start: 3264076

End: 3264726

Strand: Reverse

Name: adk

Synonym: STH3054

Alternate gene names: 51894189

Gene position: 3264726-3264076 (Counterclockwise)

Preceding gene: 51894190

Following gene: 51894188

Centisome position: 91.55

GC content: 66.82

Gene sequence:

>651_bases
ATGCACATCATTCTGATGGGCCCGCCGGGAGCAGGCAAGGGAACCCAGGCCGTGCTGCTGGCCGGGCAGGAAGGCATTCC
ACACATCTCCACCGGGGACATCTTCCGTGCCCACATGAGCCAGGGCACTCCCCTGGGCAAGCTGGCCAAGGAGTACGTGG
ATGCTGGCAAGTATGTACCGGATGACGTGACCAACGCCATGGTCAGGGACCGGCTTGCACAGCCCGACTGCAAGAAGGGG
TTCGTCCTGGACGGATACCCGCGGACGCCGGAGCAGGCCCGGGCGCTGGACGAGATGCTGGCTGAGCTGGGCCTCGCGTT
GGACGCCGTCATCAACATCGACGTGCCGGACGAACTGCTGGTCGAGCGTGCGGTGGGCCGCCGGGTGTGCCGCTCCTGTG
GGGCCACCTATCACGTCCGGTTCAACCCGCCCCGCGAGGCCGGCCGCTGTGACCGGTGCGGCGGCGAGCTGTACCAGCGC
AGCGACGACCAGGAAGAGAAGGTTGCGGTGCGCCTCAACCTGTACCATTCCCAGACGGCGCCGCTTCTCCAGTTCTATAA
GGAACGCGGGCTGGTTCGCACCGTCCGCGGAGACCAGCCCATGGACCAGGTCACGGCCGACATCAAGGAGGCCGTGCGGG
CTTCCCGCTGA

Upstream 100 bases:

>100_bases
CGAGGGTGCGCAGAGGACCGGACCGTCCTCCCCGTCCGGAGGACGCCGGTCCTCGCGGGTCCCGTCTGCGCGCCCGGTTT
GGTGAAAGCGAGGTAGGGGG

Downstream 100 bases:

>100_bases
GGCCGCATCGGCCGCGCTTGCAAACGTGGCAGTGCGGTGCTATCCTGGCTATCGGCTGGGAAATCCGGGAAGCGCTGCGC
ACAGGCAGGCGCAGGCCGAG

Product: adenylate kinase

Products: NA

Alternate protein names: AK; ATP-AMP transphosphorylase

Number of amino acids: Translated: 216; Mature: 216

Protein sequence:

>216_residues
MHIILMGPPGAGKGTQAVLLAGQEGIPHISTGDIFRAHMSQGTPLGKLAKEYVDAGKYVPDDVTNAMVRDRLAQPDCKKG
FVLDGYPRTPEQARALDEMLAELGLALDAVINIDVPDELLVERAVGRRVCRSCGATYHVRFNPPREAGRCDRCGGELYQR
SDDQEEKVAVRLNLYHSQTAPLLQFYKERGLVRTVRGDQPMDQVTADIKEAVRASR

Sequences:

>Translated_216_residues
MHIILMGPPGAGKGTQAVLLAGQEGIPHISTGDIFRAHMSQGTPLGKLAKEYVDAGKYVPDDVTNAMVRDRLAQPDCKKG
FVLDGYPRTPEQARALDEMLAELGLALDAVINIDVPDELLVERAVGRRVCRSCGATYHVRFNPPREAGRCDRCGGELYQR
SDDQEEKVAVRLNLYHSQTAPLLQFYKERGLVRTVRGDQPMDQVTADIKEAVRASR
>Mature_216_residues
MHIILMGPPGAGKGTQAVLLAGQEGIPHISTGDIFRAHMSQGTPLGKLAKEYVDAGKYVPDDVTNAMVRDRLAQPDCKKG
FVLDGYPRTPEQARALDEMLAELGLALDAVINIDVPDELLVERAVGRRVCRSCGATYHVRFNPPREAGRCDRCGGELYQR
SDDQEEKVAVRLNLYHSQTAPLLQFYKERGLVRTVRGDQPMDQVTADIKEAVRASR

Specific function: This small ubiquitous enzyme is essential for maintenance and cell growth

COG id: COG0563

COG function: function code F; Adenylate kinase and related kinases

Gene ontology:

Cell location: Cytoplasm

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the adenylate kinase family

Homologues:

Organism=Homo sapiens, GI7524346, Length=205, Percent_Identity=43.9024390243902, Blast_Score=186, Evalue=1e-47,
Organism=Homo sapiens, GI4502013, Length=208, Percent_Identity=43.75, Blast_Score=186, Evalue=1e-47,
Organism=Homo sapiens, GI19923437, Length=199, Percent_Identity=37.6884422110553, Blast_Score=152, Evalue=3e-37,
Organism=Homo sapiens, GI310110345, Length=198, Percent_Identity=34.8484848484849, Blast_Score=127, Evalue=9e-30,
Organism=Homo sapiens, GI53832003, Length=198, Percent_Identity=34.8484848484849, Blast_Score=127, Evalue=9e-30,
Organism=Homo sapiens, GI8051579, Length=198, Percent_Identity=34.8484848484849, Blast_Score=127, Evalue=9e-30,
Organism=Homo sapiens, GI53832001, Length=198, Percent_Identity=34.8484848484849, Blast_Score=127, Evalue=9e-30,
Organism=Homo sapiens, GI4502011, Length=207, Percent_Identity=30.9178743961353, Blast_Score=107, Evalue=6e-24,
Organism=Homo sapiens, GI22749187, Length=198, Percent_Identity=31.8181818181818, Blast_Score=101, Evalue=6e-22,
Organism=Homo sapiens, GI28144899, Length=212, Percent_Identity=26.4150943396226, Blast_Score=83, Evalue=2e-16,
Organism=Homo sapiens, GI28144897, Length=212, Percent_Identity=26.4150943396226, Blast_Score=83, Evalue=2e-16,
Organism=Homo sapiens, GI7706497, Length=212, Percent_Identity=25, Blast_Score=83, Evalue=2e-16,
Organism=Escherichia coli, GI1786680, Length=215, Percent_Identity=50.2325581395349, Blast_Score=203, Evalue=6e-54,
Organism=Caenorhabditis elegans, GI17552384, Length=207, Percent_Identity=42.512077294686, Blast_Score=175, Evalue=1e-44,
Organism=Caenorhabditis elegans, GI17537943, Length=200, Percent_Identity=30.5, Blast_Score=108, Evalue=2e-24,
Organism=Caenorhabditis elegans, GI17533833, Length=219, Percent_Identity=26.4840182648402, Blast_Score=99, Evalue=1e-21,
Organism=Caenorhabditis elegans, GI17567503, Length=206, Percent_Identity=26.6990291262136, Blast_Score=87, Evalue=5e-18,
Organism=Caenorhabditis elegans, GI17550688, Length=215, Percent_Identity=23.7209302325581, Blast_Score=86, Evalue=2e-17,
Organism=Saccharomyces cerevisiae, GI6320432, Length=209, Percent_Identity=45.933014354067, Blast_Score=186, Evalue=2e-48,
Organism=Saccharomyces cerevisiae, GI6321018, Length=198, Percent_Identity=38.3838383838384, Blast_Score=132, Evalue=6e-32,
Organism=Saccharomyces cerevisiae, GI6322828, Length=216, Percent_Identity=27.3148148148148, Blast_Score=99, Evalue=6e-22,
Organism=Drosophila melanogaster, GI22026816, Length=216, Percent_Identity=43.0555555555556, Blast_Score=174, Evalue=3e-44,
Organism=Drosophila melanogaster, GI17737899, Length=196, Percent_Identity=37.7551020408163, Blast_Score=141, Evalue=3e-34,
Organism=Drosophila melanogaster, GI24645822, Length=196, Percent_Identity=37.7551020408163, Blast_Score=141, Evalue=3e-34,
Organism=Drosophila melanogaster, GI221459597, Length=214, Percent_Identity=23.8317757009346, Blast_Score=84, Evalue=6e-17,
Organism=Drosophila melanogaster, GI21356893, Length=214, Percent_Identity=23.8317757009346, Blast_Score=84, Evalue=6e-17,
Organism=Drosophila melanogaster, GI24663208, Length=211, Percent_Identity=23.696682464455, Blast_Score=80, Evalue=9e-16,
Organism=Drosophila melanogaster, GI17647141, Length=211, Percent_Identity=23.696682464455, Blast_Score=80, Evalue=1e-15,

Paralogues:

None

Copy number: 1640 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). 60 Molecules/Cell In: Stationary Phase, Rich Media (Based on E. coli). 847 Molecules/Cell In: Growth Phase, Glucose-minimal MOPS Media. [C]

Swissprot (AC and ID): KAD_SYMTH (Q67JW4)

Other databases:

- EMBL:   AP006840
- RefSeq:   YP_076880.1
- ProteinModelPortal:   Q67JW4
- SMR:   Q67JW4
- GeneID:   2982188
- GenomeReviews:   AP006840_GR
- KEGG:   sth:STH3054
- NMPDR:   fig|292459.1.peg.2926
- HOGENOM:   HBG630208
- OMA:   EINQPLE
- BioCyc:   STHE292459:STH3054-MONOMER
- BRENDA:   2.7.4.3
- GO:   GO:0005737
- HAMAP:   MF_00235
- InterPro:   IPR006259
- InterPro:   IPR000850
- InterPro:   IPR007862
- PANTHER:   PTHR23359
- PRINTS:   PR00094
- TIGRFAMs:   TIGR01351

Pfam domain/function: PF00406 ADK; PF05191 ADK_lid

EC number: =2.7.4.3

Molecular weight: Translated: 23798; Mature: 23798

Theoretical pI: Translated: 7.02; Mature: 7.02

Prosite motif: PS00113 ADENYLATE_KINASE

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.3 %Cys     (Translated Protein)
2.8 %Met     (Translated Protein)
5.1 %Cys+Met (Translated Protein)
2.3 %Cys     (Mature Protein)
2.8 %Met     (Mature Protein)
5.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MHIILMGPPGAGKGTQAVLLAGQEGIPHISTGDIFRAHMSQGTPLGKLAKEYVDAGKYVP
CEEEEECCCCCCCCCEEEEEECCCCCCCCCCCHHHHHHHHCCCCHHHHHHHHHHCCCCCC
DDVTNAMVRDRLAQPDCKKGFVLDGYPRTPEQARALDEMLAELGLALDAVINIDVPDELL
HHHHHHHHHHHHCCCCCCCCCEECCCCCCHHHHHHHHHHHHHHHHHHHHEEECCCCHHHH
VERAVGRRVCRSCGATYHVRFNPPREAGRCDRCGGELYQRSDDQEEKVAVRLNLYHSQTA
HHHHHHHHHHHHCCCEEEEEECCCHHCCCCHHHHHHHHHCCCCCCCEEEEEEEECCCCCH
PLLQFYKERGLVRTVRGDQPMDQVTADIKEAVRASR
HHHHHHHHCCCEEECCCCCCHHHHHHHHHHHHHCCC
>Mature Secondary Structure
MHIILMGPPGAGKGTQAVLLAGQEGIPHISTGDIFRAHMSQGTPLGKLAKEYVDAGKYVP
CEEEEECCCCCCCCCEEEEEECCCCCCCCCCCHHHHHHHHCCCCHHHHHHHHHHCCCCCC
DDVTNAMVRDRLAQPDCKKGFVLDGYPRTPEQARALDEMLAELGLALDAVINIDVPDELL
HHHHHHHHHHHHCCCCCCCCCEECCCCCCHHHHHHHHHHHHHHHHHHHHEEECCCCHHHH
VERAVGRRVCRSCGATYHVRFNPPREAGRCDRCGGELYQRSDDQEEKVAVRLNLYHSQTA
HHHHHHHHHHHHCCCEEEEEECCCHHCCCCHHHHHHHHHCCCCCCCEEEEEEEECCCCCH
PLLQFYKERGLVRTVRGDQPMDQVTADIKEAVRASR
HHHHHHHHCCCEEECCCCCCHHHHHHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA