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The map label for this gene is icd [H]

Identifier: 51893682

GI number: 51893682

Start: 2729853

End: 2731118

Strand: Reverse

Name: icd [H]

Synonym: STH2544

Alternate gene names: 51893682

Gene position: 2731118-2729853 (Counterclockwise)

Preceding gene: 51893683

Following gene: 51893681

Centisome position: 76.58

GC content: 66.43

Gene sequence:

>1266_bases
GTGGCGAAGTTTACCAAGCTGACCCCGCCCGAAGGCCAGAAGATCACCATGGAGAACGGCCGGTTGGTGGTACCGGACAA
CCCCATCATCCCGTTTATCGAGGGCGACGGCACGGGCCCCGACATCTGGGCGGCCGCGCAGCCCGTGATCGACGCCGCCG
TGGAGAAGGCCTACGGCGGCAGGCGGAAGATCGCCTGGTTCGAGGTCTACGCCGGCGAGAAGTGCCTGAACAAGTTCGGC
GAGTGGCTGATCGACGACACGGTGGAGGCCATCCGCGAGTACCGGGTCGCGATCAAGGGGCCCCTCACCACGCCGGTGGG
CGGCGGCATCCGGTCGCTGAACGTCACCCTGCGGCAGGTGCTGGACCTGTACGCCTGCGTCCGGCCCGTGCGCTGGTTCC
CCGGCGTGCCCAGCCCGGTGAAGGAGCCGCACAAGACCGACGTGGTGATCTTCCGGGAGAACACCGAGGACATCTACGCC
GGCATCGAGTGGAAGGCCGGCACCCCGGAGGCCCGCAAGGTCCAGGCCCTGCTGGCCGAGGAGATGGGCGTCAAGTTCCC
CAACAGCGACAAGAGCGACATGATCGGCGTGGGCATCAAGCCGGTCTCGGAGTTCGGCTCCAAGCGGCTGGTCCGCGCGG
CCATCCAGTACGCCATCGACAACAAGCGCAAGTCCGTCACGCTGGTCCACAAGGGCAACATCCAGAAGTTCACCGAGGGC
GCCTTCCGCGACTGGGGCTACCAGGTCGCGCTGGAGGAGTTCCGCCCGTACGTCATCACCGAGGAAGAGCTCTGGTCCGA
TGAGTACAAGGGCAAGATGCCCGAGGGCAAGATCCTGATCCGCGACCGCATCGCCGACATCACCTTCCAGCAGCTGCTGC
TCCGGCCCGAGGAGTGGGACGTGATCGCCACCCTCAACCTGAACGGCGACTACCTCTCTGACCACGTCGCGGCTATCGTG
GGCGGCATCGGCATCGCCCCCGGCGCCAACATCTCGTACAGCGGCGGCTACGGCCTGTTCGAGGCCACCCACGGCACCGC
GCCCAAGTACGCCGGGCTCGACAAGGTCAACCCCGGTTCGGTCATCCTCTCGGGCGAGATGATGCTCCGCTACATGGGCT
GGCACGAGGCGGCGGACCTGATCATCAAGGGCCTTTCCGCCACCATCGCCCAGAAGACGGTCACCTACGACTTCGCCCGG
CTCACCGAGGGCGCGACCGAGGTGAAGTGCTCCGAGTTCGGCCGGCTCATCATCGCGAACATGTAG

Upstream 100 bases:

>100_bases
GCAGGCTTCCCTGGTCCCGTACCTCACCGGGGCCGTCTCCAGCAGGCTGCCTGGGCCCTCCACGGCCGTGAAGGCCGCAA
AGGACGATGGAGGTGCTGTT

Downstream 100 bases:

>100_bases
ACCGACTGCGGCAAGGAAAGGGGCAGAGACCGGATGAAGCGCAAGAAGATCGCGATTGTGGGCTCCGGGTTCACCGGCCA
GGGAACCGCCCTGTTTGCGG

Product: isocitrate dehydrogenase

Products: NA

Alternate protein names: IDH; IDP; NADP(+)-specific ICDH; Oxalosuccinate decarboxylase [H]

Number of amino acids: Translated: 421; Mature: 420

Protein sequence:

>421_residues
MAKFTKLTPPEGQKITMENGRLVVPDNPIIPFIEGDGTGPDIWAAAQPVIDAAVEKAYGGRRKIAWFEVYAGEKCLNKFG
EWLIDDTVEAIREYRVAIKGPLTTPVGGGIRSLNVTLRQVLDLYACVRPVRWFPGVPSPVKEPHKTDVVIFRENTEDIYA
GIEWKAGTPEARKVQALLAEEMGVKFPNSDKSDMIGVGIKPVSEFGSKRLVRAAIQYAIDNKRKSVTLVHKGNIQKFTEG
AFRDWGYQVALEEFRPYVITEEELWSDEYKGKMPEGKILIRDRIADITFQQLLLRPEEWDVIATLNLNGDYLSDHVAAIV
GGIGIAPGANISYSGGYGLFEATHGTAPKYAGLDKVNPGSVILSGEMMLRYMGWHEAADLIIKGLSATIAQKTVTYDFAR
LTEGATEVKCSEFGRLIIANM

Sequences:

>Translated_421_residues
MAKFTKLTPPEGQKITMENGRLVVPDNPIIPFIEGDGTGPDIWAAAQPVIDAAVEKAYGGRRKIAWFEVYAGEKCLNKFG
EWLIDDTVEAIREYRVAIKGPLTTPVGGGIRSLNVTLRQVLDLYACVRPVRWFPGVPSPVKEPHKTDVVIFRENTEDIYA
GIEWKAGTPEARKVQALLAEEMGVKFPNSDKSDMIGVGIKPVSEFGSKRLVRAAIQYAIDNKRKSVTLVHKGNIQKFTEG
AFRDWGYQVALEEFRPYVITEEELWSDEYKGKMPEGKILIRDRIADITFQQLLLRPEEWDVIATLNLNGDYLSDHVAAIV
GGIGIAPGANISYSGGYGLFEATHGTAPKYAGLDKVNPGSVILSGEMMLRYMGWHEAADLIIKGLSATIAQKTVTYDFAR
LTEGATEVKCSEFGRLIIANM
>Mature_420_residues
AKFTKLTPPEGQKITMENGRLVVPDNPIIPFIEGDGTGPDIWAAAQPVIDAAVEKAYGGRRKIAWFEVYAGEKCLNKFGE
WLIDDTVEAIREYRVAIKGPLTTPVGGGIRSLNVTLRQVLDLYACVRPVRWFPGVPSPVKEPHKTDVVIFRENTEDIYAG
IEWKAGTPEARKVQALLAEEMGVKFPNSDKSDMIGVGIKPVSEFGSKRLVRAAIQYAIDNKRKSVTLVHKGNIQKFTEGA
FRDWGYQVALEEFRPYVITEEELWSDEYKGKMPEGKILIRDRIADITFQQLLLRPEEWDVIATLNLNGDYLSDHVAAIVG
GIGIAPGANISYSGGYGLFEATHGTAPKYAGLDKVNPGSVILSGEMMLRYMGWHEAADLIIKGLSATIAQKTVTYDFARL
TEGATEVKCSEFGRLIIANM

Specific function: Unknown

COG id: COG0538

COG function: function code C; Isocitrate dehydrogenases

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the isocitrate and isopropylmalate dehydrogenases family [H]

Homologues:

Organism=Homo sapiens, GI5031777, Length=386, Percent_Identity=32.1243523316062, Blast_Score=177, Evalue=2e-44,
Organism=Homo sapiens, GI28178838, Length=372, Percent_Identity=29.0322580645161, Blast_Score=125, Evalue=6e-29,
Organism=Homo sapiens, GI4758582, Length=365, Percent_Identity=29.3150684931507, Blast_Score=124, Evalue=2e-28,
Organism=Homo sapiens, GI28178816, Length=396, Percent_Identity=27.7777777777778, Blast_Score=120, Evalue=2e-27,
Organism=Homo sapiens, GI28178821, Length=356, Percent_Identity=28.9325842696629, Blast_Score=120, Evalue=3e-27,
Organism=Homo sapiens, GI28178819, Length=185, Percent_Identity=31.8918918918919, Blast_Score=80, Evalue=3e-15,
Organism=Escherichia coli, GI1787381, Length=422, Percent_Identity=65.4028436018957, Blast_Score=523, Evalue=1e-149,
Organism=Escherichia coli, GI1788101, Length=383, Percent_Identity=28.4595300261097, Blast_Score=115, Evalue=6e-27,
Organism=Escherichia coli, GI87081683, Length=407, Percent_Identity=25.3071253071253, Blast_Score=94, Evalue=2e-20,
Organism=Caenorhabditis elegans, GI71986051, Length=391, Percent_Identity=33.7595907928389, Blast_Score=167, Evalue=7e-42,
Organism=Caenorhabditis elegans, GI25144293, Length=371, Percent_Identity=29.9191374663073, Blast_Score=124, Evalue=1e-28,
Organism=Caenorhabditis elegans, GI17505779, Length=369, Percent_Identity=30.8943089430894, Blast_Score=120, Evalue=2e-27,
Organism=Saccharomyces cerevisiae, GI6324709, Length=365, Percent_Identity=32.0547945205479, Blast_Score=155, Evalue=8e-39,
Organism=Saccharomyces cerevisiae, GI6322097, Length=372, Percent_Identity=29.3010752688172, Blast_Score=134, Evalue=3e-32,
Organism=Saccharomyces cerevisiae, GI6324291, Length=378, Percent_Identity=29.6296296296296, Blast_Score=119, Evalue=8e-28,
Organism=Drosophila melanogaster, GI24661184, Length=394, Percent_Identity=32.2335025380711, Blast_Score=189, Evalue=5e-48,
Organism=Drosophila melanogaster, GI24643270, Length=395, Percent_Identity=34.1772151898734, Blast_Score=185, Evalue=4e-47,
Organism=Drosophila melanogaster, GI24643268, Length=395, Percent_Identity=34.1772151898734, Blast_Score=185, Evalue=5e-47,
Organism=Drosophila melanogaster, GI161078635, Length=315, Percent_Identity=28.5714285714286, Blast_Score=109, Evalue=4e-24,
Organism=Drosophila melanogaster, GI161078639, Length=315, Percent_Identity=28.5714285714286, Blast_Score=109, Evalue=4e-24,
Organism=Drosophila melanogaster, GI161078633, Length=315, Percent_Identity=28.5714285714286, Blast_Score=109, Evalue=4e-24,
Organism=Drosophila melanogaster, GI24650122, Length=315, Percent_Identity=28.5714285714286, Blast_Score=109, Evalue=4e-24,
Organism=Drosophila melanogaster, GI161078637, Length=315, Percent_Identity=28.5714285714286, Blast_Score=109, Evalue=4e-24,
Organism=Drosophila melanogaster, GI20130355, Length=389, Percent_Identity=25.1928020565553, Blast_Score=100, Evalue=2e-21,

Paralogues:

None

Copy number: 8180 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). 240 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). 1480 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR019818
- InterPro:   IPR001804
- InterPro:   IPR004439 [H]

Pfam domain/function: PF00180 Iso_dh [H]

EC number: =1.1.1.42 [H]

Molecular weight: Translated: 46541; Mature: 46410

Theoretical pI: Translated: 5.82; Mature: 5.82

Prosite motif: PS00470 IDH_IMDH

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.7 %Cys     (Translated Protein)
2.1 %Met     (Translated Protein)
2.9 %Cys+Met (Translated Protein)
0.7 %Cys     (Mature Protein)
1.9 %Met     (Mature Protein)
2.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MAKFTKLTPPEGQKITMENGRLVVPDNPIIPFIEGDGTGPDIWAAAQPVIDAAVEKAYGG
CCCCCCCCCCCCCEEEECCCEEECCCCCEEEEEECCCCCCCHHHHHHHHHHHHHHHHCCC
RRKIAWFEVYAGEKCLNKFGEWLIDDTVEAIREYRVAIKGPLTTPVGGGIRSLNVTLRQV
CCEEEEEEEECCHHHHHHHHHHHHHHHHHHHHHHHHHEECCCCCCCCCCHHHHHHHHHHH
LDLYACVRPVRWFPGVPSPVKEPHKTDVVIFRENTEDIYAGIEWKAGTPEARKVQALLAE
HHHHHHHHHHHHCCCCCCCCCCCCCCCEEEEECCCCEEEEEEEECCCCCHHHHHHHHHHH
EMGVKFPNSDKSDMIGVGIKPVSEFGSKRLVRAAIQYAIDNKRKSVTLVHKGNIQKFTEG
HHCCCCCCCCCCCEEECCCCCHHHHHHHHHHHHHHHHHHCCCCCEEEEEECCCCHHHHHH
AFRDWGYQVALEEFRPYVITEEELWSDEYKGKMPEGKILIRDRIADITFQQLLLRPEEWD
HHHHCCCEEEHHHCCCEEEEHHHHHCHHHCCCCCCCCEEEEHHHHHHHHHHHHCCCCCCC
VIATLNLNGDYLSDHVAAIVGGIGIAPGANISYSGGYGLFEATHGTAPKYAGLDKVNPGS
EEEEEECCCCHHHHHHHHHHHCCCCCCCCCEEECCCCCEEECCCCCCCCCCCCCCCCCCC
VILSGEMMLRYMGWHEAADLIIKGLSATIAQKTVTYDFARLTEGATEVKCSEFGRLIIAN
EEEEHHHHHHHHCHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCHHHCCCEEEEC
M
C
>Mature Secondary Structure 
AKFTKLTPPEGQKITMENGRLVVPDNPIIPFIEGDGTGPDIWAAAQPVIDAAVEKAYGG
CCCCCCCCCCCCEEEECCCEEECCCCCEEEEEECCCCCCCHHHHHHHHHHHHHHHHCCC
RRKIAWFEVYAGEKCLNKFGEWLIDDTVEAIREYRVAIKGPLTTPVGGGIRSLNVTLRQV
CCEEEEEEEECCHHHHHHHHHHHHHHHHHHHHHHHHHEECCCCCCCCCCHHHHHHHHHHH
LDLYACVRPVRWFPGVPSPVKEPHKTDVVIFRENTEDIYAGIEWKAGTPEARKVQALLAE
HHHHHHHHHHHHCCCCCCCCCCCCCCCEEEEECCCCEEEEEEEECCCCCHHHHHHHHHHH
EMGVKFPNSDKSDMIGVGIKPVSEFGSKRLVRAAIQYAIDNKRKSVTLVHKGNIQKFTEG
HHCCCCCCCCCCCEEECCCCCHHHHHHHHHHHHHHHHHHCCCCCEEEEEECCCCHHHHHH
AFRDWGYQVALEEFRPYVITEEELWSDEYKGKMPEGKILIRDRIADITFQQLLLRPEEWD
HHHHCCCEEEHHHCCCEEEEHHHHHCHHHCCCCCCCCEEEEHHHHHHHHHHHHCCCCCCC
VIATLNLNGDYLSDHVAAIVGGIGIAPGANISYSGGYGLFEATHGTAPKYAGLDKVNPGS
EEEEEECCCCHHHHHHHHHHHCCCCCCCCCEEECCCCCEEECCCCCCCCCCCCCCCCCCC
VILSGEMMLRYMGWHEAADLIIKGLSATIAQKTVTYDFARLTEGATEVKCSEFGRLIIAN
EEEEHHHHHHHHCHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCHHHCCCEEEEC
M
C

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 8045898; 9387221; 9384377; 11751849; 11290745 [H]