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The map label for this gene is ydgK [H]

Identifier: 51892202

GI number: 51892202

Start: 1176406

End: 1177641

Strand: Reverse

Name: ydgK [H]

Synonym: STH1064

Alternate gene names: 51892202

Gene position: 1177641-1176406 (Counterclockwise)

Preceding gene: 51892203

Following gene: 51892201

Centisome position: 33.02

GC content: 69.01

Gene sequence:

>1236_bases
ATGCAGCAAGGGTTGCTCGCCCCGCAGAAACGGCTGGGGACGGCAGGCCTCATCGCCCTGATCACCGTCCTCAACATGAC
GGCCCCGCTCTCCACCGACATGTACCTGCCGTCGTTCCCCACCATGATGGACGAGTTCGGCGTGACCGCCGGCGTCCTCA
ACCTGACCCTCGTGGGCTTCTTCTTCTTTTTTGCGGTGGGGATGCTGGTCTTCGGCCCCTTCAGCGACCGCTACGGGCGG
AAGCCGGTGCTGGTGGCCGGGCTCGGCCTGTACCTCGCCGCGTCCCTCGCCTGCGCCGGGGCCGGCTCCATCTGGCAGCT
CATCCTGTTCCGGGTCCTCCAGGCCCTGGGGGCGGGCTGCATGGTCTCGGTGTCCACGGCCCTGGTGAAGGACTGCTTCG
ACGGCCGGATGCGGGGCACCATCCTCGCCACCATCCAGTCGATGAGCGTCGTCGCGCCCATGCTGGCGCCCATCATCGGC
GCCTTCATCGTGCAGTACGCCACCTGGCGGACCACCTTCCTGATGCTGGCCGGGATCTCGCTCTGCTCGCTGACGGCGGC
GCTGCTGCTGCAGGAGCCGCTCCCGCCCGGGGCGCGCCTCCGGGGCCCGATCCTGGGCAGCCTGGGGCGGCTGTTCGTGG
TGGCCCGGAACCCGTCGTTCACCAGCCTGCTGCTGGTGGTCGCGCTGATCCCGGCCGGCTTCATGGCCTACATCTCCGTC
AGCTCGTACATCTACCAGGACTTCTTCGGCCTGTCGGAGACCGCCTACAGCCTCTTCTTCGCCACCAACGCCGGGGTCTC
TGTGCTGGGGCCCCTCACGTACATCGCGATCAACCGGAAGGTGCCGCCCCGCCTCATCATCACCGGCGCACTCGGGCTCG
CGCTCTGCGGCGGGCTGGCGGTCCTCCTCCTCGGCCGGACGGCCCCGCTGGCCTTCCTGCTCTCGTTCATTCCCTACTCC
TTCGGCTCCAGCCTGATCCGGCCGGTTTCCACCAACACCCTGCTGAGCCAGCAGGACTCCGACACCGGCTCCGCCTCGGC
GCTCATCAACTTCGGGAACACGGCGATGGGGTCGCTGGGCATGGTCCTGGCGGCGCTGCCCTGGCCTGACTTCGTCACCG
GGCTGGGCACCATCGCCGCGGGATGCGCGCTGCTGGCCCTCCTGGGGTGGGCGGTGCTGCTCCTCTCCTCCATCCCGCTG
CGGGGCATAAAGGAGGGCCTCTCCTCCGGAGACTGA

Upstream 100 bases:

>100_bases
GGTCGGCCACTGGGACAGCGCGGGCCGGCTGGTGGTGACGGAGCGCCCCGCCGACACCGTGAACCCCGATTAGCCTGAAC
ATCCGGGAGGACGACCGCGC

Downstream 100 bases:

>100_bases
TCCCGTGAAGGGAGTTGTGAACATGACCGAGTTGCCGCAGAATCCGTGTGACGTCCTCGAAGCGATCGCCCGCCGCCACA
GCGTGCGGGAGTTCCGGCCC

Product: membrane transport protein

Products: Proton [Cytoplasm]; multidrug [Periplasm] [C]

Alternate protein names: NA

Number of amino acids: Translated: 411; Mature: 411

Protein sequence:

>411_residues
MQQGLLAPQKRLGTAGLIALITVLNMTAPLSTDMYLPSFPTMMDEFGVTAGVLNLTLVGFFFFFAVGMLVFGPFSDRYGR
KPVLVAGLGLYLAASLACAGAGSIWQLILFRVLQALGAGCMVSVSTALVKDCFDGRMRGTILATIQSMSVVAPMLAPIIG
AFIVQYATWRTTFLMLAGISLCSLTAALLLQEPLPPGARLRGPILGSLGRLFVVARNPSFTSLLLVVALIPAGFMAYISV
SSYIYQDFFGLSETAYSLFFATNAGVSVLGPLTYIAINRKVPPRLIITGALGLALCGGLAVLLLGRTAPLAFLLSFIPYS
FGSSLIRPVSTNTLLSQQDSDTGSASALINFGNTAMGSLGMVLAALPWPDFVTGLGTIAAGCALLALLGWAVLLLSSIPL
RGIKEGLSSGD

Sequences:

>Translated_411_residues
MQQGLLAPQKRLGTAGLIALITVLNMTAPLSTDMYLPSFPTMMDEFGVTAGVLNLTLVGFFFFFAVGMLVFGPFSDRYGR
KPVLVAGLGLYLAASLACAGAGSIWQLILFRVLQALGAGCMVSVSTALVKDCFDGRMRGTILATIQSMSVVAPMLAPIIG
AFIVQYATWRTTFLMLAGISLCSLTAALLLQEPLPPGARLRGPILGSLGRLFVVARNPSFTSLLLVVALIPAGFMAYISV
SSYIYQDFFGLSETAYSLFFATNAGVSVLGPLTYIAINRKVPPRLIITGALGLALCGGLAVLLLGRTAPLAFLLSFIPYS
FGSSLIRPVSTNTLLSQQDSDTGSASALINFGNTAMGSLGMVLAALPWPDFVTGLGTIAAGCALLALLGWAVLLLSSIPL
RGIKEGLSSGD
>Mature_411_residues
MQQGLLAPQKRLGTAGLIALITVLNMTAPLSTDMYLPSFPTMMDEFGVTAGVLNLTLVGFFFFFAVGMLVFGPFSDRYGR
KPVLVAGLGLYLAASLACAGAGSIWQLILFRVLQALGAGCMVSVSTALVKDCFDGRMRGTILATIQSMSVVAPMLAPIIG
AFIVQYATWRTTFLMLAGISLCSLTAALLLQEPLPPGARLRGPILGSLGRLFVVARNPSFTSLLLVVALIPAGFMAYISV
SSYIYQDFFGLSETAYSLFFATNAGVSVLGPLTYIAINRKVPPRLIITGALGLALCGGLAVLLLGRTAPLAFLLSFIPYS
FGSSLIRPVSTNTLLSQQDSDTGSASALINFGNTAMGSLGMVLAALPWPDFVTGLGTIAAGCALLALLGWAVLLLSSIPL
RGIKEGLSSGD

Specific function: Involved In Sulfonamide (Sulfathiazole) And Bicyclomycin Resistance. Probable Membrane Translocase. [C]

COG id: NA

COG function: NA

Gene ontology:

Cell location: Cell membrane; Multi-pass membrane protein (Potential) [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the major facilitator superfamily. Bcr/CmlA family [H]

Homologues:

Organism=Escherichia coli, GI1788509, Length=255, Percent_Identity=29.8039215686275, Blast_Score=119, Evalue=5e-28,
Organism=Escherichia coli, GI1790146, Length=243, Percent_Identity=28.8065843621399, Blast_Score=99, Evalue=5e-22,
Organism=Escherichia coli, GI48994889, Length=229, Percent_Identity=30.1310043668122, Blast_Score=94, Evalue=1e-20,
Organism=Escherichia coli, GI1787065, Length=388, Percent_Identity=25.7731958762887, Blast_Score=81, Evalue=1e-16,
Organism=Escherichia coli, GI87082312, Length=235, Percent_Identity=27.2340425531915, Blast_Score=74, Evalue=2e-14,
Organism=Escherichia coli, GI1790794, Length=348, Percent_Identity=25.8620689655172, Blast_Score=69, Evalue=4e-13,
Organism=Saccharomyces cerevisiae, GI6324264, Length=221, Percent_Identity=27.6018099547511, Blast_Score=84, Evalue=4e-17,
Organism=Saccharomyces cerevisiae, GI6322071, Length=191, Percent_Identity=25.6544502617801, Blast_Score=69, Evalue=9e-13,
Organism=Saccharomyces cerevisiae, GI6319657, Length=165, Percent_Identity=29.6969696969697, Blast_Score=68, Evalue=2e-12,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR004812
- InterPro:   IPR020846
- InterPro:   IPR011701
- InterPro:   IPR016196 [H]

Pfam domain/function: PF07690 MFS_1 [H]

EC number: NA

Molecular weight: Translated: 42973; Mature: 42973

Theoretical pI: Translated: 9.19; Mature: 9.19

Prosite motif: PS50850 MFS

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.5 %Cys     (Translated Protein)
3.4 %Met     (Translated Protein)
4.9 %Cys+Met (Translated Protein)
1.5 %Cys     (Mature Protein)
3.4 %Met     (Mature Protein)
4.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure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HHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHCCCCC
>Mature Secondary Structure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HHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: Proton [Periplasm]; multidrug [Cytoplasm] [C]

Specific reaction: Proton [Periplasm] + multidrug [Cytoplasm] = Proton [Cytoplasm] + multidrug [Periplasm] [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 9384377; 9202461 [H]