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The map label for this gene is serA [H]

Identifier: 51893369

GI number: 51893369

Start: 2397900

End: 2398475

Strand: Reverse

Name: serA [H]

Synonym: STH2231

Alternate gene names: 51893369

Gene position: 2398475-2397900 (Counterclockwise)

Preceding gene: 51893370

Following gene: 51893368

Centisome position: 67.26

GC content: 70.14

Gene sequence:

>576_bases
GTGCTGGGGCTGGTGGGCATCGGCCGCATCGGCACTCAGGTTGCCCGGAAGGCGCAGGCCGCCTTCGACATGCAGGTCAT
CGGCTACGACCCGTACGTGGCGCCCGAGGCGGCGCAGGCCCATGGCATCCGCATGGTGGCGGACCTGGCGGAGCTCTTCC
GCACAGCGGACGTGGTGTCCATCCACGCGCCGCTCACGCCGGAGACCCGGGGCCTGGTCACCCGGGAACTGATCGGCATG
ATGAAGCCCACCGCTTTCCTGGTCAACTTCGCCCGCGGGGAGATCGTCGACGAGGGCGCCCTGGTGGAGGCCCTCCGGGA
GGAGCGCATCGCCGGGGCCGCCCTGGACGTGTTTGAACGGGAGCCCGTGGACCCGGAGAACCCCCTCTTGCAGCTGGATA
ACGTGTTGCTCTCGCCGCACAGCGCGGCGCAGACCCGGGAGTGCGTCATCCGCATGTCGGTTACCACCGCCCAGGGCGTG
ATCGACGCCCTCACCGGCCGGCGGCCCCGGTATATCGTCAACCCCGAGGTGCTTCTGCGCAGCGGTCGAGCGGGTGAGGG
GGAGATGGGCGGATGA

Upstream 100 bases:

>100_bases
CGCGGCCCTGGCCAAGCGGGTGGTGTTCATGGACCGGGCCGTCCGGGACGGGCGGTGGCAGGCGCGCGGCGATCTGAAGG
CCATCGACCTGTAAGGCAAG

Downstream 100 bases:

>100_bases
AGAAGCACGATCGGATCGGGGCTGTGGTTCTCATCGTGATCGGCGTGGCTGCGGCCGTCTACTCCGTGATCAAGCTGAAG
GTCGGCACCCTGCGGGTGCC

Product: phosphoglycerate dehydrogenase

Products: NA

Alternate protein names: PGDH [H]

Number of amino acids: Translated: 191; Mature: 191

Protein sequence:

>191_residues
MLGLVGIGRIGTQVARKAQAAFDMQVIGYDPYVAPEAAQAHGIRMVADLAELFRTADVVSIHAPLTPETRGLVTRELIGM
MKPTAFLVNFARGEIVDEGALVEALREERIAGAALDVFEREPVDPENPLLQLDNVLLSPHSAAQTRECVIRMSVTTAQGV
IDALTGRRPRYIVNPEVLLRSGRAGEGEMGG

Sequences:

>Translated_191_residues
MLGLVGIGRIGTQVARKAQAAFDMQVIGYDPYVAPEAAQAHGIRMVADLAELFRTADVVSIHAPLTPETRGLVTRELIGM
MKPTAFLVNFARGEIVDEGALVEALREERIAGAALDVFEREPVDPENPLLQLDNVLLSPHSAAQTRECVIRMSVTTAQGV
IDALTGRRPRYIVNPEVLLRSGRAGEGEMGG
>Mature_191_residues
MLGLVGIGRIGTQVARKAQAAFDMQVIGYDPYVAPEAAQAHGIRMVADLAELFRTADVVSIHAPLTPETRGLVTRELIGM
MKPTAFLVNFARGEIVDEGALVEALREERIAGAALDVFEREPVDPENPLLQLDNVLLSPHSAAQTRECVIRMSVTTAQGV
IDALTGRRPRYIVNPEVLLRSGRAGEGEMGG

Specific function: Unknown

COG id: COG0111

COG function: function code HE; Phosphoglycerate dehydrogenase and related dehydrogenases

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 ACT domain [H]

Homologues:

Organism=Homo sapiens, GI23308577, Length=177, Percent_Identity=39.5480225988701, Blast_Score=127, Evalue=9e-30,
Organism=Homo sapiens, GI145580578, Length=184, Percent_Identity=40.7608695652174, Blast_Score=122, Evalue=1e-28,
Organism=Homo sapiens, GI4557499, Length=184, Percent_Identity=40.7608695652174, Blast_Score=122, Evalue=1e-28,
Organism=Homo sapiens, GI4557497, Length=174, Percent_Identity=39.6551724137931, Blast_Score=122, Evalue=1e-28,
Organism=Homo sapiens, GI61743967, Length=174, Percent_Identity=39.6551724137931, Blast_Score=122, Evalue=2e-28,
Organism=Homo sapiens, GI145580575, Length=184, Percent_Identity=40.7608695652174, Blast_Score=120, Evalue=6e-28,
Organism=Homo sapiens, GI6912396, Length=168, Percent_Identity=33.9285714285714, Blast_Score=90, Evalue=9e-19,
Organism=Escherichia coli, GI87082289, Length=176, Percent_Identity=38.6363636363636, Blast_Score=119, Evalue=9e-29,
Organism=Escherichia coli, GI1789279, Length=183, Percent_Identity=37.7049180327869, Blast_Score=103, Evalue=5e-24,
Organism=Escherichia coli, GI1787645, Length=172, Percent_Identity=35.4651162790698, Blast_Score=97, Evalue=9e-22,
Organism=Escherichia coli, GI87081824, Length=163, Percent_Identity=35.5828220858896, Blast_Score=83, Evalue=1e-17,
Organism=Caenorhabditis elegans, GI17532191, Length=166, Percent_Identity=37.3493975903614, Blast_Score=106, Evalue=9e-24,
Organism=Caenorhabditis elegans, GI25147481, Length=186, Percent_Identity=32.258064516129, Blast_Score=105, Evalue=2e-23,
Organism=Saccharomyces cerevisiae, GI6320925, Length=193, Percent_Identity=33.160621761658, Blast_Score=96, Evalue=4e-21,
Organism=Saccharomyces cerevisiae, GI6322116, Length=193, Percent_Identity=33.160621761658, Blast_Score=96, Evalue=5e-21,
Organism=Saccharomyces cerevisiae, GI6324055, Length=169, Percent_Identity=34.3195266272189, Blast_Score=88, Evalue=9e-19,
Organism=Saccharomyces cerevisiae, GI6324980, Length=147, Percent_Identity=31.2925170068027, Blast_Score=76, Evalue=3e-15,
Organism=Saccharomyces cerevisiae, GI6324964, Length=147, Percent_Identity=31.2925170068027, Blast_Score=76, Evalue=4e-15,
Organism=Saccharomyces cerevisiae, GI6325144, Length=176, Percent_Identity=26.1363636363636, Blast_Score=74, Evalue=2e-14,
Organism=Drosophila melanogaster, GI19921140, Length=184, Percent_Identity=36.9565217391304, Blast_Score=115, Evalue=2e-26,
Organism=Drosophila melanogaster, GI24646446, Length=184, Percent_Identity=38.0434782608696, Blast_Score=111, Evalue=3e-25,
Organism=Drosophila melanogaster, GI24646448, Length=184, Percent_Identity=38.0434782608696, Blast_Score=111, Evalue=3e-25,
Organism=Drosophila melanogaster, GI24646452, Length=184, Percent_Identity=38.0434782608696, Blast_Score=111, Evalue=3e-25,
Organism=Drosophila melanogaster, GI24646450, Length=184, Percent_Identity=38.0434782608696, Blast_Score=111, Evalue=3e-25,
Organism=Drosophila melanogaster, GI62472511, Length=184, Percent_Identity=38.0434782608696, Blast_Score=110, Evalue=5e-25,
Organism=Drosophila melanogaster, GI28571528, Length=167, Percent_Identity=37.125748502994, Blast_Score=107, Evalue=6e-24,
Organism=Drosophila melanogaster, GI28574284, Length=167, Percent_Identity=37.125748502994, Blast_Score=100, Evalue=4e-22,
Organism=Drosophila melanogaster, GI45552429, Length=167, Percent_Identity=37.125748502994, Blast_Score=100, Evalue=4e-22,
Organism=Drosophila melanogaster, GI24585514, Length=167, Percent_Identity=37.125748502994, Blast_Score=100, Evalue=4e-22,
Organism=Drosophila melanogaster, GI28574282, Length=167, Percent_Identity=37.125748502994, Blast_Score=100, Evalue=4e-22,
Organism=Drosophila melanogaster, GI45551003, Length=167, Percent_Identity=37.125748502994, Blast_Score=100, Evalue=5e-22,
Organism=Drosophila melanogaster, GI28574286, Length=167, Percent_Identity=35.3293413173653, Blast_Score=94, Evalue=7e-20,
Organism=Drosophila melanogaster, GI24585516, Length=174, Percent_Identity=31.0344827586207, Blast_Score=86, Evalue=1e-17,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR002912
- InterPro:   IPR006236
- InterPro:   IPR006139
- InterPro:   IPR006140
- InterPro:   IPR015508
- InterPro:   IPR016040 [H]

Pfam domain/function: PF00389 2-Hacid_dh; PF02826 2-Hacid_dh_C; PF01842 ACT [H]

EC number: =1.1.1.95 [H]

Molecular weight: Translated: 20569; Mature: 20569

Theoretical pI: Translated: 4.90; Mature: 4.90

Prosite motif: PS00671 D_2_HYDROXYACID_DH_3

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.5 %Cys     (Translated Protein)
3.7 %Met     (Translated Protein)
4.2 %Cys+Met (Translated Protein)
0.5 %Cys     (Mature Protein)
3.7 %Met     (Mature Protein)
4.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MLGLVGIGRIGTQVARKAQAAFDMQVIGYDPYVAPEAAQAHGIRMVADLAELFRTADVVS
CCCCCCCCHHHHHHHHHHHHHHCEEEECCCCCCCCCCHHHCCHHHHHHHHHHHHHHCEEE
IHAPLTPETRGLVTRELIGMMKPTAFLVNFARGEIVDEGALVEALREERIAGAALDVFER
EECCCCCCHHHHHHHHHHHHHCHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHHHHHHC
EPVDPENPLLQLDNVLLSPHSAAQTRECVIRMSVTTAQGVIDALTGRRPRYIVNPEVLLR
CCCCCCCCHHHHHHHHCCCCCHHHHHHEEEEEEHHHHHHHHHHHCCCCCEEEECHHHHEE
SGRAGEGEMGG
CCCCCCCCCCC
>Mature Secondary Structure
MLGLVGIGRIGTQVARKAQAAFDMQVIGYDPYVAPEAAQAHGIRMVADLAELFRTADVVS
CCCCCCCCHHHHHHHHHHHHHHCEEEECCCCCCCCCCHHHCCHHHHHHHHHHHHHHCEEE
IHAPLTPETRGLVTRELIGMMKPTAFLVNFARGEIVDEGALVEALREERIAGAALDVFER
EECCCCCCHHHHHHHHHHHHHCHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHHHHHHC
EPVDPENPLLQLDNVLLSPHSAAQTRECVIRMSVTTAQGVIDALTGRRPRYIVNPEVLLR
CCCCCCCCHHHHHHHHCCCCCHHHHHHEEEEEEHHHHHHHHHHHCCCCCEEEECHHHHEE
SGRAGEGEMGG
CCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 8688087 [H]