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The map label for this gene is gluD [H]

Identifier: 51892334

GI number: 51892334

Start: 1326852

End: 1328105

Strand: Reverse

Name: gluD [H]

Synonym: STH1196

Alternate gene names: 51892334

Gene position: 1328105-1326852 (Counterclockwise)

Preceding gene: 51892370

Following gene: 51892333

Centisome position: 37.24

GC content: 68.98

Gene sequence:

>1254_bases
ATGACTGGCCAGGAGTTCTTCCGAGATACCCAGGAGACGATTCGTGCTGCCGTCGCGAAACTGGGCCACTCGGAAGGCGT
CTACAAGATCCTGCGTAACCCTCGTCGTACGCTTGAGGTTCACATTGCGGTGACGATGCCCGACGGATCCGTTGAGACCT
TCCTGGGTTACCGGTCGCAGCACGCCGCCGTCTTCGGCCCCTACAAGGGCGGCGTCCGGTTCCACCCCAACGTCACCAAG
GAAGAGGTCGAGGCGCTGGCGATGCTCATGACCCTGAAGAACGCCGTGCTCGGCCTGCCTTACGGGGGCGCCAAGGGAGG
CGTCATCTGCGATCCCAACGCCCTGCCGCCCACCGCGGTGGAGCAGATCGCCCGGGGCTACGTGCGCGGGCTGCGTGACA
TGATCGGTCCCGATACGGACATCCCCGCGCCGGACGTCAACACCAACTCCCGGGTCATGGGCTGGATGCTCGACGAGTAC
CTGAAGTGCACCAACGCCATCGACTTCTCGGTCTTCACCGGCAAGAGCCTCAACCTGGGCGGCATTGAGGGCCGCACCGG
GGCCACCGGCCTCGGCATCGCCTACGTGACCCGCGAGGCCTGCAAGGTCCGGGGGGTGGACCTGAAGGGCGCCAGGGTCG
CCGTGCAGGGCTTTGGCAACGTGGGCCGCGGCGCGGCGCAGGCCCTCACCGCGCTGGGGGCCAGGATCGTCGGCGTCACC
GACATCACCGGCGGCGTCTACAAGGAGGACGGCCTCGACGTGGCCGCGCTGACGGAGTACGCCAGGGACCGCGGCGGCGT
CGCCGGCTTCCCCGGCGCCGAGCCCCTCACCAACGAGCAGCTCTTCGCCCTGCCGGTGGATGTGCTGATCCCGGCGGCCT
TGGAGGGACAGATCACGGGCAAGGTCGCCGAGACCATCCAGGCGCCGATCGTGGTGGAGGGCGCCAACGGCCCGACCACC
CCCGAGGGCGCCCAGGTGCTGGCGGACCGGGGCATCATGCAGGTCCCGGACATCCTGGCCAACGGCGGCGGCGTGACCGT
CTCTTATTTCGAGTGGGTGCAGGGCCAGCAGGGCGGCCTCCGCTGGTCCGAACGCACCGTGCACCGCCGCCTCGACCGGT
ACATGACCAGCGCCTTCGCCGCCGTGCTGGCGTACAGCGAGCGCTACAACGTCTCCATGCGTGAGGCGGCCTACCTGTTC
GCCGTGGACCGGCTCGCCACCGGCATGATCGAGCGCGGCTGGGTCCCGAGGTAG

Upstream 100 bases:

>100_bases
GGGGGCGTTCGCCCCCCCTCCGGCGGCAGGACTGGCGACCAGGCGTGCTGAATACAGCCATGGGTGTCCGTACCGAAGGA
TCGAAGGGAGGATCTCACTC

Downstream 100 bases:

>100_bases
CCCGACCGGCCGCGCGGCGCTGATCAGTTCGCAGGGCATGACGCGCCAGGCCGGAACCCCCGACGGTTCCGGCCTGGCGC
CTATAAGGCCGGGGCGGCGC

Product: glutamate/leucine dehydrogenase

Products: NA

Alternate protein names: NAD-GDH [H]

Number of amino acids: Translated: 417; Mature: 416

Protein sequence:

>417_residues
MTGQEFFRDTQETIRAAVAKLGHSEGVYKILRNPRRTLEVHIAVTMPDGSVETFLGYRSQHAAVFGPYKGGVRFHPNVTK
EEVEALAMLMTLKNAVLGLPYGGAKGGVICDPNALPPTAVEQIARGYVRGLRDMIGPDTDIPAPDVNTNSRVMGWMLDEY
LKCTNAIDFSVFTGKSLNLGGIEGRTGATGLGIAYVTREACKVRGVDLKGARVAVQGFGNVGRGAAQALTALGARIVGVT
DITGGVYKEDGLDVAALTEYARDRGGVAGFPGAEPLTNEQLFALPVDVLIPAALEGQITGKVAETIQAPIVVEGANGPTT
PEGAQVLADRGIMQVPDILANGGGVTVSYFEWVQGQQGGLRWSERTVHRRLDRYMTSAFAAVLAYSERYNVSMREAAYLF
AVDRLATGMIERGWVPR

Sequences:

>Translated_417_residues
MTGQEFFRDTQETIRAAVAKLGHSEGVYKILRNPRRTLEVHIAVTMPDGSVETFLGYRSQHAAVFGPYKGGVRFHPNVTK
EEVEALAMLMTLKNAVLGLPYGGAKGGVICDPNALPPTAVEQIARGYVRGLRDMIGPDTDIPAPDVNTNSRVMGWMLDEY
LKCTNAIDFSVFTGKSLNLGGIEGRTGATGLGIAYVTREACKVRGVDLKGARVAVQGFGNVGRGAAQALTALGARIVGVT
DITGGVYKEDGLDVAALTEYARDRGGVAGFPGAEPLTNEQLFALPVDVLIPAALEGQITGKVAETIQAPIVVEGANGPTT
PEGAQVLADRGIMQVPDILANGGGVTVSYFEWVQGQQGGLRWSERTVHRRLDRYMTSAFAAVLAYSERYNVSMREAAYLF
AVDRLATGMIERGWVPR
>Mature_416_residues
TGQEFFRDTQETIRAAVAKLGHSEGVYKILRNPRRTLEVHIAVTMPDGSVETFLGYRSQHAAVFGPYKGGVRFHPNVTKE
EVEALAMLMTLKNAVLGLPYGGAKGGVICDPNALPPTAVEQIARGYVRGLRDMIGPDTDIPAPDVNTNSRVMGWMLDEYL
KCTNAIDFSVFTGKSLNLGGIEGRTGATGLGIAYVTREACKVRGVDLKGARVAVQGFGNVGRGAAQALTALGARIVGVTD
ITGGVYKEDGLDVAALTEYARDRGGVAGFPGAEPLTNEQLFALPVDVLIPAALEGQITGKVAETIQAPIVVEGANGPTTP
EGAQVLADRGIMQVPDILANGGGVTVSYFEWVQGQQGGLRWSERTVHRRLDRYMTSAFAAVLAYSERYNVSMREAAYLFA
VDRLATGMIERGWVPR

Specific function: Unknown

COG id: COG0334

COG function: function code E; Glutamate dehydrogenase/leucine dehydrogenase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the Glu/Leu/Phe/Val dehydrogenases family [H]

Homologues:

Organism=Homo sapiens, GI31377775, Length=342, Percent_Identity=38.3040935672515, Blast_Score=243, Evalue=2e-64,
Organism=Homo sapiens, GI4885281, Length=360, Percent_Identity=38.0555555555556, Blast_Score=241, Evalue=9e-64,
Organism=Escherichia coli, GI1788059, Length=394, Percent_Identity=32.2335025380711, Blast_Score=179, Evalue=3e-46,
Organism=Caenorhabditis elegans, GI17544676, Length=347, Percent_Identity=36.8876080691643, Blast_Score=218, Evalue=4e-57,
Organism=Saccharomyces cerevisiae, GI6324951, Length=426, Percent_Identity=29.3427230046948, Blast_Score=158, Evalue=2e-39,
Organism=Saccharomyces cerevisiae, GI6319256, Length=460, Percent_Identity=28.9130434782609, Blast_Score=154, Evalue=3e-38,
Organism=Drosophila melanogaster, GI24649283, Length=332, Percent_Identity=40.0602409638554, Blast_Score=251, Evalue=9e-67,
Organism=Drosophila melanogaster, GI45549226, Length=344, Percent_Identity=38.0813953488372, Blast_Score=243, Evalue=2e-64,
Organism=Drosophila melanogaster, GI45553475, Length=344, Percent_Identity=38.0813953488372, Blast_Score=243, Evalue=2e-64,
Organism=Drosophila melanogaster, GI24649460, Length=278, Percent_Identity=39.568345323741, Blast_Score=200, Evalue=1e-51,

Paralogues:

None

Copy number: 140 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). 9362 Molecules/Cell In: Growth Phase, Glucose-minimal MOPS Media. [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR006095
- InterPro:   IPR006096
- InterPro:   IPR006097
- InterPro:   IPR014362
- InterPro:   IPR016040 [H]

Pfam domain/function: PF00208 ELFV_dehydrog; PF02812 ELFV_dehydrog_N [H]

EC number: =1.4.1.2 [H]

Molecular weight: Translated: 44560; Mature: 44428

Theoretical pI: Translated: 6.69; Mature: 6.69

Prosite motif: PS00074 GLFV_DEHYDROGENASE

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.7 %Cys     (Translated Protein)
2.6 %Met     (Translated Protein)
3.4 %Cys+Met (Translated Protein)
0.7 %Cys     (Mature Protein)
2.4 %Met     (Mature Protein)
3.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTGQEFFRDTQETIRAAVAKLGHSEGVYKILRNPRRTLEVHIAVTMPDGSVETFLGYRSQ
CCCHHHHHHHHHHHHHHHHHCCCCCCHHHHHCCCCEEEEEEEEEECCCCCHHHHHCCCCC
HAAVFGPYKGGVRFHPNVTKEEVEALAMLMTLKNAVLGLPYGGAKGGVICDPNALPPTAV
CCEEECCCCCCEEECCCCCHHHHHHHHHHHHHHHHHHCCCCCCCCCCEEECCCCCCHHHH
EQIARGYVRGLRDMIGPDTDIPAPDVNTNSRVMGWMLDEYLKCTNAIDFSVFTGKSLNLG
HHHHHHHHHHHHHHCCCCCCCCCCCCCCCCHHHHHHHHHHHHHCCCCEEEEECCCCCCCC
GIEGRTGATGLGIAYVTREACKVRGVDLKGARVAVQGFGNVGRGAAQALTALGARIVGVT
CCCCCCCCCCCHHHHHHHHHHHCCCCCCCCCEEEEECCCCCCHHHHHHHHHHHHHEEEEE
DITGGVYKEDGLDVAALTEYARDRGGVAGFPGAEPLTNEQLFALPVDVLIPAALEGQITG
ECCCCCCCCCCCCHHHHHHHHHHCCCCCCCCCCCCCCCCCEEEECHHHHHCHHHCCCCHH
KVAETIQAPIVVEGANGPTTPEGAQVLADRGIMQVPDILANGGGVTVSYFEWVQGQQGGL
HHHHHHCCCEEEECCCCCCCCCHHHHHHHCCCHHCCHHHHCCCCEEEEHHHHHCCCCCCC
RWSERTVHRRLDRYMTSAFAAVLAYSERYNVSMREAAYLFAVDRLATGMIERGWVPR
CHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHCCCCCC
>Mature Secondary Structure 
TGQEFFRDTQETIRAAVAKLGHSEGVYKILRNPRRTLEVHIAVTMPDGSVETFLGYRSQ
CCHHHHHHHHHHHHHHHHHCCCCCCHHHHHCCCCEEEEEEEEEECCCCCHHHHHCCCCC
HAAVFGPYKGGVRFHPNVTKEEVEALAMLMTLKNAVLGLPYGGAKGGVICDPNALPPTAV
CCEEECCCCCCEEECCCCCHHHHHHHHHHHHHHHHHHCCCCCCCCCCEEECCCCCCHHHH
EQIARGYVRGLRDMIGPDTDIPAPDVNTNSRVMGWMLDEYLKCTNAIDFSVFTGKSLNLG
HHHHHHHHHHHHHHCCCCCCCCCCCCCCCCHHHHHHHHHHHHHCCCCEEEEECCCCCCCC
GIEGRTGATGLGIAYVTREACKVRGVDLKGARVAVQGFGNVGRGAAQALTALGARIVGVT
CCCCCCCCCCCHHHHHHHHHHHCCCCCCCCCEEEEECCCCCCHHHHHHHHHHHHHEEEEE
DITGGVYKEDGLDVAALTEYARDRGGVAGFPGAEPLTNEQLFALPVDVLIPAALEGQITG
ECCCCCCCCCCCCHHHHHHHHHHCCCCCCCCCCCCCCCCCEEEECHHHHHCHHHCCCCHH
KVAETIQAPIVVEGANGPTTPEGAQVLADRGIMQVPDILANGGGVTVSYFEWVQGQQGGL
HHHHHHCCCEEEECCCCCCCCCHHHHHHHCCCHHCCHHHHCCCCEEEEHHHHHCCCCCCC
RWSERTVHRRLDRYMTSAFAAVLAYSERYNVSMREAAYLFAVDRLATGMIERGWVPR
CHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA