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The map label for this gene is trxA [H]

Identifier: 51893542

GI number: 51893542

Start: 2588719

End: 2589057

Strand: Reverse

Name: trxA [H]

Synonym: STH2404

Alternate gene names: 51893542

Gene position: 2589057-2588719 (Counterclockwise)

Preceding gene: 51893543

Following gene: 51893541

Centisome position: 72.6

GC content: 64.6

Gene sequence:

>339_bases
GTGGCCGGCGACAAGGTCGTCACGCTGTCGGCCAGCAACTGGGCCGCGGAGGTGGAGCAGTCTTCGCTGCCCGTGCTGGT
GGACTTCTGGGCCGTCTGGTGCGGCCCGTGCCGGATGATCGCGCCTGTGGTCGAGGAGATCGCGGCAGACTATGAAGGCC
GCATGAAGGTCGGTAAGCTCAATGTCGATGAAAATAACGATCTGGCCGCCCGGTACGGCGTGATGTCGATTCCGACGCTG
ATCCTGTTCAAGAACGGGGAGCCGGTGGAGCGGATCGTCGGCTTCCAGCCCAAGAAGGAGCTGGCCGCCAAGATCGACCG
GGCTCTGGCCCAGGCCTAG

Upstream 100 bases:

>100_bases
GTCGCTGCGGCTCACCCGCGCTGCCTTTACAGCTTACTTCGCGATTGGTTAGAATAGGGGCTGTCAGTTGGGTGCATATA
CGTAAAGGAGGATGCAGAAA

Downstream 100 bases:

>100_bases
ATGACGGAGCGGGCGACCCCTGGCGGGTCGCTCGTTTTCACACTTGAAGGGATGGGGCGAAGAACATGCGGGCAATCGAC
CTGCGAAGCGACACCGTAAC

Product: thioredoxin

Products: NA

Alternate protein names: Trx [H]

Number of amino acids: Translated: 112; Mature: 111

Protein sequence:

>112_residues
MAGDKVVTLSASNWAAEVEQSSLPVLVDFWAVWCGPCRMIAPVVEEIAADYEGRMKVGKLNVDENNDLAARYGVMSIPTL
ILFKNGEPVERIVGFQPKKELAAKIDRALAQA

Sequences:

>Translated_112_residues
MAGDKVVTLSASNWAAEVEQSSLPVLVDFWAVWCGPCRMIAPVVEEIAADYEGRMKVGKLNVDENNDLAARYGVMSIPTL
ILFKNGEPVERIVGFQPKKELAAKIDRALAQA
>Mature_111_residues
AGDKVVTLSASNWAAEVEQSSLPVLVDFWAVWCGPCRMIAPVVEEIAADYEGRMKVGKLNVDENNDLAARYGVMSIPTLI
LFKNGEPVERIVGFQPKKELAAKIDRALAQA

Specific function: Component of the thioredoxin-thioredoxin reductase system. Participates in various redox reactions through the reversible oxidation of its active center dithiol to a disulfide and catalyzes dithiol-disulfide exchange reactions [H]

COG id: COG0526

COG function: function code OC; Thiol-disulfide isomerase and thioredoxins

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 thioredoxin domain [H]

Homologues:

Organism=Homo sapiens, GI21361403, Length=98, Percent_Identity=34.6938775510204, Blast_Score=83, Evalue=6e-17,
Organism=Homo sapiens, GI5031973, Length=109, Percent_Identity=33.9449541284404, Blast_Score=67, Evalue=4e-12,
Organism=Escherichia coli, GI87082331, Length=107, Percent_Identity=46.7289719626168, Blast_Score=112, Evalue=6e-27,
Organism=Escherichia coli, GI1788936, Length=90, Percent_Identity=40, Blast_Score=91, Evalue=2e-20,
Organism=Escherichia coli, GI87081747, Length=110, Percent_Identity=36.3636363636364, Blast_Score=86, Evalue=9e-19,
Organism=Caenorhabditis elegans, GI212646193, Length=101, Percent_Identity=39.6039603960396, Blast_Score=86, Evalue=4e-18,
Organism=Caenorhabditis elegans, GI71980565, Length=70, Percent_Identity=42.8571428571429, Blast_Score=74, Evalue=2e-14,
Organism=Caenorhabditis elegans, GI71980562, Length=70, Percent_Identity=42.8571428571429, Blast_Score=74, Evalue=2e-14,
Organism=Caenorhabditis elegans, GI17507705, Length=105, Percent_Identity=35.2380952380952, Blast_Score=72, Evalue=7e-14,
Organism=Caenorhabditis elegans, GI17509965, Length=76, Percent_Identity=39.4736842105263, Blast_Score=72, Evalue=7e-14,
Organism=Caenorhabditis elegans, GI71998175, Length=70, Percent_Identity=47.1428571428571, Blast_Score=70, Evalue=2e-13,
Organism=Caenorhabditis elegans, GI17510299, Length=70, Percent_Identity=42.8571428571429, Blast_Score=64, Evalue=2e-11,
Organism=Saccharomyces cerevisiae, GI6323072, Length=101, Percent_Identity=43.5643564356436, Blast_Score=85, Evalue=3e-18,
Organism=Saccharomyces cerevisiae, GI6321648, Length=101, Percent_Identity=43.5643564356436, Blast_Score=84, Evalue=6e-18,
Organism=Saccharomyces cerevisiae, GI6319925, Length=73, Percent_Identity=35.6164383561644, Blast_Score=62, Evalue=1e-11,
Organism=Drosophila melanogaster, GI24664269, Length=77, Percent_Identity=53.2467532467532, Blast_Score=87, Evalue=3e-18,
Organism=Drosophila melanogaster, GI28573567, Length=102, Percent_Identity=35.2941176470588, Blast_Score=84, Evalue=1e-17,
Organism=Drosophila melanogaster, GI24639826, Length=75, Percent_Identity=46.6666666666667, Blast_Score=83, Evalue=4e-17,
Organism=Drosophila melanogaster, GI21358065, Length=103, Percent_Identity=37.8640776699029, Blast_Score=82, Evalue=7e-17,
Organism=Drosophila melanogaster, GI17648013, Length=75, Percent_Identity=41.3333333333333, Blast_Score=75, Evalue=7e-15,
Organism=Drosophila melanogaster, GI24583090, Length=75, Percent_Identity=41.3333333333333, Blast_Score=75, Evalue=7e-15,
Organism=Drosophila melanogaster, GI24658597, Length=84, Percent_Identity=39.2857142857143, Blast_Score=69, Evalue=5e-13,
Organism=Drosophila melanogaster, GI19921434, Length=80, Percent_Identity=36.25, Blast_Score=63, Evalue=3e-11,

Paralogues:

None

Copy number: 3,500 Molecules/Cell In: Glucose minimal media [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR005746
- InterPro:   IPR017936
- InterPro:   IPR012336
- InterPro:   IPR017937
- InterPro:   IPR013766
- InterPro:   IPR012335 [H]

Pfam domain/function: PF00085 Thioredoxin [H]

EC number: NA

Molecular weight: Translated: 12233; Mature: 12102

Theoretical pI: Translated: 4.64; Mature: 4.64

Prosite motif: PS00194 THIOREDOXIN

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.8 %Cys     (Translated Protein)
3.6 %Met     (Translated Protein)
5.4 %Cys+Met (Translated Protein)
1.8 %Cys     (Mature Protein)
2.7 %Met     (Mature Protein)
4.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MAGDKVVTLSASNWAAEVEQSSLPVLVDFWAVWCGPCRMIAPVVEEIAADYEGRMKVGKL
CCCCEEEEEECCCCHHHHHCCCCCHHHHHHHHHHCHHHHHHHHHHHHHCCCCCCEEEEEE
NVDENNDLAARYGVMSIPTLILFKNGEPVERIVGFQPKKELAAKIDRALAQA
CCCCCCCHHHHCCHHHCCEEEEEECCCCHHHHHCCCCHHHHHHHHHHHHHCC
>Mature Secondary Structure 
AGDKVVTLSASNWAAEVEQSSLPVLVDFWAVWCGPCRMIAPVVEEIAADYEGRMKVGKL
CCCEEEEEECCCCHHHHHCCCCCHHHHHHHHHHCHHHHHHHHHHHHHCCCCCCEEEEEE
NVDENNDLAARYGVMSIPTLILFKNGEPVERIVGFQPKKELAAKIDRALAQA
CCCCCCCHHHHCCHHHCCEEEEEECCCCHHHHHCCCCHHHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: Reduction reactions; participates in dithiol-disulfide exchange reactions [C]

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA