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The map label for this gene is gltA [H]

Identifier: 51893680

GI number: 51893680

Start: 2727518

End: 2728837

Strand: Reverse

Name: gltA [H]

Synonym: STH2542

Alternate gene names: 51893680

Gene position: 2728837-2727518 (Counterclockwise)

Preceding gene: 51893681

Following gene: 51893679

Centisome position: 76.52

GC content: 66.36

Gene sequence:

>1320_bases
GTGTCACAGCTGAAAGCCACCCTGGTTCGGAAGATCGAGGAGCATCGCCCGCGGACCCAGCGGCTGCTGAAGGAGTTCGG
GCACGTGGTCATCGACGAGGTGACCATCGAGAAGGCCATCGGCGGCGCGCGGGACGTCCGCTGCCTGGTCACCGACATCT
CCTACCTGGACCCGATGGAGGGGATCCGCTTCCGCGGCAAGACCATCGAGGAGACCTTCGCCGCCCTGCCCAAGGCGCCG
GGCGGGGAGTACCCGACGGTGGAGGCGTTCTGGTTCTTCCTGCTCACCGGCGAGGTGCCGACCCAGGAGCAGGTGGACGA
GGTCATCGCCGAGTGGAAAGAGCGGCGGAACGTGCCGCAGTACGTGTACGACGTGATCCGGGCGCTGCCCAAGGACAGCC
ACCCGATGACCATGCTGTCCGCGGGCATCCTGGCGATGCAGCGGGAGTCAAAGTTCGCCCGGTACTACCACTCGGGCGAG
TACAACAAGCAGCGCGCCTGGGAGTACATGTACGAGGACGCGAGCGATCTGGTGGCCCGCATCCCGATGATCGCCGCCTA
CATCTACCGCTACAAGTACAAGGACGACGTCCATATTCCGCCCGATCCCAACCTGGACATGGGCGCGAACTTCGCCCACA
TGATGGGCGTGCCGAAGCCTTACGATGATGTCTCCCGCATGTACTTCATCCTGCATTCCGACCACGAGTCGGGCAACGTC
TCCGCCCACACCGGCCACCTGGTGGCCTCGGCTCTGTCGGACGCCTACCTCGCGTACTCGGCGGCCCTGAACGGCCTGGC
GGGCCCGCTGCACGGGCTGGCCAACCAGGAGGTCCTGCGCTGGATCATGGACTTCCAGGCGAAGCTGGGCGAGGGCGTAG
AGCCCACCCGGGAGAACGTCACCCAGGCGCTCTGGGACACGCTCAACGCCGGCCAGGTGATCCCGGGCTACGGCCATGCG
GTGCTGCGCAAGACCGACCCGCGCTACACCGCGCAGCGGGAGTTCTGCCTGAAGCACATGCCCGACGATCCGCTGTTCAA
GCTGGTCAGCATGATCTACGAGGTCGCCCCGGGCGTGCTGATGCAGCACGGCAAGGCCAAGAACCCGTGGCCGAACGTCG
ATGCCCAGTCCGGTGTCATCCAGTGGCACTACGGCGTGCGCGAGTGGGACTTCTACACGGTCCTGTTCGGTGTCGGCCGG
GCGCTGGGCGTCATGGCCAACATCGTCTGGGACCGGGCCCTGGGATATCCGATCGAGCGGCCCAAGTCGGTGACCACCGA
GATGCTGGAGCAGTGGGCCGCGGCCGGCGGCCGCAAGTGA

Upstream 100 bases:

>100_bases
GACAAGGGCGCCCAGGGCGTCAGGAACCTGATCGAGATGCTGAAGGCCGGCATCCTGGCGCAGTAGGTCGATCGCATCCA
ACAGGGGGAGGAAGGGGACT

Downstream 100 bases:

>100_bases
TCCGGCGTCGTCTGCCGAAGCTGCGGGAGGAGATGCGAGGGGCATCTCCTCCCGCTTCTGTCCGCGTCGCCGGACCGTAA
GGCCCGCCCCCGGCGCGCGG

Product: type I citrate synthase

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 439; Mature: 438

Protein sequence:

>439_residues
MSQLKATLVRKIEEHRPRTQRLLKEFGHVVIDEVTIEKAIGGARDVRCLVTDISYLDPMEGIRFRGKTIEETFAALPKAP
GGEYPTVEAFWFFLLTGEVPTQEQVDEVIAEWKERRNVPQYVYDVIRALPKDSHPMTMLSAGILAMQRESKFARYYHSGE
YNKQRAWEYMYEDASDLVARIPMIAAYIYRYKYKDDVHIPPDPNLDMGANFAHMMGVPKPYDDVSRMYFILHSDHESGNV
SAHTGHLVASALSDAYLAYSAALNGLAGPLHGLANQEVLRWIMDFQAKLGEGVEPTRENVTQALWDTLNAGQVIPGYGHA
VLRKTDPRYTAQREFCLKHMPDDPLFKLVSMIYEVAPGVLMQHGKAKNPWPNVDAQSGVIQWHYGVREWDFYTVLFGVGR
ALGVMANIVWDRALGYPIERPKSVTTEMLEQWAAAGGRK

Sequences:

>Translated_439_residues
MSQLKATLVRKIEEHRPRTQRLLKEFGHVVIDEVTIEKAIGGARDVRCLVTDISYLDPMEGIRFRGKTIEETFAALPKAP
GGEYPTVEAFWFFLLTGEVPTQEQVDEVIAEWKERRNVPQYVYDVIRALPKDSHPMTMLSAGILAMQRESKFARYYHSGE
YNKQRAWEYMYEDASDLVARIPMIAAYIYRYKYKDDVHIPPDPNLDMGANFAHMMGVPKPYDDVSRMYFILHSDHESGNV
SAHTGHLVASALSDAYLAYSAALNGLAGPLHGLANQEVLRWIMDFQAKLGEGVEPTRENVTQALWDTLNAGQVIPGYGHA
VLRKTDPRYTAQREFCLKHMPDDPLFKLVSMIYEVAPGVLMQHGKAKNPWPNVDAQSGVIQWHYGVREWDFYTVLFGVGR
ALGVMANIVWDRALGYPIERPKSVTTEMLEQWAAAGGRK
>Mature_438_residues
SQLKATLVRKIEEHRPRTQRLLKEFGHVVIDEVTIEKAIGGARDVRCLVTDISYLDPMEGIRFRGKTIEETFAALPKAPG
GEYPTVEAFWFFLLTGEVPTQEQVDEVIAEWKERRNVPQYVYDVIRALPKDSHPMTMLSAGILAMQRESKFARYYHSGEY
NKQRAWEYMYEDASDLVARIPMIAAYIYRYKYKDDVHIPPDPNLDMGANFAHMMGVPKPYDDVSRMYFILHSDHESGNVS
AHTGHLVASALSDAYLAYSAALNGLAGPLHGLANQEVLRWIMDFQAKLGEGVEPTRENVTQALWDTLNAGQVIPGYGHAV
LRKTDPRYTAQREFCLKHMPDDPLFKLVSMIYEVAPGVLMQHGKAKNPWPNVDAQSGVIQWHYGVREWDFYTVLFGVGRA
LGVMANIVWDRALGYPIERPKSVTTEMLEQWAAAGGRK

Specific function: Tricarboxylic acid cycle. [C]

COG id: COG0372

COG function: function code C; Citrate synthase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the citrate synthase family [H]

Homologues:

Organism=Homo sapiens, GI38327625, Length=433, Percent_Identity=50.5773672055427, Blast_Score=461, Evalue=1e-130,
Organism=Escherichia coli, GI1786939, Length=392, Percent_Identity=29.0816326530612, Blast_Score=110, Evalue=1e-25,
Organism=Escherichia coli, GI1786527, Length=333, Percent_Identity=24.9249249249249, Blast_Score=82, Evalue=6e-17,
Organism=Caenorhabditis elegans, GI17555174, Length=439, Percent_Identity=49.4305239179954, Blast_Score=444, Evalue=1e-125,
Organism=Saccharomyces cerevisiae, GI6324328, Length=427, Percent_Identity=54.0983606557377, Blast_Score=459, Evalue=1e-130,
Organism=Saccharomyces cerevisiae, GI6319850, Length=431, Percent_Identity=50.5800464037123, Blast_Score=437, Evalue=1e-123,
Organism=Saccharomyces cerevisiae, GI6325257, Length=454, Percent_Identity=40.0881057268723, Blast_Score=332, Evalue=7e-92,
Organism=Drosophila melanogaster, GI24640126, Length=428, Percent_Identity=51.6355140186916, Blast_Score=456, Evalue=1e-128,
Organism=Drosophila melanogaster, GI24640124, Length=428, Percent_Identity=51.6355140186916, Blast_Score=456, Evalue=1e-128,
Organism=Drosophila melanogaster, GI21356863, Length=428, Percent_Identity=44.6261682242991, Blast_Score=378, Evalue=1e-105,

Paralogues:

None

Copy number: 624 Molecules/Cell In: Growth Phase, Glucose-minimal MOPS Media. 2,000 Molecules/Cell In: Glucose minimal media [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR016142
- InterPro:   IPR016143
- InterPro:   IPR002020
- InterPro:   IPR016141
- InterPro:   IPR019810
- InterPro:   IPR010953 [H]

Pfam domain/function: PF00285 Citrate_synt [H]

EC number: =2.3.3.1 [H]

Molecular weight: Translated: 49811; Mature: 49679

Theoretical pI: Translated: 6.57; Mature: 6.57

Prosite motif: PS00480 CITRATE_SYNTHASE

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.5 %Cys     (Translated Protein)
3.9 %Met     (Translated Protein)
4.3 %Cys+Met (Translated Protein)
0.5 %Cys     (Mature Protein)
3.7 %Met     (Mature Protein)
4.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure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CHHHHHHHHHHHHHCCCCC
>Mature Secondary Structure 
SQLKATLVRKIEEHRPRTQRLLKEFGHVVIDEVTIEKAIGGARDVRCLVTDISYLDPME
CHHHHHHHHHHHHHCCHHHHHHHHHCHHHHHHHHHHHHHCCCHHHHHHHHHHHHHCCHH
GIRFRGKTIEETFAALPKAPGGEYPTVEAFWFFLLTGEVPTQEQVDEVIAEWKERRNVPQ
HHHHCCCHHHHHHHHCCCCCCCCCCHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHCCCHH
YVYDVIRALPKDSHPMTMLSAGILAMQRESKFARYYHSGEYNKQRAWEYMYEDASDLVAR
HHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHCHHHHHHH
IPMIAAYIYRYKYKDDVHIPPDPNLDMGANFAHMMGVPKPYDDVSRMYFILHSDHESGNV
HHHHHHHHHHHCCCCCCCCCCCCCCCCCCCHHHHCCCCCCHHHHHHEEEEEECCCCCCCC
SAHTGHLVASALSDAYLAYSAALNGLAGPLHGLANQEVLRWIMDFQAKLGEGVEPTRENV
CCHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHCCHHHHHHHHHHHHHHHCCCCCHHHHHH
TQALWDTLNAGQVIPGYGHAVLRKTDPRYTAQREFCLKHMPDDPLFKLVSMIYEVAPGVL
HHHHHHHCCCCCCCCCCCCHHEECCCCCHHHHHHHHHHCCCCCHHHHHHHHHHHHCCHHH
MQHGKAKNPWPNVDAQSGVIQWHYGVREWDFYTVLFGVGRALGVMANIVWDRALGYPIER
HHCCCCCCCCCCCCCCCCEEEEECCCCHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCC
PKSVTTEMLEQWAAAGGRK
CHHHHHHHHHHHHHCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 7522844; 12948626 [H]