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The map label for this gene is gcvT

Identifier: 51893060

GI number: 51893060

Start: 2065536

End: 2066663

Strand: Reverse

Name: gcvT

Synonym: STH1922

Alternate gene names: 51893060

Gene position: 2066663-2065536 (Counterclockwise)

Preceding gene: 51893061

Following gene: 51893059

Centisome position: 57.95

GC content: 68.53

Gene sequence:

>1128_bases
GTGAACGAGTCGCTGAAACGGACGCCCCTGTACGAGCTGCATCTGAAGCTGGGCGCCCGCATGGTGCCCTTCGGCGGCTG
GGAGATGCCCGTGCAGTACTCCAGCGTCATCGAGGAGCACCGGGCCGTGCGTGAGGCGGCGGGCCTCTTCGACGTGTCGC
ACATGGGCGAGTTTGAGGTGAGGGGGCCCCAGGCCCTGGACCTCATCCAGCTGGTGAGCACCAACGACGCCGCCAAACTG
GCGGTCGGGCGGGTTCAGTACGCGCTGATGTGCTACGAGAACGGCACCGTGGTCGACGACATCCTCATCTACCGGCTGGA
CGAGCACCGCTACTGGCTGGTGGTCAACGCCGGGAACACCCAGAAGGACTGGGAATGGATCAACACCGCCCGGGAGCGGG
CCGGCCTGCACAACCTGGAGCTCATCGACCGGTCGGCGGAGATCGCCCTGCTGGCCCTGCAGGGGCCGAAGGCGGAGGAG
ATCCTGCAGCCGCTCGCGACCGGCGTCGTGCTGTCGCAGCTGGAGCCCTTCAGCCTGGCGAAGAACGTCACGGTATCCGG
GGTGCCGACCCTGGTGCTCTCCCGCACGGGGTACACCGGCGAGGACGGCTTCGAGATCTACGTGAAGGCCGAAGACGTCG
CCGCCCTCTGGGAGGCCTTGCTGGAGGCGGGCGACGAGCAGGGGCTCCTGCCCTGCGGCCTCGGCGCCCGGGACACCCTG
CGGTTCGAGGCGAAGCTGCCCCTTTACGGCCACGAGATCAGCGACCAGCACAACCCGCTGGAGGCGGGGCTGGGCTTCGC
CGTCAAGCTGAAGAAGGGCGTGGACTTCATCGGCCGGGACGCCCTGGCCAGGATCAAAGAGCAGGGGCCGACCCGGAAGC
TGGTGGGCATCGAGATGATCGACCGGGGCGTGCCCCGGCAGGGTTACCCCGTCGCCGTGGGGGGCGAGGTGGTCGGCGAG
GTGACCACGGGAAGCTTCTCGCCCACGCTGGAGAAGAACATTGCATTGGCCTACGTGCCCGTCGCCCACAGCGCCGTGGG
CACCGAGGTGGAGGTCATCATCCGGGGCCGGGCGCTGAAGGCGCGGGTCGTGGAGACCCCCTTCTACCGGTCGCCGCACA
GACGATAA

Upstream 100 bases:

>100_bases
AAGCCCGGGTGCAGGGGCTGTCCCCGTTTTGCACGCTCCCGAGGGGAGTAGCCCCCCTGGCTCGTTGGCCAGACTATGCA
AGCGGAAGCGAGGTGTGGTG

Downstream 100 bases:

>100_bases
CCGGCACGGTTGAGAATTACGCACAGGGAGGACGCGGAACATGGCGAACGTACCGGCGGATCTCAAGTACTCGAAGGAGC
ACGAGTGGATCAGGGTCGAA

Product: glycine cleavage system protein T

Products: NA

Alternate protein names: Glycine cleavage system T protein

Number of amino acids: Translated: 375; Mature: 375

Protein sequence:

>375_residues
MNESLKRTPLYELHLKLGARMVPFGGWEMPVQYSSVIEEHRAVREAAGLFDVSHMGEFEVRGPQALDLIQLVSTNDAAKL
AVGRVQYALMCYENGTVVDDILIYRLDEHRYWLVVNAGNTQKDWEWINTARERAGLHNLELIDRSAEIALLALQGPKAEE
ILQPLATGVVLSQLEPFSLAKNVTVSGVPTLVLSRTGYTGEDGFEIYVKAEDVAALWEALLEAGDEQGLLPCGLGARDTL
RFEAKLPLYGHEISDQHNPLEAGLGFAVKLKKGVDFIGRDALARIKEQGPTRKLVGIEMIDRGVPRQGYPVAVGGEVVGE
VTTGSFSPTLEKNIALAYVPVAHSAVGTEVEVIIRGRALKARVVETPFYRSPHRR

Sequences:

>Translated_375_residues
MNESLKRTPLYELHLKLGARMVPFGGWEMPVQYSSVIEEHRAVREAAGLFDVSHMGEFEVRGPQALDLIQLVSTNDAAKL
AVGRVQYALMCYENGTVVDDILIYRLDEHRYWLVVNAGNTQKDWEWINTARERAGLHNLELIDRSAEIALLALQGPKAEE
ILQPLATGVVLSQLEPFSLAKNVTVSGVPTLVLSRTGYTGEDGFEIYVKAEDVAALWEALLEAGDEQGLLPCGLGARDTL
RFEAKLPLYGHEISDQHNPLEAGLGFAVKLKKGVDFIGRDALARIKEQGPTRKLVGIEMIDRGVPRQGYPVAVGGEVVGE
VTTGSFSPTLEKNIALAYVPVAHSAVGTEVEVIIRGRALKARVVETPFYRSPHRR
>Mature_375_residues
MNESLKRTPLYELHLKLGARMVPFGGWEMPVQYSSVIEEHRAVREAAGLFDVSHMGEFEVRGPQALDLIQLVSTNDAAKL
AVGRVQYALMCYENGTVVDDILIYRLDEHRYWLVVNAGNTQKDWEWINTARERAGLHNLELIDRSAEIALLALQGPKAEE
ILQPLATGVVLSQLEPFSLAKNVTVSGVPTLVLSRTGYTGEDGFEIYVKAEDVAALWEALLEAGDEQGLLPCGLGARDTL
RFEAKLPLYGHEISDQHNPLEAGLGFAVKLKKGVDFIGRDALARIKEQGPTRKLVGIEMIDRGVPRQGYPVAVGGEVVGE
VTTGSFSPTLEKNIALAYVPVAHSAVGTEVEVIIRGRALKARVVETPFYRSPHRR

Specific function: The glycine cleavage system catalyzes the degradation of glycine

COG id: COG0404

COG function: function code E; Glycine cleavage system T protein (aminomethyltransferase)

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the gcvT family

Homologues:

Organism=Homo sapiens, GI44662838, Length=381, Percent_Identity=35.4330708661417, Blast_Score=192, Evalue=4e-49,
Organism=Homo sapiens, GI257796258, Length=365, Percent_Identity=35.6164383561644, Blast_Score=186, Evalue=4e-47,
Organism=Homo sapiens, GI24797151, Length=337, Percent_Identity=32.3442136498516, Blast_Score=181, Evalue=1e-45,
Organism=Homo sapiens, GI257796254, Length=374, Percent_Identity=33.1550802139037, Blast_Score=161, Evalue=9e-40,
Organism=Homo sapiens, GI194306651, Length=374, Percent_Identity=26.7379679144385, Blast_Score=136, Evalue=3e-32,
Organism=Homo sapiens, GI257796256, Length=325, Percent_Identity=32.6153846153846, Blast_Score=133, Evalue=2e-31,
Organism=Homo sapiens, GI197927446, Length=325, Percent_Identity=28.6153846153846, Blast_Score=131, Evalue=8e-31,
Organism=Homo sapiens, GI21361378, Length=325, Percent_Identity=28.6153846153846, Blast_Score=131, Evalue=8e-31,
Organism=Escherichia coli, GI1789272, Length=375, Percent_Identity=40.2666666666667, Blast_Score=245, Evalue=4e-66,
Organism=Caenorhabditis elegans, GI17560118, Length=376, Percent_Identity=35.6382978723404, Blast_Score=189, Evalue=3e-48,
Organism=Caenorhabditis elegans, GI71994052, Length=376, Percent_Identity=26.063829787234, Blast_Score=122, Evalue=3e-28,
Organism=Caenorhabditis elegans, GI71994045, Length=376, Percent_Identity=26.063829787234, Blast_Score=122, Evalue=4e-28,
Organism=Caenorhabditis elegans, GI32563613, Length=359, Percent_Identity=25.6267409470752, Blast_Score=103, Evalue=1e-22,
Organism=Saccharomyces cerevisiae, GI6320222, Length=391, Percent_Identity=34.7826086956522, Blast_Score=194, Evalue=2e-50,
Organism=Drosophila melanogaster, GI20129441, Length=379, Percent_Identity=35.0923482849604, Blast_Score=212, Evalue=3e-55,
Organism=Drosophila melanogaster, GI28571104, Length=317, Percent_Identity=26.4984227129338, Blast_Score=112, Evalue=4e-25,
Organism=Drosophila melanogaster, GI20130091, Length=437, Percent_Identity=25.629290617849, Blast_Score=102, Evalue=4e-22,

Paralogues:

None

Copy number: 40 Molecules/Cell In: Stationary Phase, Rich Media (Based on E. coli). [C]

Swissprot (AC and ID): GCST_SYMTH (Q67N36)

Other databases:

- EMBL:   AP006840
- RefSeq:   YP_075751.1
- ProteinModelPortal:   Q67N36
- SMR:   Q67N36
- GeneID:   2980570
- GenomeReviews:   AP006840_GR
- KEGG:   sth:STH1922
- NMPDR:   fig|292459.1.peg.1855
- HOGENOM:   HBG299834
- OMA:   KALYGGM
- BioCyc:   STHE292459:STH1922-MONOMER
- BRENDA:   2.1.2.10
- GO:   GO:0005737
- HAMAP:   MF_00259
- InterPro:   IPR013977
- InterPro:   IPR006222
- InterPro:   IPR006223
- InterPro:   IPR022903
- PIRSF:   PIRSF006487
- TIGRFAMs:   TIGR00528

Pfam domain/function: PF01571 GCV_T; PF08669 GCV_T_C

EC number: =2.1.2.10

Molecular weight: Translated: 41244; Mature: 41244

Theoretical pI: Translated: 5.48; Mature: 5.48

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.5 %Cys     (Translated Protein)
1.6 %Met     (Translated Protein)
2.1 %Cys+Met (Translated Protein)
0.5 %Cys     (Mature Protein)
1.6 %Met     (Mature Protein)
2.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MNESLKRTPLYELHLKLGARMVPFGGWEMPVQYSSVIEEHRAVREAAGLFDVSHMGEFEV
CCCCCCCCCHHEEHHHHCCEEECCCCCCCCCHHHHHHHHHHHHHHHHCCCCCCCCCCEEE
RGPQALDLIQLVSTNDAAKLAVGRVQYALMCYENGTVVDDILIYRLDEHRYWLVVNAGNT
CCCCHHHHHHHHCCCCHHHHHHHEEEEEEEEECCCCEEEEEEEEEECCCEEEEEEECCCC
QKDWEWINTARERAGLHNLELIDRSAEIALLALQGPKAEEILQPLATGVVLSQLEPFSLA
CHHHHHHHHHHHHCCCCCCEEECCCCCEEEEEECCCCHHHHHHHHHHHHHHHCCCCHHHH
KNVTVSGVPTLVLSRTGYTGEDGFEIYVKAEDVAALWEALLEAGDEQGLLPCGLGARDTL
CCCEECCCCEEEEECCCCCCCCCEEEEEEEHHHHHHHHHHHHCCCCCCCEECCCCCCCEE
RFEAKLPLYGHEISDQHNPLEAGLGFAVKLKKGVDFIGRDALARIKEQGPTRKLVGIEMI
EEEEECCCCCCCCCCCCCCHHHCCCEEEEEECCCCHHCHHHHHHHHHCCCCEEEEEHHHH
DRGVPRQGYPVAVGGEVVGEVTTGSFSPTLEKNIALAYVPVAHSAVGTEVEVIIRGRALK
HCCCCCCCCCEEECCCEEEEEECCCCCCCHHCCEEEEEEECCCCCCCCEEEEEEECCCEE
ARVVETPFYRSPHRR
EEEECCCCCCCCCCC
>Mature Secondary Structure
MNESLKRTPLYELHLKLGARMVPFGGWEMPVQYSSVIEEHRAVREAAGLFDVSHMGEFEV
CCCCCCCCCHHEEHHHHCCEEECCCCCCCCCHHHHHHHHHHHHHHHHCCCCCCCCCCEEE
RGPQALDLIQLVSTNDAAKLAVGRVQYALMCYENGTVVDDILIYRLDEHRYWLVVNAGNT
CCCCHHHHHHHHCCCCHHHHHHHEEEEEEEEECCCCEEEEEEEEEECCCEEEEEEECCCC
QKDWEWINTARERAGLHNLELIDRSAEIALLALQGPKAEEILQPLATGVVLSQLEPFSLA
CHHHHHHHHHHHHCCCCCCEEECCCCCEEEEEECCCCHHHHHHHHHHHHHHHCCCCHHHH
KNVTVSGVPTLVLSRTGYTGEDGFEIYVKAEDVAALWEALLEAGDEQGLLPCGLGARDTL
CCCEECCCCEEEEECCCCCCCCCEEEEEEEHHHHHHHHHHHHCCCCCCCEECCCCCCCEE
RFEAKLPLYGHEISDQHNPLEAGLGFAVKLKKGVDFIGRDALARIKEQGPTRKLVGIEMI
EEEEECCCCCCCCCCCCCCHHHCCCEEEEEECCCCHHCHHHHHHHHHCCCCEEEEEHHHH
DRGVPRQGYPVAVGGEVVGEVTTGSFSPTLEKNIALAYVPVAHSAVGTEVEVIIRGRALK
HCCCCCCCCCEEECCCEEEEEECCCCCCCHHCCEEEEEEECCCCCCCCEEEEEEECCCEE
ARVVETPFYRSPHRR
EEEECCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA