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The map label for this gene is acpS

Identifier: 51894074

GI number: 51894074

Start: 3163605

End: 3163982

Strand: Reverse

Name: acpS

Synonym: STH2938

Alternate gene names: 51894074

Gene position: 3163982-3163605 (Counterclockwise)

Preceding gene: 51894075

Following gene: 51894073

Centisome position: 88.72

GC content: 72.75

Gene sequence:

>378_bases
GTGATCCTGGGCACCGGCGTCGACATCGTGGCGGTGGAGCGGGTGGCGCGCGCCGTCGAACGCCACGGGGACCGGTTCCT
CCGGCGCGTCTTCACCCCGGGGGAGCTCGCCTACTGCACATCCAGCGAAGCGCACCGGGCGGCGCGCCTCGCGGCCCGGT
TCGCCGCGAAGGAGGCGGTGCTGAAGGCCCTGGGGATCGGGCTGCGGGAGGTGCGCTGGACCGACGCGGAGGTCTGCCGC
GACGAACGCGGCCGCCCGTCGGTGCGGCTTACGGGCCGGCTCGCCGAGATCGCCGCCGCGCGGGGCGCAACTCGCATTCA
TCTTTCCCTGTCCCATACACAGGAGTACGCGGTGGCACAGGTGGTGATCGAGGGATGA

Upstream 100 bases:

>100_bases
CTCCGCCTGGCGGGGGACGAGGCCGGGCTGGATCGCCTGGTCTAGGTCCCGGGGAGATGGGGCACGCGGGCTTCAGACAG
GTGGAAAGGGGTGGCTCGGC

Downstream 100 bases:

>100_bases
AGGTCGTTTCCGGCGAGCAGATGCGGGCGATTGAGGCGCGCCTTTTCGATCAGTACGGCTTCACCTCCGCGATCTTGATG
GAGCTGGCGGGGCGGCAGGT

Product: 4'-phosphopantetheinyl transferase

Products: NA

Alternate protein names: Holo-ACP synthase; 4'-phosphopantetheinyl transferase AcpS

Number of amino acids: Translated: 125; Mature: 125

Protein sequence:

>125_residues
MILGTGVDIVAVERVARAVERHGDRFLRRVFTPGELAYCTSSEAHRAARLAARFAAKEAVLKALGIGLREVRWTDAEVCR
DERGRPSVRLTGRLAEIAAARGATRIHLSLSHTQEYAVAQVVIEG

Sequences:

>Translated_125_residues
MILGTGVDIVAVERVARAVERHGDRFLRRVFTPGELAYCTSSEAHRAARLAARFAAKEAVLKALGIGLREVRWTDAEVCR
DERGRPSVRLTGRLAEIAAARGATRIHLSLSHTQEYAVAQVVIEG
>Mature_125_residues
MILGTGVDIVAVERVARAVERHGDRFLRRVFTPGELAYCTSSEAHRAARLAARFAAKEAVLKALGIGLREVRWTDAEVCR
DERGRPSVRLTGRLAEIAAARGATRIHLSLSHTQEYAVAQVVIEG

Specific function: Transfers the 4'-phosphopantetheine moiety from coenzyme A to a Ser of acyl-carrier-protein

COG id: COG0736

COG function: function code I; Phosphopantetheinyl transferase (holo-ACP synthase)

Gene ontology:

Cell location: Cytoplasm

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the P-Pant transferase superfamily. AcpS family

Homologues:

Organism=Escherichia coli, GI1788916, Length=125, Percent_Identity=40.8, Blast_Score=85, Evalue=1e-18,
Organism=Saccharomyces cerevisiae, GI6325025, Length=123, Percent_Identity=32.520325203252, Blast_Score=62, Evalue=3e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): ACPS_SYMTH (Q67K77)

Other databases:

- EMBL:   AP006840
- RefSeq:   YP_076765.1
- ProteinModelPortal:   Q67K77
- SMR:   Q67K77
- GeneID:   2981705
- GenomeReviews:   AP006840_GR
- KEGG:   sth:STH2938
- NMPDR:   fig|292459.1.peg.2812
- HOGENOM:   HBG734479
- OMA:   QGVFWRD
- ProtClustDB:   PRK14660
- BioCyc:   STHE292459:STH2938-MONOMER
- BRENDA:   2.7.8.7
- GO:   GO:0005737
- HAMAP:   MF_00101
- InterPro:   IPR008278
- InterPro:   IPR002582
- InterPro:   IPR004568
- ProDom:   PD004282
- TIGRFAMs:   TIGR00516
- TIGRFAMs:   TIGR00556

Pfam domain/function: PF01648 ACPS; SSF56214 4-PPT_transf

EC number: =2.7.8.7

Molecular weight: Translated: 13676; Mature: 13676

Theoretical pI: Translated: 10.40; Mature: 10.40

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.6 %Cys     (Translated Protein)
0.8 %Met     (Translated Protein)
2.4 %Cys+Met (Translated Protein)
1.6 %Cys     (Mature Protein)
0.8 %Met     (Mature Protein)
2.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MILGTGVDIVAVERVARAVERHGDRFLRRVFTPGELAYCTSSEAHRAARLAARFAAKEAV
CEECCCCHHHHHHHHHHHHHHHHHHHHHHHCCCCCEEEECCCHHHHHHHHHHHHHHHHHH
LKALGIGLREVRWTDAEVCRDERGRPSVRLTGRLAEIAAARGATRIHLSLSHTQEYAVAQ
HHHHCCCHHHHCCCCHHHHHCCCCCCCEEEHHHHHHHHHHCCCEEEEEEECCCHHHHHHE
VVIEG
EEECC
>Mature Secondary Structure
MILGTGVDIVAVERVARAVERHGDRFLRRVFTPGELAYCTSSEAHRAARLAARFAAKEAV
CEECCCCHHHHHHHHHHHHHHHHHHHHHHHCCCCCEEEECCCHHHHHHHHHHHHHHHHHH
LKALGIGLREVRWTDAEVCRDERGRPSVRLTGRLAEIAAARGATRIHLSLSHTQEYAVAQ
HHHHCCCHHHHCCCCHHHHHCCCCCCCEEEHHHHHHHHHHCCCEEEEEEECCCHHHHHHE
VVIEG
EEECC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA