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The map label for this gene is yfeW [C]

Identifier: 51893159

GI number: 51893159

Start: 2162430

End: 2163638

Strand: Reverse

Name: yfeW [C]

Synonym: STH2021

Alternate gene names: 51893159

Gene position: 2163638-2162430 (Counterclockwise)

Preceding gene: 51893164

Following gene: 51893156

Centisome position: 60.67

GC content: 71.88

Gene sequence:

>1209_bases
ATGCGCCGGTGGCAACGCCTGGCGCTGGTCGCCCTCGCGGGGGCCGTGGCGCTGGGCGCGGGATCGATCGGGTACCTGCG
CTGGCACACCCGGGCGGTGGTGACGGCGGCGGTGCCGGCGGGTTCGCACGCGGTGGCGACGACGCTGGACCCGGCCGCCT
CCGACCGGCTGATGCAGGTGGTCTCGGACGCCCGGGAGCGGCTGGGCGTGCCGGCGCTGCAGGTGGCGGTGGTGAAGGGC
GGCGAGCTGGTCTGGACCGGCGCCGTGGGCTGGGCCGACCCGCCGGCCGGGCGGCCGGTGACGGCGGAGGACCGGTTCCA
CATCGGCAGCGTGAGCAAGCTGTACACCGCCGCCCTCGTCCTGCGGCTCGCCGAGGAGGGCCGGCTGTCCCTGGAGGATC
CGGTGAGCCGGTTCGTCCCGGACGTGCCCAACGGGGACCGGATTACGGTGCGGCAGCTGCTCAACCACACCAGCGGGCTT
GCCAACTACACCGAGGACACGGCCTTCAACCTGAAGACGGTCCTCCTGCGCCGGCGCTGGAGCGTGGACGAGGTGCTGGA
TGTCATCCGGCAGCAGGCGCCCCGCTCGGCGCCGGGAACCGAGCACTACTACTCCAACAGCAACTACGTGCTCCTGGGCC
GCATCGCCGAGGTGGCGGGGGGACGGCCGTTTGCCGACCTGCTGCACGACGAGGTGCTCCGCCCCCTCGGGCTGACCAAC
ACCTACCTGGCTGCGGGCGAGCCCGAGTCTGTCGGGACCGTGCGCGGGTACGACGTGACGGTGCTGGGCACCGGCCGGAT
GGGGATCAAGCTAGACATGGAGCGGTTCAGGGCGCCGTTTGAGACCTCGGCCTTTGCCGCCGGCGCCGTGACGGCCAGCG
CCGCCGACGTGGCCCGGTTCACCTCCGGCCTCTTGGGCGGCCGGCTGCTGGCGGATTCCACGCTCCAGTCCATGCTGACC
TTCGTGGACGCCCCTGACGAGGACATGCCGGCGCAGACAGGGTATGGCCTGGGGGTACGGCGTCTGGTCATCGGCGGCGA
GGAGATGGTGGGCCACACCGGTACCCTCCCGGGGTACAGCAACGTGGCGCTGTACGCCCCGGCCCATGACCACGCCGTCG
CCGTGCTCTCCAACCTGTCCATGTCGGACGTCACAGATGTCCTTGCGGAGGTCCAGGCCGTGCTTCTGGAGCCTGCCTCG
ACCAGGTGA

Upstream 100 bases:

>100_bases
AGGGCGGCGCAGGAAACGGCGCGGGAAGGGCGAATCATGCGAAGTTGGCCACCGAAGGGGCGGTGGCCAGGTTTCACGAC
AATGGGAAGGAGCGGATTCG

Downstream 100 bases:

>100_bases
GCCACGGGGACGCCGCACCGGCACCGCAGGCGAGCTGGTGGCCCTGCCCCGGGTTCACGGACGTGGACGGCTGCCACATC
CCGCCGTCTACGCTGGACTC

Product: D-alanyl-D-alanine carboxypeptidase

Products: NA

Alternate protein names: DD-carboxypeptidase; DD-peptidase [H]

Number of amino acids: Translated: 402; Mature: 402

Protein sequence:

>402_residues
MRRWQRLALVALAGAVALGAGSIGYLRWHTRAVVTAAVPAGSHAVATTLDPAASDRLMQVVSDARERLGVPALQVAVVKG
GELVWTGAVGWADPPAGRPVTAEDRFHIGSVSKLYTAALVLRLAEEGRLSLEDPVSRFVPDVPNGDRITVRQLLNHTSGL
ANYTEDTAFNLKTVLLRRRWSVDEVLDVIRQQAPRSAPGTEHYYSNSNYVLLGRIAEVAGGRPFADLLHDEVLRPLGLTN
TYLAAGEPESVGTVRGYDVTVLGTGRMGIKLDMERFRAPFETSAFAAGAVTASAADVARFTSGLLGGRLLADSTLQSMLT
FVDAPDEDMPAQTGYGLGVRRLVIGGEEMVGHTGTLPGYSNVALYAPAHDHAVAVLSNLSMSDVTDVLAEVQAVLLEPAS
TR

Sequences:

>Translated_402_residues
MRRWQRLALVALAGAVALGAGSIGYLRWHTRAVVTAAVPAGSHAVATTLDPAASDRLMQVVSDARERLGVPALQVAVVKG
GELVWTGAVGWADPPAGRPVTAEDRFHIGSVSKLYTAALVLRLAEEGRLSLEDPVSRFVPDVPNGDRITVRQLLNHTSGL
ANYTEDTAFNLKTVLLRRRWSVDEVLDVIRQQAPRSAPGTEHYYSNSNYVLLGRIAEVAGGRPFADLLHDEVLRPLGLTN
TYLAAGEPESVGTVRGYDVTVLGTGRMGIKLDMERFRAPFETSAFAAGAVTASAADVARFTSGLLGGRLLADSTLQSMLT
FVDAPDEDMPAQTGYGLGVRRLVIGGEEMVGHTGTLPGYSNVALYAPAHDHAVAVLSNLSMSDVTDVLAEVQAVLLEPAS
TR
>Mature_402_residues
MRRWQRLALVALAGAVALGAGSIGYLRWHTRAVVTAAVPAGSHAVATTLDPAASDRLMQVVSDARERLGVPALQVAVVKG
GELVWTGAVGWADPPAGRPVTAEDRFHIGSVSKLYTAALVLRLAEEGRLSLEDPVSRFVPDVPNGDRITVRQLLNHTSGL
ANYTEDTAFNLKTVLLRRRWSVDEVLDVIRQQAPRSAPGTEHYYSNSNYVLLGRIAEVAGGRPFADLLHDEVLRPLGLTN
TYLAAGEPESVGTVRGYDVTVLGTGRMGIKLDMERFRAPFETSAFAAGAVTASAADVARFTSGLLGGRLLADSTLQSMLT
FVDAPDEDMPAQTGYGLGVRRLVIGGEEMVGHTGTLPGYSNVALYAPAHDHAVAVLSNLSMSDVTDVLAEVQAVLLEPAS
TR

Specific function: Catalyzes distinct carboxypeptidation and transpeptidation reactions during the last stages of wall peptidoglycan synthesis. Mistaking a beta-lactam antibiotic molecule for a normal substrate (i.e., a D-alanyl-D-alanine- terminated peptide), it becomes im

COG id: COG1680

COG function: function code V; Beta-lactamase class C and other penicillin binding proteins

Gene ontology:

Cell location: Secreted [H]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the peptidase S12 family [H]

Homologues:

Organism=Homo sapiens, GI239747261, Length=312, Percent_Identity=25, Blast_Score=73, Evalue=5e-13,
Organism=Homo sapiens, GI239752721, Length=312, Percent_Identity=25, Blast_Score=73, Evalue=5e-13,
Organism=Homo sapiens, GI239741085, Length=312, Percent_Identity=25, Blast_Score=73, Evalue=5e-13,
Organism=Homo sapiens, GI26051231, Length=134, Percent_Identity=31.3432835820896, Blast_Score=65, Evalue=8e-11,
Organism=Homo sapiens, GI26051233, Length=134, Percent_Identity=31.3432835820896, Blast_Score=65, Evalue=9e-11,
Organism=Escherichia coli, GI87082101, Length=406, Percent_Identity=25.1231527093596, Blast_Score=84, Evalue=2e-17,
Organism=Escherichia coli, GI1790593, Length=269, Percent_Identity=26.0223048327138, Blast_Score=76, Evalue=4e-15,
Organism=Escherichia coli, GI1786574, Length=216, Percent_Identity=27.7777777777778, Blast_Score=70, Evalue=2e-13,
Organism=Caenorhabditis elegans, GI115533026, Length=405, Percent_Identity=23.7037037037037, Blast_Score=91, Evalue=9e-19,
Organism=Caenorhabditis elegans, GI17565630, Length=216, Percent_Identity=27.3148148148148, Blast_Score=79, Evalue=4e-15,
Organism=Caenorhabditis elegans, GI17550934, Length=203, Percent_Identity=28.0788177339901, Blast_Score=76, Evalue=3e-14,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR012338
- InterPro:   IPR001466 [H]

Pfam domain/function: PF00144 Beta-lactamase [H]

EC number: =3.4.16.4 [H]

Molecular weight: Translated: 42756; Mature: 42756

Theoretical pI: Translated: 6.06; Mature: 6.06

Prosite motif: PS00146 BETA_LACTAMASE_A ; PS00455 AMP_BINDING

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
2.0 %Met     (Translated Protein)
2.0 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
2.0 %Met     (Mature Protein)
2.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MRRWQRLALVALAGAVALGAGSIGYLRWHTRAVVTAAVPAGSHAVATTLDPAASDRLMQV
CCHHHHHHHHHHHHHHHHCCCCEEEEEEEEEEEEEEECCCCCCEEEEECCCHHHHHHHHH
VSDARERLGVPALQVAVVKGGELVWTGAVGWADPPAGRPVTAEDRFHIGSVSKLYTAALV
HHHHHHHHCCCEEEEEEEECCEEEEECCCCCCCCCCCCCCCCCCCEECCCHHHHHHHHHH
LRLAEEGRLSLEDPVSRFVPDVPNGDRITVRQLLNHTSGLANYTEDTAFNLKTVLLRRRW
HHHHHCCCCCCCCHHHHHCCCCCCCCEEHHHHHHHHHCCCCCCCCCHHHHHHHHHHHHCC
SVDEVLDVIRQQAPRSAPGTEHYYSNSNYVLLGRIAEVAGGRPFADLLHDEVLRPLGLTN
CHHHHHHHHHHHCCCCCCCCCCEECCCCEEEEEEHHHHHCCCCHHHHHHHHHHHHCCCCC
TYLAAGEPESVGTVRGYDVTVLGTGRMGIKLDMERFRAPFETSAFAAGAVTASAADVARF
CEEECCCCCCCCEECCCEEEEEECCCCCEEEEHHHHCCCCCCCHHHHHHHHHHHHHHHHH
TSGLLGGRLLADSTLQSMLTFVDAPDEDMPAQTGYGLGVRRLVIGGEEMVGHTGTLPGYS
HHHHHCCHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCEEEEEECCHHHCCCCCCCCCCC
NVALYAPAHDHAVAVLSNLSMSDVTDVLAEVQAVLLEPASTR
CEEEECCCCCHHHHHHHCCCHHHHHHHHHHHHHHHHCCCCCC
>Mature Secondary Structure
MRRWQRLALVALAGAVALGAGSIGYLRWHTRAVVTAAVPAGSHAVATTLDPAASDRLMQV
CCHHHHHHHHHHHHHHHHCCCCEEEEEEEEEEEEEEECCCCCCEEEEECCCHHHHHHHHH
VSDARERLGVPALQVAVVKGGELVWTGAVGWADPPAGRPVTAEDRFHIGSVSKLYTAALV
HHHHHHHHCCCEEEEEEEECCEEEEECCCCCCCCCCCCCCCCCCCEECCCHHHHHHHHHH
LRLAEEGRLSLEDPVSRFVPDVPNGDRITVRQLLNHTSGLANYTEDTAFNLKTVLLRRRW
HHHHHCCCCCCCCHHHHHCCCCCCCCEEHHHHHHHHHCCCCCCCCCHHHHHHHHHHHHCC
SVDEVLDVIRQQAPRSAPGTEHYYSNSNYVLLGRIAEVAGGRPFADLLHDEVLRPLGLTN
CHHHHHHHHHHHCCCCCCCCCCEECCCCEEEEEEHHHHHCCCCHHHHHHHHHHHHCCCCC
TYLAAGEPESVGTVRGYDVTVLGTGRMGIKLDMERFRAPFETSAFAAGAVTASAADVARF
CEEECCCCCCCCEECCCEEEEEECCCCCEEEEHHHHCCCCCCCHHHHHHHHHHHHHHHHH
TSGLLGGRLLADSTLQSMLTFVDAPDEDMPAQTGYGLGVRRLVIGGEEMVGHTGTLPGYS
HHHHHCCHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCEEEEEECCHHHCCCCCCCCCCC
NVALYAPAHDHAVAVLSNLSMSDVTDVLAEVQAVLLEPASTR
CEEEECCCCCHHHHHHHCCCHHHHHHHHHHHHHHHHCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 3830154; 7925404; 3030739; 2175384; 2386365; 3997832; 7490745 [H]