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The map label for this gene is aroK

Identifier: 51893087

GI number: 51893087

Start: 2090299

End: 2090823

Strand: Reverse

Name: aroK

Synonym: STH1949

Alternate gene names: 51893087

Gene position: 2090823-2090299 (Counterclockwise)

Preceding gene: 51893088

Following gene: 51893086

Centisome position: 58.63

GC content: 73.33

Gene sequence:

>525_bases
GTGAACATCGTTCTCGTGGGACTCATGGGATCCGGCAAGACGGCTGTGGGCCGGCTCCTGGCCGAGCGGCTGGGCCGGCC
CTTCGTGGACACGGACAGGCTCGTGGAGGCGGACGCCGGCCGCACCGTCGCCGACATCTTCGCCGCAGAGGGCGAGGAGG
GGTTCCGCCGCCGGGAGGCGGAGGTGGTGGCGCGGGCGGCCGCCGGCGACAACCAGGTGATCGCGACCGGGGGCGGCGCC
GTGCTGCGGACGGAGAACCGGGAGGCGCTGCGCCGCACGGGGTTCGTGATCTGGCTGGATGCGGAGCCGGAAACGCTGTA
TGACCGGGCCCGCGGGCAGGGGCTGCACCGCCGGCCGCTGCTCAGCGGCCCTGATCCGCTGGGGCGGCTGCGGGCGCTGG
CGGCCGCGCGCCGGCCGTTCTACGCCCAGGCCGCCCACGTGCGGATCTGTACGGACCGTCGTTCGCTGCAGGACGTCGTG
GCAGAGATCATGGAAAAGCTACAGGAAAGGGGAGAGCGCGGGTGA

Upstream 100 bases:

>100_bases
AACTTCCGCGGGTACCTGGAACAGATCGCCCGGCGCTGACGGGCCGGGGGGCGCCCGCGGACGGGCTCGCGGGAGCGCGC
GGCGGCAGGGGGGCGGTGCG

Downstream 100 bases:

>100_bases
CAGAGGTCTGGGTGGAACTCGGCGAGGAACGCTACCCGATTTACGTGGGCGCCGGGCTGATGGCGCAGCTGGGCGCGCTG
GTGCGGCGGCACCTGCCGGA

Product: shikimate kinase

Products: NA

Alternate protein names: SK

Number of amino acids: Translated: 174; Mature: 174

Protein sequence:

>174_residues
MNIVLVGLMGSGKTAVGRLLAERLGRPFVDTDRLVEADAGRTVADIFAAEGEEGFRRREAEVVARAAAGDNQVIATGGGA
VLRTENREALRRTGFVIWLDAEPETLYDRARGQGLHRRPLLSGPDPLGRLRALAAARRPFYAQAAHVRICTDRRSLQDVV
AEIMEKLQERGERG

Sequences:

>Translated_174_residues
MNIVLVGLMGSGKTAVGRLLAERLGRPFVDTDRLVEADAGRTVADIFAAEGEEGFRRREAEVVARAAAGDNQVIATGGGA
VLRTENREALRRTGFVIWLDAEPETLYDRARGQGLHRRPLLSGPDPLGRLRALAAARRPFYAQAAHVRICTDRRSLQDVV
AEIMEKLQERGERG
>Mature_174_residues
MNIVLVGLMGSGKTAVGRLLAERLGRPFVDTDRLVEADAGRTVADIFAAEGEEGFRRREAEVVARAAAGDNQVIATGGGA
VLRTENREALRRTGFVIWLDAEPETLYDRARGQGLHRRPLLSGPDPLGRLRALAAARRPFYAQAAHVRICTDRRSLQDVV
AEIMEKLQERGERG

Specific function: Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate

COG id: COG0703

COG function: function code E; Shikimate kinase

Gene ontology:

Cell location: Cytoplasm (Probable)

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the shikimate kinase family

Homologues:

Organism=Escherichia coli, GI87082255, Length=168, Percent_Identity=41.0714285714286, Blast_Score=108, Evalue=2e-25,
Organism=Escherichia coli, GI1786587, Length=166, Percent_Identity=34.9397590361446, Blast_Score=83, Evalue=9e-18,

Paralogues:

None

Copy number: 140 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). 200 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). [C]

Swissprot (AC and ID): AROK_SYMTH (Q67N09)

Other databases:

- EMBL:   AP006840
- RefSeq:   YP_075778.1
- ProteinModelPortal:   Q67N09
- SMR:   Q67N09
- GeneID:   2981342
- GenomeReviews:   AP006840_GR
- KEGG:   sth:STH1949
- NMPDR:   fig|292459.1.peg.1879
- HOGENOM:   HBG335815
- OMA:   VIYLRAN
- BioCyc:   STHE292459:STH1949-MONOMER
- BRENDA:   2.7.1.71
- GO:   GO:0005737
- HAMAP:   MF_00109
- InterPro:   IPR000623
- InterPro:   IPR023000
- PRINTS:   PR01100

Pfam domain/function: PF01202 SKI

EC number: =2.7.1.71

Molecular weight: Translated: 19043; Mature: 19043

Theoretical pI: Translated: 9.92; Mature: 9.92

Prosite motif: PS01128 SHIKIMATE_KINASE

Important sites: BINDING 32-32 BINDING 56-56 BINDING 78-78 BINDING 118-118 BINDING 137-137 BINDING 154-154

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.6 %Cys     (Translated Protein)
1.7 %Met     (Translated Protein)
2.3 %Cys+Met (Translated Protein)
0.6 %Cys     (Mature Protein)
1.7 %Met     (Mature Protein)
2.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MNIVLVGLMGSGKTAVGRLLAERLGRPFVDTDRLVEADAGRTVADIFAAEGEEGFRRREA
CCEEEEEECCCCHHHHHHHHHHHHCCCCCCCCHHEECCCCCHHHHHHHHCCHHHHHHHHH
EVVARAAAGDNQVIATGGGAVLRTENREALRRTGFVIWLDAEPETLYDRARGQGLHRRPL
HHHHHHCCCCCEEEEECCCEEEEECCHHHHHHCCEEEEEECCCHHHHHHHHCCCCCCCCC
LSGPDPLGRLRALAAARRPFYAQAAHVRICTDRRSLQDVVAEIMEKLQERGERG
CCCCCHHHHHHHHHHHCCCCHHHHCEEEEECCHHHHHHHHHHHHHHHHHHCCCC
>Mature Secondary Structure
MNIVLVGLMGSGKTAVGRLLAERLGRPFVDTDRLVEADAGRTVADIFAAEGEEGFRRREA
CCEEEEEECCCCHHHHHHHHHHHHCCCCCCCCHHEECCCCCHHHHHHHHCCHHHHHHHHH
EVVARAAAGDNQVIATGGGAVLRTENREALRRTGFVIWLDAEPETLYDRARGQGLHRRPL
HHHHHHCCCCCEEEEECCCEEEEECCHHHHHHCCEEEEEECCCHHHHHHHHCCCCCCCCC
LSGPDPLGRLRALAAARRPFYAQAAHVRICTDRRSLQDVVAEIMEKLQERGERG
CCCCCHHHHHHHHHHHCCCCHHHHCEEEEECCHHHHHHHHHHHHHHHHHHCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA