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The map label for this gene is ldh [H]

Identifier: 51892968

GI number: 51892968

Start: 1974976

End: 1976049

Strand: Reverse

Name: ldh [H]

Synonym: STH1830

Alternate gene names: 51892968

Gene position: 1976049-1974976 (Counterclockwise)

Preceding gene: 51892969

Following gene: 51892967

Centisome position: 55.41

GC content: 71.42

Gene sequence:

>1074_bases
GTGGGTGTGTTCGAGCGCATGATGCGTGACGGACACGAGCAGGTGGTGTTCTGCTACGACAAGGCCACGGGGCTCAGGGC
GATCATCGCCATACACGACACGACCCTCGGCCCGGCCCTGGGAGGGTGCCGGATGTGGCCTTACGCCACGGAGGAGGAGG
CGCTGGAGGACGCGCTGCGGCTGGCGCGGGGCATGACCTACAAGTCGGCCGCCTCGGGCCAGAACCACGGAGGGGGCAAG
GTGGTCATCTGGGGCGACCCGGCCAGGGACAAGTCCGAACCGCTGTTCCGGGCCCTCGGCCGGTTCGTCGGGACGCTCCG
GGGCCGGATCATCACCGGTACCGACGTCGGCACCGACAAGACCGACTTTGTCTGGGCCCGCCAGGAGTCGCCCTGGTTCG
TCGGCCTGCCCGAGGACGAGGGCGGGTCCGGCGACACGGCGGTGCTCACCGCCTACGGCGTCTGGCAGGGCATGCGGGCC
TGCGCCCGGTTCCTGTGGGGGGAGAGCAGCCTGCGGAATCGGCGGATCGCCCTTCAGGGGCTGGGCAAAGTGGGCTCCCG
CCTGCTGGCGCACCTGCTGGAGGACGGCGCCCGGGTGACGGTGACCGACCTGCGCCCGGAGCGGGTGGAGGCGGTCTGCG
CCCGCCACCCCGAGGTGGTTGGGGTGGAGCCGGACGCCATCTATGACGTGCCGTGCGACATCTTCTCGCCCAGCGCGCTG
GGCGGCGTGCTCAACGACGCGACGATCCCCCGGCTCCGGTGCGCGGCGGTGGCCGGGTCCGCCAACAACCAGCTGGCCGA
GGCGCGGCATGGCGACCTGCTGCACGCGCGGGGAATTCTGTACGCGCCGGACTACGTCATCAACGCGGGCGGGTTGATCC
AGGTGGCGGACGAGATCCTGGGCTTCAACCCGGAGCGGGCCCGCCGCAAGACCGCGGCCATCCACGACCTGCTGCTGCGG
ATCTTCGCCATCAGCAGGGACGAGCGGATCCCGACTTACCAGGCCGCCGACCGCCTGGCCGAGCAGCGCATCGACCGGAT
CGGCCGGCGGCGGGGCATCTACATCCCGGAGTGA

Upstream 100 bases:

>100_bases
GTGGTCGAGGCCGGACGCAGGTGGCACGGATTTTGCGATAGTTGGGGGCAGCGACGGGCAGCGGCCTTGCCCGGCCGCTG
CCAGTGGGGGGTCGGCCATC

Downstream 100 bases:

>100_bases
GGGACGGTGAACCGGAGTGTCCGCTGAGGGATTCCGCATTCTCGTGATCAACCCCACGGCTACCGCCACACGGATTGCAC
TGTTCGACGACGATGAGGAG

Product: leucine dehydrogenase

Products: NA

Alternate protein names: LeuDH [H]

Number of amino acids: Translated: 357; Mature: 356

Protein sequence:

>357_residues
MGVFERMMRDGHEQVVFCYDKATGLRAIIAIHDTTLGPALGGCRMWPYATEEEALEDALRLARGMTYKSAASGQNHGGGK
VVIWGDPARDKSEPLFRALGRFVGTLRGRIITGTDVGTDKTDFVWARQESPWFVGLPEDEGGSGDTAVLTAYGVWQGMRA
CARFLWGESSLRNRRIALQGLGKVGSRLLAHLLEDGARVTVTDLRPERVEAVCARHPEVVGVEPDAIYDVPCDIFSPSAL
GGVLNDATIPRLRCAAVAGSANNQLAEARHGDLLHARGILYAPDYVINAGGLIQVADEILGFNPERARRKTAAIHDLLLR
IFAISRDERIPTYQAADRLAEQRIDRIGRRRGIYIPE

Sequences:

>Translated_357_residues
MGVFERMMRDGHEQVVFCYDKATGLRAIIAIHDTTLGPALGGCRMWPYATEEEALEDALRLARGMTYKSAASGQNHGGGK
VVIWGDPARDKSEPLFRALGRFVGTLRGRIITGTDVGTDKTDFVWARQESPWFVGLPEDEGGSGDTAVLTAYGVWQGMRA
CARFLWGESSLRNRRIALQGLGKVGSRLLAHLLEDGARVTVTDLRPERVEAVCARHPEVVGVEPDAIYDVPCDIFSPSAL
GGVLNDATIPRLRCAAVAGSANNQLAEARHGDLLHARGILYAPDYVINAGGLIQVADEILGFNPERARRKTAAIHDLLLR
IFAISRDERIPTYQAADRLAEQRIDRIGRRRGIYIPE
>Mature_356_residues
GVFERMMRDGHEQVVFCYDKATGLRAIIAIHDTTLGPALGGCRMWPYATEEEALEDALRLARGMTYKSAASGQNHGGGKV
VIWGDPARDKSEPLFRALGRFVGTLRGRIITGTDVGTDKTDFVWARQESPWFVGLPEDEGGSGDTAVLTAYGVWQGMRAC
ARFLWGESSLRNRRIALQGLGKVGSRLLAHLLEDGARVTVTDLRPERVEAVCARHPEVVGVEPDAIYDVPCDIFSPSALG
GVLNDATIPRLRCAAVAGSANNQLAEARHGDLLHARGILYAPDYVINAGGLIQVADEILGFNPERARRKTAAIHDLLLRI
FAISRDERIPTYQAADRLAEQRIDRIGRRRGIYIPE

Specific function: Functions catabolically in the bacterial metabolism of branched-chain L-amino acids, and plays an important role in spore germination in cooperation with alanine dehydrogenase [H]

COG id: COG0334

COG function: function code E; Glutamate dehydrogenase/leucine dehydrogenase

Gene ontology:

Cell location: Cytoplasmic

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: Belongs to the Glu/Leu/Phe/Val dehydrogenases family [H]

Homologues:

Organism=Homo sapiens, GI31377775, Length=311, Percent_Identity=25.08038585209, Blast_Score=67, Evalue=4e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR006095
- InterPro:   IPR006096
- InterPro:   IPR006097
- InterPro:   IPR016211
- InterPro:   IPR016040 [H]

Pfam domain/function: PF00208 ELFV_dehydrog; PF02812 ELFV_dehydrog_N [H]

EC number: =1.4.1.9 [H]

Molecular weight: Translated: 39097; Mature: 38966

Theoretical pI: Translated: 7.21; Mature: 7.21

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.7 %Cys     (Translated Protein)
1.7 %Met     (Translated Protein)
3.4 %Cys+Met (Translated Protein)
1.7 %Cys     (Mature Protein)
1.4 %Met     (Mature Protein)
3.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MGVFERMMRDGHEQVVFCYDKATGLRAIIAIHDTTLGPALGGCRMWPYATEEEALEDALR
CCHHHHHHHCCCCEEEEEEECCCCCEEEEEEECCCCCCCCCCCCCCCCCCHHHHHHHHHH
LARGMTYKSAASGQNHGGGKVVIWGDPARDKSEPLFRALGRFVGTLRGRIITGTDVGTDK
HHHCCCCCCCCCCCCCCCCEEEEECCCCCCCCCHHHHHHHHHHHHHCCCEEECCCCCCCC
TDFVWARQESPWFVGLPEDEGGSGDTAVLTAYGVWQGMRACARFLWGESSLRNRRIALQG
CCEEEEECCCCEEEECCCCCCCCCCEEEEEHHHHHHHHHHHHHHHCCCCHHCCCHHHHHH
LGKVGSRLLAHLLEDGARVTVTDLRPERVEAVCARHPEVVGVEPDAIYDVPCDIFSPSAL
HHHHHHHHHHHHHHCCCEEEEECCCHHHHHHHHHCCCCEEECCCCCEEECCCCCCCCHHH
GGVLNDATIPRLRCAAVAGSANNQLAEARHGDLLHARGILYAPDYVINAGGLIQVADEIL
HHHHCCCCCCHHHHHHHCCCCCCHHHHHHCCCEEEECCEEECCCEEECCCCHHHHHHHHH
GFNPERARRKTAAIHDLLLRIFAISRDERIPTYQAADRLAEQRIDRIGRRRGIYIPE
CCCHHHHHHHHHHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHHHHHCCCCCCC
>Mature Secondary Structure 
GVFERMMRDGHEQVVFCYDKATGLRAIIAIHDTTLGPALGGCRMWPYATEEEALEDALR
CHHHHHHHCCCCEEEEEEECCCCCEEEEEEECCCCCCCCCCCCCCCCCCHHHHHHHHHH
LARGMTYKSAASGQNHGGGKVVIWGDPARDKSEPLFRALGRFVGTLRGRIITGTDVGTDK
HHHCCCCCCCCCCCCCCCCEEEEECCCCCCCCCHHHHHHHHHHHHHCCCEEECCCCCCCC
TDFVWARQESPWFVGLPEDEGGSGDTAVLTAYGVWQGMRACARFLWGESSLRNRRIALQG
CCEEEEECCCCEEEECCCCCCCCCCEEEEEHHHHHHHHHHHHHHHCCCCHHCCCHHHHHH
LGKVGSRLLAHLLEDGARVTVTDLRPERVEAVCARHPEVVGVEPDAIYDVPCDIFSPSAL
HHHHHHHHHHHHHHCCCEEEEECCCHHHHHHHHHCCCCEEECCCCCEEECCCCCCCCHHH
GGVLNDATIPRLRCAAVAGSANNQLAEARHGDLLHARGILYAPDYVINAGGLIQVADEIL
HHHHCCCCCCHHHHHHHCCCCCCHHHHHHCCCEEEECCEEECCCEEECCCCHHHHHHHHH
GFNPERARRKTAAIHDLLLRIFAISRDERIPTYQAADRLAEQRIDRIGRRRGIYIPE
CCCHHHHHHHHHHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHHHHHCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 3069133; 1400267 [H]