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The map label for this gene is thrS

Identifier: 51893696

GI number: 51893696

Start: 2744090

End: 2746045

Strand: Reverse

Name: thrS

Synonym: STH2558

Alternate gene names: 51893696

Gene position: 2746045-2744090 (Counterclockwise)

Preceding gene: 51893697

Following gene: 51893695

Centisome position: 77.0

GC content: 67.23

Gene sequence:

>1956_bases
ATGTCCAGCGTCGTGCACGTGACCCTGCCGGACGGCAGCGTGCGGGAGTACCCGCAGGGAATCACCATTGCCGAGGCGGT
GGCCCAGATCGGGCCGCGGCTGGCGAAGGCCGCGCTCGCCGCGAAGGTGGACGGCCGGCTCGTCGACCTGTCCGCCCGAC
TCGAGAAGGACTGCACCCTGCAGGTCCTGACCTTCAAGGATGAGGAGGGCCGCGAGGTCTTCCGCCACACCTCCACCCAC
ATCATGGCCCAGGCGGTGAAGCGGCTCTTCCCGGAGGCCAAGCTGACCGTCGGCCCGCCCCTGGAAAACTCCTTCTACTA
CGATTTCGACCTGCCCCGGCCCCTGACGCCGGAGGACCTGGAGAAGATCGAGGCCGAGATGGCCAAGATCGTCGAGGCCG
ACTACCCCATCGTCCGCCAGGAGGTGGACCGGGAGGAAGCCAAGCGGTTCTTCGCCGAGCGCGGCGAGGACTACAAGGTG
CTCCTGGTCGACAAGATCCCCGAGGACGAGGTGGTGTCGATCTACACCCAGGGCGAGTTCACCGACCTGTGCGTGGGCCC
GCACCTGCCCTCCACCGGCCGGGTGAAGGCGTTTAAGCTGCTGAGCGTCGCCGGCGCCTACTGGGAGGGGAACCAGGCCA
ACAAGCAGCTCCAGCGGGTCTACGGTACCTCCTTCGAGTCGAAGAAAGACCTGGAGGATTACCTGTTCCGGCTGGAGGAG
GCCAGGCGGCGCGACCACCGCAGACTGGGCCCGGAGCTGGGGCTGTACCGGTTCGAGGAGGTGGCTCCCGGCTTCGCCTT
CTGGCTCGACAAGGGCTACCGGCTCTACCGGGAGCTGGAGAACTGGAGCCGGAAGCTGCAGGAGGCCCGGGGGTACGAGG
AGGTCAGCACGCCGTGGATCGTCTCGTCCAAGCTGTATGAGACGTCGGGCCACTGGCAGCATTACCGGCAGAACATGTTC
GAGATCCGGGCGGAGGACCAGGACTTCGCCACCAAGCCGATGAACTGCCCGTGCCACTGCGTGCTGTACAAGAGCCAGAT
CCGGTCCTACCGGGACCTGCCGCTGAAGATCGCCGAGTACGGTCCGCTCTCCCGCTTCGAGGCCTCGGGCACGCTCCACG
GTCTGCTGCGGGTGCGGGGCTTCCATCAGGACGACGCCCACCTCTTCGTGCGGCCGGATCAGATCGAGGAGCAGATCCGG
GAGGTCATCGGCCTGGTGGACACCATCTACGGCACTCTGGGGCTGGAGTACGAGATCAAGCTCTCCACCCGGCCGGAGGA
CTTCATGGGCGACATCGAGCTGTGGAACGAGGCCGAGGCCGCCCTCGCCCGGGCGCTGGACGGCATGGGCCGCAGCTACA
AGCTGAACCCCGGCGACGGCGCGTTCTACGGGCCGAAGCTGGACTTCGACGTCACCGACGCCCTGGGCCGCAAGTGGCAG
TGCGCCACGGTGCAGCTGGACTTCCAGCTTCCCATCAAGTTCGACCTTACCTATATCGGCGAGGACGGCAAGGAGCACCG
GCCGGTGATGATCCACCGGGCGATCATGGGCACGCTGGAGCGGTTCATCGGTATCCTCACCGAGCACTACGCCGGCAACT
TCCCGCTGTGGATGGCCCCGGTGCAGGCCCGGGTGCTGCCCATCACGGACCGGCACCACGCGTACGCGGGCGAGGTGGTG
GCGAAGCTGCAGGAGGCCGGGTTGCGGGTCGAGGGCGACTACCGCAACGAGAAGGTGGGTTACAAGATCCGCGAGGCGGA
GCTGCTGAAGATCCCCTTCATCCTGGTCGTCGGCGACAAGGAGGCCGAAGCGGGCGCCGTGGCGGTGCGCCGCCGGGGCA
TGAAGGACCTGGGTCCCATGCCGCTGGCCGACTTCCTGGCACTGGCGCAGTCGGAGATCGCCTCCAAGGCCATGGATGAG
GCCTGCCGCAAGGCGGCCTCCGGGACGAGGGACTAG

Upstream 100 bases:

>100_bases
GGATGCGGACCCGCATGTCCGGTGGTGTGAGAGGACGGGGGCTAGCCGCCCCCTCCTACTCGATTTTTCTGACCACTTGT
TGCGAAAGGAGCTTGACACG

Downstream 100 bases:

>100_bases
GACCGGGGCGGCTTGTCAGATGGGGCCCGGGCCGGGTCACACGGGTCCGGGCCCAGCCATCCCGTCCGTCCTGCGGCGGT
TGGGCGGAGGTTTCTGACGG

Product: threonyl-tRNA synthetase

Products: NA

Alternate protein names: Threonine--tRNA ligase; ThrRS

Number of amino acids: Translated: 651; Mature: 650

Protein sequence:

>651_residues
MSSVVHVTLPDGSVREYPQGITIAEAVAQIGPRLAKAALAAKVDGRLVDLSARLEKDCTLQVLTFKDEEGREVFRHTSTH
IMAQAVKRLFPEAKLTVGPPLENSFYYDFDLPRPLTPEDLEKIEAEMAKIVEADYPIVRQEVDREEAKRFFAERGEDYKV
LLVDKIPEDEVVSIYTQGEFTDLCVGPHLPSTGRVKAFKLLSVAGAYWEGNQANKQLQRVYGTSFESKKDLEDYLFRLEE
ARRRDHRRLGPELGLYRFEEVAPGFAFWLDKGYRLYRELENWSRKLQEARGYEEVSTPWIVSSKLYETSGHWQHYRQNMF
EIRAEDQDFATKPMNCPCHCVLYKSQIRSYRDLPLKIAEYGPLSRFEASGTLHGLLRVRGFHQDDAHLFVRPDQIEEQIR
EVIGLVDTIYGTLGLEYEIKLSTRPEDFMGDIELWNEAEAALARALDGMGRSYKLNPGDGAFYGPKLDFDVTDALGRKWQ
CATVQLDFQLPIKFDLTYIGEDGKEHRPVMIHRAIMGTLERFIGILTEHYAGNFPLWMAPVQARVLPITDRHHAYAGEVV
AKLQEAGLRVEGDYRNEKVGYKIREAELLKIPFILVVGDKEAEAGAVAVRRRGMKDLGPMPLADFLALAQSEIASKAMDE
ACRKAASGTRD

Sequences:

>Translated_651_residues
MSSVVHVTLPDGSVREYPQGITIAEAVAQIGPRLAKAALAAKVDGRLVDLSARLEKDCTLQVLTFKDEEGREVFRHTSTH
IMAQAVKRLFPEAKLTVGPPLENSFYYDFDLPRPLTPEDLEKIEAEMAKIVEADYPIVRQEVDREEAKRFFAERGEDYKV
LLVDKIPEDEVVSIYTQGEFTDLCVGPHLPSTGRVKAFKLLSVAGAYWEGNQANKQLQRVYGTSFESKKDLEDYLFRLEE
ARRRDHRRLGPELGLYRFEEVAPGFAFWLDKGYRLYRELENWSRKLQEARGYEEVSTPWIVSSKLYETSGHWQHYRQNMF
EIRAEDQDFATKPMNCPCHCVLYKSQIRSYRDLPLKIAEYGPLSRFEASGTLHGLLRVRGFHQDDAHLFVRPDQIEEQIR
EVIGLVDTIYGTLGLEYEIKLSTRPEDFMGDIELWNEAEAALARALDGMGRSYKLNPGDGAFYGPKLDFDVTDALGRKWQ
CATVQLDFQLPIKFDLTYIGEDGKEHRPVMIHRAIMGTLERFIGILTEHYAGNFPLWMAPVQARVLPITDRHHAYAGEVV
AKLQEAGLRVEGDYRNEKVGYKIREAELLKIPFILVVGDKEAEAGAVAVRRRGMKDLGPMPLADFLALAQSEIASKAMDE
ACRKAASGTRD
>Mature_650_residues
SSVVHVTLPDGSVREYPQGITIAEAVAQIGPRLAKAALAAKVDGRLVDLSARLEKDCTLQVLTFKDEEGREVFRHTSTHI
MAQAVKRLFPEAKLTVGPPLENSFYYDFDLPRPLTPEDLEKIEAEMAKIVEADYPIVRQEVDREEAKRFFAERGEDYKVL
LVDKIPEDEVVSIYTQGEFTDLCVGPHLPSTGRVKAFKLLSVAGAYWEGNQANKQLQRVYGTSFESKKDLEDYLFRLEEA
RRRDHRRLGPELGLYRFEEVAPGFAFWLDKGYRLYRELENWSRKLQEARGYEEVSTPWIVSSKLYETSGHWQHYRQNMFE
IRAEDQDFATKPMNCPCHCVLYKSQIRSYRDLPLKIAEYGPLSRFEASGTLHGLLRVRGFHQDDAHLFVRPDQIEEQIRE
VIGLVDTIYGTLGLEYEIKLSTRPEDFMGDIELWNEAEAALARALDGMGRSYKLNPGDGAFYGPKLDFDVTDALGRKWQC
ATVQLDFQLPIKFDLTYIGEDGKEHRPVMIHRAIMGTLERFIGILTEHYAGNFPLWMAPVQARVLPITDRHHAYAGEVVA
KLQEAGLRVEGDYRNEKVGYKIREAELLKIPFILVVGDKEAEAGAVAVRRRGMKDLGPMPLADFLALAQSEIASKAMDEA
CRKAASGTRD

Specific function: Thrs Is Also A Translational Repressor Protein, It Controls The Translation Of Its Own Gene By Binding To Its mRNA. [C]

COG id: COG0441

COG function: function code J; Threonyl-tRNA synthetase

Gene ontology:

Cell location: Cytoplasm

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the class-II aminoacyl-tRNA synthetase family

Homologues:

Organism=Homo sapiens, GI38570111, Length=623, Percent_Identity=42.3756019261637, Blast_Score=528, Evalue=1e-150,
Organism=Homo sapiens, GI38202255, Length=645, Percent_Identity=42.1705426356589, Blast_Score=522, Evalue=1e-148,
Organism=Homo sapiens, GI20070344, Length=636, Percent_Identity=39.937106918239, Blast_Score=459, Evalue=1e-129,
Organism=Escherichia coli, GI1788013, Length=636, Percent_Identity=47.3270440251572, Blast_Score=642, Evalue=0.0,
Organism=Caenorhabditis elegans, GI71984184, Length=634, Percent_Identity=41.9558359621451, Blast_Score=528, Evalue=1e-150,
Organism=Caenorhabditis elegans, GI71984192, Length=634, Percent_Identity=41.9558359621451, Blast_Score=528, Evalue=1e-150,
Organism=Saccharomyces cerevisiae, GI6322112, Length=628, Percent_Identity=41.0828025477707, Blast_Score=511, Evalue=1e-145,
Organism=Saccharomyces cerevisiae, GI6322654, Length=416, Percent_Identity=37.9807692307692, Blast_Score=312, Evalue=1e-85,
Organism=Drosophila melanogaster, GI24583842, Length=629, Percent_Identity=42.7662957074722, Blast_Score=535, Evalue=1e-152,
Organism=Drosophila melanogaster, GI28574141, Length=629, Percent_Identity=42.7662957074722, Blast_Score=535, Evalue=1e-152,
Organism=Drosophila melanogaster, GI24583839, Length=629, Percent_Identity=42.7662957074722, Blast_Score=535, Evalue=1e-152,

Paralogues:

None

Copy number: 700 Molecules/Cell In: Glucose minimal media [C]

Swissprot (AC and ID): SYT_SYMTH (Q67LA3)

Other databases:

- EMBL:   AP006840
- RefSeq:   YP_076387.1
- ProteinModelPortal:   Q67LA3
- SMR:   Q67LA3
- GeneID:   2980192
- GenomeReviews:   AP006840_GR
- KEGG:   sth:STH2558
- NMPDR:   fig|292459.1.peg.2448
- HOGENOM:   HBG352811
- OMA:   GFEYEVE
- BioCyc:   STHE292459:STH2558-MONOMER
- BRENDA:   6.1.1.3
- GO:   GO:0005737
- HAMAP:   MF_00184_B
- InterPro:   IPR002314
- InterPro:   IPR006195
- InterPro:   IPR004154
- InterPro:   IPR012675
- InterPro:   IPR004095
- InterPro:   IPR012676
- InterPro:   IPR002320
- InterPro:   IPR018163
- InterPro:   IPR012947
- Gene3D:   G3DSA:3.40.50.800
- Gene3D:   G3DSA:3.10.20.30
- PRINTS:   PR01047
- SMART:   SM00863
- TIGRFAMs:   TIGR00418

Pfam domain/function: PF03129 HGTP_anticodon; PF02824 TGS; PF00587 tRNA-synt_2b; PF07973 tRNA_SAD; SSF52954 Anticodon_bd; SSF81271 TGS-like; SSF55186 Thr/Ala-tRNA-synth_IIc_edit

EC number: =6.1.1.3

Molecular weight: Translated: 74078; Mature: 73947

Theoretical pI: Translated: 5.59; Mature: 5.59

Prosite motif: PS50862 AA_TRNA_LIGASE_II

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.1 %Cys     (Translated Protein)
2.0 %Met     (Translated Protein)
3.1 %Cys+Met (Translated Protein)
1.1 %Cys     (Mature Protein)
1.8 %Met     (Mature Protein)
2.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSSVVHVTLPDGSVREYPQGITIAEAVAQIGPRLAKAALAAKVDGRLVDLSARLEKDCTL
CCCEEEEECCCCCHHHCCCCCHHHHHHHHHHHHHHHHHHHHHCCCEEEEEHHHCCCCCEE
QVLTFKDEEGREVFRHTSTHIMAQAVKRLFPEAKLTVGPPLENSFYYDFDLPRPLTPEDL
EEEEECCCCHHHHHHHHHHHHHHHHHHHHCCCCCEEECCCCCCCEEEECCCCCCCCHHHH
EKIEAEMAKIVEADYPIVRQEVDREEAKRFFAERGEDYKVLLVDKIPEDEVVSIYTQGEF
HHHHHHHHHHHHCCCCHHHHHCCHHHHHHHHHHCCCCEEEEEEECCCCCCEEEEEECCCE
TDLCVGPHLPSTGRVKAFKLLSVAGAYWEGNQANKQLQRVYGTSFESKKDLEDYLFRLEE
EEEEECCCCCCCCCCHHHHHHHHHCCCCCCCHHHHHHHHHHCCCCCCCCCHHHHHHHHHH
ARRRDHRRLGPELGLYRFEEVAPGFAFWLDKGYRLYRELENWSRKLQEARGYEEVSTPWI
HHHHHHHHCCCHHCCHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCEE
VSSKLYETSGHWQHYRQNMFEIRAEDQDFATKPMNCPCHCVLYKSQIRSYRDLPLKIAEY
EECHHHCCCCHHHHHHHHHHEEECCCCCCCCCCCCCCEEEEEEHHHHHHHCCCCEEEECC
GPLSRFEASGTLHGLLRVRGFHQDDAHLFVRPDQIEEQIREVIGLVDTIYGTLGLEYEIK
CCCCHHCCCCHHHHHHHHCCCCCCCCEEEECCHHHHHHHHHHHHHHHHHHHHHCCEEEEE
LSTRPEDFMGDIELWNEAEAALARALDGMGRSYKLNPGDGAFYGPKLDFDVTDALGRKWQ
ECCCCHHHHCCHHHHHHHHHHHHHHHHCCCCEEEECCCCCCCCCCCCCCCHHHHHCCCEE
CATVQLDFQLPIKFDLTYIGEDGKEHRPVMIHRAIMGTLERFIGILTEHYAGNFPLWMAP
EEEEEEEEEECEEEEEEEECCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHCCCCCEEECC
VQARVLPITDRHHAYAGEVVAKLQEAGLRVEGDYRNEKVGYKIREAELLKIPFILVVGDK
CCEEEEEECCCCHHHHHHHHHHHHHCCCEEECCCCCCCCCEEECCCEEEEEEEEEEECCC
EAEAGAVAVRRRGMKDLGPMPLADFLALAQSEIASKAMDEACRKAASGTRD
CCCHHHHHHHHCCCHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHHCCCCCC
>Mature Secondary Structure 
SSVVHVTLPDGSVREYPQGITIAEAVAQIGPRLAKAALAAKVDGRLVDLSARLEKDCTL
CCEEEEECCCCCHHHCCCCCHHHHHHHHHHHHHHHHHHHHHCCCEEEEEHHHCCCCCEE
QVLTFKDEEGREVFRHTSTHIMAQAVKRLFPEAKLTVGPPLENSFYYDFDLPRPLTPEDL
EEEEECCCCHHHHHHHHHHHHHHHHHHHHCCCCCEEECCCCCCCEEEECCCCCCCCHHHH
EKIEAEMAKIVEADYPIVRQEVDREEAKRFFAERGEDYKVLLVDKIPEDEVVSIYTQGEF
HHHHHHHHHHHHCCCCHHHHHCCHHHHHHHHHHCCCCEEEEEEECCCCCCEEEEEECCCE
TDLCVGPHLPSTGRVKAFKLLSVAGAYWEGNQANKQLQRVYGTSFESKKDLEDYLFRLEE
EEEEECCCCCCCCCCHHHHHHHHHCCCCCCCHHHHHHHHHHCCCCCCCCCHHHHHHHHHH
ARRRDHRRLGPELGLYRFEEVAPGFAFWLDKGYRLYRELENWSRKLQEARGYEEVSTPWI
HHHHHHHHCCCHHCCHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCEE
VSSKLYETSGHWQHYRQNMFEIRAEDQDFATKPMNCPCHCVLYKSQIRSYRDLPLKIAEY
EECHHHCCCCHHHHHHHHHHEEECCCCCCCCCCCCCCEEEEEEHHHHHHHCCCCEEEECC
GPLSRFEASGTLHGLLRVRGFHQDDAHLFVRPDQIEEQIREVIGLVDTIYGTLGLEYEIK
CCCCHHCCCCHHHHHHHHCCCCCCCCEEEECCHHHHHHHHHHHHHHHHHHHHHCCEEEEE
LSTRPEDFMGDIELWNEAEAALARALDGMGRSYKLNPGDGAFYGPKLDFDVTDALGRKWQ
ECCCCHHHHCCHHHHHHHHHHHHHHHHCCCCEEEECCCCCCCCCCCCCCCHHHHHCCCEE
CATVQLDFQLPIKFDLTYIGEDGKEHRPVMIHRAIMGTLERFIGILTEHYAGNFPLWMAP
EEEEEEEEEECEEEEEEEECCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHCCCCCEEECC
VQARVLPITDRHHAYAGEVVAKLQEAGLRVEGDYRNEKVGYKIREAELLKIPFILVVGDK
CCEEEEEECCCCHHHHHHHHHHHHHCCCEEECCCCCCCCCEEECCCEEEEEEEEEEECCC
EAEAGAVAVRRRGMKDLGPMPLADFLALAQSEIASKAMDEACRKAASGTRD
CCCHHHHHHHHCCCHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHHCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA