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The map label for this gene is purM

Identifier: 51893991

GI number: 51893991

Start: 3074675

End: 3075736

Strand: Reverse

Name: purM

Synonym: STH2853

Alternate gene names: 51893991

Gene position: 3075736-3074675 (Counterclockwise)

Preceding gene: 51893992

Following gene: 51893990

Centisome position: 86.25

GC content: 73.07

Gene sequence:

>1062_bases
GTGACTGAGAAGGGGCTCACCTACGCCGACGCCGGCGTCAACCGGGAGCGGCACTACGAACTGGTGCGGCGGATCGCCGC
CCACACGGCCCGCACCCTCCGGCGGCCCGGTACCCTGGGCAACATCGGGGCCTTCGGCGGCCTGTTCCAGCTGGACCCGG
CCAGGTACCCCGAGCCGGTGCTGGTCAGCGGCACCGACGGGGTGGGCACCAAGCTGCGGCTGGCGTTCCTGAGCGGCCGG
CACGACACGGTGGGCATCGACCTGGTGGCCATGTCGGTGAACGACATCCTCTGCCAGGGAGCGGAACCGCTCTTCTTCCT
GGACTACATCGGCATCGGGCAGAAGGACCTGGCCGTGCTGGAGCAGGTGGTGAAGGGCATCGCCGACGGCTGCCTGCAGG
CCGGCTGTGCCCTGATCGGCGGCGAGACCGCCGAGCTGCCCGGCATGTACCCGCCCGGCGAGTACGACCTGGCGGGGTTC
GCCGTGGGCATCGTCAACCGGGACCGGCTCCTCACCGGCGAGAAGGTCGCGCCGGGGGACGCGCTGGTGGGCCTCGCCTC
CAGCGGGCTGCACGCCAACGGGTACTCGCTGGCCCGGCGGGTGCTGCTGAAGGTGGACGGCGGCGCCTTCGACCTGGATG
ACCGGCCGCCCGAGCTGGGCGGCCGGACGGTGCTGGAGGTCATGCTGACCCCGACCCGCATCTACGTCCGCACGGTGCTC
CGGCTGCTGGCGCGGTTCGACGTGCACGGCATCGCCAACATCACCGGGGGCGGGCTGCACGAGAACATCCCGCGCATGCT
GCCCGAGGGCACGGCCGCCGTGCTGCGGCGGGGCGCCTGGAAGGAGCCGCCGGTTTTCGACCTCATCCGGCGGCTGGGGC
CCGTGGCGCAGGCGGAGATGGAGGCCACCTTCAACCTCGGCCTCGGGATGGTGCTGGCGGTGCCGGCGGACCAGGCCGAG
GCGGTTGCGGCCGCCGCGCGGGAGTTGGGCGAGGAGGCGTGGGTTGTGGGTGAGGTCGCGGCCGCCGAGCCCGGCGGTCC
GAGGGTGGTGGTGCGGCGATGA

Upstream 100 bases:

>100_bases
TCGCCGGAAGCGGGCTTCTGCCTGGCCTGCTTCACCGGCGACTACCCGGTGCCCGTGCCGGAAGAGGCCGACAAGTACGC
GCTGGAGGGGGGCTGCGGCT

Downstream 100 bases:

>100_bases
TCCGCATCGGCGTGTTGATCTCCGGCTCGGGCACCAACCTGCAGGCGATCCTGGACGGCTGCCGGGAGGGGCGCATCCCC
GGCCGGGTGGCGGTGGTCAT

Product: phosphoribosylaminoimidazole synthetase

Products: NA

Alternate protein names: AIR synthase; AIRS; Phosphoribosyl-aminoimidazole synthetase

Number of amino acids: Translated: 353; Mature: 352

Protein sequence:

>353_residues
MTEKGLTYADAGVNRERHYELVRRIAAHTARTLRRPGTLGNIGAFGGLFQLDPARYPEPVLVSGTDGVGTKLRLAFLSGR
HDTVGIDLVAMSVNDILCQGAEPLFFLDYIGIGQKDLAVLEQVVKGIADGCLQAGCALIGGETAELPGMYPPGEYDLAGF
AVGIVNRDRLLTGEKVAPGDALVGLASSGLHANGYSLARRVLLKVDGGAFDLDDRPPELGGRTVLEVMLTPTRIYVRTVL
RLLARFDVHGIANITGGGLHENIPRMLPEGTAAVLRRGAWKEPPVFDLIRRLGPVAQAEMEATFNLGLGMVLAVPADQAE
AVAAAARELGEEAWVVGEVAAAEPGGPRVVVRR

Sequences:

>Translated_353_residues
MTEKGLTYADAGVNRERHYELVRRIAAHTARTLRRPGTLGNIGAFGGLFQLDPARYPEPVLVSGTDGVGTKLRLAFLSGR
HDTVGIDLVAMSVNDILCQGAEPLFFLDYIGIGQKDLAVLEQVVKGIADGCLQAGCALIGGETAELPGMYPPGEYDLAGF
AVGIVNRDRLLTGEKVAPGDALVGLASSGLHANGYSLARRVLLKVDGGAFDLDDRPPELGGRTVLEVMLTPTRIYVRTVL
RLLARFDVHGIANITGGGLHENIPRMLPEGTAAVLRRGAWKEPPVFDLIRRLGPVAQAEMEATFNLGLGMVLAVPADQAE
AVAAAARELGEEAWVVGEVAAAEPGGPRVVVRR
>Mature_352_residues
TEKGLTYADAGVNRERHYELVRRIAAHTARTLRRPGTLGNIGAFGGLFQLDPARYPEPVLVSGTDGVGTKLRLAFLSGRH
DTVGIDLVAMSVNDILCQGAEPLFFLDYIGIGQKDLAVLEQVVKGIADGCLQAGCALIGGETAELPGMYPPGEYDLAGFA
VGIVNRDRLLTGEKVAPGDALVGLASSGLHANGYSLARRVLLKVDGGAFDLDDRPPELGGRTVLEVMLTPTRIYVRTVLR
LLARFDVHGIANITGGGLHENIPRMLPEGTAAVLRRGAWKEPPVFDLIRRLGPVAQAEMEATFNLGLGMVLAVPADQAEA
VAAAARELGEEAWVVGEVAAAEPGGPRVVVRR

Specific function: De novo purine biosynthesis; fifth step. [C]

COG id: COG0150

COG function: function code F; Phosphoribosylaminoimidazole (AIR) synthetase

Gene ontology:

Cell location: Cytoplasm

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the AIR synthase family

Homologues:

Organism=Homo sapiens, GI4503915, Length=352, Percent_Identity=49.4318181818182, Blast_Score=330, Evalue=1e-90,
Organism=Homo sapiens, GI209869995, Length=352, Percent_Identity=49.4318181818182, Blast_Score=330, Evalue=1e-90,
Organism=Homo sapiens, GI209869993, Length=352, Percent_Identity=49.4318181818182, Blast_Score=330, Evalue=1e-90,
Organism=Escherichia coli, GI1788845, Length=353, Percent_Identity=50.7082152974504, Blast_Score=344, Evalue=4e-96,
Organism=Caenorhabditis elegans, GI17567511, Length=346, Percent_Identity=39.3063583815029, Blast_Score=223, Evalue=2e-58,
Organism=Saccharomyces cerevisiae, GI6321203, Length=356, Percent_Identity=45.2247191011236, Blast_Score=288, Evalue=6e-79,
Organism=Drosophila melanogaster, GI24582400, Length=305, Percent_Identity=43.6065573770492, Blast_Score=228, Evalue=5e-60,

Paralogues:

None

Copy number: 180 Molecules/Cell In: Growth-Phase, Minimal-Media (Based on E. coli). [C]

Swissprot (AC and ID): PUR5_SYMTH (Q67KG0)

Other databases:

- EMBL:   AP006840
- RefSeq:   YP_076682.1
- HSSP:   P08178
- ProteinModelPortal:   Q67KG0
- SMR:   Q67KG0
- GeneID:   2980448
- GenomeReviews:   AP006840_GR
- KEGG:   sth:STH2853
- NMPDR:   fig|292459.1.peg.2728
- HOGENOM:   HBG531222
- OMA:   GIDMIAM
- ProtClustDB:   PRK05385
- BioCyc:   STHE292459:STH2853-MONOMER
- BRENDA:   6.3.3.1
- GO:   GO:0005737
- HAMAP:   MF_00741_B
- InterPro:   IPR000728
- InterPro:   IPR010918
- InterPro:   IPR004733
- InterPro:   IPR016188
- TIGRFAMs:   TIGR00878

Pfam domain/function: PF00586 AIRS; PF02769 AIRS_C; SSF56042 AIR_synth_C; SSF55326 PurM_N-like

EC number: =6.3.3.1

Molecular weight: Translated: 37410; Mature: 37278

Theoretical pI: Translated: 5.71; Mature: 5.71

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.8 %Cys     (Translated Protein)
2.0 %Met     (Translated Protein)
2.8 %Cys+Met (Translated Protein)
0.9 %Cys     (Mature Protein)
1.7 %Met     (Mature Protein)
2.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTEKGLTYADAGVNRERHYELVRRIAAHTARTLRRPGTLGNIGAFGGLFQLDPARYPEPV
CCCCCCEEECCCCCHHHHHHHHHHHHHHHHHHHHCCCCCCCHHHCCCEEEECCCCCCCCE
LVSGTDGVGTKLRLAFLSGRHDTVGIDLVAMSVNDILCQGAEPLFFLDYIGIGQKDLAVL
EEECCCCCCCEEEEEEECCCCCEEEEEEEEEEHHHHHHCCCCCEEEEEECCCCHHHHHHH
EQVVKGIADGCLQAGCALIGGETAELPGMYPPGEYDLAGFAVGIVNRDRLLTGEKVAPGD
HHHHHHHHHHHHHHCHHHCCCCCCCCCCCCCCCCCCCCEEEEEEECCCCEECCCCCCCCH
ALVGLASSGLHANGYSLARRVLLKVDGGAFDLDDRPPELGGRTVLEVMLTPTRIYVRTVL
HHHHHHCCCCCCCHHHHHHHHHEEECCCEECCCCCCCCCCCCEEEHHHHCCHHHHHHHHH
RLLARFDVHGIANITGGGLHENIPRMLPEGTAAVLRRGAWKEPPVFDLIRRLGPVAQAEM
HHHHHHCCCCCCCCCCCCHHHHHHHHCCCCHHHHHHCCCCCCCCHHHHHHHHCCHHHHHH
EATFNLGLGMVLAVPADQAEAVAAAARELGEEAWVVGEVAAAEPGGPRVVVRR
HHHHCCCCEEEEEECCCHHHHHHHHHHHHCCHHEEEEEECCCCCCCCEEEEEC
>Mature Secondary Structure 
TEKGLTYADAGVNRERHYELVRRIAAHTARTLRRPGTLGNIGAFGGLFQLDPARYPEPV
CCCCCEEECCCCCHHHHHHHHHHHHHHHHHHHHCCCCCCCHHHCCCEEEECCCCCCCCE
LVSGTDGVGTKLRLAFLSGRHDTVGIDLVAMSVNDILCQGAEPLFFLDYIGIGQKDLAVL
EEECCCCCCCEEEEEEECCCCCEEEEEEEEEEHHHHHHCCCCCEEEEEECCCCHHHHHHH
EQVVKGIADGCLQAGCALIGGETAELPGMYPPGEYDLAGFAVGIVNRDRLLTGEKVAPGD
HHHHHHHHHHHHHHCHHHCCCCCCCCCCCCCCCCCCCCEEEEEEECCCCEECCCCCCCCH
ALVGLASSGLHANGYSLARRVLLKVDGGAFDLDDRPPELGGRTVLEVMLTPTRIYVRTVL
HHHHHHCCCCCCCHHHHHHHHHEEECCCEECCCCCCCCCCCCEEEHHHHCCHHHHHHHHH
RLLARFDVHGIANITGGGLHENIPRMLPEGTAAVLRRGAWKEPPVFDLIRRLGPVAQAEM
HHHHHHCCCCCCCCCCCCHHHHHHHHCCCCHHHHHHCCCCCCCCHHHHHHHHCCHHHHHH
EATFNLGLGMVLAVPADQAEAVAAAARELGEEAWVVGEVAAAEPGGPRVVVRR
HHHHCCCCEEEEEECCCHHHHHHHHHHHHCCHHEEEEEECCCCCCCCEEEEEC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA