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The map label for this gene is yfhQ [H]

Identifier: 51892865

GI number: 51892865

Start: 1876451

End: 1877548

Strand: Reverse

Name: yfhQ [H]

Synonym: STH1727

Alternate gene names: 51892865

Gene position: 1877548-1876451 (Counterclockwise)

Preceding gene: 51892866

Following gene: 51892864

Centisome position: 52.65

GC content: 70.58

Gene sequence:

>1098_bases
GTGGCCGACCGCCTGTTGGACTGGTACTCGGCGAGCGCGCGCGACCTGCCGTGGCGCCGGACCCGGGATCCTTACCACAT
CTGGGTCTCCGAGATCATGCTGCAGCAGACCCGGGTGGAGACGGTGATCCCCTATTACGAACGGTGGATGGCCCGGTTTC
CCACCCTCGAGGCTCTGGCGGACGCGCCGGAGGAGCAGGTGCTGAAGGCCTGGGAAGGGCTGGGCTATTATTCACGCGCG
CGCAACCTGCACGCGGCCGCGCGGGAGGTTGTGGCACGGTACGGCGGCACGGTCCCCGACGATCCCGACGCCGTGGCGTC
GCTGAAGGGGATCGGGCCGTACACCGCCGGGGCGATCCTCTCCATCGCCTTCAACCGGCCGGTGCCTGCGGTGGACGGGA
ACGTGCTGCGCGTCATCGCGCGGCTCTATGCCATCGTGGACGACATCGCACAGCTGGCGACCCGCAGGACGATCGAGGAG
CTGGTGCGGGCCATGATCCCGCAGGATCGGCCCGGCGACTTCAACCAGGCCCTGATGGATCTCGGTGCGACGATCTGCAC
GCCACGCCGCCCCCGGTGCCTGCTGTGCCCCGTGCGGGACCTCTGTGAGGGGCGCAGGGCCGGAAGGGAGACCGAGCTTC
CCGTGAAGGGACGGGCGAAGGCCCCCAGGCTGGTGGAGCGCGCGGCCGCGGTGATCGAACGGGAAGGCCGGCTTCTCATC
GTGCGGCGGCCGCAGGAGGGGCTGCTGGCCGGGCTGTGGGAGCTGCCCGGCGGCGATGTGCCTCCGGGCGTGGGCCCTGA
AGAGGCGCTTCAGACGCTCCTGCGGAATGCCCTGGGCGCGGAGGTGGCGGTGGGGGAGCACCTGGCCGATGTCACCCACG
TCTTCTCGCACCTGGTGTGGCACCTGCGCTGCTTCCGGGCGGAGGTGGTGCCGGGGACGGAGGTGGCGGAGCGGGCCGAT
GTGCGATGGGTGAAGGTGGACGCGCTGGGCGCCTACCCGTTCCCTGCGATTTACCACAAGGTCTTTGAGCGGGTACTCCC
ACACACGGCGCACGGAGGCGGCGGACGGACCCGGAGGAATGCGCAGGATCGGGGGTAG

Upstream 100 bases:

>100_bases
CGGGCCATCATGGCGCCGCAGATGGGAGCGAAGAGAGGGCCGACGAGCGTTGCACACACCGCAGCAAGACGAAGAGCGCG
AGCGCAGGCGGTCGGCGGAG

Downstream 100 bases:

>100_bases
CCCCCCGGCTGTCGGCTTCTTCTGGGGGGAGCTCTGTGAGGCCCGTTGTCGCTGCCACAAGTGCGGCAACGTCCACTGAG
ACCAACGCCGACGAGTTGTC

Product: A/G-specific adenine glycosylase

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 365; Mature: 364

Protein sequence:

>365_residues
MADRLLDWYSASARDLPWRRTRDPYHIWVSEIMLQQTRVETVIPYYERWMARFPTLEALADAPEEQVLKAWEGLGYYSRA
RNLHAAAREVVARYGGTVPDDPDAVASLKGIGPYTAGAILSIAFNRPVPAVDGNVLRVIARLYAIVDDIAQLATRRTIEE
LVRAMIPQDRPGDFNQALMDLGATICTPRRPRCLLCPVRDLCEGRRAGRETELPVKGRAKAPRLVERAAAVIEREGRLLI
VRRPQEGLLAGLWELPGGDVPPGVGPEEALQTLLRNALGAEVAVGEHLADVTHVFSHLVWHLRCFRAEVVPGTEVAERAD
VRWVKVDALGAYPFPAIYHKVFERVLPHTAHGGGGRTRRNAQDRG

Sequences:

>Translated_365_residues
MADRLLDWYSASARDLPWRRTRDPYHIWVSEIMLQQTRVETVIPYYERWMARFPTLEALADAPEEQVLKAWEGLGYYSRA
RNLHAAAREVVARYGGTVPDDPDAVASLKGIGPYTAGAILSIAFNRPVPAVDGNVLRVIARLYAIVDDIAQLATRRTIEE
LVRAMIPQDRPGDFNQALMDLGATICTPRRPRCLLCPVRDLCEGRRAGRETELPVKGRAKAPRLVERAAAVIEREGRLLI
VRRPQEGLLAGLWELPGGDVPPGVGPEEALQTLLRNALGAEVAVGEHLADVTHVFSHLVWHLRCFRAEVVPGTEVAERAD
VRWVKVDALGAYPFPAIYHKVFERVLPHTAHGGGGRTRRNAQDRG
>Mature_364_residues
ADRLLDWYSASARDLPWRRTRDPYHIWVSEIMLQQTRVETVIPYYERWMARFPTLEALADAPEEQVLKAWEGLGYYSRAR
NLHAAAREVVARYGGTVPDDPDAVASLKGIGPYTAGAILSIAFNRPVPAVDGNVLRVIARLYAIVDDIAQLATRRTIEEL
VRAMIPQDRPGDFNQALMDLGATICTPRRPRCLLCPVRDLCEGRRAGRETELPVKGRAKAPRLVERAAAVIEREGRLLIV
RRPQEGLLAGLWELPGGDVPPGVGPEEALQTLLRNALGAEVAVGEHLADVTHVFSHLVWHLRCFRAEVVPGTEVAERADV
RWVKVDALGAYPFPAIYHKVFERVLPHTAHGGGGRTRRNAQDRG

Specific function: Involved in the GO system responsible for removing an oxidatively damaged form of guanine (7,8-dihydro-8-oxoguanine, 8- oxo-dGTP) from DNA and the nucleotide pool. 8-oxo-dGTP is inserted opposite dA and dC residues of template DNA with almost equal effici

COG id: COG1194

COG function: function code L; A/G-specific DNA glycosylase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 HhH domain [H]

Homologues:

Organism=Homo sapiens, GI115298648, Length=350, Percent_Identity=40.2857142857143, Blast_Score=231, Evalue=7e-61,
Organism=Homo sapiens, GI190358497, Length=350, Percent_Identity=40.2857142857143, Blast_Score=231, Evalue=8e-61,
Organism=Homo sapiens, GI6912520, Length=350, Percent_Identity=40.2857142857143, Blast_Score=231, Evalue=8e-61,
Organism=Homo sapiens, GI115298650, Length=350, Percent_Identity=40.2857142857143, Blast_Score=231, Evalue=8e-61,
Organism=Homo sapiens, GI115298654, Length=350, Percent_Identity=40.2857142857143, Blast_Score=231, Evalue=8e-61,
Organism=Homo sapiens, GI115298652, Length=350, Percent_Identity=40.2857142857143, Blast_Score=231, Evalue=8e-61,
Organism=Escherichia coli, GI1789331, Length=317, Percent_Identity=39.7476340694006, Blast_Score=223, Evalue=1e-59,
Organism=Escherichia coli, GI1787920, Length=131, Percent_Identity=32.824427480916, Blast_Score=74, Evalue=1e-14,
Organism=Escherichia coli, GI1788056, Length=113, Percent_Identity=34.5132743362832, Blast_Score=65, Evalue=6e-12,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR011257
- InterPro:   IPR003651
- InterPro:   IPR003265
- InterPro:   IPR023170
- InterPro:   IPR005760
- InterPro:   IPR000086
- InterPro:   IPR015797 [H]

Pfam domain/function: PF00730 HhH-GPD [H]

EC number: 3.2.2.-

Molecular weight: Translated: 40652; Mature: 40521

Theoretical pI: Translated: 8.46; Mature: 8.46

Prosite motif: PS00764 ENDONUCLEASE_III_1

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.4 %Cys     (Translated Protein)
1.4 %Met     (Translated Protein)
2.7 %Cys+Met (Translated Protein)
1.4 %Cys     (Mature Protein)
1.1 %Met     (Mature Protein)
2.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MADRLLDWYSASARDLPWRRTRDPYHIWVSEIMLQQTRVETVIPYYERWMARFPTLEALA
CCCHHHHHHCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHH
DAPEEQVLKAWEGLGYYSRARNLHAAAREVVARYGGTVPDDPDAVASLKGIGPYTAGAIL
CCCHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHCCCCHHHHHHH
SIAFNRPVPAVDGNVLRVIARLYAIVDDIAQLATRRTIEELVRAMIPQDRPGDFNQALMD
HHHCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCHHHHHHH
LGATICTPRRPRCLLCPVRDLCEGRRAGRETELPVKGRAKAPRLVERAAAVIEREGRLLI
CCHHHCCCCCCCEEECCHHHHHHHHHCCCCCCCCCCCCCCCHHHHHHHHHHHHCCCCEEE
VRRPQEGLLAGLWELPGGDVPPGVGPEEALQTLLRNALGAEVAVGEHLADVTHVFSHLVW
EECCHHHHHHHHHHCCCCCCCCCCCHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHH
HLRCFRAEVVPGTEVAERADVRWVKVDALGAYPFPAIYHKVFERVLPHTAHGGGGRTRRN
HHHHHHHHCCCCHHHHHHCCCEEEEEECCCCCCHHHHHHHHHHHHCCCCCCCCCCCCCCC
AQDRG
CCCCC
>Mature Secondary Structure 
ADRLLDWYSASARDLPWRRTRDPYHIWVSEIMLQQTRVETVIPYYERWMARFPTLEALA
CCHHHHHHCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHH
DAPEEQVLKAWEGLGYYSRARNLHAAAREVVARYGGTVPDDPDAVASLKGIGPYTAGAIL
CCCHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHCCCCHHHHHHH
SIAFNRPVPAVDGNVLRVIARLYAIVDDIAQLATRRTIEELVRAMIPQDRPGDFNQALMD
HHHCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCHHHHHHH
LGATICTPRRPRCLLCPVRDLCEGRRAGRETELPVKGRAKAPRLVERAAAVIEREGRLLI
CCHHHCCCCCCCEEECCHHHHHHHHHCCCCCCCCCCCCCCCHHHHHHHHHHHHCCCCEEE
VRRPQEGLLAGLWELPGGDVPPGVGPEEALQTLLRNALGAEVAVGEHLADVTHVFSHLVW
EECCHHHHHHHHHHCCCCCCCCCCCHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHH
HLRCFRAEVVPGTEVAERADVRWVKVDALGAYPFPAIYHKVFERVLPHTAHGGGGRTRRN
HHHHHHHHCCCCHHHHHHCCCEEEEEECCCCCCHHHHHHHHHHHHCCCCCCCCCCCCCCC
AQDRG
CCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha

Cofactors: 4Fe-4S Cluster [C]

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: Hydrolase; Glycosylases; Hydrolysing N-glycosyl compounds [C]

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 8946165; 9384377 [H]