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The map label for this gene is yprA [H]

Identifier: 51892761

GI number: 51892761

Start: 1762664

End: 1764940

Strand: Reverse

Name: yprA [H]

Synonym: STH1623

Alternate gene names: 51892761

Gene position: 1764940-1762664 (Counterclockwise)

Preceding gene: 51892763

Following gene: 51892760

Centisome position: 49.49

GC content: 67.76

Gene sequence:

>2277_bases
ATGAACCTCGAACAGTTCCTCGATCAGCTTCGCAGCGACCCGGCCATCGGGCCCAACATCGTCCACTGGCAGACGCTGCC
GCCGGCTCCCGCCCAATACGCGGACTGGCCGGCGGCGCTCGATCCGCGCCTCGTCGCCGCCCTGAAGGAGCGGGGCATCC
ACCGGCTGTACACCCACCAGGCAGAGGCCATCGCGGCCGCCCTGGCCGGCCAGAACACGGTGGTGGTGACCCCCACCGCC
TCCGGCAAGTCCATGTGCTACAACCTGCCGGTGCTCAACACGATCCTGCACGAGCCCGCAGCCCGGGCGCTGTACCTCTT
CCCCACCAAGGCCCTGGCTCAGGACCAGGTGGCGGAGGTGAAGTCGCTGGCCGACCGGCTGGGGGCGGAGATCAAGTCCT
ACGTGTACGACGGCGACACCCCGCCCCAGGTGCGCCAGGTCTGCCGCCAGGCGGGCCATATCGTCATCACCAACCCCGAC
ATGCTGCACACCGGGGTACTGCCGCACCACACCAAGTGGGTGAAGCTCTTCGAGAACCTGCGGTACGTGGTCATCGACGA
ACTGCACCAGTACCGCGGGGTCTTCGGCTCGCACCTCGCCAACCTGATGCGCCGGCTGCGCCGCATCTGTGATTTCTACG
GCAGCCGGCCCGTCTTCCTCTGTTCCTCCGCCACCATCGCCAACCCGCAGGAGCTGGCCGAGCGGCTCATCGAGCAGCCC
GTCCGGCTGATCGACCAGAACGGCGCGCCCCGCGGCGAGAAGCACTTCATCTTCCTCAACCCGCCGGCGGTCGGCCGGGA
CGGCGTCCGGGAGCCGGTGGTCAAGGCCTCCGCCCGGGTGGCGGGCAAGCTGCTGCAGAACGACATCCAGACCATCGTCT
TCGCCCGGAGCCGGAACAACGTGGAGGTGCTCACCACCTACCTGAAGGAGCGGGTCGGCCCCAACAAGGCCCACCGGGTG
ATGGGCTACCGGGGCGGCTACCGGCCCCTGGAGCGGCGCCAGATCGAGGCCGGTCTGCGGGAGGGCAGGATCCTCGGCGT
CGTCTCCACGAATGCGTTGGAGCTGGGCATCGACATCGGCCAGCTGGAGGCCTGCGTGATGACGGGCTACCCCGGCACGG
TGGCGTCGGCCTGGCAGCAGGCGGGCCGGGCCGGGCGGCGGGCCTCCACCTCCCTCACGGTGCTGGTGGGATCGGCCTCC
CCGCTGGACCAGTACATCATGGAACACCCCGAGTTCTTCTTTGAGCGTGCCCCGGAGCAGGCCCTGATCAACCCCGACAA
CCTCCTGATCCTCGTCAGCCACCTGAAGTGCGCCGCCTTCGAGCTGCCCTTCCTGGAAGGCGAGAAGTTCGGGGTGGAGA
CCACCGGGGAGATCCTGGACTACCTGGAGGAGGAAGGAATCCTCCGCAAGGTCGGCGGCAAGTACCACTGGTCTGCCGAG
AACTTCCCGGCGGAAAGCATCAGCCTGCGCAGCGTCGACGCGGAGAACGTGGTCATCATCGACCAGTCCGTGCCGGGCCA
GACTCGCGTTCTCGGCGAGATCGATCAGTTGGGTGCGATGACCATGGTCCACACCAACGCGATCTACCTGCACCAGGCGG
AACAGTATCACGTGGACCGGCTGGACTGGGACGAGAAGAAGGCATACGTGCACAAGGTCGACGTGGAGTACTACACCGAC
GCCAACCTGGCCGTCACCATCAAGCCGCTGGACGTGCTGAAGGAAAAGGAGGAACTCGGCCTGCGGGTCCGCTTCGGCGA
GGTGATGACGGCCGCGAAGGCGACGATCTTTAAAAAGATCCGGCTGCACACCCACGAGAACCTGGGCTGGGGTGAGATCC
ACCTGCCCGAGTACCAGATGCACACTGCGGCCTACTGGCTTTCGCTGCCCGAGTCCATGTGCGAGGGGTTCACGCAGGAC
GAACTGCAGTCGGCCCTCGCCGGCCTCGGCCATCTCCTCCGGGGGCTGGCGCCGCTGTTCCTGATGTGCGACCCGGCCGA
CCTGCGGTCGGTGATCCAGGTGCGCTCCCCCTTCGAGGAGGCGCCGACCATCTACCTCTACGACGCCTACCCGGCGGGAA
TCGGCCTCGGGGAGAAGTGCTACGACCTGCATGCCGAGCTCCTCGCCACCGCCTATGAGCGGGTCCGCGCCTGCGGCTGC
GAGCGCGGCTGCCCCGCCTGCGTCGGCCCCGCGGCGGAGACGGGCAACCTCACAGGCGCCAAGGCCGGGGTGATCAGGAT
CCTGGAGCGGGCCCTGGCGCACCGCAACCTGCAGTGA

Upstream 100 bases:

>100_bases
TCCGATTCACGGCGGGATGAGCGGGCTGCAGGGTTTGACCCCCGCACCGCTGAAATATGTAGGCGTACGACTCCGCGGAG
GATATCCGGGAGGTCTCTGC

Downstream 100 bases:

>100_bases
TTCCCCCTGCGGCGGACGGCTGCCGCGCCTCCGGACACCACCGCCCGGTCACCGCAGGCGGCATACAGGCGCCCGCCGCG
GATTCCCGCAACTCCACACC

Product: ATP-dependent RNA helicase

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 758; Mature: 758

Protein sequence:

>758_residues
MNLEQFLDQLRSDPAIGPNIVHWQTLPPAPAQYADWPAALDPRLVAALKERGIHRLYTHQAEAIAAALAGQNTVVVTPTA
SGKSMCYNLPVLNTILHEPAARALYLFPTKALAQDQVAEVKSLADRLGAEIKSYVYDGDTPPQVRQVCRQAGHIVITNPD
MLHTGVLPHHTKWVKLFENLRYVVIDELHQYRGVFGSHLANLMRRLRRICDFYGSRPVFLCSSATIANPQELAERLIEQP
VRLIDQNGAPRGEKHFIFLNPPAVGRDGVREPVVKASARVAGKLLQNDIQTIVFARSRNNVEVLTTYLKERVGPNKAHRV
MGYRGGYRPLERRQIEAGLREGRILGVVSTNALELGIDIGQLEACVMTGYPGTVASAWQQAGRAGRRASTSLTVLVGSAS
PLDQYIMEHPEFFFERAPEQALINPDNLLILVSHLKCAAFELPFLEGEKFGVETTGEILDYLEEEGILRKVGGKYHWSAE
NFPAESISLRSVDAENVVIIDQSVPGQTRVLGEIDQLGAMTMVHTNAIYLHQAEQYHVDRLDWDEKKAYVHKVDVEYYTD
ANLAVTIKPLDVLKEKEELGLRVRFGEVMTAAKATIFKKIRLHTHENLGWGEIHLPEYQMHTAAYWLSLPESMCEGFTQD
ELQSALAGLGHLLRGLAPLFLMCDPADLRSVIQVRSPFEEAPTIYLYDAYPAGIGLGEKCYDLHAELLATAYERVRACGC
ERGCPACVGPAAETGNLTGAKAGVIRILERALAHRNLQ

Sequences:

>Translated_758_residues
MNLEQFLDQLRSDPAIGPNIVHWQTLPPAPAQYADWPAALDPRLVAALKERGIHRLYTHQAEAIAAALAGQNTVVVTPTA
SGKSMCYNLPVLNTILHEPAARALYLFPTKALAQDQVAEVKSLADRLGAEIKSYVYDGDTPPQVRQVCRQAGHIVITNPD
MLHTGVLPHHTKWVKLFENLRYVVIDELHQYRGVFGSHLANLMRRLRRICDFYGSRPVFLCSSATIANPQELAERLIEQP
VRLIDQNGAPRGEKHFIFLNPPAVGRDGVREPVVKASARVAGKLLQNDIQTIVFARSRNNVEVLTTYLKERVGPNKAHRV
MGYRGGYRPLERRQIEAGLREGRILGVVSTNALELGIDIGQLEACVMTGYPGTVASAWQQAGRAGRRASTSLTVLVGSAS
PLDQYIMEHPEFFFERAPEQALINPDNLLILVSHLKCAAFELPFLEGEKFGVETTGEILDYLEEEGILRKVGGKYHWSAE
NFPAESISLRSVDAENVVIIDQSVPGQTRVLGEIDQLGAMTMVHTNAIYLHQAEQYHVDRLDWDEKKAYVHKVDVEYYTD
ANLAVTIKPLDVLKEKEELGLRVRFGEVMTAAKATIFKKIRLHTHENLGWGEIHLPEYQMHTAAYWLSLPESMCEGFTQD
ELQSALAGLGHLLRGLAPLFLMCDPADLRSVIQVRSPFEEAPTIYLYDAYPAGIGLGEKCYDLHAELLATAYERVRACGC
ERGCPACVGPAAETGNLTGAKAGVIRILERALAHRNLQ
>Mature_758_residues
MNLEQFLDQLRSDPAIGPNIVHWQTLPPAPAQYADWPAALDPRLVAALKERGIHRLYTHQAEAIAAALAGQNTVVVTPTA
SGKSMCYNLPVLNTILHEPAARALYLFPTKALAQDQVAEVKSLADRLGAEIKSYVYDGDTPPQVRQVCRQAGHIVITNPD
MLHTGVLPHHTKWVKLFENLRYVVIDELHQYRGVFGSHLANLMRRLRRICDFYGSRPVFLCSSATIANPQELAERLIEQP
VRLIDQNGAPRGEKHFIFLNPPAVGRDGVREPVVKASARVAGKLLQNDIQTIVFARSRNNVEVLTTYLKERVGPNKAHRV
MGYRGGYRPLERRQIEAGLREGRILGVVSTNALELGIDIGQLEACVMTGYPGTVASAWQQAGRAGRRASTSLTVLVGSAS
PLDQYIMEHPEFFFERAPEQALINPDNLLILVSHLKCAAFELPFLEGEKFGVETTGEILDYLEEEGILRKVGGKYHWSAE
NFPAESISLRSVDAENVVIIDQSVPGQTRVLGEIDQLGAMTMVHTNAIYLHQAEQYHVDRLDWDEKKAYVHKVDVEYYTD
ANLAVTIKPLDVLKEKEELGLRVRFGEVMTAAKATIFKKIRLHTHENLGWGEIHLPEYQMHTAAYWLSLPESMCEGFTQD
ELQSALAGLGHLLRGLAPLFLMCDPADLRSVIQVRSPFEEAPTIYLYDAYPAGIGLGEKCYDLHAELLATAYERVRACGC
ERGCPACVGPAAETGNLTGAKAGVIRILERALAHRNLQ

Specific function: Unknown

COG id: COG1205

COG function: function code R; Distinct helicase family with a unique C-terminal domain including a metal-binding cysteine cluster

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 helicase C-terminal domain [H]

Homologues:

Organism=Homo sapiens, GI9506931, Length=215, Percent_Identity=29.3023255813954, Blast_Score=68, Evalue=3e-11,
Organism=Saccharomyces cerevisiae, GI6320497, Length=788, Percent_Identity=31.7258883248731, Blast_Score=400, Evalue=1e-112,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR014001
- InterPro:   IPR018973
- InterPro:   IPR011545
- InterPro:   IPR001650
- InterPro:   IPR014021 [H]

Pfam domain/function: PF00270 DEAD; PF09369 DUF1998; PF00271 Helicase_C [H]

EC number: 3.6.1.- [C]

Molecular weight: Translated: 84164; Mature: 84164

Theoretical pI: Translated: 6.64; Mature: 6.64

Prosite motif: PS00430 TONB_DEPENDENT_REC_1

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.7 %Cys     (Translated Protein)
1.7 %Met     (Translated Protein)
3.4 %Cys+Met (Translated Protein)
1.7 %Cys     (Mature Protein)
1.7 %Met     (Mature Protein)
3.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MNLEQFLDQLRSDPAIGPNIVHWQTLPPAPAQYADWPAALDPRLVAALKERGIHRLYTHQ
CCHHHHHHHHHCCCCCCCCEEEECCCCCCCCCCCCCCCCCCHHHHHHHHHCCHHHHHHHH
AEAIAAALAGQNTVVVTPTASGKSMCYNLPVLNTILHEPAARALYLFPTKALAQDQVAEV
HHHHHHHHCCCCEEEEEECCCCCCEEEECHHHHHHHCCHHHCEEEEECCHHHHHHHHHHH
KSLADRLGAEIKSYVYDGDTPPQVRQVCRQAGHIVITNPDMLHTGVLPHHTKWVKLFENL
HHHHHHHHHHHHHHHCCCCCCHHHHHHHHHCCEEEEECCCHHCCCCCCCHHHHHHHHHCC
RYVVIDELHQYRGVFGSHLANLMRRLRRICDFYGSRPVFLCSSATIANPQELAERLIEQP
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCEEEECCCCCCCHHHHHHHHHHHH
VRLIDQNGAPRGEKHFIFLNPPAVGRDGVREPVVKASARVAGKLLQNDIQTIVFARSRNN
HHHHCCCCCCCCCEEEEEECCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHEEEECCCCC
VEVLTTYLKERVGPNKAHRVMGYRGGYRPLERRQIEAGLREGRILGVVSTNALELGIDIG
HHHHHHHHHHHCCCCHHHHHHCCCCCCCCHHHHHHHHHHCCCCEEEEEECCCEEECCCHH
QLEACVMTGYPGTVASAWQQAGRAGRRASTSLTVLVGSASPLDQYIMEHPEFFFERAPEQ
HHCEEEEECCCCHHHHHHHHHHHCCCCCCCEEEEEEECCCCHHHHHHHCCHHHHHCCCHH
ALINPDNLLILVSHLKCAAFELPFLEGEKFGVETTGEILDYLEEEGILRKVGGKYHWSAE
HCCCCCCEEEEEEHHHHHHEECCCCCCCCCCCCCHHHHHHHHHHCCHHHHHCCCEEECCC
NFPAESISLRSVDAENVVIIDQSVPGQTRVLGEIDQLGAMTMVHTNAIYLHQAEQYHVDR
CCCCCCEEEEEECCCCEEEEECCCCCCHHHHHHHHHHCCEEEEECCEEEEECCCHHCCCC
LDWDEKKAYVHKVDVEYYTDANLAVTIKPLDVLKEKEELGLRVRFGEVMTAAKATIFKKI
CCCCCCCCEEEEEEEEEEECCCEEEEEEHHHHHHHHHHCCEEEEHHHHHHHHHHHHHHHH
RLHTHENLGWGEIHLPEYQMHTAAYWLSLPESMCEGFTQDELQSALAGLGHLLRGLAPLF
HHHCCCCCCCCEEECCCHHHHHHHHHHHCCHHHHCCCCHHHHHHHHHHHHHHHHHHHHHE
LMCDPADLRSVIQVRSPFEEAPTIYLYDAYPAGIGLGEKCYDLHAELLATAYERVRACGC
EEECCHHHHHHHHHHCCHHHCCEEEEEECCCCCCCCCHHHHHHHHHHHHHHHHHHHHHCC
ERGCPACVGPAAETGNLTGAKAGVIRILERALAHRNLQ
CCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHCCCC
>Mature Secondary Structure
MNLEQFLDQLRSDPAIGPNIVHWQTLPPAPAQYADWPAALDPRLVAALKERGIHRLYTHQ
CCHHHHHHHHHCCCCCCCCEEEECCCCCCCCCCCCCCCCCCHHHHHHHHHCCHHHHHHHH
AEAIAAALAGQNTVVVTPTASGKSMCYNLPVLNTILHEPAARALYLFPTKALAQDQVAEV
HHHHHHHHCCCCEEEEEECCCCCCEEEECHHHHHHHCCHHHCEEEEECCHHHHHHHHHHH
KSLADRLGAEIKSYVYDGDTPPQVRQVCRQAGHIVITNPDMLHTGVLPHHTKWVKLFENL
HHHHHHHHHHHHHHHCCCCCCHHHHHHHHHCCEEEEECCCHHCCCCCCCHHHHHHHHHCC
RYVVIDELHQYRGVFGSHLANLMRRLRRICDFYGSRPVFLCSSATIANPQELAERLIEQP
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCEEEECCCCCCCHHHHHHHHHHHH
VRLIDQNGAPRGEKHFIFLNPPAVGRDGVREPVVKASARVAGKLLQNDIQTIVFARSRNN
HHHHCCCCCCCCCEEEEEECCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHEEEECCCCC
VEVLTTYLKERVGPNKAHRVMGYRGGYRPLERRQIEAGLREGRILGVVSTNALELGIDIG
HHHHHHHHHHHCCCCHHHHHHCCCCCCCCHHHHHHHHHHCCCCEEEEEECCCEEECCCHH
QLEACVMTGYPGTVASAWQQAGRAGRRASTSLTVLVGSASPLDQYIMEHPEFFFERAPEQ
HHCEEEEECCCCHHHHHHHHHHHCCCCCCCEEEEEEECCCCHHHHHHHCCHHHHHCCCHH
ALINPDNLLILVSHLKCAAFELPFLEGEKFGVETTGEILDYLEEEGILRKVGGKYHWSAE
HCCCCCCEEEEEEHHHHHHEECCCCCCCCCCCCCHHHHHHHHHHCCHHHHHCCCEEECCC
NFPAESISLRSVDAENVVIIDQSVPGQTRVLGEIDQLGAMTMVHTNAIYLHQAEQYHVDR
CCCCCCEEEEEECCCCEEEEECCCCCCHHHHHHHHHHCCEEEEECCEEEEECCCHHCCCC
LDWDEKKAYVHKVDVEYYTDANLAVTIKPLDVLKEKEELGLRVRFGEVMTAAKATIFKKI
CCCCCCCCEEEEEEEEEEECCCEEEEEEHHHHHHHHHHCCEEEEHHHHHHHHHHHHHHHH
RLHTHENLGWGEIHLPEYQMHTAAYWLSLPESMCEGFTQDELQSALAGLGHLLRGLAPLF
HHHCCCCCCCCEEECCCHHHHHHHHHHHCCHHHHCCCCHHHHHHHHHHHHHHHHHHHHHE
LMCDPADLRSVIQVRSPFEEAPTIYLYDAYPAGIGLGEKCYDLHAELLATAYERVRACGC
EEECCHHHHHHHHHHCCHHHCCEEEEEECCCCCCCCCHHHHHHHHHHHHHHHHHHHHHCC
ERGCPACVGPAAETGNLTGAKAGVIRILERALAHRNLQ
CCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: Hydrolase; Acting on acid anhydrides [C]

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 8760912; 9384377 [H]