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The map label for this gene is purH

Identifier: 51893988

GI number: 51893988

Start: 3071788

End: 3073410

Strand: Reverse

Name: purH

Synonym: STH2850

Alternate gene names: 51893988

Gene position: 3073410-3071788 (Counterclockwise)

Preceding gene: 51893989

Following gene: 51893987

Centisome position: 86.18

GC content: 70.12

Gene sequence:

>1623_bases
GTGAAGCGCGCCCTGATCAGCGTCTACGACAAGCAGGGGATCGTGGAGTTCGCACGGGGGCTGGCCGACCTGGGGGTGGA
GATCATCTCCACGGGCGGTACGTACCGCACGCTGCAGGGAGCGGGCATTCCCGTGCGGGAGGTGGCCGAGGTGGCCGGTT
TCCCGGAGATCCTGGACGGGCGGGTGAAGAGCCTGCAGCCGCAGATCCACGCGGGGATCCTGGCGATGCGCGCCAACCCC
ACCCACATGGCGCAGCTGGCCGAGCACGGAATCGGCCTCATCGACCTGGTGGTGGTCAACCTGTATCCCTTCCGGGAGAC
GGTGGCCAACCCCGCGGTGACCCTGGAGGAGGCCATCGAGAAGATCGACATCGGCGGGCCCGCGATGGTGCGGGCGGCGG
CGAAGAATTACCAGGACGTGGGGGTCGTCGTAAACCCGGCGCGCTACCCCGCCGTGCTGGCCGAGCTGCGGGAGACGGGC
GACCTGTCGCTGCCGACCCGGTTCAGCCTGATGCTGGAAGCCTTCCAGCACACGGCCGCGTACGACGGCGCCATCGCCGG
CTGGATGGCCACGCGGGGCAGGGAGATCGTCGCCACCCGGGCCTTGGGGGAGACGGCCCCCGAACGACCCATCGGAGCGG
ACCCGGGCCCGCAGAAGCCGGCCGCGCCCTCTCCCTTCCCGGATGTCCTGAGCCTCACGTTCACCAAGGTGCAGGAGCTG
CGCTACGGCGAGAACCCGCACCAGGCGGCGGCGTTCTACAGCGACGGATCCGACGGGGGCACGGTGATCGCCCGGGCGAA
GCAGCTGCACGGCAAGGAGCTCTCGTTCAACAACATCAACGACGCCCACGCGGCCCTGGAGCTGGTGAAGGAGTTCGAGG
AGCCGGCCGCGGTGGCGATCAAGCATGCCAACCCCTGCGGCGTGGCCGTGGCCCCGACCATCGCCGAGGCGTTCCGCAAG
GCCTACGAGGCCGACACCGTGTCGATCTTCGGGGGCATCGTCGCGCTGAACCGGCCCTGCGACCGGGAGACCGCCGAGGC
GCTGAGCAAGATCTTCCTGGAGATCGTGATCGCCCCGGCGTTTGCGCCGGAAGCCCTGGAGGTGCTCACCAGGAAGAAGA
ACCTGCGGCTCCTGGCGGTGGGGCCGATCGACCGCAATCCGCCGTCCGGGTTCGACATGAAGCGGGTCGGCGGTGGCCTG
CTGGTCCAGAGCTGGGACGCGATCGCCGAGGACCCGGTGGCCTGGAAGCCGGTGACCAAGGCCGCACCCACGCCGGAACA
GCTGCGCGACCTGGCCTTTGCCATGAAGGTGTGCAAGCACGTCAAGTCCAACGCCATCGTGGTGGCCAGGGACGGCCAGA
CCCTGGGCGTGGGCGCGGGGCAGATGAACCGCATTGACGCGGCGCGGTTCGCCCTCCGGCAGGCCGGGGAGAAGGCCCGC
GGGGCGGTGCTGGCCTCGGACGCCTTTTTCCCCTTCCCGGACGTGGTGGAGGCGGCCGGCGAGGCGGGTATCGCGGCCAT
CGTGCAGCCGGGCGGGTCGATCCGGGACGAGGAGTCGATCGCCAGGGCGGACGAGCTGGGTCTGGCGATGGTGTTTACGG
GCGTGCGGCACTTCCGGCACTGA

Upstream 100 bases:

>100_bases
TCGCCGGCCACGAGCGGCGCTATTGGTTGGACCGGGACGGGTACCGCCCGGAGCTGGGGAAGGGGCCGGACCGGAAGGGG
AAGGAGGAAAACGGATGGCA

Downstream 100 bases:

>100_bases
GCGGCGGTAACCTGAGCCGCCCCTGCCCGCTGGCCGGGGGCTCTCGTGCACGTCCAGCGATCAGATGTCAGGGCGCCGGC
AGGGGGTCTGGCGCCGGGCG

Product: phosphoribosylaminoimidazole carboxy formyl formyltransferase; inosine-monophosphate cyclohydrolase

Products: NA

Alternate protein names: Phosphoribosylaminoimidazolecarboxamide formyltransferase; AICAR transformylase; IMP cyclohydrolase; ATIC; IMP synthase; Inosinicase

Number of amino acids: Translated: 540; Mature: 540

Protein sequence:

>540_residues
MKRALISVYDKQGIVEFARGLADLGVEIISTGGTYRTLQGAGIPVREVAEVAGFPEILDGRVKSLQPQIHAGILAMRANP
THMAQLAEHGIGLIDLVVVNLYPFRETVANPAVTLEEAIEKIDIGGPAMVRAAAKNYQDVGVVVNPARYPAVLAELRETG
DLSLPTRFSLMLEAFQHTAAYDGAIAGWMATRGREIVATRALGETAPERPIGADPGPQKPAAPSPFPDVLSLTFTKVQEL
RYGENPHQAAAFYSDGSDGGTVIARAKQLHGKELSFNNINDAHAALELVKEFEEPAAVAIKHANPCGVAVAPTIAEAFRK
AYEADTVSIFGGIVALNRPCDRETAEALSKIFLEIVIAPAFAPEALEVLTRKKNLRLLAVGPIDRNPPSGFDMKRVGGGL
LVQSWDAIAEDPVAWKPVTKAAPTPEQLRDLAFAMKVCKHVKSNAIVVARDGQTLGVGAGQMNRIDAARFALRQAGEKAR
GAVLASDAFFPFPDVVEAAGEAGIAAIVQPGGSIRDEESIARADELGLAMVFTGVRHFRH

Sequences:

>Translated_540_residues
MKRALISVYDKQGIVEFARGLADLGVEIISTGGTYRTLQGAGIPVREVAEVAGFPEILDGRVKSLQPQIHAGILAMRANP
THMAQLAEHGIGLIDLVVVNLYPFRETVANPAVTLEEAIEKIDIGGPAMVRAAAKNYQDVGVVVNPARYPAVLAELRETG
DLSLPTRFSLMLEAFQHTAAYDGAIAGWMATRGREIVATRALGETAPERPIGADPGPQKPAAPSPFPDVLSLTFTKVQEL
RYGENPHQAAAFYSDGSDGGTVIARAKQLHGKELSFNNINDAHAALELVKEFEEPAAVAIKHANPCGVAVAPTIAEAFRK
AYEADTVSIFGGIVALNRPCDRETAEALSKIFLEIVIAPAFAPEALEVLTRKKNLRLLAVGPIDRNPPSGFDMKRVGGGL
LVQSWDAIAEDPVAWKPVTKAAPTPEQLRDLAFAMKVCKHVKSNAIVVARDGQTLGVGAGQMNRIDAARFALRQAGEKAR
GAVLASDAFFPFPDVVEAAGEAGIAAIVQPGGSIRDEESIARADELGLAMVFTGVRHFRH
>Mature_540_residues
MKRALISVYDKQGIVEFARGLADLGVEIISTGGTYRTLQGAGIPVREVAEVAGFPEILDGRVKSLQPQIHAGILAMRANP
THMAQLAEHGIGLIDLVVVNLYPFRETVANPAVTLEEAIEKIDIGGPAMVRAAAKNYQDVGVVVNPARYPAVLAELRETG
DLSLPTRFSLMLEAFQHTAAYDGAIAGWMATRGREIVATRALGETAPERPIGADPGPQKPAAPSPFPDVLSLTFTKVQEL
RYGENPHQAAAFYSDGSDGGTVIARAKQLHGKELSFNNINDAHAALELVKEFEEPAAVAIKHANPCGVAVAPTIAEAFRK
AYEADTVSIFGGIVALNRPCDRETAEALSKIFLEIVIAPAFAPEALEVLTRKKNLRLLAVGPIDRNPPSGFDMKRVGGGL
LVQSWDAIAEDPVAWKPVTKAAPTPEQLRDLAFAMKVCKHVKSNAIVVARDGQTLGVGAGQMNRIDAARFALRQAGEKAR
GAVLASDAFFPFPDVVEAAGEAGIAAIVQPGGSIRDEESIARADELGLAMVFTGVRHFRH

Specific function: De novo purine biosynthesis; ninth step. De novo purine biosynthesis; tenth step. [C]

COG id: COG0138

COG function: function code F; AICAR transformylase/IMP cyclohydrolase PurH (only IMP cyclohydrolase domain in Aful)

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the purH family

Homologues:

Organism=Homo sapiens, GI20127454, Length=505, Percent_Identity=37.8217821782178, Blast_Score=276, Evalue=5e-74,
Organism=Escherichia coli, GI1790439, Length=545, Percent_Identity=50.0917431192661, Blast_Score=507, Evalue=1e-145,
Organism=Caenorhabditis elegans, GI71985564, Length=510, Percent_Identity=34.1176470588235, Blast_Score=236, Evalue=2e-62,
Organism=Caenorhabditis elegans, GI71985574, Length=344, Percent_Identity=28.4883720930233, Blast_Score=91, Evalue=2e-18,
Organism=Saccharomyces cerevisiae, GI6323056, Length=500, Percent_Identity=35.6, Blast_Score=250, Evalue=5e-67,
Organism=Saccharomyces cerevisiae, GI6323768, Length=508, Percent_Identity=34.8425196850394, Blast_Score=245, Evalue=1e-65,
Organism=Drosophila melanogaster, GI24649832, Length=507, Percent_Identity=37.2781065088757, Blast_Score=285, Evalue=5e-77,

Paralogues:

None

Copy number: 160 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). 640 Molecules/Cell In: Growth-Phase, Minimal-Media (Based on E. coli). [C]

Swissprot (AC and ID): PUR9_SYMTH (Q67KG3)

Other databases:

- EMBL:   AP006840
- RefSeq:   YP_076679.1
- HSSP:   P31939
- ProteinModelPortal:   Q67KG3
- SMR:   Q67KG3
- GeneID:   2980007
- GenomeReviews:   AP006840_GR
- KEGG:   sth:STH2850
- NMPDR:   fig|292459.1.peg.2725
- HOGENOM:   HBG498048
- OMA:   ASDGFFP
- BioCyc:   STHE292459:STH2850-MONOMER
- BRENDA:   2.1.2.3
- BRENDA:   3.5.4.10
- HAMAP:   MF_00139
- InterPro:   IPR002695
- InterPro:   IPR013982
- InterPro:   IPR016193
- InterPro:   IPR011607
- Gene3D:   G3DSA:3.40.50.1380
- PANTHER:   PTHR11692
- PIRSF:   PIRSF000414
- SMART:   SM00798
- SMART:   SM00851
- TIGRFAMs:   TIGR00355

Pfam domain/function: PF01808 AICARFT_IMPCHas; PF02142 MGS; SSF53927 Cytidine_deaminase-like; SSF52335 MGS-like_dom

EC number: =2.1.2.3; =3.5.4.10

Molecular weight: Translated: 57508; Mature: 57508

Theoretical pI: Translated: 6.16; Mature: 6.16

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.6 %Cys     (Translated Protein)
1.9 %Met     (Translated Protein)
2.4 %Cys+Met (Translated Protein)
0.6 %Cys     (Mature Protein)
1.9 %Met     (Mature Protein)
2.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKRALISVYDKQGIVEFARGLADLGVEIISTGGTYRTLQGAGIPVREVAEVAGFPEILDG
CCCCHHHHHHHCCHHHHHHHHHHCCHHEEECCCCEEEECCCCCCHHHHHHHCCCHHHHHH
RVKSLQPQIHAGILAMRANPTHMAQLAEHGIGLIDLVVVNLYPFRETVANPAVTLEEAIE
HHHHCCCHHHHCEEEEECCHHHHHHHHHCCCCHHHHHHHHHCHHHHHHCCCCHHHHHHHH
KIDIGGPAMVRAAAKNYQDVGVVVNPARYPAVLAELRETGDLSLPTRFSLMLEAFQHTAA
HHCCCCHHHHHHHHCCCCCCCEEECCHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHH
YDGAIAGWMATRGREIVATRALGETAPERPIGADPGPQKPAAPSPFPDVLSLTFTKVQEL
HCCHHHHHHHHCCCCEEEEHHHCCCCCCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHH
RYGENPHQAAAFYSDGSDGGTVIARAKQLHGKELSFNNINDAHAALELVKEFEEPAAVAI
HCCCCHHHHEEEECCCCCCCHHHHHHHHHCCCCCCCCCCCHHHHHHHHHHHHCCCCEEEE
KHANPCGVAVAPTIAEAFRKAYEADTVSIFGGIVALNRPCDRETAEALSKIFLEIVIAPA
ECCCCCCCCHHHHHHHHHHHHHCCCHHHHHHHHHEECCCCCHHHHHHHHHHHHHHHHCCC
FAPEALEVLTRKKNLRLLAVGPIDRNPPSGFDMKRVGGGLLVQSWDAIAEDPVAWKPVTK
CCHHHHHHHHHCCCCEEEEECCCCCCCCCCCCHHHHCCCEEEECCHHHHCCCCCCCCCCC
AAPTPEQLRDLAFAMKVCKHVKSNAIVVARDGQTLGVGAGQMNRIDAARFALRQAGEKAR
CCCCHHHHHHHHHHHHHHHHHCCCEEEEEECCCEEECCCCCCHHHHHHHHHHHHCCHHHC
GAVLASDAFFPFPDVVEAAGEAGIAAIVQPGGSIRDEESIARADELGLAMVFTGVRHFRH
CEEEECCCCCCCHHHHHHCCCCCEEEEECCCCCCCCHHHHHHHHHCCHHHHHHHHHHHCC
>Mature Secondary Structure
MKRALISVYDKQGIVEFARGLADLGVEIISTGGTYRTLQGAGIPVREVAEVAGFPEILDG
CCCCHHHHHHHCCHHHHHHHHHHCCHHEEECCCCEEEECCCCCCHHHHHHHCCCHHHHHH
RVKSLQPQIHAGILAMRANPTHMAQLAEHGIGLIDLVVVNLYPFRETVANPAVTLEEAIE
HHHHCCCHHHHCEEEEECCHHHHHHHHHCCCCHHHHHHHHHCHHHHHHCCCCHHHHHHHH
KIDIGGPAMVRAAAKNYQDVGVVVNPARYPAVLAELRETGDLSLPTRFSLMLEAFQHTAA
HHCCCCHHHHHHHHCCCCCCCEEECCHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHH
YDGAIAGWMATRGREIVATRALGETAPERPIGADPGPQKPAAPSPFPDVLSLTFTKVQEL
HCCHHHHHHHHCCCCEEEEHHHCCCCCCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHH
RYGENPHQAAAFYSDGSDGGTVIARAKQLHGKELSFNNINDAHAALELVKEFEEPAAVAI
HCCCCHHHHEEEECCCCCCCHHHHHHHHHCCCCCCCCCCCHHHHHHHHHHHHCCCCEEEE
KHANPCGVAVAPTIAEAFRKAYEADTVSIFGGIVALNRPCDRETAEALSKIFLEIVIAPA
ECCCCCCCCHHHHHHHHHHHHHCCCHHHHHHHHHEECCCCCHHHHHHHHHHHHHHHHCCC
FAPEALEVLTRKKNLRLLAVGPIDRNPPSGFDMKRVGGGLLVQSWDAIAEDPVAWKPVTK
CCHHHHHHHHHCCCCEEEEECCCCCCCCCCCCHHHHCCCEEEECCHHHHCCCCCCCCCCC
AAPTPEQLRDLAFAMKVCKHVKSNAIVVARDGQTLGVGAGQMNRIDAARFALRQAGEKAR
CCCCHHHHHHHHHHHHHHHHHCCCEEEEEECCCEEECCCCCCHHHHHHHHHHHHCCHHHC
GAVLASDAFFPFPDVVEAAGEAGIAAIVQPGGSIRDEESIARADELGLAMVFTGVRHFRH
CEEEECCCCCCCHHHHHHCCCCCEEEEECCCCCCCCHHHHHHHHHCCHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA