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The map label for this gene is dxs

Identifier: 51892980

GI number: 51892980

Start: 1986562

End: 1988508

Strand: Reverse

Name: dxs

Synonym: STH1842

Alternate gene names: 51892980

Gene position: 1988508-1986562 (Counterclockwise)

Preceding gene: 51892981

Following gene: 51892979

Centisome position: 55.76

GC content: 70.57

Gene sequence:

>1947_bases
ATGCACCTGCGGGACCTGACCGGTCCGGAGCAGCTGAAGCGGCTGGCGCCCGCCGAGCTGGCCCAGCTGGCGGCCGAGAT
CCGGCGCGTCATCCTGGAGACGGTGGCGACCAACGGCGGTCACCTCGCCCCCAACCTGGGCGTGGTGGAGCTGACGCTGG
CACTGCACATCGTGTTCGACAGCCCGCGGGACAAGATCCTCTGGGACGTGTCGCACCAGAGCTACGTGCACAAGCTGCTT
ACGGGACGGCTGCACCAGTTCCATACCCTGCGTCAGTTCGGCGGCATTGCCGGCTTCACCGATCCGCGCGAGTCGGTCCA
TGACCACTTCCACTGGGGCCATGCCTCCACCTCCATTTCCGCGGCGGTGGGCATGGCCAAGGCGCGCGACCTCGCCGGCG
ACGACTATGAGGTGGTCGCCGTGATCGGCGACGGCGCCCTGACCGGCGGCATGGCCTACGAGGCGCTGGACCACGCCGGC
CACGACAAGACCAAAGTGATCGTGGTGCTCAACGACAACTCCATGTCCATCGCCCCCAACGTGGGCGGCATCTCCAACTA
CCTCGCCCGTATCCGGACCGGCCCCTCCTACCAGCGGGTCAAGCACGACGTCGCCGAGGCCCTGCGGCAGATCCCGCTGA
TCGGCCCCCAGGCGCTGGAGCTGGCGGACCGGCTGAAGGAGGGCGTGAAGCACCTGCTGGTGCACAACATGTTCTTTGAG
GACCTGGGCTTCACGTACCTGGGGCCCGTGGACGGGCACAACGTGAGCGCCCTGGTGGACGTGCTGCGCCAGGCGCGCGC
CTACCCCGGGCCGACGGTGGTCCACGTGGTCACCACCAAGGGCAAGGGGGTGCCCTACGCGGAGCAGCTGCCCGACAAGT
TCCACGGCGGCGGCCCCTTCGACGTCGCCACCGGCCGGACCGGGCCCGGCAGCCTGACCTACAGCGAGGTCTTCGGCAAC
GTGATGTGCAAGCTGGCGGCCGAGGATCCCCGGGTGTGCGCGATCACGGCCGCGATGCCCTCCGGCACCGGGCTCAGCCG
CTTCGCCCGGCAGTTCCCCGACCGGTACTTCGACGTGGGCATCGCAGAGCAGCACGCGGTGACCTTTGCGGCCGGCCTGG
CCAAGGGCGGGATGCGGCCTGTCTTCGCCGTGTACTCCACCTTCCTGCAGCGGGCCTACGACCAGGTGATCCACGACGTG
GCCCTGCAGAACCTGCCGGTCACCCTGGCCATTGACCGGGGTGGGCTGGTGGAGGACGGCGCGACCCACCAGGGCGTCTT
CGATGTCGCGTACCTGCGGGCGATCCCCAACATGGTGGTCATGGCGCCCAAGGACGAAAACGAGCTGCAGCACATGCTCT
ATACGGCGCTGTGCCACGACGGCCCGGCGGCGCTGCGCTATCCCCGGGGCAAGGCGCAGGGGGTGCCGCTGGACGAGACG
CTGCAGCCGCTGCCCATCGGCCGGGGCGAGGTGATGCAGGAGGGCGCCGACGTGGCGCTGATCGGCCTGGGCACCATGGC
CCGGGTGTGCCAGGAGGCCGCCCGCCTGCTGGCGGAGAAGTCCATCTCCGCGATGGTCATCAACCCGCGGTTCGTCAAGC
CCCTGGACGCCGAGCTGCTGCTGCGGGCCGGCCGGGAGGTGGGCGCGGTGGTGACCGTGGAGGAGGCCTGCCTTGCCGGG
GGCTTCGGTTCCGCCGTCCTGGAGCTGTACGCCGCCCACGGGGTGAACGCCCGCGTGGAGCGGATGGGCATTCCGGATGA
GTTTGTGGATCACGGCCAGCCGGCCCGGTACCTGGAACGCTACGGGCTCACGCCGGAGGGCGTGGCGCAGCGGGCCGAGG
CGCTGTTGCTCCGGATGCGTTCCGACCTGGCGGCGCAGCCGGCCCGGCGCAGCCGCAGCGTGCGGCGGCTGAGCGGGGCG
AAGGCGGCCGGCAACGGGGAGACCTGA

Upstream 100 bases:

>100_bases
TGGCGGCCGGACGGATCATCTACTGGGCGGAGAACATCACCGGCCGCTCCTTCACCGGCGGCCGTTCCGGGAGCAACGGG
CGAAGGAGGAACTCGTAGCG

Downstream 100 bases:

>100_bases
GGAGCTATGGCAGGAGAACGACTCGACGTGGCCCTGGTCAGCCGGGGCCACTTTCCTTCCCGGGAGCGGGCGCAGGAGGC
CATCGCGGCCGGGATGGTCC

Product: 1-deoxy-D-xylulose-5-phosphate synthase

Products: NA

Alternate protein names: 1-deoxyxylulose-5-phosphate synthase; DXP synthase; DXPS

Number of amino acids: Translated: 648; Mature: 648

Protein sequence:

>648_residues
MHLRDLTGPEQLKRLAPAELAQLAAEIRRVILETVATNGGHLAPNLGVVELTLALHIVFDSPRDKILWDVSHQSYVHKLL
TGRLHQFHTLRQFGGIAGFTDPRESVHDHFHWGHASTSISAAVGMAKARDLAGDDYEVVAVIGDGALTGGMAYEALDHAG
HDKTKVIVVLNDNSMSIAPNVGGISNYLARIRTGPSYQRVKHDVAEALRQIPLIGPQALELADRLKEGVKHLLVHNMFFE
DLGFTYLGPVDGHNVSALVDVLRQARAYPGPTVVHVVTTKGKGVPYAEQLPDKFHGGGPFDVATGRTGPGSLTYSEVFGN
VMCKLAAEDPRVCAITAAMPSGTGLSRFARQFPDRYFDVGIAEQHAVTFAAGLAKGGMRPVFAVYSTFLQRAYDQVIHDV
ALQNLPVTLAIDRGGLVEDGATHQGVFDVAYLRAIPNMVVMAPKDENELQHMLYTALCHDGPAALRYPRGKAQGVPLDET
LQPLPIGRGEVMQEGADVALIGLGTMARVCQEAARLLAEKSISAMVINPRFVKPLDAELLLRAGREVGAVVTVEEACLAG
GFGSAVLELYAAHGVNARVERMGIPDEFVDHGQPARYLERYGLTPEGVAQRAEALLLRMRSDLAAQPARRSRSVRRLSGA
KAAGNGET

Sequences:

>Translated_648_residues
MHLRDLTGPEQLKRLAPAELAQLAAEIRRVILETVATNGGHLAPNLGVVELTLALHIVFDSPRDKILWDVSHQSYVHKLL
TGRLHQFHTLRQFGGIAGFTDPRESVHDHFHWGHASTSISAAVGMAKARDLAGDDYEVVAVIGDGALTGGMAYEALDHAG
HDKTKVIVVLNDNSMSIAPNVGGISNYLARIRTGPSYQRVKHDVAEALRQIPLIGPQALELADRLKEGVKHLLVHNMFFE
DLGFTYLGPVDGHNVSALVDVLRQARAYPGPTVVHVVTTKGKGVPYAEQLPDKFHGGGPFDVATGRTGPGSLTYSEVFGN
VMCKLAAEDPRVCAITAAMPSGTGLSRFARQFPDRYFDVGIAEQHAVTFAAGLAKGGMRPVFAVYSTFLQRAYDQVIHDV
ALQNLPVTLAIDRGGLVEDGATHQGVFDVAYLRAIPNMVVMAPKDENELQHMLYTALCHDGPAALRYPRGKAQGVPLDET
LQPLPIGRGEVMQEGADVALIGLGTMARVCQEAARLLAEKSISAMVINPRFVKPLDAELLLRAGREVGAVVTVEEACLAG
GFGSAVLELYAAHGVNARVERMGIPDEFVDHGQPARYLERYGLTPEGVAQRAEALLLRMRSDLAAQPARRSRSVRRLSGA
KAAGNGET
>Mature_648_residues
MHLRDLTGPEQLKRLAPAELAQLAAEIRRVILETVATNGGHLAPNLGVVELTLALHIVFDSPRDKILWDVSHQSYVHKLL
TGRLHQFHTLRQFGGIAGFTDPRESVHDHFHWGHASTSISAAVGMAKARDLAGDDYEVVAVIGDGALTGGMAYEALDHAG
HDKTKVIVVLNDNSMSIAPNVGGISNYLARIRTGPSYQRVKHDVAEALRQIPLIGPQALELADRLKEGVKHLLVHNMFFE
DLGFTYLGPVDGHNVSALVDVLRQARAYPGPTVVHVVTTKGKGVPYAEQLPDKFHGGGPFDVATGRTGPGSLTYSEVFGN
VMCKLAAEDPRVCAITAAMPSGTGLSRFARQFPDRYFDVGIAEQHAVTFAAGLAKGGMRPVFAVYSTFLQRAYDQVIHDV
ALQNLPVTLAIDRGGLVEDGATHQGVFDVAYLRAIPNMVVMAPKDENELQHMLYTALCHDGPAALRYPRGKAQGVPLDET
LQPLPIGRGEVMQEGADVALIGLGTMARVCQEAARLLAEKSISAMVINPRFVKPLDAELLLRAGREVGAVVTVEEACLAG
GFGSAVLELYAAHGVNARVERMGIPDEFVDHGQPARYLERYGLTPEGVAQRAEALLLRMRSDLAAQPARRSRSVRRLSGA
KAAGNGET

Specific function: Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP)

COG id: COG1154

COG function: function code HI; Deoxyxylulose-5-phosphate synthase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the transketolase family. DXPS subfamily

Homologues:

Organism=Homo sapiens, GI205277463, Length=422, Percent_Identity=25.1184834123223, Blast_Score=110, Evalue=6e-24,
Organism=Homo sapiens, GI4507521, Length=422, Percent_Identity=25.1184834123223, Blast_Score=110, Evalue=6e-24,
Organism=Homo sapiens, GI133778974, Length=498, Percent_Identity=25.1004016064257, Blast_Score=102, Evalue=1e-21,
Organism=Homo sapiens, GI225637459, Length=429, Percent_Identity=24.4755244755245, Blast_Score=90, Evalue=6e-18,
Organism=Homo sapiens, GI225637463, Length=429, Percent_Identity=24.4755244755245, Blast_Score=90, Evalue=7e-18,
Organism=Homo sapiens, GI225637461, Length=429, Percent_Identity=24.4755244755245, Blast_Score=90, Evalue=7e-18,
Organism=Homo sapiens, GI4557353, Length=227, Percent_Identity=26.8722466960352, Blast_Score=85, Evalue=2e-16,
Organism=Homo sapiens, GI34101272, Length=227, Percent_Identity=26.8722466960352, Blast_Score=85, Evalue=2e-16,
Organism=Homo sapiens, GI156564403, Length=227, Percent_Identity=24.2290748898678, Blast_Score=68, Evalue=3e-11,
Organism=Escherichia coli, GI1786622, Length=612, Percent_Identity=46.7320261437908, Blast_Score=544, Evalue=1e-156,
Organism=Caenorhabditis elegans, GI17539652, Length=413, Percent_Identity=27.3607748184019, Blast_Score=109, Evalue=4e-24,
Organism=Saccharomyces cerevisiae, GI6325331, Length=296, Percent_Identity=27.7027027027027, Blast_Score=72, Evalue=2e-13,
Organism=Saccharomyces cerevisiae, GI6319698, Length=297, Percent_Identity=24.2424242424242, Blast_Score=66, Evalue=2e-11,
Organism=Drosophila melanogaster, GI45551847, Length=553, Percent_Identity=25.497287522604, Blast_Score=123, Evalue=4e-28,
Organism=Drosophila melanogaster, GI45550715, Length=553, Percent_Identity=25.497287522604, Blast_Score=123, Evalue=4e-28,
Organism=Drosophila melanogaster, GI24645119, Length=553, Percent_Identity=25.497287522604, Blast_Score=122, Evalue=5e-28,
Organism=Drosophila melanogaster, GI24666278, Length=310, Percent_Identity=30.3225806451613, Blast_Score=110, Evalue=3e-24,
Organism=Drosophila melanogaster, GI21358145, Length=287, Percent_Identity=24.390243902439, Blast_Score=71, Evalue=3e-12,
Organism=Drosophila melanogaster, GI24650940, Length=287, Percent_Identity=24.390243902439, Blast_Score=71, Evalue=3e-12,
Organism=Drosophila melanogaster, GI160714832, Length=240, Percent_Identity=24.5833333333333, Blast_Score=67, Evalue=3e-11,
Organism=Drosophila melanogaster, GI160714828, Length=240, Percent_Identity=24.5833333333333, Blast_Score=67, Evalue=4e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): DXS_SYMTH (Q67NB6)

Other databases:

- EMBL:   AP006840
- RefSeq:   YP_075671.1
- ProteinModelPortal:   Q67NB6
- SMR:   Q67NB6
- GeneID:   2981876
- GenomeReviews:   AP006840_GR
- KEGG:   sth:STH1842
- NMPDR:   fig|292459.1.peg.1777
- HOGENOM:   HBG571647
- OMA:   IMEYAYL
- ProtClustDB:   PRK05444
- BioCyc:   STHE292459:STH1842-MONOMER
- BRENDA:   2.2.1.7
- HAMAP:   MF_00315
- InterPro:   IPR005477
- InterPro:   IPR011766
- InterPro:   IPR009014
- InterPro:   IPR015941
- InterPro:   IPR005475
- InterPro:   IPR005476
- InterPro:   IPR005474
- Gene3D:   G3DSA:3.40.50.920
- SMART:   SM00861
- TIGRFAMs:   TIGR00204

Pfam domain/function: PF02775 TPP_enzyme_C; PF02779 Transket_pyr; PF02780 Transketolase_C; SSF52922 Transketo_C_like

EC number: =2.2.1.7

Molecular weight: Translated: 69790; Mature: 69790

Theoretical pI: Translated: 6.93; Mature: 6.93

Prosite motif: PS00801 TRANSKETOLASE_1; PS00802 TRANSKETOLASE_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.8 %Cys     (Translated Protein)
2.5 %Met     (Translated Protein)
3.2 %Cys+Met (Translated Protein)
0.8 %Cys     (Mature Protein)
2.5 %Met     (Mature Protein)
3.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MHLRDLTGPEQLKRLAPAELAQLAAEIRRVILETVATNGGHLAPNLGVVELTLALHIVFD
CCCCCCCCHHHHHHCCHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCEEEEEEEEEEEC
SPRDKILWDVSHQSYVHKLLTGRLHQFHTLRQFGGIAGFTDPRESVHDHFHWGHASTSIS
CCCCCEEEECCHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCHHHHHHHCCCCCCCCHHH
AAVGMAKARDLAGDDYEVVAVIGDGALTGGMAYEALDHAGHDKTKVIVVLNDNSMSIAPN
HHHHHHHHHHCCCCCEEEEEEEECCCCCCCHHHHHHHHCCCCCEEEEEEECCCCEEECCC
VGGISNYLARIRTGPSYQRVKHDVAEALRQIPLIGPQALELADRLKEGVKHLLVHNMFFE
CCHHHHHHHHHCCCCCHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHHH
DLGFTYLGPVDGHNVSALVDVLRQARAYPGPTVVHVVTTKGKGVPYAEQLPDKFHGGGPF
HCCCEEECCCCCCCHHHHHHHHHHHHCCCCCEEEEEEEECCCCCCCHHHCCHHHCCCCCC
DVATGRTGPGSLTYSEVFGNVMCKLAAEDPRVCAITAAMPSGTGLSRFARQFPDRYFDVG
EECCCCCCCCCCCHHHHHHHHHHHHCCCCCCEEEEEECCCCCCCHHHHHHHCCHHHHCCC
IAEQHAVTFAAGLAKGGMRPVFAVYSTFLQRAYDQVIHDVALQNLPVTLAIDRGGLVEDG
CCHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHHCCCEEEEECCCCCCCCC
ATHQGVFDVAYLRAIPNMVVMAPKDENELQHMLYTALCHDGPAALRYPRGKAQGVPLDET
CCCCCHHHHHHHHHCCCEEEECCCCHHHHHHHHHHHHHCCCCHHCCCCCCCCCCCCHHHC
LQPLPIGRGEVMQEGADVALIGLGTMARVCQEAARLLAEKSISAMVINPRFVKPLDAELL
CCCCCCCCHHHHHCCCCEEEEEHHHHHHHHHHHHHHHHHCCCCEEEECCCCCCCCCHHHH
LRAGREVGAVVTVEEACLAGGFGSAVLELYAAHGVNARVERMGIPDEFVDHGQPARYLER
HHCCCCCCEEEEEHHHHHCCCHHHHHHHHHHHCCCCCHHHHCCCCHHHHHCCCHHHHHHH
YGLTPEGVAQRAEALLLRMRSDLAAQPARRSRSVRRLSGAKAAGNGET
CCCCHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHCCCCCCCCCC
>Mature Secondary Structure
MHLRDLTGPEQLKRLAPAELAQLAAEIRRVILETVATNGGHLAPNLGVVELTLALHIVFD
CCCCCCCCHHHHHHCCHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCEEEEEEEEEEEC
SPRDKILWDVSHQSYVHKLLTGRLHQFHTLRQFGGIAGFTDPRESVHDHFHWGHASTSIS
CCCCCEEEECCHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCHHHHHHHCCCCCCCCHHH
AAVGMAKARDLAGDDYEVVAVIGDGALTGGMAYEALDHAGHDKTKVIVVLNDNSMSIAPN
HHHHHHHHHHCCCCCEEEEEEEECCCCCCCHHHHHHHHCCCCCEEEEEEECCCCEEECCC
VGGISNYLARIRTGPSYQRVKHDVAEALRQIPLIGPQALELADRLKEGVKHLLVHNMFFE
CCHHHHHHHHHCCCCCHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHHH
DLGFTYLGPVDGHNVSALVDVLRQARAYPGPTVVHVVTTKGKGVPYAEQLPDKFHGGGPF
HCCCEEECCCCCCCHHHHHHHHHHHHCCCCCEEEEEEEECCCCCCCHHHCCHHHCCCCCC
DVATGRTGPGSLTYSEVFGNVMCKLAAEDPRVCAITAAMPSGTGLSRFARQFPDRYFDVG
EECCCCCCCCCCCHHHHHHHHHHHHCCCCCCEEEEEECCCCCCCHHHHHHHCCHHHHCCC
IAEQHAVTFAAGLAKGGMRPVFAVYSTFLQRAYDQVIHDVALQNLPVTLAIDRGGLVEDG
CCHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHHCCCEEEEECCCCCCCCC
ATHQGVFDVAYLRAIPNMVVMAPKDENELQHMLYTALCHDGPAALRYPRGKAQGVPLDET
CCCCCHHHHHHHHHCCCEEEECCCCHHHHHHHHHHHHHCCCCHHCCCCCCCCCCCCHHHC
LQPLPIGRGEVMQEGADVALIGLGTMARVCQEAARLLAEKSISAMVINPRFVKPLDAELL
CCCCCCCCHHHHHCCCCEEEEEHHHHHHHHHHHHHHHHHCCCCEEEECCCCCCCCCHHHH
LRAGREVGAVVTVEEACLAGGFGSAVLELYAAHGVNARVERMGIPDEFVDHGQPARYLER
HHCCCCCCEEEEEHHHHHCCCHHHHHHHHHHHCCCCCHHHHCCCCHHHHHCCCHHHHHHH
YGLTPEGVAQRAEALLLRMRSDLAAQPARRSRSVRRLSGAKAAGNGET
CCCCHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA