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The map label for this gene is groEL

Identifier: 51894033

GI number: 51894033

Start: 3120548

End: 3122170

Strand: Reverse

Name: groEL

Synonym: STH2897

Alternate gene names: 51894033

Gene position: 3122170-3120548 (Counterclockwise)

Preceding gene: 51894034

Following gene: 51894032

Centisome position: 87.55

GC content: 66.42

Gene sequence:

>1623_bases
ATGACTGCGAAGCAGATTATCTTTGATGAGGCCGCCCGGCGCAAGCTGCAGGCCGGTGTGGACGCTCTTGCCAATACCGT
GAAGGTCACCCTCGGTCCCCGCGGCCGCAACGTCGTGCTGGACAAGAAGTTCGGCGCCCCGGCCGTCGCCAACGACGGCG
TGACGATCGCCCGTGAGATCGAGCTGGAGGATCCGTTCGAGAACATGGGCGCCCAGCTGGTGAAGGAGGTCGCCACCAAG
ACCAACGACGTCGCGGGTGACGGCACCACCACCTCCACTGTGCTGGCCCAGGCCATCGTGAAGGAGGGCCTGAAGAACGT
CACCGGCGGCGCGAACCCGATGATCCTGAAGCGGGGCATCGAGAAGGCCGTCCAGGTGGCGGTTGAGGAGCTGCGCAAGC
AGGCTATCCCCGTCGAGACCAACAAGGCCATCGCCGAGGTCGCGGCCATCTCCGCCAACAACGACCGGGAGATCGGCGAG
CTCGTGGCCAAGGCGATGGACACCGTGGGCAAGGACGGCGTGATCACCGTCGAGGAGTCCAAGACGCTCCACACCGAGCT
GGAGACCGTCGAGGGCATGCAGTTCGACCGGGGCTACGTCTCCGCCTACATGGTCACCGACACCGAGAAGATGGAGGCCG
TCCTGAACGAGCCCTACATCCTGATCACCGATAAGAAGATCTCCGCGGTCCAGGACCTGCTGCCGATCCTGGAGAAGGTC
GTGCAGCGCGGCAAGCCGCTGCTGATCATCGCGGAGGACGTCGAGGGCGAGGCGCTGGCCACCCTGGTGGTCAACAAGCT
GCGCGGCACCCTGCAGGTCGCGGCGGTCAAGGCCCCGGGCTTCGGCGACCGGCGCAAGGCCATGCTGGAGGACATCGCCA
TCCTGACCGGCGGCGAGGTCGTCTCCGAGGAGCTGGGCCGCAAGCTCGAGAACGCCACCATCGAGATGCTCGGCCAGGCC
CGCCAGGTGCGCATCGAGAAGGAGAAGACCACCATCATCGATGGCGCCGGCTCCAGCGAGGCCATCAAGAACCGGGTCGC
CGCCATCAAGCGGCAGATTGAGGAGACCACTTCGGACTTCGACCGCGAGAAGCTGCAGGAGCGGCTGGCCAAGCTGGCCG
GCGGCGTGGCGGTCATCAAGGTCGGCGCCGCCACCGAGGTCGAGCTGAAGGAGAAGAAGCTGCGCATCGAGGACGCCCTG
AACGCGACCCGTGCGGCCGTTGAGGAGGGCATCGTCGCCGGCGGCGGCGTGGCGCTGCTGCAGACCCAGAAGGCCATCGA
CGAGCTGATCAAGACGCTGGAGGGCGACGAGAAGGTCGGCGCCCAGATCGTCCGGCGTGCGGTCGAGGAGCCGCTGCGCT
GCATCGTCGAGAACGGCGGCCTCGAGGGCTCCGTCGTCGTCGAGAAGGTGCGCACCCTGCCGGTTGGCCACGGCTTCGAC
GCCATGAAGGAGGAGTACGTGGACATGGTCGCCGCCGGCATCATCGACCCGGTCAAGGTGACCCGTTCCGCCCTCCAGAA
CGCCGCTTCCATCGCTGCGCTGATCCTGACCACCGAGGCCCTGGTCACCGAGAAGCCCGAGAAGAAGGAGAACAACCCCG
CGCCCAACATGGATATGATGTAA

Upstream 100 bases:

>100_bases
CGGGCACCGAGGTCAAGATCGACGGCGAGGAGTACATCATCCTGGACGGCGAGCGGGACATTCTCGCCATCGTTCAGGGT
TAGAGGGAGGTCTTCCATAG

Downstream 100 bases:

>100_bases
TCCGGGTGCGGACAAGTGGACCCCCTGGCGCAACGCCGGGGGGTCTTCTTATCGGGGCGGGTATGGTAAGATGGCCCAAA
CGGCAGGAGGTGGCGCGATT

Product: chaperonin GroEL

Products: NA

Alternate protein names: GroEL protein; Protein Cpn60

Number of amino acids: Translated: 540; Mature: 539

Protein sequence:

>540_residues
MTAKQIIFDEAARRKLQAGVDALANTVKVTLGPRGRNVVLDKKFGAPAVANDGVTIAREIELEDPFENMGAQLVKEVATK
TNDVAGDGTTTSTVLAQAIVKEGLKNVTGGANPMILKRGIEKAVQVAVEELRKQAIPVETNKAIAEVAAISANNDREIGE
LVAKAMDTVGKDGVITVEESKTLHTELETVEGMQFDRGYVSAYMVTDTEKMEAVLNEPYILITDKKISAVQDLLPILEKV
VQRGKPLLIIAEDVEGEALATLVVNKLRGTLQVAAVKAPGFGDRRKAMLEDIAILTGGEVVSEELGRKLENATIEMLGQA
RQVRIEKEKTTIIDGAGSSEAIKNRVAAIKRQIEETTSDFDREKLQERLAKLAGGVAVIKVGAATEVELKEKKLRIEDAL
NATRAAVEEGIVAGGGVALLQTQKAIDELIKTLEGDEKVGAQIVRRAVEEPLRCIVENGGLEGSVVVEKVRTLPVGHGFD
AMKEEYVDMVAAGIIDPVKVTRSALQNAASIAALILTTEALVTEKPEKKENNPAPNMDMM

Sequences:

>Translated_540_residues
MTAKQIIFDEAARRKLQAGVDALANTVKVTLGPRGRNVVLDKKFGAPAVANDGVTIAREIELEDPFENMGAQLVKEVATK
TNDVAGDGTTTSTVLAQAIVKEGLKNVTGGANPMILKRGIEKAVQVAVEELRKQAIPVETNKAIAEVAAISANNDREIGE
LVAKAMDTVGKDGVITVEESKTLHTELETVEGMQFDRGYVSAYMVTDTEKMEAVLNEPYILITDKKISAVQDLLPILEKV
VQRGKPLLIIAEDVEGEALATLVVNKLRGTLQVAAVKAPGFGDRRKAMLEDIAILTGGEVVSEELGRKLENATIEMLGQA
RQVRIEKEKTTIIDGAGSSEAIKNRVAAIKRQIEETTSDFDREKLQERLAKLAGGVAVIKVGAATEVELKEKKLRIEDAL
NATRAAVEEGIVAGGGVALLQTQKAIDELIKTLEGDEKVGAQIVRRAVEEPLRCIVENGGLEGSVVVEKVRTLPVGHGFD
AMKEEYVDMVAAGIIDPVKVTRSALQNAASIAALILTTEALVTEKPEKKENNPAPNMDMM
>Mature_539_residues
TAKQIIFDEAARRKLQAGVDALANTVKVTLGPRGRNVVLDKKFGAPAVANDGVTIAREIELEDPFENMGAQLVKEVATKT
NDVAGDGTTTSTVLAQAIVKEGLKNVTGGANPMILKRGIEKAVQVAVEELRKQAIPVETNKAIAEVAAISANNDREIGEL
VAKAMDTVGKDGVITVEESKTLHTELETVEGMQFDRGYVSAYMVTDTEKMEAVLNEPYILITDKKISAVQDLLPILEKVV
QRGKPLLIIAEDVEGEALATLVVNKLRGTLQVAAVKAPGFGDRRKAMLEDIAILTGGEVVSEELGRKLENATIEMLGQAR
QVRIEKEKTTIIDGAGSSEAIKNRVAAIKRQIEETTSDFDREKLQERLAKLAGGVAVIKVGAATEVELKEKKLRIEDALN
ATRAAVEEGIVAGGGVALLQTQKAIDELIKTLEGDEKVGAQIVRRAVEEPLRCIVENGGLEGSVVVEKVRTLPVGHGFDA
MKEEYVDMVAAGIIDPVKVTRSALQNAASIAALILTTEALVTEKPEKKENNPAPNMDMM

Specific function: Prevents misfolding and promotes the refolding and proper assembly of unfolded polypeptides generated under stress conditions

COG id: COG0459

COG function: function code O; Chaperonin GroEL (HSP60 family)

Gene ontology:

Cell location: Cytoplasm

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the chaperonin (HSP60) family

Homologues:

Organism=Homo sapiens, GI41399285, Length=532, Percent_Identity=49.812030075188, Blast_Score=506, Evalue=1e-143,
Organism=Homo sapiens, GI31542947, Length=532, Percent_Identity=49.812030075188, Blast_Score=506, Evalue=1e-143,
Organism=Homo sapiens, GI5453607, Length=533, Percent_Identity=22.7016885553471, Blast_Score=84, Evalue=3e-16,
Organism=Escherichia coli, GI1790586, Length=527, Percent_Identity=63.5673624288425, Blast_Score=645, Evalue=0.0,
Organism=Caenorhabditis elegans, GI17555558, Length=527, Percent_Identity=47.8178368121442, Blast_Score=485, Evalue=1e-137,
Organism=Caenorhabditis elegans, GI193210679, Length=240, Percent_Identity=45.8333333333333, Blast_Score=192, Evalue=5e-49,
Organism=Caenorhabditis elegans, GI17564182, Length=530, Percent_Identity=23.0188679245283, Blast_Score=79, Evalue=9e-15,
Organism=Caenorhabditis elegans, GI25144674, Length=176, Percent_Identity=30.6818181818182, Blast_Score=67, Evalue=3e-11,
Organism=Caenorhabditis elegans, GI25147750, Length=131, Percent_Identity=33.587786259542, Blast_Score=65, Evalue=8e-11,
Organism=Saccharomyces cerevisiae, GI6323288, Length=527, Percent_Identity=51.4231499051233, Blast_Score=525, Evalue=1e-149,
Organism=Saccharomyces cerevisiae, GI6322350, Length=543, Percent_Identity=22.4677716390424, Blast_Score=74, Evalue=8e-14,
Organism=Saccharomyces cerevisiae, GI6322524, Length=584, Percent_Identity=21.4041095890411, Blast_Score=70, Evalue=1e-12,
Organism=Drosophila melanogaster, GI24641193, Length=526, Percent_Identity=50, Blast_Score=510, Evalue=1e-145,
Organism=Drosophila melanogaster, GI24641191, Length=526, Percent_Identity=50, Blast_Score=510, Evalue=1e-145,
Organism=Drosophila melanogaster, GI45550936, Length=525, Percent_Identity=46.8571428571429, Blast_Score=483, Evalue=1e-136,
Organism=Drosophila melanogaster, GI45550132, Length=525, Percent_Identity=46.8571428571429, Blast_Score=483, Evalue=1e-136,
Organism=Drosophila melanogaster, GI45550935, Length=525, Percent_Identity=46.8571428571429, Blast_Score=483, Evalue=1e-136,
Organism=Drosophila melanogaster, GI17864606, Length=526, Percent_Identity=42.7756653992395, Blast_Score=417, Evalue=1e-117,
Organism=Drosophila melanogaster, GI24584129, Length=528, Percent_Identity=35.2272727272727, Blast_Score=306, Evalue=3e-83,
Organism=Drosophila melanogaster, GI19921262, Length=528, Percent_Identity=35.2272727272727, Blast_Score=306, Evalue=3e-83,
Organism=Drosophila melanogaster, GI24645179, Length=531, Percent_Identity=23.3521657250471, Blast_Score=85, Evalue=1e-16,
Organism=Drosophila melanogaster, GI17647245, Length=569, Percent_Identity=23.5500878734622, Blast_Score=70, Evalue=3e-12,
Organism=Drosophila melanogaster, GI24652903, Length=542, Percent_Identity=23.4317343173432, Blast_Score=68, Evalue=2e-11,

Paralogues:

None

Copy number: 2180 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). 360 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). 480 Molecules/Cell In: Stationary Phase, Rich Media (Based on E. coli). 15012 Molecules/Cell In: Growth Phase,

Swissprot (AC and ID): CH60_SYMTH (Q67KB8)

Other databases:

- EMBL:   AP006840
- RefSeq:   YP_076724.1
- ProteinModelPortal:   Q67KB8
- SMR:   Q67KB8
- GeneID:   2980018
- GenomeReviews:   AP006840_GR
- KEGG:   sth:STH2897
- NMPDR:   fig|292459.1.peg.2771
- HOGENOM:   HBG625289
- OMA:   ATDKYED
- BioCyc:   STHE292459:STH2897-MONOMER
- GO:   GO:0005737
- HAMAP:   MF_00600
- InterPro:   IPR018370
- InterPro:   IPR001844
- InterPro:   IPR002423
- PANTHER:   PTHR11353
- PRINTS:   PR00298
- TIGRFAMs:   TIGR02348

Pfam domain/function: PF00118 Cpn60_TCP1; SSF48592 GroEL-ATPase

EC number: NA

Molecular weight: Translated: 57899; Mature: 57767

Theoretical pI: Translated: 4.79; Mature: 4.79

Prosite motif: PS00296 CHAPERONINS_CPN60

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.2 %Cys     (Translated Protein)
2.6 %Met     (Translated Protein)
2.8 %Cys+Met (Translated Protein)
0.2 %Cys     (Mature Protein)
2.4 %Met     (Mature Protein)
2.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTAKQIIFDEAARRKLQAGVDALANTVKVTLGPRGRNVVLDKKFGAPAVANDGVTIAREI
CCCHHHHHHHHHHHHHHHHHHHHHHCEEEEECCCCCEEEEECCCCCCCCCCCCCEEEEEE
ELEDPFENMGAQLVKEVATKTNDVAGDGTTTSTVLAQAIVKEGLKNVTGGANPMILKRGI
ECCCCHHHHHHHHHHHHHHCCCCCCCCCCHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHH
EKAVQVAVEELRKQAIPVETNKAIAEVAAISANNDREIGELVAKAMDTVGKDGVITVEES
HHHHHHHHHHHHHHCCCCCCHHHHHHHHHHCCCCCHHHHHHHHHHHHHCCCCCEEEEECC
KTLHTELETVEGMQFDRGYVSAYMVTDTEKMEAVLNEPYILITDKKISAVQDLLPILEKV
CHHHHHHHHHCCCEECCCEEEEEEEECHHHHHHHHCCCEEEEECCHHHHHHHHHHHHHHH
VQRGKPLLIIAEDVEGEALATLVVNKLRGTLQVAAVKAPGFGDRRKAMLEDIAILTGGEV
HHCCCCEEEEEECCCCHHHHHHHHHHHCCCEEEEEEECCCCCHHHHHHHHHHHHHCCCHH
VSEELGRKLENATIEMLGQARQVRIEKEKTTIIDGAGSSEAIKNRVAAIKRQIEETTSDF
HHHHHHHHHHHHHHHHHCCHHHEEEECCCEEEEECCCCHHHHHHHHHHHHHHHHHHHHHH
DREKLQERLAKLAGGVAVIKVGAATEVELKEKKLRIEDALNATRAAVEEGIVAGGGVALL
HHHHHHHHHHHHHCCEEEEEECCCCCHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCHHHH
QTQKAIDELIKTLEGDEKVGAQIVRRAVEEPLRCIVENGGLEGSVVVEKVRTLPVGHGFD
HHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHCCCCCCHH
AMKEEYVDMVAAGIIDPVKVTRSALQNAASIAALILTTEALVTEKPEKKENNPAPNMDMM
HHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCC
>Mature Secondary Structure 
TAKQIIFDEAARRKLQAGVDALANTVKVTLGPRGRNVVLDKKFGAPAVANDGVTIAREI
CCHHHHHHHHHHHHHHHHHHHHHHCEEEEECCCCCEEEEECCCCCCCCCCCCCEEEEEE
ELEDPFENMGAQLVKEVATKTNDVAGDGTTTSTVLAQAIVKEGLKNVTGGANPMILKRGI
ECCCCHHHHHHHHHHHHHHCCCCCCCCCCHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHH
EKAVQVAVEELRKQAIPVETNKAIAEVAAISANNDREIGELVAKAMDTVGKDGVITVEES
HHHHHHHHHHHHHHCCCCCCHHHHHHHHHHCCCCCHHHHHHHHHHHHHCCCCCEEEEECC
KTLHTELETVEGMQFDRGYVSAYMVTDTEKMEAVLNEPYILITDKKISAVQDLLPILEKV
CHHHHHHHHHCCCEECCCEEEEEEEECHHHHHHHHCCCEEEEECCHHHHHHHHHHHHHHH
VQRGKPLLIIAEDVEGEALATLVVNKLRGTLQVAAVKAPGFGDRRKAMLEDIAILTGGEV
HHCCCCEEEEEECCCCHHHHHHHHHHHCCCEEEEEEECCCCCHHHHHHHHHHHHHCCCHH
VSEELGRKLENATIEMLGQARQVRIEKEKTTIIDGAGSSEAIKNRVAAIKRQIEETTSDF
HHHHHHHHHHHHHHHHHCCHHHEEEECCCEEEEECCCCHHHHHHHHHHHHHHHHHHHHHH
DREKLQERLAKLAGGVAVIKVGAATEVELKEKKLRIEDALNATRAAVEEGIVAGGGVALL
HHHHHHHHHHHHHCCEEEEEECCCCCHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCHHHH
QTQKAIDELIKTLEGDEKVGAQIVRRAVEEPLRCIVENGGLEGSVVVEKVRTLPVGHGFD
HHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHCCCCCCHH
AMKEEYVDMVAAGIIDPVKVTRSALQNAASIAALILTTEALVTEKPEKKENNPAPNMDMM
HHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA