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The map label for this gene is dmsA1 [H]

Identifier: 51893470

GI number: 51893470

Start: 2517903

End: 2520281

Strand: Reverse

Name: dmsA1 [H]

Synonym: STH2332

Alternate gene names: 51893470

Gene position: 2520281-2517903 (Counterclockwise)

Preceding gene: 51893471

Following gene: 51893469

Centisome position: 70.67

GC content: 67.47

Gene sequence:

>2379_bases
ATGCTGCCGGAGATTTCCCGCAGGAGCTTCCTCAAGTGGTCGGCGGTGGTCGGTGCCGGCGCTGCCCTCGGCGGGGCGGC
GGCGCTGGATACGGGCCTGAAACCGCTGGCGCGCACGGCGGAAGCGACCGGAACCCCCGTGCCGGACAAGATGGTGTGGC
AGCAGTGTACCGTCAACTGTGGCGGCTACTCGTGCGCCCTGCGGCTGCACGTGAAGGACGACGTCATCGTCCGCGTCGAC
ACGGACCAGCTGGACCGGTCCGGTTTCCCGGCGATGCGCGCCTGCCTGCGCGGCCGGGCCACCCGGAAGTTCGTGTACAA
CCCTGACCGGCTGAAGCAGCCCATGAAGCGGGTAGGCAAGCGGGGCGAGGGCAAGTTCGAACCCATCACCTGGGACGAGG
CCTACACGCTGATCGCGGAGAACCTGGACCGGATCATCAAGACGTACGGCAATCAGGCCGTGTTCAACCACTACGCCTCC
GGCACGGACGGCACGAGCCGCACCCCCATTCCGCGCCTGCTCAACATGCTCGGCGGTTACCTGGGCTACTACGGGACTTA
CTCCTCCGCTTGTTATACGTGGGCGGCGCCGTACACGTACGGCAGCGCGGGCTGCAACTCGGCCGATGACCTGGTCAACT
CCCGTCTCATCGTGCTGTTTGCCAGCAACCCAGGTGAGACCCAGCCGGGCGGCGGCAACGAGTTCCACTGGCTGATGCAG
GCCAAGCGGGCCGGCGTCAAGATCATCGTGGTCGATCCGCGCCTCTCCGACACGGCGAAGGCCCTGGCGGACGAGTGGAT
CCCCATCCGCCCGACCACGGACAACGCGCTGATCGACGCGATGGCCTACGTCATGATCACCGAGAATCTCCACGACCAGG
CCTTCCTGGACAAGTACTGCGTGGGCTTCGATGACGCGCACCTGCCGGCAGGCGCCCCGCCCAAGTCCAGCTACAAGAGC
TACGTGCTGGGTGAGGCCGACGGGGTGCCCAAGACCCCGGAGTGGGCGGAGGCGATCACCGGCGTGCCGCGGCAGACCAT
CGTCCGCCTGGCCCGGGAGATCGCCATCACAAAGCCCTGCGCGCTGCTCCAGCACTACGGCTGGCAGCGGAACGCCTACG
GCGAGCAACCGGTGCGGGGCCTGCCCGTGCTGATGGCCATGACCGGGAACATCGGCCGGAGCGGAGGCGGCACCGGGCTG
ACCCCCTCCCGCAAGGGCGCGCCGAGCCCGAGCATCCCCACCGGTACCAATCCGGTGAAAGCGCAGATCCCGGTCTTCAT
GTGGACCGAGGCCATCGTGCGGGGCAAGGAACTAACGGCCAAGGACGGCGTGCTCGGGGCGGACAAGCTGGACGCGAACA
TCAAGTTCATCTGGAACTACGGCGGCAACACCCTGATCAACCAGCACTCCGACGCGGGCGCCACGCACCGCATCCTGCAG
GATGAGTCCCTCTGCGAGTTTATCGTGGTCCACGACGTCATGATGACCCCGTCGGCCCGGTACGCCGACCTCCTGCTGCC
CGACCGGACCAGCTACGAGCGGCTCCACCTGGGCCGGGGCAGCACCAACGTGATGGGCGACCGCTTCTACCTCGGCGTCC
CGGCCATCACGCCGCTCTTCGATGCCAAGACCAATTACGAGGTCTGCGCCGGCGTCGCCGCGAAGCTGGGCATCTACGAC
CAGTTCACCGAGGGCAAGACCTGGGAGGACTGGTGCCGGGAGGCCATTGCGGCGCTGGGCGAGAAGAACCCGGGCTTCCC
CACCTGGGAGAAGTTGCTGGAGGATCCGATCGTGCGCGGCACGCAGGAGAAGCCGGTGATCGCCTTCGCCAGCTTCATCG
CGGATCCCGAGAGCAATCCGCTCAAGACGCCCTCGGGCAAGATCGAGATCTACTCCGAGCAGCTGGCCAGGCTGGGCGCG
GAGCGGGGCAACGCGGATGAGCTCCCGCCCATCCCGAAGTATGTTCCCGCCTGGGAGGGTCCCAACGCCCCCGCCGAGCT
GCGGGAGAAGTACCCCCTGCAGCTGGTCGGCCACCACACCAAGCGGCGGGTCCACTCCACCCACGACAACAACCCGTGGC
TGGAGGAAGTGGAGCCGCAGATGCTCACCATCAACGAGATCGACGCGGCCGAGCGGGGCATCAGGGACGGCGACATGGTG
CGGGTCTGGAACGACCGGGGCGAGGTCCACGTGCGGTGCCGGGTCTCCAAGGCCATCATGCCCGGCGTCGTCGACCTGCC
GCAGGGTGCCTGGTACACGCCGAACGCGAACGGCATCGACACCCGCGGCTGCATCAACGTGCTGACCAAGTACCATCCGA
CCCCGGGCGCCAAGGGCAACCCCCAGCACACCAACCTGGTCCAGGTGGCCAAGCTCTGA

Upstream 100 bases:

>100_bases
CTGGCCCGGCTGACCCTGGGTCTGCTCCGGGTGGACTGCAAGTTCCTGGAAGAGGTAGCCGCGGAACCTGTTCGCACCTG
ACACCGAAGGAGGTAACAAG

Downstream 100 bases:

>100_bases
GGAGGTGAGCAGGAATGCAATACGGGTTCTTCATCGATGCCAAGTACTGCGCCGGATGCAAGACCTGCCAGATCGCCTGT
AAGGACCGGGCGAGCCTCGA

Product: anaerobic dimethyl sulfoxide reductase subunit A

Products: Reduced form of N-Oxide compounds [C]

Alternate protein names: DMSO reductase [H]

Number of amino acids: Translated: 792; Mature: 792

Protein sequence:

>792_residues
MLPEISRRSFLKWSAVVGAGAALGGAAALDTGLKPLARTAEATGTPVPDKMVWQQCTVNCGGYSCALRLHVKDDVIVRVD
TDQLDRSGFPAMRACLRGRATRKFVYNPDRLKQPMKRVGKRGEGKFEPITWDEAYTLIAENLDRIIKTYGNQAVFNHYAS
GTDGTSRTPIPRLLNMLGGYLGYYGTYSSACYTWAAPYTYGSAGCNSADDLVNSRLIVLFASNPGETQPGGGNEFHWLMQ
AKRAGVKIIVVDPRLSDTAKALADEWIPIRPTTDNALIDAMAYVMITENLHDQAFLDKYCVGFDDAHLPAGAPPKSSYKS
YVLGEADGVPKTPEWAEAITGVPRQTIVRLAREIAITKPCALLQHYGWQRNAYGEQPVRGLPVLMAMTGNIGRSGGGTGL
TPSRKGAPSPSIPTGTNPVKAQIPVFMWTEAIVRGKELTAKDGVLGADKLDANIKFIWNYGGNTLINQHSDAGATHRILQ
DESLCEFIVVHDVMMTPSARYADLLLPDRTSYERLHLGRGSTNVMGDRFYLGVPAITPLFDAKTNYEVCAGVAAKLGIYD
QFTEGKTWEDWCREAIAALGEKNPGFPTWEKLLEDPIVRGTQEKPVIAFASFIADPESNPLKTPSGKIEIYSEQLARLGA
ERGNADELPPIPKYVPAWEGPNAPAELREKYPLQLVGHHTKRRVHSTHDNNPWLEEVEPQMLTINEIDAAERGIRDGDMV
RVWNDRGEVHVRCRVSKAIMPGVVDLPQGAWYTPNANGIDTRGCINVLTKYHPTPGAKGNPQHTNLVQVAKL

Sequences:

>Translated_792_residues
MLPEISRRSFLKWSAVVGAGAALGGAAALDTGLKPLARTAEATGTPVPDKMVWQQCTVNCGGYSCALRLHVKDDVIVRVD
TDQLDRSGFPAMRACLRGRATRKFVYNPDRLKQPMKRVGKRGEGKFEPITWDEAYTLIAENLDRIIKTYGNQAVFNHYAS
GTDGTSRTPIPRLLNMLGGYLGYYGTYSSACYTWAAPYTYGSAGCNSADDLVNSRLIVLFASNPGETQPGGGNEFHWLMQ
AKRAGVKIIVVDPRLSDTAKALADEWIPIRPTTDNALIDAMAYVMITENLHDQAFLDKYCVGFDDAHLPAGAPPKSSYKS
YVLGEADGVPKTPEWAEAITGVPRQTIVRLAREIAITKPCALLQHYGWQRNAYGEQPVRGLPVLMAMTGNIGRSGGGTGL
TPSRKGAPSPSIPTGTNPVKAQIPVFMWTEAIVRGKELTAKDGVLGADKLDANIKFIWNYGGNTLINQHSDAGATHRILQ
DESLCEFIVVHDVMMTPSARYADLLLPDRTSYERLHLGRGSTNVMGDRFYLGVPAITPLFDAKTNYEVCAGVAAKLGIYD
QFTEGKTWEDWCREAIAALGEKNPGFPTWEKLLEDPIVRGTQEKPVIAFASFIADPESNPLKTPSGKIEIYSEQLARLGA
ERGNADELPPIPKYVPAWEGPNAPAELREKYPLQLVGHHTKRRVHSTHDNNPWLEEVEPQMLTINEIDAAERGIRDGDMV
RVWNDRGEVHVRCRVSKAIMPGVVDLPQGAWYTPNANGIDTRGCINVLTKYHPTPGAKGNPQHTNLVQVAKL
>Mature_792_residues
MLPEISRRSFLKWSAVVGAGAALGGAAALDTGLKPLARTAEATGTPVPDKMVWQQCTVNCGGYSCALRLHVKDDVIVRVD
TDQLDRSGFPAMRACLRGRATRKFVYNPDRLKQPMKRVGKRGEGKFEPITWDEAYTLIAENLDRIIKTYGNQAVFNHYAS
GTDGTSRTPIPRLLNMLGGYLGYYGTYSSACYTWAAPYTYGSAGCNSADDLVNSRLIVLFASNPGETQPGGGNEFHWLMQ
AKRAGVKIIVVDPRLSDTAKALADEWIPIRPTTDNALIDAMAYVMITENLHDQAFLDKYCVGFDDAHLPAGAPPKSSYKS
YVLGEADGVPKTPEWAEAITGVPRQTIVRLAREIAITKPCALLQHYGWQRNAYGEQPVRGLPVLMAMTGNIGRSGGGTGL
TPSRKGAPSPSIPTGTNPVKAQIPVFMWTEAIVRGKELTAKDGVLGADKLDANIKFIWNYGGNTLINQHSDAGATHRILQ
DESLCEFIVVHDVMMTPSARYADLLLPDRTSYERLHLGRGSTNVMGDRFYLGVPAITPLFDAKTNYEVCAGVAAKLGIYD
QFTEGKTWEDWCREAIAALGEKNPGFPTWEKLLEDPIVRGTQEKPVIAFASFIADPESNPLKTPSGKIEIYSEQLARLGA
ERGNADELPPIPKYVPAWEGPNAPAELREKYPLQLVGHHTKRRVHSTHDNNPWLEEVEPQMLTINEIDAAERGIRDGDMV
RVWNDRGEVHVRCRVSKAIMPGVVDLPQGAWYTPNANGIDTRGCINVLTKYHPTPGAKGNPQHTNLVQVAKL

Specific function: Terminal reductase during anaerobic growth on various sulfoxide and N-oxide compounds. Allows E.coli to grow anaerobically on Me(2)SO as respiratory oxidant [H]

COG id: COG0243

COG function: function code C; Anaerobic dehydrogenases, typically selenocysteine-containing

Gene ontology:

Cell location: Cell membrane; Peripheral membrane protein; Cytoplasmic side [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the prokaryotic molybdopterin-containing oxidoreductase family [H]

Homologues:

Organism=Escherichia coli, GI87081797, Length=812, Percent_Identity=48.8916256157635, Blast_Score=737, Evalue=0.0,
Organism=Escherichia coli, GI171474008, Length=808, Percent_Identity=47.1534653465347, Blast_Score=694, Evalue=0.0,
Organism=Escherichia coli, GI1787870, Length=808, Percent_Identity=47.1534653465347, Blast_Score=691, Evalue=0.0,
Organism=Escherichia coli, GI145693196, Length=743, Percent_Identity=31.2247644683715, Blast_Score=277, Evalue=2e-75,
Organism=Escherichia coli, GI87081994, Length=838, Percent_Identity=30.4295942720764, Blast_Score=274, Evalue=2e-74,
Organism=Escherichia coli, GI1787231, Length=814, Percent_Identity=28.992628992629, Blast_Score=239, Evalue=6e-64,
Organism=Escherichia coli, GI3868721, Length=723, Percent_Identity=26.9709543568465, Blast_Score=153, Evalue=3e-38,
Organism=Escherichia coli, GI3868720, Length=459, Percent_Identity=27.0152505446623, Blast_Score=106, Evalue=7e-24,
Organism=Escherichia coli, GI1787741, Length=366, Percent_Identity=25.9562841530055, Blast_Score=80, Evalue=7e-16,
Organism=Escherichia coli, GI1787477, Length=346, Percent_Identity=27.4566473988439, Blast_Score=78, Evalue=3e-15,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR011888
- InterPro:   IPR009010
- InterPro:   IPR006657
- InterPro:   IPR006656
- InterPro:   IPR006963
- InterPro:   IPR006655
- InterPro:   IPR006311 [H]

Pfam domain/function: PF04879 Molybdop_Fe4S4; PF00384 Molybdopterin; PF01568 Molydop_binding [H]

EC number: 1.8.99.- [C]

Molecular weight: Translated: 86831; Mature: 86831

Theoretical pI: Translated: 7.54; Mature: 7.54

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.6 %Cys     (Translated Protein)
2.1 %Met     (Translated Protein)
3.8 %Cys+Met (Translated Protein)
1.6 %Cys     (Mature Protein)
2.1 %Met     (Mature Protein)
3.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MLPEISRRSFLKWSAVVGAGAALGGAAALDTGLKPLARTAEATGTPVPDKMVWQQCTVNC
CCCCCCHHHHHHHHHHHHCCHHHCCHHHHHHCCHHHHHHHHCCCCCCCHHHHHHHHCCCC
GGYSCALRLHVKDDVIVRVDTDQLDRSGFPAMRACLRGRATRKFVYNPDRLKQPMKRVGK
CCEEEEEEEEECCCEEEEECCHHHCCCCCHHHHHHHCCCCCCEEEECHHHHHHHHHHHCC
RGEGKFEPITWDEAYTLIAENLDRIIKTYGNQAVFNHYASGTDGTSRTPIPRLLNMLGGY
CCCCCCCCCCHHHHHHHHHHHHHHHHHHHCCHHHHHHHCCCCCCCCCCCHHHHHHHHHHH
LGYYGTYSSACYTWAAPYTYGSAGCNSADDLVNSRLIVLFASNPGETQPGGGNEFHWLMQ
HHHHCCCCCCEEEEECCCCCCCCCCCCHHHHCCCCEEEEEECCCCCCCCCCCCCHHHHHH
AKRAGVKIIVVDPRLSDTAKALADEWIPIRPTTDNALIDAMAYVMITENLHDQAFLDKYC
HHHCCEEEEEECCCCCHHHHHHHHCCCCCCCCCCHHHHHHHHHHHHHCCCCHHHHHHHHH
VGFDDAHLPAGAPPKSSYKSYVLGEADGVPKTPEWAEAITGVPRQTIVRLAREIAITKPC
CCCCCCCCCCCCCCCCCCCCEEEECCCCCCCCCHHHHHHCCCCHHHHHHHHHHHHHCCHH
ALLQHYGWQRNAYGEQPVRGLPVLMAMTGNIGRSGGGTGLTPSRKGAPSPSIPTGTNPVK
HHHHHCCCCCCCCCCCCCCCCCEEEEECCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCE
AQIPVFMWTEAIVRGKELTAKDGVLGADKLDANIKFIWNYGGNTLINQHSDAGATHRILQ
EECCHHHHHHHHHCCCCCCCCCCCCCCCCCCCCEEEEEECCCCEEECCCCCCCHHHHHHC
DESLCEFIVVHDVMMTPSARYADLLLPDRTSYERLHLGRGSTNVMGDRFYLGVPAITPLF
CCHHHHHHHHHHHHHCCCCCHHEEECCCCCCCHHEECCCCCCCCCCCEEEECCCCCCHHH
DAKTNYEVCAGVAAKLGIYDQFTEGKTWEDWCREAIAALGEKNPGFPTWEKLLEDPIVRG
CCCCCHHHHHHHHHHHCCHHHCCCCCCHHHHHHHHHHHHCCCCCCCCHHHHHHHCHHHCC
TQEKPVIAFASFIADPESNPLKTPSGKIEIYSEQLARLGAERGNADELPPIPKYVPAWEG
CCCCCHHHHHHHHCCCCCCCCCCCCCCEEEHHHHHHHHHCCCCCCCCCCCCCCCCCCCCC
PNAPAELREKYPLQLVGHHTKRRVHSTHDNNPWLEEVEPQMLTINEIDAAERGIRDGDMV
CCCCHHHHHCCCHHEECCHHHHHHHCCCCCCCCHHHCCCCEEEEEHHHHHHCCCCCCCEE
RVWNDRGEVHVRCRVSKAIMPGVVDLPQGAWYTPNANGIDTRGCINVLTKYHPTPGAKGN
EEECCCCCEEEEEEECCHHCCCCEECCCCCEECCCCCCCCHHHHHHHHHHCCCCCCCCCC
PQHTNLVQVAKL
CCCCCEEEEECC
>Mature Secondary Structure
MLPEISRRSFLKWSAVVGAGAALGGAAALDTGLKPLARTAEATGTPVPDKMVWQQCTVNC
CCCCCCHHHHHHHHHHHHCCHHHCCHHHHHHCCHHHHHHHHCCCCCCCHHHHHHHHCCCC
GGYSCALRLHVKDDVIVRVDTDQLDRSGFPAMRACLRGRATRKFVYNPDRLKQPMKRVGK
CCEEEEEEEEECCCEEEEECCHHHCCCCCHHHHHHHCCCCCCEEEECHHHHHHHHHHHCC
RGEGKFEPITWDEAYTLIAENLDRIIKTYGNQAVFNHYASGTDGTSRTPIPRLLNMLGGY
CCCCCCCCCCHHHHHHHHHHHHHHHHHHHCCHHHHHHHCCCCCCCCCCCHHHHHHHHHHH
LGYYGTYSSACYTWAAPYTYGSAGCNSADDLVNSRLIVLFASNPGETQPGGGNEFHWLMQ
HHHHCCCCCCEEEEECCCCCCCCCCCCHHHHCCCCEEEEEECCCCCCCCCCCCCHHHHHH
AKRAGVKIIVVDPRLSDTAKALADEWIPIRPTTDNALIDAMAYVMITENLHDQAFLDKYC
HHHCCEEEEEECCCCCHHHHHHHHCCCCCCCCCCHHHHHHHHHHHHHCCCCHHHHHHHHH
VGFDDAHLPAGAPPKSSYKSYVLGEADGVPKTPEWAEAITGVPRQTIVRLAREIAITKPC
CCCCCCCCCCCCCCCCCCCCEEEECCCCCCCCCHHHHHHCCCCHHHHHHHHHHHHHCCHH
ALLQHYGWQRNAYGEQPVRGLPVLMAMTGNIGRSGGGTGLTPSRKGAPSPSIPTGTNPVK
HHHHHCCCCCCCCCCCCCCCCCEEEEECCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCE
AQIPVFMWTEAIVRGKELTAKDGVLGADKLDANIKFIWNYGGNTLINQHSDAGATHRILQ
EECCHHHHHHHHHCCCCCCCCCCCCCCCCCCCCEEEEEECCCCEEECCCCCCCHHHHHHC
DESLCEFIVVHDVMMTPSARYADLLLPDRTSYERLHLGRGSTNVMGDRFYLGVPAITPLF
CCHHHHHHHHHHHHHCCCCCHHEEECCCCCCCHHEECCCCCCCCCCCEEEECCCCCCHHH
DAKTNYEVCAGVAAKLGIYDQFTEGKTWEDWCREAIAALGEKNPGFPTWEKLLEDPIVRG
CCCCCHHHHHHHHHHHCCHHHCCCCCCHHHHHHHHHHHHCCCCCCCCHHHHHHHCHHHCC
TQEKPVIAFASFIADPESNPLKTPSGKIEIYSEQLARLGAERGNADELPPIPKYVPAWEG
CCCCCHHHHHHHHCCCCCCCCCCCCCCEEEHHHHHHHHHCCCCCCCCCCCCCCCCCCCCC
PNAPAELREKYPLQLVGHHTKRRVHSTHDNNPWLEEVEPQMLTINEIDAAERGIRDGDMV
CCCCHHHHHCCCHHEECCHHHHHHHCCCCCCCCHHHCCCCEEEEEHHHHHHCCCCCCCEE
RVWNDRGEVHVRCRVSKAIMPGVVDLPQGAWYTPNANGIDTRGCINVLTKYHPTPGAKGN
EEECCCCCEEEEEEECCHHCCCCEECCCCCEECCCCCCCCHHHHHHHHHHCCCCCCCCCC
PQHTNLVQVAKL
CCCCCEEEEECC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: May Bind 4Fe-4S Cluster. [C]

Metal ions: Fe; Mo [C]

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: N-Oxide; Sulfoxide Compounds Including Trimethylamine N-Oxide. [C]

Specific reaction: Reduces Various N-Oxide And Sulfoxide Compounds Including Trimethylamine N-Oxide. [C]

General reaction: Oxidoreductases [C]

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 3062312; 8905232; 9278503; 2170332; 8125918; 10801884 [H]