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The map label for this gene is cymR [H]

Identifier: 51893529

GI number: 51893529

Start: 2575656

End: 2576096

Strand: Reverse

Name: cymR [H]

Synonym: STH2391

Alternate gene names: 51893529

Gene position: 2576096-2575656 (Counterclockwise)

Preceding gene: 51893530

Following gene: 51893528

Centisome position: 72.24

GC content: 68.03

Gene sequence:

>441_bases
GTGAAGCTGTCGACCAAGGGAAAATACGGCGTTAAGGCCCTGTTCGAGCTCGCGATGCACGAGGGTTCGGGTCCGGTCTC
GCTGCGGACCATCGCCGAGCGTCAGGGGCTTTCGGAACACTATCTCGAACAGCTGGCGGCGCCGCTGCGCCGGGCGGGGA
TCATCACCGCCGTGCGCGGGGCGCAGGGCGGCTACATGCTGGCCCGGCCGGCCAACCAGATTACCGTGGGCGACATCATC
CGGGTGCTGGAAGGGCCCATCGGCTACACGGACTGTGCCACCGAGGGCGAGCCCGACCCGGAGTGCGCGAGCACCTGCCC
GGTCCACGGGGTGTGGGAGCGGGTGACGCAGCAGATCATCGCCGTCATCGACTCCATCACGCTGCAGGACCTGGTCGACC
AGGCCCTGGCGGAGCGGGGGAACCCGATGTACCACATCTAG

Upstream 100 bases:

>100_bases
GCCCCTGATCCCGGAAATCCGGTCTTGACAGTCGGGATTATGGCGCATAGACTCTAGGTGGCGATCCCGATATTGTTGGT
CGGAATTGGGGGCGGTACAC

Downstream 100 bases:

>100_bases
CGTTGCCGGTCCTTCTGCGGCGCCGTACGGCTCCGTGTGTGGCCCGCCCAGGCGCCGGTGGGGGCCGGGGTCCGGTGGTG
TGGCCCGCCGGAGCGCGCCG

Product: putative transcriptional regulator

Products: NA

Alternate protein names: Cysteine metabolism repressor [H]

Number of amino acids: Translated: 146; Mature: 146

Protein sequence:

>146_residues
MKLSTKGKYGVKALFELAMHEGSGPVSLRTIAERQGLSEHYLEQLAAPLRRAGIITAVRGAQGGYMLARPANQITVGDII
RVLEGPIGYTDCATEGEPDPECASTCPVHGVWERVTQQIIAVIDSITLQDLVDQALAERGNPMYHI

Sequences:

>Translated_146_residues
MKLSTKGKYGVKALFELAMHEGSGPVSLRTIAERQGLSEHYLEQLAAPLRRAGIITAVRGAQGGYMLARPANQITVGDII
RVLEGPIGYTDCATEGEPDPECASTCPVHGVWERVTQQIIAVIDSITLQDLVDQALAERGNPMYHI
>Mature_146_residues
MKLSTKGKYGVKALFELAMHEGSGPVSLRTIAERQGLSEHYLEQLAAPLRRAGIITAVRGAQGGYMLARPANQITVGDII
RVLEGPIGYTDCATEGEPDPECASTCPVHGVWERVTQQIIAVIDSITLQDLVDQALAERGNPMYHI

Specific function: Master repressor of cysteine metabolism in B.subtilis. Controls the expression of genes involved either in cysteine synthesis from sulfide (cysK), sulfonates (ssu), or methionine (mccAB) or in cystine uptake (tcyP). Activity of CymR is positively regulate

COG id: COG1959

COG function: function code K; Predicted transcriptional regulator

Gene ontology:

Cell location: Cytoplasmic

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 HTH rrf2-type DNA-binding domain [H]

Homologues:

Organism=Escherichia coli, GI1788880, Length=134, Percent_Identity=36.5671641791045, Blast_Score=100, Evalue=4e-23,
Organism=Escherichia coli, GI1790621, Length=148, Percent_Identity=31.0810810810811, Blast_Score=77, Evalue=4e-16,

Paralogues:

None

Copy number: 10-20 Molecules/Cell [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000944 [H]

Pfam domain/function: PF02082 Rrf2 [H]

EC number: NA

Molecular weight: Translated: 15784; Mature: 15784

Theoretical pI: Translated: 5.61; Mature: 5.61

Prosite motif: PS01332 UPF0074

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.1 %Cys     (Translated Protein)
2.7 %Met     (Translated Protein)
4.8 %Cys+Met (Translated Protein)
2.1 %Cys     (Mature Protein)
2.7 %Met     (Mature Protein)
4.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKLSTKGKYGVKALFELAMHEGSGPVSLRTIAERQGLSEHYLEQLAAPLRRAGIITAVRG
CCCCCCCCHHHHHHHHHHHHCCCCCCHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHEEC
AQGGYMLARPANQITVGDIIRVLEGPIGYTDCATEGEPDPECASTCPVHGVWERVTQQII
CCCCEEEECCCCCCCHHHHHHHHHCCCCCCCCCCCCCCCCCHHHCCCCHHHHHHHHHHHH
AVIDSITLQDLVDQALAERGNPMYHI
HHHHHHHHHHHHHHHHHHCCCCCCCC
>Mature Secondary Structure
MKLSTKGKYGVKALFELAMHEGSGPVSLRTIAERQGLSEHYLEQLAAPLRRAGIITAVRG
CCCCCCCCHHHHHHHHHHHHCCCCCCHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHEEC
AQGGYMLARPANQITVGDIIRVLEGPIGYTDCATEGEPDPECASTCPVHGVWERVTQQII
CCCCEEEECCCCCCCHHHHHHHHHCCCCCCCCCCCCCCCCCHHHCCCCHHHHHHHHHHHH
AVIDSITLQDLVDQALAERGNPMYHI
HHHHHHHHHHHHHHHHHHCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 9384377 [H]