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The map label for this gene is pcrA [H]

Identifier: 51894104

GI number: 51894104

Start: 3190541

End: 3192490

Strand: Reverse

Name: pcrA [H]

Synonym: STH2968

Alternate gene names: 51894104

Gene position: 3192490-3190541 (Counterclockwise)

Preceding gene: 51894105

Following gene: 51894103

Centisome position: 89.52

GC content: 72.56

Gene sequence:

>1950_bases
GTGCCCGGCGCCGGCAAGACCACGGTGCTGGCGTATCTGGCCGCCGACCTCATCGCCGAGGGGCGCCACCTCCCCGGCCG
GATCCTGATCGTCACCTACACCAACTCCGCCGTGGGCAATTTCAAGAACCGCATCGGTCAGTTCCTGGAGGCTCGGGGCC
TGCCCCGCGCGGGCTTCGAGGTGCGCACCATCCACTCCCTGGCCGTGCAGATCGTCCGGGAGCGGCCGGAGGCCATCGGC
TGGCCGGACACGTTCGCCGTGCTGGACGAGGTTCGCCGCAGGACCCTGGTCAACGCCCTCACGGCCGGGTGGATCGCCGC
ACACCGGGACACCTGGGAGGCGCTGGTCCGGGAGGATGTCCGCAACCGCGACCAGGCGCTGGCGCGGTGGGCGGAGCACA
CCCCCGAGCTGATGAGCCGGTTGATCCAGTCCTTCAAGGCGCGGCAGCTTTCGCCGGACGACGCGCTGTCACTGACCCGG
GGCCTCCCCGACACCGAGCCCCTCCGCTGGGCGGCGGAGATCTACCGGGACTACCAGCGGGCTCTGGCCCGGGAGGGACT
GGTGGACTTCGACGACATGATGCTGGGAGCCTACCGGCTCCTGACCGGCGAGCCCGACCTGCTGGAGCGGCTCCGGCAGC
GGTGGACCTACGTGTTTGAGGATGAGGCGCAGGACTCGTACCGGCTGCAGGAGCAGGTGCTCCGCCTCCTGGCCGGCCCT
GGCGGCAACTTCGTGCGGGTGGGCGACCCCAACCAGGCGATCATGGGCAGCTTCACCACGGCGGAGCCGGCGCTCTTCCG
GGCCTTCATCCGTGAACCGGGGGTGGACGTCCGCCCCCTCACCATGGCCGGCCGCTCCAGCCAGGAGATCATCGACCTGG
CCAATGAACTGGTGCGCTGGACCTGCCAGGACTACCCGGAGCCCGGCTGCCGGGACGCCCTCGAGCCGCAGTATATCCAG
CGGGTTCCCAGGGGGATGGGGCAGTCCAACCCGGAGCCGGAGGGGCGCCGCGTCCTCGTCCGGGACTTTCCGGCCTACGA
GGAGGAGATGGACCGGATTGCGGGGCTGGCCGCCCGGTCCGTGCGGCTCTACCCGGAGGCGACCGTGGGCGTGCTGCTCC
CCACCCACGCGATGGTGGACCGGATGCTGGCGCTCCTGCGGGACCGGGAAGCCCCGGCCATCCCGGTGGGCAGGACGGCC
CCCCTGGAGCGGCTGCGGCTGGGGTCGGACCTCCTGGCCGCCCTGGCCTTCCTGGCGGCGCCCCACGTGCCGGAGCGGCG
CGCGGCGGCCGCCCGCCTGGAACCGTACCTCGACCGCTGGCTGGCGGACGCCGTGCAGCCGGCGGATGTCCTGCTCCTGC
GGATGGCGGCCGACCTGCGGCTCTCCGGCGAGGACCTGGCCCTGGCGCAGTACCTGGCCCTGCGGGCCAGGCGGCTCCTG
GAGGAGGAGCCGCTCTACGGCCCCGGCGACGTGGCCCGGGAGCTGGCGGACGCCCTCGGCCGATCGGGCTGGCTGGCCGA
TGCGCTGTACGACCGGCAGGGCTTCGAGCCCCAGCCCGGCGTGGTGTACGTGACCACCTGCCACGCCGCCAAGGGGCTGG
AGTGGGACACCGTCTACGTCGCGGGCCTCACCCGGGGCTTCTTCACCGGCGGACTGCGCGACCGGACCCTCTCGGAGCAA
TGGTCGCTGGTGCCGGGGCAGGTCAACCCCGAGGCGAGGGCGCTGGCCCTGCTGGATCAGCTGGCCGGCGCCGGCGGGGT
TTCCGAAGATCCCGCGGCGGCGTTCAAGCGGGAGCAGATCGGCGAGAAGATCCGGCTGCTCTACGTGGCCATCACCCGGG
CTCGCCGCAACCTCCTGCTCTCCTATCACTGGCGCAACGAGCGGGGATACGACACCGCTCCCCCGCCGGCGGTGGTGCGG
CTTCGGCAGTTCGTCCAGGCGAGGAGGTGA

Upstream 100 bases:

>100_bases
TCCAGGAGCAGGAAGGGGGGCTGTGGGCGTGACCATCACCCTGCGTCCCGACCAGGTCCAGGTGGCCGCGTACCGGGGCG
GGTACATGGCCGTCCCGGCG

Downstream 100 bases:

>100_bases
CCGGATCCGTGGCGCAGCCGATCCCTCTGCACGAGCGGCACTTCAGCGCCCTTGCCCTGCGGCTCTACGCGGAATGCCCC
CTGCGCTTCCGCCGGCGGTA

Product: putative ATP-dependent DNA helicase

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 649; Mature: 648

Protein sequence:

>649_residues
MPGAGKTTVLAYLAADLIAEGRHLPGRILIVTYTNSAVGNFKNRIGQFLEARGLPRAGFEVRTIHSLAVQIVRERPEAIG
WPDTFAVLDEVRRRTLVNALTAGWIAAHRDTWEALVREDVRNRDQALARWAEHTPELMSRLIQSFKARQLSPDDALSLTR
GLPDTEPLRWAAEIYRDYQRALAREGLVDFDDMMLGAYRLLTGEPDLLERLRQRWTYVFEDEAQDSYRLQEQVLRLLAGP
GGNFVRVGDPNQAIMGSFTTAEPALFRAFIREPGVDVRPLTMAGRSSQEIIDLANELVRWTCQDYPEPGCRDALEPQYIQ
RVPRGMGQSNPEPEGRRVLVRDFPAYEEEMDRIAGLAARSVRLYPEATVGVLLPTHAMVDRMLALLRDREAPAIPVGRTA
PLERLRLGSDLLAALAFLAAPHVPERRAAAARLEPYLDRWLADAVQPADVLLLRMAADLRLSGEDLALAQYLALRARRLL
EEEPLYGPGDVARELADALGRSGWLADALYDRQGFEPQPGVVYVTTCHAAKGLEWDTVYVAGLTRGFFTGGLRDRTLSEQ
WSLVPGQVNPEARALALLDQLAGAGGVSEDPAAAFKREQIGEKIRLLYVAITRARRNLLLSYHWRNERGYDTAPPPAVVR
LRQFVQARR

Sequences:

>Translated_649_residues
MPGAGKTTVLAYLAADLIAEGRHLPGRILIVTYTNSAVGNFKNRIGQFLEARGLPRAGFEVRTIHSLAVQIVRERPEAIG
WPDTFAVLDEVRRRTLVNALTAGWIAAHRDTWEALVREDVRNRDQALARWAEHTPELMSRLIQSFKARQLSPDDALSLTR
GLPDTEPLRWAAEIYRDYQRALAREGLVDFDDMMLGAYRLLTGEPDLLERLRQRWTYVFEDEAQDSYRLQEQVLRLLAGP
GGNFVRVGDPNQAIMGSFTTAEPALFRAFIREPGVDVRPLTMAGRSSQEIIDLANELVRWTCQDYPEPGCRDALEPQYIQ
RVPRGMGQSNPEPEGRRVLVRDFPAYEEEMDRIAGLAARSVRLYPEATVGVLLPTHAMVDRMLALLRDREAPAIPVGRTA
PLERLRLGSDLLAALAFLAAPHVPERRAAAARLEPYLDRWLADAVQPADVLLLRMAADLRLSGEDLALAQYLALRARRLL
EEEPLYGPGDVARELADALGRSGWLADALYDRQGFEPQPGVVYVTTCHAAKGLEWDTVYVAGLTRGFFTGGLRDRTLSEQ
WSLVPGQVNPEARALALLDQLAGAGGVSEDPAAAFKREQIGEKIRLLYVAITRARRNLLLSYHWRNERGYDTAPPPAVVR
LRQFVQARR
>Mature_648_residues
PGAGKTTVLAYLAADLIAEGRHLPGRILIVTYTNSAVGNFKNRIGQFLEARGLPRAGFEVRTIHSLAVQIVRERPEAIGW
PDTFAVLDEVRRRTLVNALTAGWIAAHRDTWEALVREDVRNRDQALARWAEHTPELMSRLIQSFKARQLSPDDALSLTRG
LPDTEPLRWAAEIYRDYQRALAREGLVDFDDMMLGAYRLLTGEPDLLERLRQRWTYVFEDEAQDSYRLQEQVLRLLAGPG
GNFVRVGDPNQAIMGSFTTAEPALFRAFIREPGVDVRPLTMAGRSSQEIIDLANELVRWTCQDYPEPGCRDALEPQYIQR
VPRGMGQSNPEPEGRRVLVRDFPAYEEEMDRIAGLAARSVRLYPEATVGVLLPTHAMVDRMLALLRDREAPAIPVGRTAP
LERLRLGSDLLAALAFLAAPHVPERRAAAARLEPYLDRWLADAVQPADVLLLRMAADLRLSGEDLALAQYLALRARRLLE
EEPLYGPGDVARELADALGRSGWLADALYDRQGFEPQPGVVYVTTCHAAKGLEWDTVYVAGLTRGFFTGGLRDRTLSEQW
SLVPGQVNPEARALALLDQLAGAGGVSEDPAAAFKREQIGEKIRLLYVAITRARRNLLLSYHWRNERGYDTAPPPAVVRL
RQFVQARR

Specific function: Essential helicase [H]

COG id: COG0210

COG function: function code L; Superfamily I DNA and RNA helicases

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 uvrD-like helicase C-terminal domain [H]

Homologues:

Organism=Escherichia coli, GI2367296, Length=297, Percent_Identity=30.6397306397306, Blast_Score=112, Evalue=6e-26,
Organism=Escherichia coli, GI48994965, Length=703, Percent_Identity=24.3243243243243, Blast_Score=93, Evalue=5e-20,
Organism=Saccharomyces cerevisiae, GI6322369, Length=308, Percent_Identity=25, Blast_Score=92, Evalue=4e-19,

Paralogues:

None

Copy number: 3000 [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR005751
- InterPro:   IPR013986
- InterPro:   IPR014017
- InterPro:   IPR000212
- InterPro:   IPR014016 [H]

Pfam domain/function: PF00580 UvrD-helicase [H]

EC number: =3.6.4.12 [H]

Molecular weight: Translated: 72662; Mature: 72531

Theoretical pI: Translated: 6.55; Mature: 6.55

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.5 %Cys     (Translated Protein)
1.7 %Met     (Translated Protein)
2.2 %Cys+Met (Translated Protein)
0.5 %Cys     (Mature Protein)
1.5 %Met     (Mature Protein)
2.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MPGAGKTTVLAYLAADLIAEGRHLPGRILIVTYTNSAVGNFKNRIGQFLEARGLPRAGFE
CCCCCHHHHHHHHHHHHHHCCCCCCCEEEEEEECCCHHHHHHHHHHHHHHHCCCCCCCCH
VRTIHSLAVQIVRERPEAIGWPDTFAVLDEVRRRTLVNALTAGWIAAHRDTWEALVREDV
HHHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
RNRDQALARWAEHTPELMSRLIQSFKARQLSPDDALSLTRGLPDTEPLRWAAEIYRDYQR
HHHHHHHHHHHHCCHHHHHHHHHHHHHCCCCCHHHHHHHCCCCCCCHHHHHHHHHHHHHH
ALAREGLVDFDDMMLGAYRLLTGEPDLLERLRQRWTYVFEDEAQDSYRLQEQVLRLLAGP
HHHHCCCCCHHHHHHHHHHHHCCCHHHHHHHHHHCCEEECCCCCHHHHHHHHHHHHHHCC
GGNFVRVGDPNQAIMGSFTTAEPALFRAFIREPGVDVRPLTMAGRSSQEIIDLANELVRW
CCCEEEECCCCHHHHCCCCCCHHHHHHHHHHCCCCCEEEEEECCCCHHHHHHHHHHHHHH
TCQDYPEPGCRDALEPQYIQRVPRGMGQSNPEPEGRRVLVRDFPAYEEEMDRIAGLAARS
HHHCCCCCCCCCCCCHHHHHHHHHHCCCCCCCCCCCEEEEECCCCHHHHHHHHHHHHHHH
VRLYPEATVGVLLPTHAMVDRMLALLRDREAPAIPVGRTAPLERLRLGSDLLAALAFLAA
EEECCCCCHHHEECHHHHHHHHHHHHHCCCCCCCCCCCCCCHHHHHCCHHHHHHHHHHHC
PHVPERRAAAARLEPYLDRWLADAVQPADVLLLRMAADLRLSGEDLALAQYLALRARRLL
CCCCHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHH
EEEPLYGPGDVARELADALGRSGWLADALYDRQGFEPQPGVVYVTTCHAAKGLEWDTVYV
HCCCCCCCHHHHHHHHHHHCCCCCHHHHHHHCCCCCCCCCEEEEEECCCCCCCCCCEEEE
AGLTRGFFTGGLRDRTLSEQWSLVPGQVNPEARALALLDQLAGAGGVSEDPAAAFKREQI
HHHHHHHHCCCCCCCCHHHHHCCCCCCCCHHHHHHHHHHHHHCCCCCCCCHHHHHHHHHH
GEKIRLLYVAITRARRNLLLSYHWRNERGYDTAPPPAVVRLRQFVQARR
HHHHHHHHHHHHHHHHCCEEEEEECCCCCCCCCCCHHHHHHHHHHHHCC
>Mature Secondary Structure 
PGAGKTTVLAYLAADLIAEGRHLPGRILIVTYTNSAVGNFKNRIGQFLEARGLPRAGFE
CCCCHHHHHHHHHHHHHHCCCCCCCEEEEEEECCCHHHHHHHHHHHHHHHCCCCCCCCH
VRTIHSLAVQIVRERPEAIGWPDTFAVLDEVRRRTLVNALTAGWIAAHRDTWEALVREDV
HHHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
RNRDQALARWAEHTPELMSRLIQSFKARQLSPDDALSLTRGLPDTEPLRWAAEIYRDYQR
HHHHHHHHHHHHCCHHHHHHHHHHHHHCCCCCHHHHHHHCCCCCCCHHHHHHHHHHHHHH
ALAREGLVDFDDMMLGAYRLLTGEPDLLERLRQRWTYVFEDEAQDSYRLQEQVLRLLAGP
HHHHCCCCCHHHHHHHHHHHHCCCHHHHHHHHHHCCEEECCCCCHHHHHHHHHHHHHHCC
GGNFVRVGDPNQAIMGSFTTAEPALFRAFIREPGVDVRPLTMAGRSSQEIIDLANELVRW
CCCEEEECCCCHHHHCCCCCCHHHHHHHHHHCCCCCEEEEEECCCCHHHHHHHHHHHHHH
TCQDYPEPGCRDALEPQYIQRVPRGMGQSNPEPEGRRVLVRDFPAYEEEMDRIAGLAARS
HHHCCCCCCCCCCCCHHHHHHHHHHCCCCCCCCCCCEEEEECCCCHHHHHHHHHHHHHHH
VRLYPEATVGVLLPTHAMVDRMLALLRDREAPAIPVGRTAPLERLRLGSDLLAALAFLAA
EEECCCCCHHHEECHHHHHHHHHHHHHCCCCCCCCCCCCCCHHHHHCCHHHHHHHHHHHC
PHVPERRAAAARLEPYLDRWLADAVQPADVLLLRMAADLRLSGEDLALAQYLALRARRLL
CCCCHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHH
EEEPLYGPGDVARELADALGRSGWLADALYDRQGFEPQPGVVYVTTCHAAKGLEWDTVYV
HCCCCCCCHHHHHHHHHHHCCCCCHHHHHHHCCCCCCCCCEEEEEECCCCCCCCCCEEEE
AGLTRGFFTGGLRDRTLSEQWSLVPGQVNPEARALALLDQLAGAGGVSEDPAAAFKREQI
HHHHHHHHCCCCCCCCHHHHHCCCCCCCCHHHHHHHHHHHHHCCCCCCCCHHHHHHHHHH
GEKIRLLYVAITRARRNLLLSYHWRNERGYDTAPPPAVVRLRQFVQARR
HHHHHHHHHHHHHHHHCCEEEEEECCCCCCCCCCCHHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA