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The map label for this gene is ald [H]

Identifier: 51892960

GI number: 51892960

Start: 1967018

End: 1968136

Strand: Reverse

Name: ald [H]

Synonym: STH1822

Alternate gene names: 51892960

Gene position: 1968136-1967018 (Counterclockwise)

Preceding gene: 51892961

Following gene: 51892959

Centisome position: 55.19

GC content: 68.36

Gene sequence:

>1119_bases
GTGAGGGTTGGCGTAGTGCGCGAGCTGAAGGCCTACGAGAACCGGGTGGCCATGACCCCCGCGGGCGTCATGGCGATGGT
CAGGGCCGGCCATGAGGTGTACGTGGAGCACGATGCCGGCAGGGGCTCCGGGTTCGACGACTCGGAGTACGTCGCCGCGG
GCGCCAGGATCCTGCCCAGCAATGAGGACGTCTGGGCCACCGCCGACATGATCGTCAAGGTGAAAGAGCCGCTGCCGCCC
GAGTACGATCTCATGCGTGAGGGCCAGATCATCTTCACCTACCTGCACCTGGCCGCCGAACCGGAGCTGACCCGGAAGCT
GATCGAGCGGAAGAGCATCGCCATCGCCTACGAGACGGTGCAACCGGCCGACCGGTCCCTGCCGCTCTTGACGCCCATGT
CCGAGGTGGCCGGCCGCATGGCCGTCCAGATCGGCGCCCACTACCTGGAGAAGGCCCACGGCGGGCGGGGTGTGCTGCTG
GGCGGCGTGCCCGGCGTCGCCCCCGGCCGGGTGGCGATCATCGGTGGCGGCACCGTCGGCACCAATGCGGCGAAGATCGC
CCTGGGGATGGGCGCGCACGTCACCATCCTGGACATCAACGCCGATCGGCTGCGCTACCTGGACGACATCTTCGGCTCCC
GGGTGGAGACGCGGATCTCCAACGAGTTCGAAATTGCCAATGCCGTGGCGCAGGCCGACCTGGTCATCGGGGCGGTGCTG
ATCCCCGGCGCCAAGGCGCCGAAGCTGGTAACGGCGGAGATGGTCAAGCGGATGGCCCCGGGTTCCGTCATCGTGGATGT
GGCCATCGACCAGGGCGGGTCGGTGGAGACCATCGACCGGGTGACGACCCACCAGGATCCCGTCTACGAGCGGTTCGGCG
TCGTTCACTACGCCGTCGCCAACATCCCTGGCGCGGTGCCCCGGACCTCCACCTGGGCTCTGACCAACGTGACGCTGCCT
TATGCCCTGAAGCTGGCCAACCTGGGCTGGAAGGAGGCGCTGCGTCAGGATCCGGCGCTGGCGAAGGGCGCCAACGTGGT
CAGCGGCCACGTCACCTACCCGGCGGTCGCCGAGGCCCACGGGCTGGAGTACGTGGAGCTGGACAACGTGCTCAGGTAG

Upstream 100 bases:

>100_bases
ATGGGATAATTCGTAAGAGAGTCGGGCTTGCATGGTTTCACCGGTGAAACCACCATCTCACTACTGGCGCGGCGCGCCGA
ACGCGGAAGGAGCGAGAGCA

Downstream 100 bases:

>100_bases
GCCGCAGGAGGCGGAGGACGGCCCCGCATCGGACTGATGCGGGGCCCTTGCTATTGGTTGAAAGCAGGGCGGGGAGGGGG
GCATAACCCGGCGCCGGTCG

Product: alanine dehydrogenase

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 372; Mature: 372

Protein sequence:

>372_residues
MRVGVVRELKAYENRVAMTPAGVMAMVRAGHEVYVEHDAGRGSGFDDSEYVAAGARILPSNEDVWATADMIVKVKEPLPP
EYDLMREGQIIFTYLHLAAEPELTRKLIERKSIAIAYETVQPADRSLPLLTPMSEVAGRMAVQIGAHYLEKAHGGRGVLL
GGVPGVAPGRVAIIGGGTVGTNAAKIALGMGAHVTILDINADRLRYLDDIFGSRVETRISNEFEIANAVAQADLVIGAVL
IPGAKAPKLVTAEMVKRMAPGSVIVDVAIDQGGSVETIDRVTTHQDPVYERFGVVHYAVANIPGAVPRTSTWALTNVTLP
YALKLANLGWKEALRQDPALAKGANVVSGHVTYPAVAEAHGLEYVELDNVLR

Sequences:

>Translated_372_residues
MRVGVVRELKAYENRVAMTPAGVMAMVRAGHEVYVEHDAGRGSGFDDSEYVAAGARILPSNEDVWATADMIVKVKEPLPP
EYDLMREGQIIFTYLHLAAEPELTRKLIERKSIAIAYETVQPADRSLPLLTPMSEVAGRMAVQIGAHYLEKAHGGRGVLL
GGVPGVAPGRVAIIGGGTVGTNAAKIALGMGAHVTILDINADRLRYLDDIFGSRVETRISNEFEIANAVAQADLVIGAVL
IPGAKAPKLVTAEMVKRMAPGSVIVDVAIDQGGSVETIDRVTTHQDPVYERFGVVHYAVANIPGAVPRTSTWALTNVTLP
YALKLANLGWKEALRQDPALAKGANVVSGHVTYPAVAEAHGLEYVELDNVLR
>Mature_372_residues
MRVGVVRELKAYENRVAMTPAGVMAMVRAGHEVYVEHDAGRGSGFDDSEYVAAGARILPSNEDVWATADMIVKVKEPLPP
EYDLMREGQIIFTYLHLAAEPELTRKLIERKSIAIAYETVQPADRSLPLLTPMSEVAGRMAVQIGAHYLEKAHGGRGVLL
GGVPGVAPGRVAIIGGGTVGTNAAKIALGMGAHVTILDINADRLRYLDDIFGSRVETRISNEFEIANAVAQADLVIGAVL
IPGAKAPKLVTAEMVKRMAPGSVIVDVAIDQGGSVETIDRVTTHQDPVYERFGVVHYAVANIPGAVPRTSTWALTNVTLP
YALKLANLGWKEALRQDPALAKGANVVSGHVTYPAVAEAHGLEYVELDNVLR

Specific function: This enzyme is a key factor in the assimilation of L- alanine as an energy source through the tricarboxylic acid cycle during sporulation [H]

COG id: COG0686

COG function: function code E; Alanine dehydrogenase

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the AlaDH/PNT family [H]

Homologues:

Organism=Homo sapiens, GI122939155, Length=347, Percent_Identity=31.700288184438, Blast_Score=147, Evalue=1e-35,
Organism=Homo sapiens, GI122939153, Length=347, Percent_Identity=31.700288184438, Blast_Score=147, Evalue=1e-35,
Organism=Escherichia coli, GI1787887, Length=383, Percent_Identity=32.6370757180157, Blast_Score=147, Evalue=1e-36,
Organism=Caenorhabditis elegans, GI17550456, Length=348, Percent_Identity=30.1724137931034, Blast_Score=144, Evalue=8e-35,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR007698
- InterPro:   IPR008142
- InterPro:   IPR008143
- InterPro:   IPR007886
- InterPro:   IPR008141 [H]

Pfam domain/function: PF01262 AlaDh_PNT_C; PF05222 AlaDh_PNT_N [H]

EC number: =1.4.1.1 [H]

Molecular weight: Translated: 39777; Mature: 39777

Theoretical pI: Translated: 6.19; Mature: 6.19

Prosite motif: PS00837 ALADH_PNT_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
3.0 %Met     (Translated Protein)
3.0 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
3.0 %Met     (Mature Protein)
3.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MRVGVVRELKAYENRVAMTPAGVMAMVRAGHEVYVEHDAGRGSGFDDSEYVAAGARILPS
CCCCHHHHHHHHHCEEEECCHHHHHHHHCCCEEEEEECCCCCCCCCCCHHHCCCCEECCC
NEDVWATADMIVKVKEPLPPEYDLMREGQIIFTYLHLAAEPELTRKLIERKSIAIAYETV
CCCEEEEEEEEEEECCCCCCCHHHHCCCCEEEEEEEHHCCHHHHHHHHHHCCEEEEEEEC
QPADRSLPLLTPMSEVAGRMAVQIGAHYLEKAHGGRGVLLGGVPGVAPGRVAIIGGGTVG
CCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHCCCCCEEEEECCCCCCCCEEEEEECCCCC
TNAAKIALGMGAHVTILDINADRLRYLDDIFGSRVETRISNEFEIANAVAQADLVIGAVL
CCCEEEEEECCCEEEEEECCHHHHHHHHHHHCCHHHHHHCCCHHHHHHHHHHHHHEEEEE
IPGAKAPKLVTAEMVKRMAPGSVIVDVAIDQGGSVETIDRVTTHQDPVYERFGVVHYAVA
ECCCCCCCHHHHHHHHHHCCCCEEEEEEECCCCCCHHHHHHHCCCCHHHHHHHHHHHHHH
NIPGAVPRTSTWALTNVTLPYALKLANLGWKEALRQDPALAKGANVVSGHVTYPAVAEAH
CCCCCCCCCCCEEEEEECHHHHEEECCCCHHHHHHCCCCHHCCCCEEECCCCCCCHHHHC
GLEYVELDNVLR
CCEEEEHHHHCC
>Mature Secondary Structure
MRVGVVRELKAYENRVAMTPAGVMAMVRAGHEVYVEHDAGRGSGFDDSEYVAAGARILPS
CCCCHHHHHHHHHCEEEECCHHHHHHHHCCCEEEEEECCCCCCCCCCCHHHCCCCEECCC
NEDVWATADMIVKVKEPLPPEYDLMREGQIIFTYLHLAAEPELTRKLIERKSIAIAYETV
CCCEEEEEEEEEEECCCCCCCHHHHCCCCEEEEEEEHHCCHHHHHHHHHHCCEEEEEEEC
QPADRSLPLLTPMSEVAGRMAVQIGAHYLEKAHGGRGVLLGGVPGVAPGRVAIIGGGTVG
CCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHCCCCCEEEEECCCCCCCCEEEEEECCCCC
TNAAKIALGMGAHVTILDINADRLRYLDDIFGSRVETRISNEFEIANAVAQADLVIGAVL
CCCEEEEEECCCEEEEEECCHHHHHHHHHHHCCHHHHHHCCCHHHHHHHHHHHHHEEEEE
IPGAKAPKLVTAEMVKRMAPGSVIVDVAIDQGGSVETIDRVTTHQDPVYERFGVVHYAVA
ECCCCCCCHHHHHHHHHHCCCCEEEEEEECCCCCCHHHHHHHCCCCHHHHHHHHHHHHHH
NIPGAVPRTSTWALTNVTLPYALKLANLGWKEALRQDPALAKGANVVSGHVTYPAVAEAH
CCCCCCCCCCCEEEEEECHHHHEEECCCCHHHHHHCCCCHHCCCCEEECCCCCCCHHHHC
GLEYVELDNVLR
CCEEEEHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 2340274 [H]